57-66-9

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Showing 1-30 of 45 results for "57-66-9" within Papers

Porphyromonas gingivalis in the tongue biofilm is associated with clinical outcome in rheumatoid arthritis patients.

F Ceccarelli et al.

Clinical and experimental immunology, 194(2), 244-252 (2018-07-17)

Several studies have suggested a link between human microbiome and rheumatoid arthritis (RA) development. Porphyromonas gingivalis seems involved in RA initiation and progression, as supported by the high occurrence of periodontitis. In this case-control study, we analysed tongue P. gingivalis

Synthesis and evaluation of (17alpha,20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17beta-diols as ligands for the estrogen receptor-alpha hormone binding domain: comparison with 20E-isomers.

Robert N Hanson et al.

Journal of medicinal chemistry, 48(13), 4300-4311 (2005-06-25)

As part of our ongoing program to develop probes for the hormone binding domain of the estrogen receptor-alpha (ERalpha), we prepared and evaluated a series of 17alpha,Z-(4-substituted-phenyl)vinyl estradiol derivatives. The results indicated that the relative binding affinities (RBAs) at 25

Myocardial inflammation and non-ischaemic heart failure: is there a role for C-reactive protein?

Oliver Zimmermann et al.

Basic research in cardiology, 104(5), 591-599 (2009-04-04)

Whereas C-reactive protein (CRP) is acknowledged as a cardiovascular risk marker, there is ongoing discussion about its role as a risk factor. Previous studies focused on the effects of CRP on ischaemic heart failure and atherosclerosis. In this study we

Transcatheter Arterial Chemoembolization Combined with Simultaneous Computed Tomography-guided Radiofrequency Ablation for Large Hepatocellular Carcinomas.

Tai-Yang Zuo et al.

Chinese medical journal, 130(22), 2666-2673 (2017-11-15)

Currently, the treatment of large hepatocellular carcinoma (HCC) is still a challenging problem. Transcatheter arterial chemoembolization (TACE) is the main treatment for intermediate end-stage HCC, while it is only a palliative and not a curative treatment due to the existence

Mutation analysis of PAH gene and characterization of a recurrent deletion mutation in Korean patients with phenylketonuria.

Yong Wha Lee et al.

Experimental & molecular medicine, 40(5), 533-540 (2008-11-06)

Phenylketonuria (PKU; MIM 261600) is an autosomal recessive metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH; EC 1.14.16.1). Point mutations in the PAH gene are known to cause PKU in various ethnic groups, and large deletions or duplications

Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals.

Mev Dominguez Valentin et al.

Familial cancer, 10(4), 641-647 (2011-06-18)

Lynch syndrome (LS) is an autosomal dominant syndrome that predisposes individuals to development of cancers early in life. These cancers are mainly the following: colorectal, endometrial, ovarian, small intestine, stomach and urinary tract cancers. LS is caused by germline mutations

Immunoexpression of the hepatocyte growth factor (HGF), HGF-receptor (c-met) and STAT3 on placental tissues from malformed fetuses.

M Trovato et al.

Histology and histopathology, 17(3), 691-698 (2002-08-10)

To characterize the possible relationship between the expression of the HGF/HGF-R system with transcription factor STAT3, responsible for morphogenetic response of HGF stimulation, and the embryonic development alterations, we investigated, by immunohistochemistry, the expression of HGF, c-met and STAT3 in

COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress.

Gilbert W Moeckel et al.

The Journal of biological chemistry, 278(21), 19352-19357 (2003-03-15)

The mechanism by which COX2 inhibition decreases renal cell survival is poorly understood. In the present study we examined the effect of COX2 activity on organic osmolyte accumulation in renal medulla and in cultured mouse renal medullary interstitial cells (MMICs)

Inhalation carcinogenesis of various alkylating agents.

A R Sellakumar et al.

Journal of the National Cancer Institute, 79(2), 285-289 (1987-08-01)

A series of earlier studies showed that inhalation exposures of rats to three water-reactive electrophilic compounds produced brisk yields of nasal cancer even when the animals were exposed for only 30 days (6 hr/day X 5 day/wk). In addition, carcinogenic

Influence of angiotensin-I-converting-enzyme insertion/deletion gene polymorphism on perioperative hemodynamics after coronary bypass graft surgery.

A F Popov et al.

The Journal of cardiovascular surgery, 49(2), 255-260 (2008-04-24)

The angiotensin I-converting enzyme insertion/ deletion polymorphism (ACE-I/D), including three genotypes (II, ID, DD), with a known impact on midterm mortality and morbidity in patients after coronary artery bypass graft surgery (CABG), was studied. Since this polymorphism has been linked

[Expression and clinical significance of ID1 gene in acute myeloid leukemia].

Ying Lu et al.

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 33(4), 278-281 (2012-07-12)

To explore the expression and clinical significance of ID1 gene in acute myeloid leukemia (AML) patients. Real-time quantitative PCR (RQ-PCR) was used to test the expression level of ID1 gene in 114 de novo adult AML patients, and the clinical

Prevalence of OPG and IL-1 gene polymorphisms in chronic periodontitis.

Judith Wagner et al.

Journal of clinical periodontology, 34(10), 823-827 (2007-08-23)

To investigate the association of polymorphisms in the osteoprotegerin (OPG) and interleukin 1 (IL-1) genes with chronic periodontitis (CP). One hundred and ninety-four individuals (97 CP patients, 97 controls) were genotyped for the OPG polymorphisms Lys3Asn and Met256Val and for

Massive accumulation of Man2GlcNAc2-Asn in nonneuronal tissues of glycosylasparaginase-deficient mice and its removal by enzyme replacement therapy.

Eira Kelo et al.

Glycobiology, 15(1), 79-85 (2004-09-03)

Aspartylglycosaminuria (AGU) is caused by deficient enzymatic activity of glycosylasparaginase (GA). The disease is characterized by accumulation of aspartylglucosamine (GlcNAc-Asn) and other glycoasparagines in tissues and body fluids of AGU patients and in an AGU mouse model. In the current

Chronic activation of endogenous angiotensin-converting enzyme 2 protects diabetic rats from cardiovascular autonomic dysfunction.

Tatiane M Murça et al.

Experimental physiology, 97(6), 699-709 (2012-01-31)

In this study, we evaluated whether the activation of endogenous angiotensin-converting enzyme 2 (ACE2) would improve the cardiovascular autonomic dysfunction of diabetic rats. Ten days after induction of type 1 diabetes (streptozotocin, 50 mg kg(-1) i.v.), the rats were treated

Intraplaque hemorrhage assessed by high-resolution magnetic resonance imaging and C-reactive protein in carotid atherosclerosis.

Luciano Cabral Albuquerque et al.

Journal of vascular surgery, 46(6), 1130-1137 (2007-10-09)

Carotid intraplaque hemorrhage is a marker of atheroma instability. Noninvasive assessment of bleeding can be performed by high-resolution magnetic resonance imaging (MRI), but its association with inflammatory markers has not been clearly demonstrated. We evaluated consecutive carotid endarterectomy patients that

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

Gerhardt Attard et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(28), 4563-4571 (2008-07-23)

Studies indicate that castration-resistant prostate cancer (CRPC) remains driven by ligand-dependent androgen receptor (AR) signaling. To evaluate this, a trial of abiraterone acetate-a potent, selective, small-molecule inhibitor of cytochrome P (CYP) 17, a key enzyme in androgen synthesis-was pursued. Chemotherapy-naïve

BRAF and RAS mutations in human lung cancer and melanoma.

Marcia S Brose et al.

Cancer research, 62(23), 6997-7000 (2002-12-04)

BRAF encodes a RAS-regulated kinase that mediates cell growth and malignant transformation kinase pathway activation. Recently, we have identified activating BRAF mutations in 66% of melanomas and a smaller percentage of many other human cancers. To determine whether BRAF mutations

BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper.

Fausto J Rodriguez et al.

Journal of neuropathology and experimental neurology, 71(9), 789-794 (2012-08-16)

Optic pathway gliomas represent a specific subtype of astrocytoma with unique clinicopathologic and biologic properties, but studies of tumors in the optic nerve proper have been hampered by limited tissue availability. We analyzed optic nerve gliomas of 59 patients (median

Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: a 10-year single institution retrospective study.

Nicole J Look Hong et al.

European journal of cancer (Oxford, England : 1990), 49(4), 875-883 (2012-10-25)

Patients with large, high-grade extremity and truncal soft tissue sarcomas (STS) are at considerable risk for recurrence. A regimen of pre-operative chemotherapy consisting of mesna, adriamycin, ifosfamide and dacarbazine (MAID), interdigitated with radiotherapy (RT), followed by resection and post-operative chemotherapy

Safety of short-term use of dabigatran or rivaroxaban for direct-current cardioversion in patients with atrial fibrillation and atrial flutter.

Ajay Yadlapati et al.

The American journal of cardiology, 113(8), 1362-1363 (2014-03-01)

Direct-current cardioversion (DCCV) for persistent atrial fibrillation or atrial flutter (AF) carries a risk of thromboembolic events (TEs). Therapeutic anticoagulation with warfarin is recommended for 3 to 4 weeks before and 4 weeks after DCCV to reduce TE; however, the

Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma.

Noriyuki Omura et al.

Cancer biology & therapy, 7(7), 1146-1156 (2008-06-07)

Many genes undergo aberrant methylation in human cancers, and microarray platforms enable more comprehensive profiling of aberrant DNA methylation patterns. 1,010 of 87,922 probes on the 88 K promoter array (606 genes) had a higher signal (log(2) > 2) in

Premeal Low-Fat Yogurt Consumption Reduces Postprandial Inflammation and Markers of Endotoxin Exposure in Healthy Premenopausal Women in a Randomized Controlled Trial.

Ruisong Pei et al.

The Journal of nutrition, 148(6), 910-916 (2018-05-17)

Metabolic endotoxemia is associated with obesity and contributes to postprandial inflammation. We aimed to determine if low-fat yogurt consumption prevents postprandial inflammation and dysmetabolism in healthy women by inhibiting biomarkers of metabolic endotoxemia. Premenopausal women defined as obese and nonobese

A gain-of-function mutation of JAK2 in myeloproliferative disorders.

Robert Kralovics et al.

The New England journal of medicine, 352(17), 1779-1790 (2005-04-29)

Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors a mutation that contributes

Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases.

S Koling et al.

International journal of clinical pharmacology and therapeutics, 45(9), 496-503 (2007-10-03)

Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations, a small fraction of the drug undergoes oxidative metabolism via cytochrome P450 forming the hepatotoxic intermediate N-acetyl-p-benzo-quinone-imine (NAPQI) which

Alum and Rainfall Effects on Ionophores in Runoff from Surface-Applied Broiler Litter.

Sarah A Doydora et al.

Journal of environmental quality, 44(5), 1657-1666 (2015-10-06)

Polyether ionophores, monensin, and salinomycin are commonly used as antiparasitic drugs in broiler production and may be present in broiler litter (bird excreta plus bedding material). Long-term application of broiler litter to pastures may lead to ionophore contamination of surface

Patterns of presentation and clinical features of toxicity after reported use of ([2-aminopropyl]-2,3-dihydrobenzofurans), the 'benzofuran' compounds. A report from the United Kingdom National Poisons Information Service.

Ashraf Kamour et al.

Clinical toxicology (Philadelphia, Pa.), 52(10), 1025-1031 (2014-10-28)

To characterise the patterns of presentation and clinical features of toxicity following reported recreational use of benzofuran compounds ((2-aminopropyl)-2,3-dihydrobenzofurans) in the UK, as reported to the National Poisons Information Service (NPIS), and to compare clinical features of toxicity with those

Tumor necrosis factor α-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice.

Vincent E de Meijer et al.

PloS one, 6(9), e25587-e25587 (2011-10-08)

Hepatic steatosis is an established risk factor for complications following major hepatic resection. Pharmacological options to reverse steatosis prior to surgery, however, are lacking. We hypothesized that treatment with the pharmacologic tumor necrosis factor-α converting enzyme (TACE)-inhibitor Marimastat would reverse

Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling.

Jamie E Chaft et al.

Molecular cancer therapeutics, 11(2), 485-491 (2011-12-03)

Phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA) encodes the p110α subunit of the mitogenic signaling protein phosphoinositide 3-kinase (PI3K). PIK3CA mutations in the helical binding domain and the catalytic subunit of the protein have been associated with tumorigenesis and treatment resistance in

Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens.

Allan R Brasier et al.

PloS one, 10(11), e0143165-e0143165 (2015-11-19)

Invasive pulmonary aspergillosis (IPA) is an opportunistic fungal infection in patients undergoing chemotherapy for hematological malignancy, hematopoietic stem cell transplant, or other forms of immunosuppression. In this group, Aspergillus infections account for the majority of deaths due to mold pathogens.

Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas.

P A Bejarano et al.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 9(4), 445-452 (1996-04-01)

Antibodies to the pulmonary epithelial cell-specific proteins surfactant proteins A and B (SP-A and SP-B) and to thyroid transcription factor-1 (TTF-1), a homeodomain nuclear transcription protein, were used as immunohistochemical markers to asses their ability to distinguish primary pulmonary non-small

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