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Showing 1-30 of 227 results for "537594" within Papers
Jason Tchao et al.
Scientific reports, 4, 6614-6614 (2014-10-15)
Cellular cardiomyoplasty has emerged as a novel therapy to restore contractile function of injured failing myocardium. Human multipotent muscle derived stem cells (MDSC) can be a potential abundant, autologous cell source for cardiac repair. However, robust conditions for cardiomyocyte (CM)
Chin-An Yang et al.
Rheumatology (Oxford, England), 54(2), 324-331 (2014-08-28)
SLE is more prevalent in females, but may cause more severe organ damage in males. The underlying mechanism is incompletely understood. Since macrophage plays a key role in SLE pathogenesis, the present work aimed to investigate whether inflammasomes in male
Charles E Wood et al.
Physiological genomics, 46(14), 523-532 (2014-05-16)
Estradiol (E2) is a well-known modulator of fetal neuroendocrine activity and has been proposed as a critical endocrine signal readying the fetus for birth and postnatal life. To investigate the modulatory role of E2 on fetal stress responsiveness and the
Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Sara Yousef et al.
Journal of translational medicine, 13, 197-197 (2015-06-20)
Most patients with multiple myeloma (MM) will relapse after an initial response and eventually succumb to their disease. This is due to the persistence of chemotherapy-resistant tumor cells in the patients' bone marrow (BM) and immunotherapeutic approaches could contribute to
F Paradis et al.
Journal of animal science, 93(7), 3331-3341 (2015-10-07)
In beef cattle, production feedstuffs are the largest variable input cost. Beef cattle also have a large carbon footprint, raising concern about their environmental impact. Unfortunately, only a small proportion of dietary energy is directed toward protein deposition and muscle
Anna E Kowalczyk et al.
International journal of oncology, 47(3), 951-962 (2015-07-03)
Pleomorphic adenoma gene-like 1 gene (PLAGL1) encodes a zinc-finger nuclear transcription factor which promotes apoptosis and cell cycle arrest. Loss or downregulation of its expression has been observed in various human neoplasms. This study compared PLAGL1 expression in colorectal cancer
Luciana N García et al.
Experimental biology and medicine (Maywood, N.J.), 240(7), 904-916 (2014-12-17)
Atopic asthma is a chronic allergic disease that involves T-helper type 2 (Th2)-inflammation and airway remodeling. Bronchiolar club cells (CC) and alveolar macrophages (AM) are sentinel cells of airway barrier against inhaled injuries, where allergy induces mucous metaplasia of CC
Claudia Cattoglio et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), E2317-E2326 (2015-04-23)
The embryonic stem cell (ESC) state is transcriptionally controlled by OCT4, SOX2, and NANOG with cofactors, chromatin regulators, noncoding RNAs, and other effectors of signaling pathways. Uncovering components of these regulatory circuits and their interplay provides the knowledge base to
Julia S Westman et al.
The Journal of biological chemistry, 290(30), 18505-18518 (2015-06-10)
The x2 glycosphingolipid is expressed on erythrocytes from individuals of all common blood group phenotypes and elevated on cells of the rare P/P1/P(k)-negative p blood group phenotype. Globoside or P antigen is synthesized by UDP-N-acetylgalactosamine:globotriaosyl-ceramide 3-β-N-acetylgalactosaminyltransferase encoded by B3GALNT1. It
Hiroshi Ono et al.
Cancer medicine, 3(3), 632-642 (2014-03-05)
Small-cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. To identify accurate predictive biomarkers and effective therapeutic modalities, we focus on a long noncoding RNA, Hox transcript antisense intergenic RNA (HOTAIR), and investigated its expression, cellular
Olusegun O Onabajo et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(11), 888-900 (2015-07-03)
Interferon lambda 4 (IFN-λ4) is a novel type-III interferon that can be generated only in individuals carrying a ΔG frame-shift allele of an exonic genetic variant (rs368234815-ΔG/TT). The rs368234815-ΔG allele is strongly associated with decreased clearance of hepatitis C virus
Jennie Lin et al.
American journal of physiology. Renal physiology, 309(11), F901-F913 (2015-09-25)
Long noncoding RNAs (lncRNAs) are emerging as key species-specific regulators of cellular and disease processes. To identify potential lncRNAs relevant to acute and chronic renal epithelial injury, we performed unbiased whole transcriptome profiling of human proximal tubular epithelial cells (PTECs)
Sandrine Obba et al.
Autophagy, 11(7), 1114-1129 (2015-06-02)
Autophagy is induced during differentiation of human monocytes into macrophages that is mediated by CSF1/CSF-1/M-CSF (colony stimulating factor 1 [macrophage]). However, little is known about the molecular mechanisms that link CSF1 receptor engagement to the induction of autophagy. Here we
Vassiliki Saloura et al.
Molecular cancer research : MCR, 13(2), 293-304 (2014-10-05)
Squamous cell carcinoma of the head and neck (SCCHN) is a relatively common malignancy with suboptimal long-term prognosis, thus new treatment strategies are urgently needed. Over the last decade, histone methyltransferases (HMT) have been recognized as promising targets for cancer
R N Daggett et al.
The British journal of dermatology, 171(4), 722-731 (2014-04-15)
Mycosis fungoides (MF) classically presents from patch stage to plaque stage over a number of years and finally progresses to tumour stage with nodal or visceral involvement. The mechanism of progression remains incompletely elucidated. Chemokines and their receptors are known
Michela Sabbatucci et al.
Retrovirology, 12, 4-4 (2015-01-23)
Macrophages are key targets of HIV-1 infection. We have previously described that the expression of CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by HIV-1 exposure. Moreover, CCL2 acts as an autocrine
Atsushi Shiozaki et al.
World journal of gastroenterology, 20(22), 6844-6859 (2014-06-20)
To investigate the role of Na(+)/K(+)/2Cl(-) cotransporter 1 (NKCC1) in the regulation of genes involved in cell cycle progression and the clinicopathological significance of its expression in esophageal squamous cell carcinoma (ESCC). An immunohistochemical analysis was performed on 68 primary
Yoshitaka Kawanishi et al.
Arthritis research & therapy, 16(6), 488-488 (2014-11-29)
The important functions of the meniscus are shock absorption, passive stabilization and load transmission of the knee. Because of the avascularity of two-thirds of the meniscal center region, the treatment of tears in this area is hard. Recently, microRNAs have
Kei Sato et al.
Scientific reports, 5, 14040-14040 (2015-09-15)
During 2001-2002 and 2008-2011, two epidemic outbreaks of infectious hemorrhagic disease have been found in Japanese macaques (Macaca fuscata) in Kyoto University Primate Research Institute, Japan. Following investigations revealed that the causative agent was simian retrovirus type 4 (SRV-4). SRV-4
Sébastien Toffoli et al.
Breast cancer research : BCR, 16(6), 466-466 (2014-11-25)
Triple Negative Breast Cancers (TNBC) represent about 12% to 20% of all breast cancers (BC) and have a worse outcome compared to other BC subtypes. TNBC often show a deficiency in DNA double-strand break repair mechanisms. This is generally related
Hideki Tagashira et al.
PloS one, 10(6), e0128678-e0128678 (2015-06-02)
Melanogenesis is the physiological process by which melanin is synthesized to protect the skin from UV damage. While paracrine interactions between keratinocytes and melanocytes are crucial for regulating epidermal pigmentation, the endothelin (EDN)-endothelin B-receptor (EDNRB) interaction is one of the
Cornelia Podjaski et al.
Brain : a journal of neurology, 138(Pt 6), 1598-1612 (2015-04-24)
Blood-brain barrier function is driven by the influence of astrocyte-secreted factors. During neuroinflammatory responses the blood-brain barrier is compromised resulting in central nervous system damage and exacerbated pathology. Here, we identified endothelial netrin 1 induction as a vascular response to
Megan Melland-Smith et al.
Autophagy, 11(4), 653-669 (2015-04-09)
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress
Lorena Barrientos et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5689-5698 (2014-10-24)
Polymorphonuclear neutrophils (PMN) play a central role in inflammation and participate in its control, notably by modulating dendritic cell (DC) functions via soluble mediators or cell-cell contacts. Neutrophil extracellular traps (NETs) released by PMN could play a role in this
D Timothy Anstine et al.
Monatshefte fur chemie, 145(7), 1117-1135 (2014-08-12)
Three new linear pentapyrrole rubinoid analogs: 2,3,7,8,17,18,22,23-octamethyl-12,13-bis-(2-carboxyethyl)-1,10,15,24,25,27,28,29-octahydro-27H-pentapyrrin-1,24-dione and 2,3,8,12,13,17,22,23-octamethyl-7,18-bis-(2-carboxyethyl)-1,10,15,24,25,26,27,28,29-octahydro-27H-pentapyrrin-1,24-dione, and its 7,18-dihexanoic acid analog were synthesized, respectively, from 2,3,7,8-tetramethyl-(10H)-dipyrrin-2-one, from 2,3,8-trimethyl-7-[2-(methoxycarbonyl)ethyl]-(10H)-dipyrrinone, and 2,3,8-trimethyl-7-[5-(methoxycarbonyl)pentyl]-(10H)-dipyrrinone. 13C NMR and 1H NMR measurements in (CD3)2SO confirmed the pentapyrrole structures, while 1H NMR data indicate
Hong Xie et al.
Oncotarget, 5(20), 10048-10057 (2014-10-11)
Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis. The regulatory mechanism and clinical significance underlying cancer-specific TERT expression have been extensively investigated in various human malignancies, but little is known about these in Merkel
Peyman Akbari et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(6), 2414-2429 (2014-02-27)
Disintegration of the colonic epithelial barrier is considered a key event in the initiation and progression of inflammatory bowel and celiac disease. As the primary etiology of these diseases remains unknown, we hypothesized that the trichothecene deoxynivalenol (DON), a fungal
M D Jansson et al.
Oncogene, 34(15), 1908-1918 (2014-06-03)
MicroRNAs (miRNAs) regulate many key cancer-relevant pathways and may themselves possess oncogenic or tumor-suppressor functions. Consequently, miRNA dysregulation has been shown to be a prominent feature in many human cancers. The p53 tumor suppressor acts as a negative regulator of
Jordan M Spatz et al.
The Journal of biological chemistry, 290(27), 16744-16758 (2015-05-09)
Although bone responds to its mechanical environment, the cellular and molecular mechanisms underlying the response of the skeleton to mechanical unloading are not completely understood. Osteocytes are the most abundant but least understood cells in bones and are thought to
Yang Zhang et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(10), 2019-2026 (2014-08-03)
To evaluate the relationship between methylation status of blood leukocyte DNA and risk of gastric cancer, a population-based study was conducted in Linqu County. Methylation levels of IGFII and N33 were determined by quantitative methylation-specific PCR. The temporal trend of
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