53319

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Showing 1-30 of 197 results for "53319" within Papers

A model for the flexibility of the distal histidine in dehaloperoxidase-hemoglobin A based on X-ray crystal structures of the carbon monoxide adduct.

Junjie Zhao et al.

Biochemistry, 53(15), 2474-2482 (2014-03-29)

Dehaloperoxidase hemoglobin A (DHP A) is a multifunctional hemoglobin that appears to have evolved oxidative pathways for the degradation of xenobiotics as a protective function that complements the oxygen transport function. DHP A possesses at least two internal binding sites

Evidence that histidine forms a coordination bond to the A(0A) and A(0B) chlorophylls and a second H-bond to the A(1A) and A(1B) phylloquinones in M688H(PsaA) and M668H(PsaB) variants of Synechocystis sp. PCC 6803.

Junlei Sun et al.

Biochimica et biophysica acta, 1837(8), 1362-1375 (2014-04-22)

The axial ligands of the acceptor chlorophylls, A(0A) and A(0B), in Photosystem I are the Met sulfur atoms of M688(PsaA) and M668(PsaB). To determine the role of the Met, His variants were generated in Synechocystis sp. PCC 6803. Molecular dynamics

Subangstrom resolution X-ray structure details aquaporin-water interactions.

Urszula Kosinska Eriksson et al.

Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)

Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the

Reversible phosphorylation of histidine residues in proteins from vertebrates.

Susanne Klumpp et al.

Science signaling, 2(61), pe13-pe13 (2009-03-13)

Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory mechanisms in mammalian cells, and research focused in this area is ongoing. We are just beginning to appreciate

Tryptophan-mediated charge-resonance stabilization in the bis-Fe(IV) redox state of MauG.

Jiafeng Geng et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9639-9644 (2013-05-31)

The diheme enzyme MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor protein to generate a tryptophan tryptophylquinone cofactor. The MauG-catalyzed reaction proceeds via a bis-Fe(IV) intermediate in which one heme is present as Fe(IV)=O and the other as Fe(IV)

Antimicrobial activity and skin permeation of iodine present in an iodine-impregnated surgical incise drape.

A L Casey et al.

The Journal of antimicrobial chemotherapy, 70(8), 2255-2260 (2015-04-24)

The antimicrobial efficacy of an iodine-impregnated incise drape against MRSA was evaluated in a skin model. The permeation of iodine from this drape into the skin was also assessed. The antimicrobial efficacy was evaluated in ex vivo studies following application

His86 from the N-terminus of frataxin coordinates iron and is required for Fe-S cluster synthesis.

Leslie E Gentry et al.

Biochemistry, 52(35), 6085-6096 (2013-08-06)

Human frataxin has a vital role in the biosynthesis of iron-sulfur (Fe-S) clusters in mitochondria, and its deficiency causes the neurodegenerative disease Friedreich's ataxia. Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery

Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses.

Thanutchaporn Kumrungsee et al.

Biochimica et biophysica acta, 1840(10), 3073-3078 (2014-08-06)

Tryptophan-histidine (Trp-His) was found to suppress the activity of the Ca²⁺/calmodulin (CaM)-dependent protein kinases II (CaMKII), which requires the Ca²⁺-CaM complex for an initial activation. In this study, we attempted to clarify whether Trp-His inhibits Ca²⁺-CaM complex formation, a CaMKII

Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

Daniela Vullo et al.

Bioorganic & medicinal chemistry letters, 17(5), 1336-1340 (2006-12-19)

The mitochondrial isozymes of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VA and hCA VB, were investigated for activation with a series of amino acids and amines. D-His, L-DOPA, histamine, dopamine, and 4-(2-aminoethyl)morpholine were excellent hCA VA activators, with KAs

Kinase regulation by hydrophobic spine assembly in cancer.

Jiancheng Hu et al.

Molecular and cellular biology, 35(1), 264-276 (2014-10-29)

A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of

Viral inactivation based on inhibition of membrane fusion: understanding the role of histidine protonation to develop new viral vaccines.

A T Da Poian et al.

Protein and peptide letters, 16(7), 779-785 (2009-07-16)

Membrane fusion is an essential step in the entry of enveloped viruses into their host cells, what makes it a potentially attractive target for viral inactivation approaches. Fusion is mediated by viral surface glycoproteins that undergo conformational changes triggered by

A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation.

Yoo-Mi Kim et al.

Metabolism: clinical and experimental, 63(1), 42-49 (2013-10-22)

17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia, characterized by hypertension and sexual infantilism and caused by loss-of-function mutations in CYP17A1. This study investigated the clinical and molecular characteristics of six adults with 17α-hydroxylase/17,20-lyase deficiency and the functional

Investigation of the stabilizing effects of hydroxyethyl cellulose on LDH during freeze drying and freeze thawing cycles.

Anas Al-Hussein et al.

Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)

The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both

Study of the matrix effects and sample dilution influence on the LC-ESI-MS/MS analysis using four derivatization reagents.

Maarja-Liisa Oldekop et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 147-155 (2014-08-12)

For liquid chromatographic analysis of amino acids involving derivatization and mass-spectrometric detection, it becomes more important to evaluate the presence of matrix effects in complex samples. This is somewhat complicated for amino acid analysis where analyte free sample matrix is

Structure-dependent activity of phthalate esters and phthalate monoesters binding to human constitutive androstane receptor.

Hong Zhang et al.

Chemical research in toxicology, 28(6), 1196-1204 (2015-05-06)

The present study investigated the human constitutive androstane receptor (CAR) binding activities of 23 phthalate esters and 10 phthalate monoesters using a fast and sensitive human CAR yeast two-hybrid assay. Of 23 phthalate esters, 16 were evaluated as positive, and

Thiohistidine biosynthesis.

Florian P Seebeck

Chimia, 67(5), 333-336 (2013-07-19)

Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis

Regulation of the histidine utilization (hut) system in bacteria.

Robert A Bender

Microbiology and molecular biology reviews : MMBR, 76(3), 565-584 (2012-08-31)

The ability to degrade the amino acid histidine to ammonia, glutamate, and a one-carbon compound (formate or formamide) is a property that is widely distributed among bacteria. The four or five enzymatic steps of the pathway are highly conserved, and

A histidine aspartate ionic lock gates the iron passage in miniferritins from Mycobacterium smegmatis.

Sunanda Margrett Williams et al.

The Journal of biological chemistry, 289(16), 11042-11058 (2014-02-28)

Dps (DNA-binding protein from starved cells) are dodecameric assemblies belonging to the ferritin family that can bind DNA, carry out ferroxidation, and store iron in their shells. The ferritin-like trimeric pore harbors the channel for the entry and exit of

Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.

Xavier Brazzolotto et al.

The Biochemical journal, 460(1), 79-89 (2014-03-15)

Iron is an essential element for almost all organisms. In eukaryotes, it is mainly used in mitochondria for the biosynthesis of iron-sulfur clusters and haem group maturation. Iron is delivered into the mitochondrion by mitoferrins, members of the MCF (mitochondrial

Opening the black box: revealing the molecular basis of thyroid hormone transport.

Alexandro J Martagón et al.

Endocrinology, 154(7), 2266-2269 (2013-06-26)

Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G.

Stefan Harjes et al.

Journal of virology, 87(12), 7008-7014 (2013-04-19)

APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd), can mutate viral cDNA and restrict infectivity. We used time-resolved nuclear magnetic resonance (NMR) spectroscopy

pH sensing by FAK-His58 regulates focal adhesion remodeling.

Chang-Hoon Choi et al.

The Journal of cell biology, 202(6), 849-859 (2013-09-18)

Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial

Detection of marine microalgal biotoxins using bioassays based on functional expression of tunicate xenobiotic receptors in yeast.

Ingrid Richter et al.

Toxicon : official journal of the International Society on Toxinology, 95, 13-22 (2015-01-01)

Marine microalgae can produce biotoxins that cause widespread poisoning in marine ecosystems and may also affect human health. While established microalgal biotoxins are detectable using chemical methods, a need remains for robust, inexpensive bioassays. Ligand-binding domains (LBDs) from a tunicate

Pathogen transfer and high variability in pathogen removal by detergent wipes.

Lauren Ramm et al.

American journal of infection control, 43(7), 724-728 (2015-05-23)

The rise in health care-associated infections has placed a greater emphasis on cleaning and disinfection practices. The majority of policies advocate using detergent-based products for routine cleaning, with detergent wipes increasingly being used; however, there is no information about their

Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8).

Doreen Braun et al.

Endocrinology, 154(7), 2553-2561 (2013-04-18)

Mutations in monocarboxylate transporter 8 (MCT8; SLC16A2) cause the Allan-Herndon-Dudley syndrome, a severe X-linked psychomotor retardation syndrome. MCT8 belongs to the major facilitator superfamily of 12 transmembrane-spanning proteins and transports thyroid hormones across the blood-brain barrier and into neurons. How

Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.

Chiheng Chu et al.

Environmental science & technology, 49(9), 5511-5519 (2015-04-02)

Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, their indirect photolysis in the presence of chromophoric dissolved organic matter (CDOM) is poorly

Cytoprotection by endogenous zinc in the vertebrate retina.

Ivan Anastassov et al.

Journal of neurochemistry, 129(2), 249-255 (2013-11-30)

Our recent studies have shown that endogenous zinc, co-released with glutamate from the synaptic terminals of vertebrate retinal photoreceptors, provides a feedback mechanism that reduces calcium entry and the concomitant vesicular release of glutamate. We hypothesized that zinc feedback may

Ultrasonication as a potential tool to predict solute crystallization in freeze-concentrates.

Vishard Ragoonanan et al.

Pharmaceutical research, 31(6), 1512-1524 (2014-01-09)

We hypothesize that ultrasonication can accelerate solute crystallization in freeze-concentrates. Our objective is to demonstrate ultrasonication as a potential predictive tool for evaluating physical stability of excipients in frozen solutions. The crystallization tendencies of lyoprotectants (trehalose, sucrose), carboxylic acid buffers

Standardized ileal digestibility of amino acids in eight genotypes of soft winter wheat fed to growing pigs.

P Rosenfelder et al.

Journal of animal science, 93(3), 1133-1144 (2015-05-29)

A study with growing pigs was conducted to determine the chemical composition and standardized ileal digestibility (SID) of CP and AA of 8 wheat genotypes that have recently been added to the German Descriptive Variety List. These genotypes included Tabasco

The third intracellular loop plays a critical role in bitter taste receptor activation.

Sai Prasad Pydi et al.

Biochimica et biophysica acta, 1838(1 Pt B), 231-236 (2013-09-03)

Bitter taste receptors (T2Rs) belong to the superfamily of G protein-coupled receptors (GPCRs). T2Rs are chemosensory receptors with important therapeutic potential. In humans, bitter taste is perceived by 25 T2Rs, which are distinct from the well-studied Class A GPCRs. The

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