CN
Search Within
553468
Applied Filters:
Keyword:'553468'
Showing 1-30 of 1307 results for "553468" within Papers
Waldemar Hauf et al.
Applied and environmental microbiology, 81(13), 4411-4422 (2015-04-26)
Cyanobacteria are photoautotrophic microorganisms which fix atmospheric carbon dioxide via the Calvin-Benson cycle to produce carbon backbones for primary metabolism. Fixed carbon can also be stored as intracellular glycogen, and in some cyanobacterial species like Synechocystis sp. strain PCC 6803
Sixian Liang et al.
Oncotarget, 6(2), 1020-1030 (2014-12-30)
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer for which there is no effective treatment. Previously, we and others demonstrated that CXCR4 surface expression is an independent prognostic factor for disease relapse and survival in breast cancer.
Gareth W Fearnley et al.
Biology open, 4(6), 731-742 (2015-04-26)
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unclear. Here we evaluated two different VEGF-A isoforms and
M Cristina Antal et al.
PloS one, 10(8), e0135710-e0135710 (2015-08-14)
Reelin, an extracellular glycoprotein is essential for migration and correct positioning of neurons during development. Since the olfactory system is known as a source of various migrating neuronal cells, we studied Reelin expression in the two chemosensory olfactory systems, main
Swastik De et al.
The Journal of biological chemistry, 290(47), 28402-28415 (2015-09-30)
Bacterial pore-forming toxins (PFTs) are structurally diverse pathogen-secreted proteins that form cell-damaging channels in the membranes of host cells. Most PFTs are released as water-soluble monomers that first oligomerize on the membrane before inserting a transmembrane channel. To modulate specificity
Martina Blank et al.
Neuroscience letters, 594, 76-81 (2015-04-04)
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days
Babak Baban et al.
PloS one, 10(4), e0124059-e0124059 (2015-04-23)
Programmed Death-1 (PD-1) and its ligand, PD-L1, are regulators of immune/ inflammatory mechanisms. We explored the potential involvement of PD-1/PD-L1 pathway in the inflammatory response and tissue damage in cardiac injury models. Ischemic-reperfused and cryoinjured hearts were processed for flow
Alessio Travaglia et al.
ACS chemical neuroscience, 6(8), 1379-1392 (2015-05-06)
Ever since the discovery of its neurite growth promoting activity in sympathetic and sensory ganglia, nerve growth factor (NGF) became the prototype of the large family of neurotrophins. The use of primary cultures and clonal cell lines has revealed several
Jeong Nam Kim et al.
Applied and environmental microbiology, 81(15), 5015-5025 (2015-05-17)
In the dental caries pathogen Streptococcus mutans, phosphotransacetylase (Pta) catalyzes the conversion of acetyl coenzyme A (acetyl-CoA) to acetyl phosphate (AcP), which can be converted to acetate by acetate kinase (Ack), with the concomitant generation of ATP. A ΔackA mutant
Antonella Spagnoletti et al.
Molecular and cellular endocrinology, 412, 56-64 (2015-06-02)
Bisphenol A (BPA) and para-Nonylphenol (p-NP) are chemicals of industrial origin which may influence human reproductive health. The effects of these substances in the prenatal life is an important topic that is receiving greater attention in the developed countries. In
Zhimin Gu et al.
Cancer research, 75(11), 2211-2221 (2015-04-10)
Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells
Astri J Meen et al.
Glycoconjugate journal, 32(9), 703-714 (2015-09-24)
Proteoglycans have been implicated in regulation of lipoprotein metabolism. However, the impact of serglycin, the major proteoglycan expressed by many hematopoietic- and endothelial cells, on lipoprotein metabolism has not been explored. Here we addressed this issue by comparing several parameters
Hala E Hussein et al.
Parasites & vectors, 8, 618-618 (2015-12-03)
Ticks are blood-feeding arthropods that can affect human and animal health both directly by blood-feeding and indirectly by transmitting pathogens. The cattle tick Rhipicephalus (Boophilus) microplus is one of the most economically important ectoparasites of bovines worldwide and it is
Andrei V Chernov et al.
The Journal of biological chemistry, 290(18), 11771-11784 (2015-03-21)
To shed light on the early immune response processes in severed peripheral nerves, we performed genome-wide transcriptional profiling and bioinformatics analyses of the proximal (P, regenerating) and distal (D, degenerating) nerve stumps on day 1 in the sciatic nerve axotomy
Toshiyuki Matsunaga et al.
Biological & pharmaceutical bulletin, 38(9), 1309-1319 (2015-09-04)
Doxorubicin (DOX) is widely used for the treatment of a wide range of cancers such as breast and lung cancers, and malignant lymphomas, but is generally less efficacious in gastrointestinal cancers. The most accepted explanation for the DOX refractoriness is
Ming-Hsuan Ou-Yang et al.
Neurobiology of aging, 36(2), 801-811 (2014-12-03)
Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity
Z Molnár et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(10), 575-581 (2014-07-24)
The extracellular ion milieu determines the exocytosis mechanism that is coupled to spontaneous electrical activity. The K(+) ion plays crucial role in this mechanism: as the potassium current is associated with membrane hyperpolarization and hormone release through protein cascade activation.
Tieying Shan et al.
International journal of clinical and experimental pathology, 8(8), 8948-8957 (2015-10-16)
Recent studies have shown that angiotensin II (Ang II) or angiotensin-(1-7) [Ang-(1-7)] has effect on the proliferation and activation of a variety of cells, however, the exact mechanisms that the role of Ang II or Ang-(1-7) in human endometrial stromal
Tu'uhevaha J Kaitu'u-Lino et al.
Pregnancy hypertension, 5(4), 294-297 (2015-11-26)
There is recent interest for uniform placental collection protocols so laboratories can share samples. However, concerns have been raised a wash step at collection causes significant loss of sFlt-1 and soluble endoglin, among the most studied proteins in placentology. We
Jinbo Song et al.
Journal of economic entomology, 108(4), 1961-1971 (2015-10-16)
Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of
Toshitsugu Fujita et al.
PloS one, 10(1), e0116579-e0116579 (2015-01-22)
Accumulating evidence suggests that Pax5 plays essential roles in B cell lineage commitment. However, molecular mechanisms of B cell-specific expression of Pax5 are not fully understood. Here, we applied insertional chromatin immunoprecipitation (iChIP) combined with stable isotope labeling using amino
Stuart H Friess et al.
Journal of neurotrauma, 32(11), 791-800 (2015-01-06)
Reduction and avoidance of increases in intracranial pressure (ICP) after severe traumatic brain injury (TBI) continue to be the mainstays of treatment. Traumatic axonal injury is a major contributor to morbidity after TBI, but it remains unclear whether elevations in
Jye-Lin Hsu et al.
PLoS pathogens, 11(4), e1004811-e1004811 (2015-04-16)
Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I
Michael M Zeineh et al.
Neurobiology of aging, 36(9), 2483-2500 (2015-07-21)
Although amyloid plaques and neurofibrillary pathology play important roles in Alzheimer disease (AD), our understanding of AD is incomplete, and the contribution of microglia and iron to neurodegeneration is unknown. High-field magnetic resonance imaging (MRI) is exquisitely sensitive to microscopic
Mervi T Hyvönen et al.
ACS chemical biology, 10(6), 1417-1424 (2015-02-18)
Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion of a specific Lys to hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine]. Deoxyhypusine synthase (DHS) is the rate-limiting enzyme of this two-step process, and the polyamine spermidine
J Evans et al.
Human reproduction (Oxford, England), 30(5), 1029-1038 (2015-03-07)
What is the in situ localization and function of hyperglycosylated hCG (hCG-H) in first trimester pregnancy tissues? HCG-H localizes to the syncytiotrophoblast, cytotrophoblast and invasive extravillous trophoblast within the maternal decidua and promotes invasion during the first trimester of pregnancy.
Sara J Henderson et al.
Thrombosis and haemostasis, 113(6), 1278-1288 (2015-03-20)
Zinc circulates free in plasma at a concentration of 0.1-2 µM, but its levels increase locally when it is released from activated platelets. Although zinc influences many processes in haemostasis, its effect on fibrinolysis has not been thoroughly investigated. Using
Julia Marschallinger et al.
Nature communications, 6, 8466-8466 (2015-10-28)
As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood-brain barrier and altered neuronal activity
Yali Zhang et al.
Nanoscale, 7(45), 19207-19221 (2015-11-04)
The hierarchical microstructure, surface and interface of biomaterials are important factors influencing their bioactivity. Porous bioceramic scaffolds have been widely used for bone tissue engineering by optimizing their chemical composition and large-pore structure. However, the surface and interface of struts
Hongwei Liu et al.
Molecular medicine reports, 12(2), 2495-2502 (2015-05-09)
Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia-reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen-rich saline (HRS) has a neuroprotective effect on retinal
Page 1 of 44