53-59-8

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Showing 1-30 of 63 results for "53-59-8" within Papers

Tumor necrosis factor alpha -- 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants.

Curtis L Hedberg et al.

The Pediatric infectious disease journal, 23(5), 424-428 (2004-05-08)

Sepsis commonly complicates the clinical course of critically ill very low birth weight infants, with as many as 30% developing hospital-acquired bacteremia. The tumor necrosis factor alpha (TNF-alpha) -- 308 G/A single nucleotide polymorphism (SNP) is associated with adverse outcome

Increased glycosylphosphatidylinositol-anchored protein-deficient granulocytes define a benign subset of bone marrow failures in patients with trisomy 8.

Kohei Hosokawa et al.

European journal of haematology, 95(3), 230-238 (2014-11-19)

Trisomy 8 (+8), one of the most common chromosomal abnormalities found in patients with myelodysplastic syndromes (MDS), is occasionally seen in patients with otherwise typical aplastic anemia (AA). Although some studies have indicated that the presence of +8 is associated

Total synthesis of (+)-batzelladine A and (-)-batzelladine D, and identification of their target protein.

Jun Shimokawa et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 11(23), 6878-6888 (2005-09-15)

Asymmetric total synthesis of batzelladine A (1) and batzelladine D (2) has been achieved. Our synthesis of batzelladines features 1) stereoselective construction of the cyclic guanidine system by means of successive 1,3-dipolar cycloaddition reaction and subsequent cyclization, 2) direct esterification

Estrogen receptor-alpha thymidine and adenine repeat polymorphism and endothelial fibrinolytic regulation in postmenopausal women.

Greta L Hoetzer et al.

American journal of obstetrics and gynecology, 193(2), 366-370 (2005-08-16)

We hypothesized that the capacity of the endothelium to release tissue-type plasminogen activator is blunted in postmenopausal women with long (TA)(n) repeat alleles (> or = 18 repeats). Forty-two healthy postmenopausal women were studied: 10 women with short allele genotypes

Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients.

Miyako Okamoto et al.

Journal of autoimmunity, 23(3), 257-266 (2004-10-27)

Alopecia areata (AA) has been suspected to be an autoimmune disease, although there is no distinct evidence, we investigated the relationship between AA and autoantibodies against dense fine speckles 70 kDa (DFS70) in 111 patients with alopecia and 105 healthy

Phase II study of an AKT inhibitor MK2206 in patients with relapsed or refractory lymphoma.

Yasuhiro Oki et al.

British journal of haematology, 171(4), 463-470 (2015-07-28)

We conducted a phase II study of the AKT inhibitor, MK2206 in patients with relapsed or refractory lymphoma of any histology excluding Burkitt lymphoma or lymphoblastic lymphoma. MK-2206 was administered orally at 200 mg once weekly in 28-d cycles up to

HLA-DRB1 alleles in Kuwaiti children with idiopathic nephrotic syndrome.

A A Al-Eisa et al.

Pediatric nephrology (Berlin, Germany), 15(1-2), 79-81 (2000-11-30)

We have studied the effect of HLA-DRB1 alleles on the clinical presentation of 61 Kuwaiti Arab children with idiopathic nephrotic syndrome. DR7(*0701) was the most prevalent DR allele, found in 41/61 patients (67%) compared with 10/59 healthy controls (17%) (p<0.001).

MN/CA9: a potential gene marker for detection of malignant cells in effusions.

G Li et al.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 12(2), 214-220 (2007-06-01)

Many cancers cause malignant effusions. The presence of malignant cells in effusions has implications in diagnosis, tumour staging and prognosis. The detection of malignant cells currently presents a challenge for cytopathologists. New adjunctive methods are needed. Although the effusions provide

Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma--results of the UK HD3 relapse treatment strategy.

Ananth Shankar et al.

British journal of haematology, 165(4), 534-544 (2014-04-24)

The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005, 80 children with relapsed [n = 69]

Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis.

Eric Bachman et al.

The Journal of clinical endocrinology and metabolism, 95(10), 4743-4747 (2010-07-28)

The mechanisms by which testosterone increases hemoglobin and hematocrit are unknown. The aim was to test the hypothesis that testosterone-induced increase in hematocrit is associated with suppression of the iron regulatory peptide hepcidin. Healthy younger men (ages 19-35 yr; n

Point-of-care hemostasis in children with congenital heart disease, the POCHEMO study: baseline reference values of thromboelastometry and impedance aggregometry.

David Longchamp et al.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 30(5), 199-204 (2019-06-04)

: Viscoelastic tests and impedance aggregometry allow coagulation evaluation at the bedside, but reference values are scarce in pediatrics. The aim of this study was to establish reference values of thromboelastometry and impedance aggregometry for this population and compare it

Prevalence of plasmid-mediated quinolone resistance determinants QnrA, QnrB, and QnrS among clinical isolates of Enterobacter cloacae in a Taiwanese hospital.

Jiunn-Jong Wu et al.

Antimicrobial agents and chemotherapy, 51(4), 1223-1227 (2007-01-24)

The prevalence of three plasmid-mediated quinolone resistance determinants, QnrA, QnrB, and QnrS, among 526 nonreplicate clinical isolates of Enterobacter cloacae collected at a Taiwanese university hospital in 2004 was determined by PCR and colony hybridization, and the association of Qnr

LDL oxidation by platelets propagates platelet activation via an oxidative stress-mediated mechanism.

Roberto Carnevale et al.

Atherosclerosis, 237(1), 108-116 (2014-09-23)

Platelets generate oxidized LDL (ox-LDL) via NOX2-derived oxidative stress. We investigated if once generated by activated platelets ox-LDL can propagate platelet activation. Experiments were performed in platelets from healthy subjects (HS), hyper-cholesterolemic patients and patients with NOX2 hereditary deficiency. Agonist-stimulated

Characterization of equine cDNA sequences for alphaS1-, beta- and kappa-casein.

Tina Lenasi et al.

The Journal of dairy research, 70(1), 29-36 (2003-03-06)

Here we report the entire cDNA sequences for equine alphaS1-, beta- and kappa-casein. Based on interspecies comparison, nine exons were found in equine beta-casein and five in kappa-casein. In equine alphaS1-casein cDNA the exon 5 was missing, which resulted in

Mild cognitive impairment in high-risk patients with chronic atrial fibrillation: a forgotten component of clinical management?

Jocasta Ball et al.

Heart (British Cardiac Society), 99(8), 542-547 (2013-01-15)

We examined cognitive function in older hospitalised patients with chronic atrial fibrillation (AF). A prospective substudy of a multicentre randomised trial of an AF-specific disease management intervention (the Standard versus Atrial Fibrillation spEcific managemenT studY; SAFETY). Three tertiary referral hospitals

Effect of infarct severity on regional and global left ventricular remodeling in patients with successfully reperfused ST segment elevation myocardial infarction.

Rolf Symons et al.

Radiology, 274(1), 93-102 (2014-09-11)

To evaluate the relationship between myocardial infarction ( MI myocardial infarction ) severity at magnetic resonance (MR) imaging and regional and global postinfarction left ventricular ( LV left ventricular ) remodeling. This HIPAA-compliant study was institutional review board approved. In

Molecular cloning and characterization of the human xanthine dehydrogenase gene (XDH).

P Xu et al.

Genomics, 34(2), 173-180 (1996-06-01)

Xanthine dehydrogenase (XDH, EC 1.1.1.204) is a rate-limiting enzyme in the oxidative metabolism of purines and is thought to play a key role in a variety of pathophysiologic processes including ischemiasolidusreperfusion injury, viral pneumonia, and renal failure. We herein report

PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial.

Frederick J Raal et al.

Lancet (London, England), 385(9965), 331-340 (2014-10-06)

Heterozygous familial hypercholesterolaemia is characterised by low cellular uptake of LDL cholesterol, increased plasma LDL cholesterol concentrations, and premature cardiovascular disease. Despite intensive statin therapy, with or without ezetimibe, many patients are unable to achieve recommended target levels of LDL

Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia.

Kudret Tureyen et al.

Journal of neurochemistry, 105(4), 1313-1324 (2008-01-23)

Early growth response-1 (Egr1) is a sequence-specific transcription factor (TF) which is induced under hypoxic conditions. We presently report that transient middle cerebral artery occlusion (MCAO) leads to increased expression of Egr1 in the brains of adult mice and rats

The largest prospective warfarin-treated cohort supports genetic forecasting.

Mia Wadelius et al.

Blood, 113(4), 784-792 (2008-06-25)

Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496

Prevalence and spectrum of SDHx mutations in pheochromocytoma and paraganglioma in patients from Belgium: an update.

A Persu et al.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 44(5), 349-353 (2012-05-09)

Since the early 2000s, the prevalence and spectrum of mutations in genes encoding subunits of succinate dehydrogenase (SDHx) were reported in large cohorts of patients with pheochromocytoma (PC) and paraganglioma (PGL) from most Western countries. Unfortunately, in Belgium, no equivalent

Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.

Hassan Brim et al.

Molecular cancer, 7, 68-68 (2008-08-23)

We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene (V600E). Colorectal cancer (CRC) is the most common cancer in

Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice.

Sanjeev Shukla et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 19(14), 2042-2044 (2005-10-19)

Epidemiological studies suggest that increased intake of fruits and vegetables may be associated with a reduced risk of prostate cancer. Apigenin (4', 5, 7,-trihydroxyflavone), a common dietary flavonoid abundantly present in fruits and vegetables, has shown remarkable anti-proliferative effects against

BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper.

Fausto J Rodriguez et al.

Journal of neuropathology and experimental neurology, 71(9), 789-794 (2012-08-16)

Optic pathway gliomas represent a specific subtype of astrocytoma with unique clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper have been hampered by limited tissue availability. We analyzed optic nerve gliomas of 59 patients (median

Expression of UTF1 in primary and metastatic testicular germ cell tumors.

Peng Wang et al.

American journal of clinical pathology, 134(4), 604-612 (2010-09-22)

We immunohistochemically evaluated UTF1 in 104 primary and 68 metastatic testicular germ cell tumors and 339 non-germ cell tumors. The percentage of tumor cells stained was semiquantitatively scored (0, no tumor cell staining; 1+, ≤30% of cells; 2+, 31%-60% of

IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL).

I Del Giudice et al.

Leukemia, 20(7), 1231-1237 (2006-04-28)

B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases with de novo B-PLL. Immunoglobulin heavy chain genes

Colocalization of NADPH-diaphorase activity and certain neuropeptides in the esophagus of opossum (Didelphis virginiana).

J Christensen et al.

Cell and tissue research, 278(3), 557-562 (1994-12-01)

Nitric oxide and various neuropeptides in the myenteric plexus regulate esophageal motility. We sought colocalization of nitric oxide synthase and neuropeptides in frozen sections of mid-portion of smooth-muscled opossum esophagus using NADPH-diaphorase activity to mark the synthase and immunoreactivity to

Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.

Nadia Tinto et al.

PloS one, 3(4), e1870-e1870 (2008-04-03)

Maturity onset diabetes of the young type 2 (or GCK MODY) is a genetic form of diabetes mellitus provoked by mutations in the glucokinase gene (GCK). We screened the GCK gene by direct sequencing in 30 patients from South Italy

Hereditary pancreatitis: clinical features and inheritance characteristics of the R122C mutation in the cationic trypsinogen gene (PRSS1) in six Spanish families.

Gonzalo de las Heras-Castaño et al.

JOP : Journal of the pancreas, 10(3), 249-255 (2009-05-21)

Hereditary pancreatitis is an autosomal dominant disease which is caused by mutations in the PRSS1 gene. The aim of our study was to describe the penetrance and phenotype-genotype correlations of the c.346C>T (p.R122C) mutation. Case series descriptive study. Forty-one members

Resistance to acetylsalicylic acid in patients after ischemic stroke.

Marcin Zytkiewicz et al.

Polskie Archiwum Medycyny Wewnetrznej, 118(12), 727-733 (2009-02-11)

Acetylsalicylic acid (ASA) due to its antiplatelet action is used in ischemic stroke therapy. The platelet response to ASA shows an interindividual variation. Decreased platelet sensitivity to ASA is termed as resistance to ASA. The aim of the study was

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