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Showing 1-30 of 357 results for "56480" within Papers
Yonghui Ding et al.
Acta biomaterialia, 15, 150-163 (2014-12-30)
A wide variety of environmental cues provided by the extracellular matrix, including biophysical and biochemical cues, are responsible for vascular cell behavior and function. In particular, substrate topography and surface chemistry have been shown to regulate blood and vascular compatibility
Yingying Geng et al.
Talanta, 89, 189-194 (2012-01-31)
Hydrophilic carbon-functionalized magnetic microspheres coated with chitosan (Fe(3)O(4)@C@CHI) were synthesized for the first time. The hydrophilic carbonaceous layer on the Fe(3)O(4) microspheres was formed by the hydrothermal reaction of Fe(3)O(4) microspheres and glucose, and then chitosan was coated on surface
Mi Lan Kang et al.
Biomaterials, 35(37), 9984-9994 (2014-09-23)
We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the selective differentiation of mesenchymal stem cells (MSCs) into chondrocytes, was conjugated with low-molecular-weight chitosan (LMWCS) and medium-molecular-weight
Ruei-Zeng Lin et al.
Tissue engineering. Part C, Methods, 21(3), 274-283 (2014-08-06)
Endothelial colony-forming cells (ECFCs) are endothelial progenitors that circulate in peripheral blood and are currently the subject of intensive investigation due to their therapeutic potential. However, in adults, ECFCs comprise a very small subset among circulating cells, which makes their
Ju-Hwan Park et al.
Colloids and surfaces. B, Biointerfaces, 121, 380-387 (2014-07-06)
Doxorubicin (DOX)-loaded nanoparticles (NPs) based on interconnected hyaluronic acid-ceramide (HACE) structure were fabricated and their anti-tumor efficacy was evaluated in vitro. Interconnected HACE was synthesized by cross-linking HACE with adipic acid dihydrazide (ADH) and its synthesis was identified by (1)H
Wen Jen Lin et al.
Carbohydrate polymers, 120, 7-14 (2015-02-11)
The aim of this study was to develop hepatocyte-targeting non-viral polymeric nono-carriers for gene delivery. Chitosan was selected as the main polymer. An asialoglycoprotein receptor recognized sugar, galactose, was introduced. The methoxy poly(ethylene glycol) (mPEG) or short chain poly(ethylene glycol)
Rammohan Devulapally et al.
ACS nano, 9(3), 2290-2302 (2015-02-06)
The current study shows the therapeutic outcome achieved in triple negative breast cancer (TNBC) by simultaneously antagonizing miR-21-induced antiapoptosis and miR-10b-induced metastasis, using antisense-miR-21-PS and antisense-miR-10b-PS delivered by polymer nanoparticles (NPs). We synthesized the antisense-miR-21 and antisense-miR-10b loaded PLGA-b-PEG polymer
Suresh Gadde et al.
Advanced healthcare materials, 3(9), 1448-1456 (2014-03-25)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing
Xiaoying Lei et al.
Scientific reports, 5, 7824-7824 (2015-01-17)
The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection
Rees F Garmann et al.
Journal of virology, 88(18), 10472-10479 (2014-06-27)
We have recently discovered (R. D. Cadena-Nava et al., J. Virol. 86:3318-3326, 2012, doi:10.1128/JVI.06566-11) that the in vitro packaging of RNA by the capsid protein (CP) of cowpea chlorotic mottle virus is optimal when there is a significant excess of
Urszula L McClurg et al.
Microbes and infection, 17(3), 205-214 (2014-12-17)
Helicobacter pylori transactivates the epidermal growth factor receptor (EGFR) on gastric epithelial cells via a signalling cascade involving a disintegrin and metalloprotease 17 (ADAM17) cleavage of membrane bound heparin binding-epidermal growth factor (HB-EGF). The effects of H. pylori on ADAM17
Chenbo Dong et al.
Environmental science. Nano, 1(6), 95-603 (2014-12-09)
Toxicity of engineered nanomaterials is associated with their inherent properties, both physical and chemical. Recent studies have shown that exposure to multi-walled carbon nanotubes (MWCNTs) promotes tumors and tumor-associated pathologies and lead to carcinogenesis in model
Ruchi Dangi et al.
Journal of microencapsulation, 31(5), 479-487 (2014-04-05)
Liver cancer is widespread liver malignancy in the world, for an estimated one million deaths annually. In present work, lactobionic acid conjugated PLGA nanoparticles (LDNPs) bearing 5-Fluorouracil (5-FU) were developed for targeted delivery to hepatocellular carcinoma. Lactobionic acid conjugated PLGA
Quirin M Kainz et al.
ChemSusChem, 6(4), 721-729 (2013-02-22)
An operationally simple method for the acylation of amines utilizing carbon-coated metal nanoparticles as recyclable supports is reported. Highly magnetic carbon-coated cobalt (Co/C) and iron (Fe/C) nanobeads were functionalized with a norbornene tag (Nb-tag) through a "click" reaction followed by
Yung-Chih Kuo et al.
International journal of pharmaceutics, 479(1), 138-149 (2015-01-07)
Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer
Bryan Hoang et al.
International journal of pharmaceutics, 471(1-2), 224-233 (2014-05-24)
Docetaxel (DTX) remains the only effective drug for prolonging survival and improving quality of life of metastatic castration resistant prostate cancer (mCRPC) patients. Despite some clinical successes with DTX-based therapies, advent of cumulative toxicity and development of drug resistance limit
Siwen Li et al.
Oncotarget, 5(11), 3622-3635 (2014-07-09)
Docosahexaenoic acid (DHA), an omega-3 C22 natural fatty acid serving as a precursor for metabolic and biochemical pathways, was reported as a targeting ligand of anticancer drugs. However, its tumor targeting ability and mechanism has not been claimed. Here we
Mussel-inspired bolaamphiphile sticky self-assemblies for the preparation of magnetic nanoparticles.
Chaemyeong Lee et al.
Colloids and surfaces. B, Biointerfaces, 127, 89-95 (2015-02-07)
Adopting the strong metal binding moiety of a mussel protein, a novel bolaamphiphile molecule was prepared and applied to the fabrication of magnetic core-shell nanoparticles. The novel bolaamphiphile molecule with 3,4-dihydroxyphenylalanine (DOPA) end groups was synthesized and its self-assembly was
Katanchalee Mai-Ngam et al.
Carbohydrate polymers, 112, 440-447 (2014-08-19)
The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm)
Kalpana Mandal et al.
Nature communications, 5, 5749-5749 (2014-12-11)
Cells sense and respond to their mechanical environment by exerting forces on their surroundings. The way forces are modulated by extra-cellular matrix (ECM) properties plays a key role in tissue homoeostasis. Using highly resolved micropatterns that constrain cells into the
Xin Li et al.
Biosensors & bioelectronics, 61, 512-518 (2014-06-22)
Matrix metalloproteinase-2 (MMP-2) is a protease related to tumor invasion and metastasis. It is heavily secreted by malignant tumor cells, allowing the protease to serve as an imaging biomarker of cancer. In this study, a novel sensing system based on
Yan Zhang et al.
Macromolecular bioscience, 14(6), 842-852 (2014-04-18)
This work deals with the synthesis of insulin loaded nanoparticles (NPs) composed of thiolated Eudragit L100 (Eul-cys) and reduced glutathione (GSH) as potential nanocarriers for oral delivery of insulin. Perfectly spherical NPs with an average particle size of nearly 200-300 nm
Sarah Unser et al.
The Analyst, 140(2), 590-599 (2014-11-27)
Development of improved glucose detection has vast significance in both clinical and point of care settings. Herein, we present a novel, label-free, enzyme-free, colorimetric method of glucose detection that relies on the reduction of a gold salt precursor facilitated by
Sachin Yadav et al.
Artificial cells, nanomedicine, and biotechnology, 43(2), 93-102 (2013-11-08)
Breast cancer accounts for 23% of all newly occurring cancers in women worldwide and represents 13.7% of all cancer deaths. Available chemotherapeutic agents are limited largely due to the low accumulation of chemotherapeutics at the tumors relative to their accumulation
Tali Ilovitsh et al.
Biomedical optics express, 6(4), 1262-1272 (2015-04-25)
Localization microscopy provides valuable insights into cellular structures and is a rapidly developing field. The precision is mainly limited by additive noise and the requirement for single molecule imaging that dictates a low density of activated emitters in the field
Farid Ouchani et al.
Investigational new drugs, 33(1), 75-85 (2014-11-19)
Angiogenesis plays a pivotal role in tumorigenesis and also contributes to the pathogenesis of hematologic malignancies. A number of plant compounds have shown efficacy in preclinical and clinical studies and some of them possess an anti-angiogenic activity. Our present findings
Kenichiro Ito et al.
Nature communications, 6, 6373-6373 (2015-03-12)
Hepatocyte growth factor (HGF) receptor, also known as Met, is a member of the receptor tyrosine kinase family. The Met-HGF interaction regulates various signalling pathways involving downstream kinases, such as Akt and Erk. Met activation is implicated in wound healing
Ameya Prabhakar et al.
ACS omega, 4(13), 15567-15580 (2019-10-02)
The ability of ultrasound contrast agents to enhance the cell membrane permeability in response to an ultrasound pulse has unveiled avenues to facilitate the delivery of a higher intracellular payload at target sites. In light of the above, we report
Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.
Adden N
Langmuir, 22(19), 8197-8204 (2006)
Yichao Wang et al.
Drug delivery, 22(2), 191-198 (2014-01-21)
The incorporation of a high percentage of targeting molecules into drug delivery system is one of the important methods for improving efficacy of targeting therapeutic drugs to cancer cells. PLGA-based drug delivery carriers with folic acid (FA) as targeting molecule
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