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Showing 1-30 of 596 results for "56496" within Papers
Hui Zhao et al.
Lab on a chip, 15(17), 3481-3494 (2015-07-30)
Phenotypic screening has regained momentum in the pharmaceutical industry owing to its success over target-based screening. Most phenotypic screening relies on nonspecific biochemical readouts regarding cellular viability, which hampers the discovery of novel drug mechanisms of action (MOAs). Here we
Chiara Palmi et al.
Molecular cancer research : MCR, 12(12), 1796-1806 (2014-07-26)
Although the ETV6-RUNX1 fusion is a frequent initiating event in childhood leukemia, its role in leukemogenesis is only partly understood. The main impact of the fusion itself is to generate and sustain a clone of clinically silent preleukemic B-cell progenitors
Alexandra Bernd et al.
Pharmaceutical research, 32(9), 2973-2982 (2015-05-20)
To characterize the human choroid plexus (CP) papilloma cell line HIBCPP with respect to ABC export protein expression and function in order to evaluate its use as an in vitro model to study carrier-mediated transport processes at the CP. Expression
Mohammed Azharuddin Savanur et al.
PloS one, 9(11), e110107-e110107 (2014-11-05)
Sclerotium rolfsii lectin (SRL) isolated from the phytopathogenic fungus Sclerotium rolfsii has exquisite binding specificity towards O-linked, Thomsen-Freidenreich (Galβ1-3GalNAcα1-Ser/Thr, TF) associated glycans. This study investigated the influence of SRL on proliferation of human breast cancer cells (MCF-7 and ZR-75), non-tumorigenic
Mugdha Patki et al.
Biochemical and biophysical research communications, 457(3), 404-411 (2015-01-15)
Estrogen (E2) supports breast cancer cell growth but suppresses invasiveness and both actions are antagonized by anti-estrogens. As a consequence, anti-estrogen treatment may increase the invasive potential of estrogen receptor (ER)+ tumor cell sub-populations that are endocrine resistant due to
Chao Wei et al.
Biomicrofluidics, 9(1), 014109-014109 (2015-02-26)
This paper presents a microfluidic device (poly-dimethylsiloxane micro channels bonded with glass slides) enabling culture of MLO-Y4 osteocyte like cells. In this study, on-chip collagen coating, cell seeding and culture, as well as staining were demonstrated in a tubing-free manner
Lan Hong et al.
Acta pharmacologica Sinica, 35(12), 1577-1585 (2014-11-25)
Para-aminosalicylic acid (PAS) is effective in the treatment of manganism-induced neurotoxicity (manganism). In this study we investigated the roles of P-glycoprotein (MDR1a) and multidrug resistance protein (MRP) in transporting PAS and its N-acetylated metabolite AcPAS through blood-brain barrier. MDR1a-null or
Carmela Ricciardelli et al.
Clinical & experimental metastasis, 32(5), 441-455 (2015-04-22)
Ovarian cancer, the most lethal gynaecological cancer, is characterised by the shedding of epithelial cells from the ovarian surface, followed by metastasis and implantation onto the peritoneal surfaces of abdominal organs. Our proteomic studies investigating the interactions between peritoneal (LP-9)
Ekaterina S Menchinskaya et al.
Natural product communications, 8(10), 1377-1380 (2013-12-21)
In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of
Kazuharu Sugawara et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 95-102 (2015-06-10)
Daunomycin penetrates the membrane of a U937 cell, which is a human histiocyte-related lymphoma cell. Several arginine-rich peptides have also exhibited a high degree of permeability with these cells. Therefore, we attempted to improve the membrane permeability of daunomycin by
María Celeste Nicolao et al.
Antimicrobial agents and chemotherapy, 58(9), 5146-5154 (2014-06-18)
Cystic echinococcosis is a zoonotic infection caused by the larval stage of the cestode Echinococcus granulosus. Chemotherapy currently employs benzimidazoles; however, 40% of cases do not respond favorably. With regard to these difficulties, novel therapeutic tools are needed to optimize
Yumi Hashiguchi et al.
Biochemical and biophysical research communications, 439(2), 221-227 (2013-08-29)
Cellular efflux and uptake transports of several anti-HIV agents are mediated by plasma membrane-localized solute transporters. However, transporters involved in raltegravir disposition have not been fully characterized. Here, we performed in vitro studies to identify transporters mediating transcellular transport of
Sabine H van Rijt et al.
ACS nano, 9(3), 2377-2389 (2015-02-24)
Nanoparticles allow for controlled and targeted drug delivery to diseased tissues and therefore bypass systemic side effects. Spatiotemporal control of drug release can be achieved by nanocarriers that respond to elevated levels of disease-specific enzymes. For example, matrix metalloproteinase 9
Jordan J Toutounchian et al.
PloS one, 9(6), e100210-e100210 (2014-06-24)
Radiation-induced damage to the retina triggers leukostasis, retinal endothelial cell (REC) death, and subsequent hypoxia. Resultant ischemia leads to visual loss and compensatory retinal neovascularization (RNV). Using human RECs, we demonstrated that radiation induced leukocyte adhesion through mechanisms involving p38MAPK
Liwen Zhang et al.
ACS nano, 8(12), 12250-12258 (2014-11-18)
Photothermal therapy (PTT) is an emerging treatment modality that is under intensive preclinical investigations for the treatment of various medical conditions, including cancer. However, the lack of targeting function of PTT agents hampers its clinical application. An effective and nontoxic
Alice Cheng et al.
Biofabrication, 6(4), 045007-045007 (2014-10-08)
Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity via laser sintering.
Edward A Phelps et al.
Drug delivery and translational research, 5(2), 125-136 (2015-03-20)
Biofunctionalized polyethylene glycol maleimide (PEG-MAL) hydrogels were engineered as a platform to deliver pancreatic islets to the small bowel mesentery and promote graft vascularization. VEGF, a potent stimulator of angiogenesis, was incorporated into the hydrogel to be released in an
Laura R Geuss et al.
Biotechnology and bioengineering, 112(7), 1446-1456 (2015-02-07)
Successful cellular cardiomyoplasty is dependent on biocompatible materials that can retain the cells in the myocardium in order to promote host tissue repair following myocardial infarction. A variety of methods have been explored for incorporating a cell-seeded matrix into the
Rui Yao et al.
Small (Weinheim an der Bergstrasse, Germany), 10(21), 4311-4323 (2014-07-26)
Directed differentiation of human embryonic stem cells (hESCs) towards hepatocyte-like cells on planar tissue culture plates has been extensively investigated with great promise to provide alternative cell sources for drug metabolism/toxicity testing. Recently, hepatic differentiation of hESCs in 3D configuration
Sandra Sanfilippo et al.
Journal of assisted reproduction and genetics, 28(12), 1151-1156 (2011-10-29)
To assess the reliability of trypan blue (TB) and calcein AM/ethidium homodimer-1 (CaAM/EthD-1) staining to evaluate the viability of fresh and thawed human ovarian follicles. Isolated follicles from fresh and thawed cortex were stained using TB versus CaAM/EthD-1 methods (n = 10
Megan E Jeffords et al.
ACS applied materials & interfaces, 7(20), 11053-11061 (2015-05-07)
Cardiac matrix hydrogel has shown great promise as an injectable biomaterial due to the possession of cardiac-specific extracellular matrix composition. A cardiac matrix hydrogel facilitating neovascularization will further improve its therapeutic outcomes in cardiac repair. In this study, we explored
Jinfeng Zhao et al.
Neurochemical research, 39(11), 2150-2159 (2014-08-22)
Neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD), which are mostly composed of hyperphosphorylated tau and directly correlate with dementia in AD patients. Okadaic acid (OA), a toxin extracted from marine life, can specifically inhibit protein phosphatases (PPs), including
Shruti Krishna Davey et al.
Tissue engineering. Part C, Methods, 21(11), 1188-1196 (2015-07-15)
Techniques that can create three-dimensional (3D) structures to provide architectural support for cells have a significant impact in generating complex and hierarchically organized tissues/organs. In recent times, a number of technologies, including photopatterning, have been developed to create such intricate
Sinan Guven et al.
Stem cells translational medicine, 4(3), 261-268 (2015-02-11)
Hormone replacement therapies have become important for treating diseases such as premature ovarian failure or menopausal complications. The clinical use of bioidentical hormones might significantly reduce some of the potential risks reportedly associated with the use of synthetic hormones. In
Sang-Eun Park et al.
International journal of nanomedicine, 10(Spec Iss), 261-271 (2015-10-02)
Silica-gold nanoshell (SGNS), which is a silica core surrounded by a gold layer, was synthesized by seed-mediated coalescence of gold clusters in an electroless plating solution. SGNS variations with different surface coverage of gold clusters were prepared by adjusting the
Xiao-Yu Zheng et al.
Experimental and therapeutic medicine, 10(5), 1883-1887 (2015-12-08)
Cataractogenic stresses are associated with the induction of endoplasmic reticulum (ER) stress. However, little is known about oxygen (O
Lidan Wu et al.
Integrative biology : quantitative biosciences from nano to macro, 7(5), 513-524 (2015-04-03)
As key components of autocrine signaling, pericellular proteases, a disintegrin and metalloproteinases (ADAMs) in particular, are known to impact the microenvironment of individual cells and have significant implications in various pathological situations including cancer, inflammatory and vascular diseases. There is
Andreas Herbert Teuschl et al.
Tissue engineering. Part C, Methods, 21(9), 945-957 (2015-03-31)
Over the past decade, silk fibroin (SF) has been emergently used in peripheral nerve tissue engineering. Current approaches aiming at producing SF-based nerve guidance conduits (SF-NGCs) used dissolved silk based on either aqueous solutions or organic solvents. In this study
Daniel A Escobar et al.
The Journal of surgical research, 194(1), 262-272 (2014-12-03)
Mortality in sepsis is most often attributed to the development of multiple organ failure. In sepsis, inflammation-mediated endothelial activation, defined as a proinflammatory and procoagulant state of the endothelial cells, has been associated with severity of disease. Thus, the objective
J E Aedo et al.
Acta biochimica et biophysica Sinica, 47(11), 932-937 (2015-09-06)
Lipopolysaccharide (LPS) is considered as a powerful inducer of muscle atrophy in higher vertebrates due to skeletal muscle cell recognition of the endotoxin and a consequent activation of catabolic signaling pathways. In contrast, there is no evidence of LPS directly
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