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Showing 1-30 of 596 results for "56496" within Papers
Tania I Fuentes et al.
PloS one, 10(7), e0132378-e0132378 (2015-07-15)
Microgravity has a profound effect on cardiovascular function, however, little is known about the impact of microgravity on progenitors that reside within the heart. We investigated the effect of simulated microgravity exposure on progenitors isolated from the neonatal and adult
Flavia Bieczynski et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 97-106 (2014-05-29)
We studied Abcc mediated-transport in middle and posterior intestine of the rainbow trout, Oncorhynchus mykiss. Luminal and serosal transport were evaluated in everted and non-everted intestinal sacs, respectively, incubated with 1-chloro-2,4-dinitrobenzene (CDNB; 200 μM). CDNB enters the cells and is
Yi Cao et al.
Environmental toxicology and pharmacology, 40(1), 164-171 (2015-07-01)
Exposure to diesel exhaust particles (DEP) has been associated with adverse cardiopulmonary health effects, which may be related to dysregulation of lipid metabolism and formation of macrophage foam cells. In this study, THP-1 derived macrophages were exposed to an automobile
Thomas J Raub et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1360-1371 (2015-07-08)
Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase inhibitor has potential for treating primary central nervous system tumors such as glioblastoma
Xuhui Tong et al.
Oncology reports, 33(1), 207-214 (2014-10-31)
Platinum agents are widely used in the chemotherapy of testicular cancer. However, adverse reactions and resistance to such agents have limited their application in antineoplastic treatment. The aim of the present study was to determine the role of gap junction
Marianna E Jung et al.
The Journal of pharmacology and experimental therapeutics, 352(2), 258-266 (2014-11-20)
The acetylation of histone proteins in the core of DNA regulates gene expression, including those affecting mitochondria. Both histone acetylation and mitochondrial deficit have been implicated in neuronal damage associated with drinking problems. Many alcoholics will repeat unsuccessful attempts at
Nafiseh Masoumi et al.
Advanced healthcare materials, 3(6), 929-939 (2014-01-24)
Tissue engineered heart valves (TEHV) can be useful in the repair of congenital or acquired valvular diseases due to their potential for growth and remodeling. The development of biomimetic scaffolds is a major challenge in heart valve tissue engineering. One
Masanori Ochi et al.
The Journal of toxicological sciences, 40(1), 71-76 (2015-03-07)
Nicardipine hydrochloride (NIC), a dihydropyridine calcium-channel blocking agent, has been widely used for the treatment of hypertension. Especially, nicardipine hydrochloride injection is used as first-line therapy for emergency treatment of abnormally high blood pressure. Although NIC has an attractive pharmacological
Apple Long et al.
Carcinogenesis, 36(5), 598-606 (2015-03-22)
Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53 mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) and mimic early invasion in esophageal squamous cell carcinoma (ESCC). We have performed laser capture microdissection with
Miriam L Ramón-Peréz et al.
Journal of medical microbiology, 63(Pt 10), 1369-1376 (2014-07-09)
Biofilm formation on medical and surgical devices is a major virulence determinant for Staphylococcus epidermidis. The bacterium S. epidermidis is able to produce biofilms on biotic and abiotic surfaces and is the cause of ocular infection (OI). Recent studies have
Damian C Genetos et al.
PloS one, 9(9), e107482-e107482 (2014-09-16)
Annexins are a class of calcium-binding proteins with diverse functions in the regulation of lipid rafts, inflammation, fibrinolysis, transcriptional programming and ion transport. Within bone, they are well-characterized as components of mineralizing matrix vesicles, although little else is known as
Bogusz Trojanowicz et al.
PloS one, 9(7), e102137-e102137 (2014-07-09)
Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They are not only epidemiologically linked with increased mortality and cardiovascular disease, but may also directly participate in the initial steps of atherosclerosis. To further address this question we
Shama R Iyer et al.
Journal of biomedical materials research. Part A, 103(6), 1899-1906 (2014-01-01)
Treatment of ventral hernias frequently makes use of synthetic and biological meshes, often resulting in scar tissue formation and incomplete muscle regeneration. Chitosan has been shown to promote a regenerative response than a fibrotic response. The objective of this study
Angela Oppelt et al.
The Biochemical journal, 461(3), 383-390 (2014-05-21)
Previously, we have shown that the phosphoinositide metabolizing enzymes PIKfyve (phosphoinositide 5-kinase, FYVE finger containing) and MTMR3 (myotubularin-related protein 3), together with their lipid product PtdIns5P, are important for migration of normal human fibroblasts. As these proteins are a kinase
Pengyun Li et al.
Expert opinion on therapeutic targets, 19(7), 997-1010 (2015-06-16)
The aim of the study was to determine whether hepatocyte mitochondrial injury instigates severe shock and to explore effective therapy. Wistar rats were randomly divided into five groups: Control (sham) group, shock + normal saline, shock + cyclosporine A, shock
Yuning Hou et al.
Stem cell research, 14(2), 133-143 (2015-01-27)
Bone marrow-derived endothelial progenitor cells (EPCs) contribute to neovessel formation in response to growth factors, cytokines, and chemokines. Chemokine receptor CXCR2 and its cognate ligands are reported to mediate EPC recruitment and angiogenesis. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif
Edyta Możdżeń et al.
Neurotoxicity research, 27(3), 300-313 (2014-12-30)
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), an endogenous compound present in the brain, was suspected of participation in the etiopathogenesis of Parkinson's disease, the most common serious movement disorder worldwide. In this study, we evaluated the effect of different (50, 100, and 500 µM)
Gwangseong Kim et al.
PloS one, 10(5), e0127219-e0127219 (2015-05-27)
It is well established that metastasis through the circulatory system is primarily caused by circulating tumor cells (CTCs). In this preliminary effort, we report an approach to eliminate circulating tumor cells from the blood stream by flowing the blood though
Xiaoxu Zheng et al.
Cardiology, 129(3), 163-173 (2014-10-11)
Ischemic preconditioning (IPC) induces cardioprotection against ischemia-reperfusion (IR) injury by inhibiting the mitochondrial permeability transition pore (mPTP). Here, we tested the hypothesis that IPC-induced cardioprotection is mediated by the phosphatase PTEN and PDE4 (phosphodiesterase 4). Isolated hearts from wild-type mice
Götz A Westphal et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 997-1005 (2015-04-22)
Inflammation is a decisive pathophysiologic mechanism of particle toxicity and accumulation of neutrophils in the lung is believed to be a crucial step in this process. This study describes an in vitro model for investigations of the chemotactic attraction of
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
Caroline Camaré et al.
British journal of pharmacology, 172(1), 106-118 (2014-09-02)
Neovascularization occurring in atherosclerotic lesions may promote plaque expansion, intraplaque haemorrhage and rupture. Oxidized LDL (oxLDL) are atherogenic, but their angiogenic effect is controversial; both angiogenic and anti-angiogenic effects have been reported. The angiogenic mechanism of oxLDL is partly understood
Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry.
Adam J Taylor et al.
Acta biomaterialia, 14, 70-83 (2014-12-20)
Cell-secreted matrices (CSMs), where extracellular matrix (ECM) deposited by monolayer cell cultures is decellularized, have been increasingly used to produce surfaces that may be reseeded with cells. Such surfaces are useful to help us understand cell-ECM interactions in a microenvironment
John M Collins et al.
Lab on a chip, 12(15), 2643-2648 (2012-05-25)
The heterogeneous nature of cells can be an issue for in vitro analysis of cell function due to cell type differences within a population. Observations are most often averaged and dependent on the homogeneity or lack thereof for most cell
Ting Zhang et al.
FEMS microbiology letters, 362(12), fnv084-fnv084 (2015-05-28)
Penetration of the brain microvascular endothelial layer is one of the routes Listeria monocytogenes use to breach the blood-brain barrier. Because host factors in the blood severely limit direct invasion of human brain microvascular endothelial cells (HBMECs) by L. monocytogenes
Siobhan V Glavey et al.
Blood, 124(11), 1765-1776 (2014-07-26)
Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation and metastasis. The role of altered sialylation in multiple myeloma (MM)
Nikolai Siebert et al.
PloS one, 9(9), e107692-e107692 (2014-09-17)
Effective treatment of high-risk neuroblastoma (NB) remains a major challenge in pediatric oncology. Human/mouse chimeric monoclonal anti-GD2 antibody (mAb) ch14.18 is emerging as a treatment option to improve outcome. After establishing a production process in Chinese hamster ovary (CHO) cells
Pablo Godoy et al.
International journal for parasitology, 45(1), 85-93 (2014-12-09)
Haemonchus contortus is a veterinary nematode that infects small ruminants, causing serious decreases in animal production worldwide. Effective control through anthelmintic treatment has been compromised by the development of resistance to these drugs, including the macrocyclic lactones. The mechanisms of
Karan M Shah et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 114-121 (2014-09-25)
Cobalt and chromium species are released in the local tissues as a result of tribo-corrosion, and affect bone cell survival and function. However we have little understanding of the mechanisms of cellular entry, intracellular distribution, and speciation of the metals
Olivier Côté et al.
PloS one, 9(4), e96217-e96217 (2014-04-30)
Secretoglobin family 1A member 1 (SCGB 1A1) is a small protein mainly secreted by mucosal epithelial cells of the lungs and uterus. SCGB 1A1, also known as club (Clara) cell secretory protein, represents a major constituent of airway surface fluid.
Ashley M Poenitzsch Strong et al.
Archives of biochemistry and biophysics, 563, 118-124 (2014-07-22)
microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells.
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