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Showing 1-30 of 200 results for "56-40-6" within Papers
Sandip B Bharate et al.
Bioorganic & medicinal chemistry, 16(15), 7167-7176 (2008-07-16)
In the present article, we have synthesized three different series of pyrazolo[3,4-b]pyridines and their structural analogues using novel synthetic strategy involving one-pot condensation of 5,6-dihydro-4H-pyran-3-carbaldehyde/2-formyl-3,4,6-tri-O-methyl-D-glucal/chromone-3-carbaldehyde with heteroaromatic amines. All synthesized compounds were evaluated for their anti-inflammatory activity against TNF-alpha and
Lei Jiang et al.
American journal of clinical pathology, 131(5), 738-743 (2009-04-17)
Growth arrest-specific gene 6 (GAS6) encodes a vitamin K-dependent protein that regulates inflammation, angiogenesis, and atherosclerotic plaque formation. The level of GAS6 expression is associated with plaque stability and stroke. We explored the role of GAS6 in cardiovascular disease, particularly
Koji Tsuta et al.
Pathology, research and practice, 208(8), 470-474 (2012-07-10)
The majority of neuroendocrine carcinomas (NECs) express somatostatin (SST) receptors (SSTRs). However, the expression of all 5 SSTR subtypes in pulmonary NECs has not been reported. We performed immunohistochemical analysis of all 5 SSTR subtypes (including the SSTR2A and 2B
Sharon Nofech-Mozes et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1147-1155 (2008-06-24)
To update the data on the expression of 'mesothelioma markers' by serous carcinomas of various sites we have studied cases from ovary (n=56), endometrium (n=37), fallopian tube (n=6), primary peritoneum (n=5) and cervix (n=3) using a panel of antibodies (WT1
R Eichner et al.
The Journal of cell biology, 98(4), 1388-1396 (1984-04-01)
Human epidermal keratinocytes express under various growth conditions a total of at least nine keratins that can be divided into two subfamilies. Subfamily A comprises 40-, 46-, 48-, 50-/50'-, and 56.5-kilodalton (kd) keratins which are relatively acidic (pI less than
Roy Fleischmann et al.
Rheumatology (Oxford, England), 53(12), 2167-2174 (2014-02-11)
The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor) in combination with febuxostat (xanthine oxidase inhibitor) in patients with gout. This study was a phase IB, multicentre
Kui Zeng et al.
Journal of photochemistry and photobiology. B, Biology, 72(1-3), 95-100 (2003-12-04)
The effect of the photosensitizer riboflavin (0, 10, 25, 50, 100 microM) and a river humic acid (0, 20, 40, 80 ppm) on the photolysis of 6-aminochrysene (6AC) in 10 mM PBS solution (pH 7.0) was studied. The presence of
Betty Gardie et al.
Journal of medical genetics, 48(4), 226-234 (2011-03-15)
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant disorder predisposing humans to cutaneous and uterine leiomyomas; in 20% of affected families, type 2 papillary renal cell cancers (PRCCII) also occur with aggressive course and poor prognosis. HLRCC
S C Mitchell et al.
Xenobiotica; the fate of foreign compounds in biological systems, 12(2), 93-99 (1982-02-01)
1. The metabolism and elimination of benzanilide and salicylanilide in rats were compared. 2. For both compounds, greater than 70% dose was excreted in urine with 20% in faeces, in 3 days. 3. With [14C]benzanilide and [14C]salicylanilide, 40% and 35%
P Przybyłowski et al.
Transplantation proceedings, 46(8), 2860-2863 (2014-11-09)
YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction and expressed in macrophages in the earliest lesions of atherosclerosis. Elevated serum YKL-40 levels are independently associated with the presence and extent of coronary artery disease and cardiovascular mortality. Because there
Tayfun Güngör et al.
Lancet (London, England), 383(9915), 436-448 (2013-10-29)
In chronic granulomatous disease allogeneic haemopoietic stem-cell transplantation (HSCT) in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease (GVHD), and transplant-related mortality. We examined the effect of a reduced-intensity conditioning regimen designed to
J D Quigley et al.
Journal of dairy science, 102(9), 8074-8091 (2019-07-22)
The objective of this research was to determine if form of calf starter (CS) and addition of a fatty acid blend (FA) influenced intake, growth, digestion, and indices of immune status and stress in calves from 0 to 4 mo
Junsong Li et al.
Se pu = Chinese journal of chromatography, 28(4), 402-407 (2010-08-18)
A method for the simultaneous determination of berberine, palmatine, jatrorrhizine, magnoflorine and coptisine from Rhizoma Coptidis samples based on the nonaqueous capillary electrophoresis (NACE) mode has been developed. The effects of several important factors, such as nonaqueous solvents, running buffer
Taro Aoki et al.
European journal of pharmacology, 444(1-2), 107-113 (2002-08-23)
The triglyceride-lowering effect of pitavastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, was investigated in a rat model of postprandial lipemia. Plasma triglyceride levels started to increase 4 h after the fat load, reached the maximum at 6 h and
S O Peters et al.
Experimental hematology, 23(5), 461-469 (1995-05-01)
Stimulatory cytokines may induce murine hematopoietic progenitor cells (HPCs) to survive, self-renew, proliferate, or differentiate. We studied the role of active cell cycling induced by the cytokines interleukin-3 (IL-3), IL-6, IL-11, and Steel factor (SF) on murine progenitor cell frequency
Li Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(8), 1411-1416 (2006-05-09)
Genotype/phenotype analysis with human hepatocytes has identified a new inactive CYP2D6 allele, CYP2D6*56. Cryopreserved human hepatocytes from 51 livers were evaluated for CYP2D6 activity with dextromethorphan as the probe substrate. Hepatocyte lots that lacked CYP2D6 activity were further evaluated for
Pietro Di Pasquale et al.
Scandinavian cardiovascular journal : SCJ, 38(2), 93-97 (2004-06-19)
The ACE-D allele has been associated with cardiovascular disease. The study evaluates the relationship between the ACE-ID genotypes and diastolic function in healthy subjects after 6 years of follow-up. Two hundred and seventy-five healthy volunteers aged 25-55 years had normal
G N Frerichs et al.
The Journal of general virology, 77 ( Pt 9), 2067-2071 (1996-09-01)
A virus causing a vacuolating encephalopathy and retinopathy in juvenile sea bass, Dicentrarchus labrax, was isolated from brain tissue in a fish cell line (SSN-1) derived from striped snakehead, Channa striatus. The isometric, non-enveloped, 30 nm diameter virus particles were
Ana Raquel Azevedo et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(12), 1472-1482 (2014-04-11)
The aim of the present study was to use fluorescence in situ hybridization to analyze the chromosome status of zygotes with a single pronucleus from in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment cycles. In addition, we performed
Yuta Aoyama et al.
Zebrafish, 12(4), 288-295 (2015-05-06)
The zebrafish (Danio rerio) has become a powerful model organism for studying developmental processes and genetic diseases. However, there remain several problems in previous rearing methods. In this study, we demonstrate a novel method for rearing zebrafish larvae by using
S A Sheweita et al.
Drug metabolism letters, 6(1), 2-6 (2012-03-01)
Xenobiotics such as insecticides are metabolized to more or less toxic metabolites by drug-metabolizing enzymes including cytochrome P450 (Cyp P450), cytochrome b5 (Cyp b5), NADPH-cytochrome c reductase (Cyt.c R), N-nitrosdimethylamine-N-demethylase I (NDMA-dI), glutathione (GSH), glutathione s-transferase (GST), and glutathione reductase
Jessica S Fortin et al.
Bioorganic & medicinal chemistry, 16(15), 7477-7488 (2008-06-27)
Recently, a subset of N-phenyl-N'-(2-chloroethyl)ureas (CEU) was found abrogating the nuclear translocation of thioredoxin-1 and arresting the cell cycle in G(0)/G(1) phase. Several derivatives were prepared to assess their effect on cell cycle progression and on the intracellular location of
L H Cavallari et al.
Clinical pharmacology and therapeutics, 87(4), 459-464 (2010-01-15)
The objective of this study was to determine whether, in African-American patients, additional vitamin K oxidoreductase complex subunit 1 (VKORC1), cytochrome P450 2C9 (CYP2C9), CYP4F2, or apolipoprotein E (APOE) polymorphisms contribute to variability in the warfarin maintenance dose beyond what
Jianguo Ji et al.
Journal of medicinal chemistry, 50(22), 5493-5508 (2007-10-13)
A series of novel, potent neuronal nicotinic acetylcholine receptor (nAChR) ligands derived from 3,6-diazabicyclo[3.2.0]heptane have been synthesized and evaluated for binding affinity and agonist activity at the alpha4beta2 nAChR subtype. Structure-activity relationship studies of these novel nAChR ligands focused on
G S M Kiruba et al.
The Journal of organic chemistry, 68(7), 2874-2881 (2003-03-29)
The tautomeric equilibria of a series of 3-hydroxypyridine derivatives including pyridoxal-5'-phosphate (PLP), the active form of vitamin B(6), have been studied using density functional calculations (B3LYP/6-311+G//B3LYP/6-31G) in the gas phase and in different solvents. Three different approaches, namely continuum, discrete
Jerzy Kaleczyc et al.
Journal of anatomy, 239(3), 720-731 (2021-05-11)
The present study investigated the influence of castration performed at neonatal age on neuronal elements in the intramural ganglia of the urinary bladder trigone (UBT) in male pigs using double-labeling immunohistochemistry. The ganglia were examined in intact (IP) 7-day-old (castration
K Katagiri et al.
European journal of biochemistry, 176(1), 81-87 (1988-09-01)
A plasminogen activator inhibitor (PAI) was purified from bovine endothelial cell conditioned medium by a simple procedure in the absence of protein denaturant. The yield was 2.2 mg from 1.61 conditioned medium in a typical experiment. The purified inhibitor showed
Chikahiko Numakura et al.
Journal of the neurological sciences, 210(1-2), 61-64 (2003-05-09)
Charcot-Marie-Tooth disease type 1 (CMT1) is a heterogeneous disorder. Most CMT1 patients are associated with a duplication of 17p11.2-p12 (CMT1A duplication), but a small number of patients have mutations of peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ), connexin
Mohammad Hossein Habibi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 104, 197-202 (2012-12-26)
Zinc zirconate (ZnZrO(3)) (ZZ), zinc oxide (ZnO) (ZO) and zirconium oxide (ZrO(2)) (ZRO) nano-particles were synthesized by simple sol-gel method. ZZ, ZO and ZRO nano-particles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and UV-Vis diffuse reflectance spectrum
Tjerk J H Bueters et al.
European journal of pharmacology, 454(2-3), 177-182 (2002-11-08)
The objective of the present study was to characterize the adenosine A(1) receptor allosteric enhancing and antagonistic actions of (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(3,4-dichlorophenyl)methanone (LUF 5484) and (2-amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone (PD 81,723) on striatal acetylcholine release. Upon local administration in conscious rats, LUF 5484 or PD
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