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Showing 1-30 of 265 results for "570699" within Papers
Timothy M Shoup et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(2), 257-263 (2014-10-03)
Fatty acid amide hydrolase (FAAH), a catabolic enzyme which regulates lipid transmitters in the endocannabinoid system, is an avidly sought therapeutic and positron emission tomography (PET) imaging target for studies involving addiction and neurological disorders. We report the synthesis of
Hanane Bafqiren et al.
Chirality, 27(12), 944-950 (2015-10-03)
Catalytic asymmetric benzylation of a dissymmetric tert-butylglycinate ketimine, incorporating 1-naphthyl and phenyl groups as the Schiff base substituents, under phase-transfer conditions was investigated. It was interesting to note that the sense of asymmetric induction of the alkylation of Z-imine stereoisomer
Ruiqin Yi et al.
Bioscience, biotechnology, and biochemistry, 79(12), 1931-1945 (2015-08-04)
The convergent synthesis of branched inner-core oligosaccharides of lipopoly- and lipooligosaccharide with a 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) disaccharide acceptor was achieved. The l-glycero-d-manno-heptopyranose (Hep) units for the branched core oligosaccharide Galβ(1-4)Glcβ(1-4)Hep and Hepα(1-3)Hep were prepared from the corresponding Hep building blocks.
Hong-Ju Ma et al.
Pest management science, 71(8), 1189-1196 (2014-09-27)
A series of novel pyrazolylpyrimidine derivatives were designed, synthesised and characterised by IR, (1) H NMR, (13) C NMR, mass spectroscopy and elemental analysis. The herbicidal activities of 30 pyrazolylpyrimidine derivatives were assessed. Nine compounds caused good herbicidal activity for
P Fonteh et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(4), 653-667 (2015-04-02)
Label free impedance technology enables the monitoring of cell response patterns post treatment with drugs or other chemicals. Using this technology, a correlation between the lipophilicity of metal complexes and the degree of cytotoxicity was observed. Au(L1)Cl (1), AuPd(L1)(SC4H8)Cl3 (1a)
Apurba K Bhattacharjee et al.
European journal of medicinal chemistry, 90, 209-220 (2014-12-03)
Utilizing our previously reported in silico pharmacophore model for reactivation efficacy of oximes, we present here a discovery of twelve new non-oxime reactivators of diisopropylfluorophosphate (DFP)-inhibited acetylcholinesterase (AChE) obtained through virtual screening of an in-house compound database. Rate constant (kr)
Mahmoud Fahmi Elsebai et al.
Natural product research, 29(15), 1426-1431 (2015-01-24)
Retrospinoside (1) is a new polyoxy pregnane glycoside which was isolated and characterised from the aerial parts of Caralluma retrospiciens (Ehrenb.) N. E. Br., family Apocynaceae. The structure was established as 3-O-[β-D-glucopyranosyl-(1 → 4)-β-D-(3-O-methyl-6-desoxygalactopyranosy)]-14,15,20-trihydroxy-4β-pregnane. Its structural elucidation was performed through extensive spectroscopic
Monika Chauhan et al.
Bioorganic chemistry, 58, 1-10 (2014-12-03)
Design, microwave-assisted synthesis of novel 4-aryl (alkyl)amino-3-nitroquinoline (1a-1l) and 2,4-diaryl (dialkyl)amino-3-nitroquinolines (2a-2k and 3a) via regioselective and complete nucleophilic substitution of 2,4-dichloro-3-nitroquinoline, respectively in water are presented. The newly synthesized compounds were evaluated for the first time for antiproliferative activity
Lignin Modification for Biopolymer/Conjugated Polymer Hybrids as Renewable Energy Storage Materials.
Ting Yang Nilsson et al.
ChemSusChem, 8(23), 4081-4085 (2015-10-29)
Lignin derivatives, which arise as waste products from the pulp and paper industry and are mainly used for heating, can be used as charge storage materials. The charge storage function is a result of the quinone groups formed in the
Bryan S Tucker et al.
Biomacromolecules, 16(8), 2374-2381 (2015-07-08)
Polymers of similar molecular weights and chemical constitution but varying in their macromolecular architectures were conjugated to osteoprotegerin (OPG) to determine the effect of polymer topology on protein activity in vitro and in vivo. OPG is a protein that inhibits
Catherine Bonnier et al.
Molecules (Basel, Switzerland), 20(10), 18237-18245 (2015-10-13)
We are reporting the unexpected reaction between bromo-boron subphthalocyanine (Br-BsubPc) and THF, 1,4-dioxane or γ-butyrolactone that results in the ring opening of the solvent and its addition into the BsubPc moiety. Under heating, the endocyclic C-O bond of the solvent
Giuseppe Consiglio et al.
Dalton transactions (Cambridge, England : 2003), 44(29), 13040-13048 (2015-06-24)
This contribution explores the effect of the bridging diamine upon the aggregation properties of a Zn(II) Schiff-base complex, , both in the solid state and in solution. The X-ray structure of , resulting from the harvest of good quality crystals
Deepansh Sharma et al.
SpringerPlus, 4, 4-4 (2015-02-13)
The objective of the present study was to isolate the biosurfactant (BS) producing lactic acid bacteria (LAB) from traditional fermented food (buttermilk) and its functional and structural characterization. BS isolated from strain MRTL9 reduced surface tension from 72.0 to 40.2
Tsurng-Juhn Huang et al.
European journal of medicinal chemistry, 90, 428-435 (2014-12-03)
Hepatitis B virus (HBV) is a causative reagent that frequently causes progressive liver diseases, leading to the development of acute, chronic hepatitis, cirrhosis, and eventually hepatocellular carcinoma (HCC). Despite several antiviral drugs including interferon-α and nucleotide derivatives are approved for
Fatih Pekdemir et al.
Dalton transactions (Cambridge, England : 2003), 44(1), 158-166 (2014-11-02)
A supramolecule, 6, based on an electron-donor zinc phthalocyanine (ZnPc) and an electron-acceptor perylene diimide (PDI) has been synthesized and characterized by elemental analysis, UV/Vis, IR, (1)H NMR and solid state (13)C CPMAS NMR and also MALDI-TOF and ICP mass
Jun Liao et al.
Archives of pharmacal research, 38(4), 470-479 (2014-05-20)
A novel series of fluconazole based mimics incorporating 1,3,4-oxadiazole moiety were designed and synthesized. All the title compounds were characterized by (1)H-NMR, (13)C-NMR, and Q-TOF-MS. Preliminary results revealed that most of analogues exhibited significant antifungal activity against seven pathogenic fungi.
Scott R Pollack et al.
Journal of labelled compounds & radiopharmaceuticals, 58(11-12), 433-441 (2015-09-19)
Omeprazole (Prilosec®) is a selective and irreversible proton pump inhibitor used to treat various medical conditions related to the production of excess stomach acids. It functions by suppressing secretion of those acids. Radiolabeled compounds are commonly employed in the drug
Katalin Devaine-Pressing et al.
Dalton transactions (Cambridge, England : 2003), 44(27), 12365-12375 (2015-03-26)
Magnesium compounds of tetradentate amino-bis(phenolato) ligands, Mg[L1] (1) and Mg[L2] (2) (where [L1] = 2-pyridyl-N,N-bis(2-methylene-4-methoxy-6-tert-butylphenolato), and [L2] = dimethylaminoethylamino-N,N-bis(2-methylene-4-methyl-6-tert-butylphenolato)) were prepared. The proligands, H2[L1] and H2[L2] were reacted with di(n-butyl)magnesium in toluene to give the desired compounds in high yields.
Guangling Jiao et al.
Marine drugs, 13(6), 3849-3876 (2015-06-23)
Northern shrimp (Pandalus borealis) oil, which is rich in omega-3 fatty acids, was recovered from the cooking water of shrimp processing facilities. The oil contains significant amounts of omega-3 fatty acids in triglyceride form, along with substantial long-chain monounsaturated fatty
Roman O Iakovenko et al.
Organic & biomolecular chemistry, 13(33), 8827-8842 (2015-07-18)
4-Aryl-1,1,1-trifluorobut-3-en-2-ones ArCH[double bond, length as m-dash]CHCOCF3 (CF3-enones) react with arenes in excess of Brønsted superacids (TfOH, FSO3H) to give, stereoselectively, trans-1,3-diaryl-1-trifluoromethyl indanes in 35-85% yields. The reaction intermediates, the O-protonated ArCH[double bond, length as m-dash]CHC(OH(+))CF3 and the O,C-diprotonated ArHC(+)CH2C(OH(+))CF3 species
Alexander J Pérez et al.
Chembiochem : a European journal of chemical biology, 16(11), 1588-1591 (2015-06-03)
Fatty acids (FAs) have numerous functions in all living organisms, ranging from structural roles and energy production to the biosynthesis of secondary metabolites. Because of the high energy content of exogenous FAs, their acquisition is central of metabolism, and several
Mohamed E Azab et al.
Molecules (Basel, Switzerland), 20(10), 18201-18218 (2015-10-13)
Treatment of 2,3-diaryloxirane-2,3-dicarbonitriles 1a-c with different nitrogen nucleophiles, e.g., hydrazine, methyl hydrazine, phenyl hydrazine, hydroxylamine, thiosemicarbazide, and/or 2-amino-5-phenyl-1,3,4-thiadiazole, afforded pyrazole, isoxazole, pyrrolotriazine, imidazolothiadiazole derivatives 2-5, respectively. Reacting pyrazoles 2a-c with aromatic aldehydes and/or methyl glycinate produced Schiff's bases 7a-d and
Wonhwa Lee et al.
Inflammation, 38(4), 1649-1661 (2015-03-07)
Inhibition of high-mobility group box 1 (HMGB1) protein and restoration of endothelial integrity are emerging as attractive therapeutic strategies in the management of sepsis. Here, new five structurally related 3'-N-substituted carbazole derivatives were examined for their effects on lipopolysaccharide (LPS)-mediated
Emilia Păunescu et al.
ChemMedChem, 10(9), 1539-1547 (2015-07-21)
Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for their antiproliferative activity. Three compounds from the series display
Vijay Pawar et al.
AAPS PharmSciTech, 16(3), 518-527 (2014-11-06)
Piperazinylalkyl ester prodrugs (4a-5d) of 6-methoxy-2-naphthylacetic acid (6-MNA) (1) were synthesized and evaluated in vitro for the purpose of percutaneous drug delivery. These ionizable prodrugs exhibited varying aqueous solubilities and lipophilicities depending on the pH of the medium. The prodrugs
Yoshifumi Maegawa et al.
Dalton transactions (Cambridge, England : 2003), 44(29), 13007-13016 (2015-03-10)
Heterogeneous catalysis for direct C-H borylation of arenes and heteroarenes in the combination of iridium (Ir) complex fixed on periodic mesoporous organosilica containing bipyridine ligands within the framework (Ir-BPy-PMO) and pinacolborane (HBpin) is reported. Ir-BPy-PMO showed higher catalytic activity toward
Andrew D Shubin et al.
Tissue engineering. Part A, 21(11-12), 1733-1751 (2015-03-13)
More than 40,000 patients are diagnosed with head and neck cancers annually in the United States with the vast majority receiving radiation therapy. Salivary glands are irreparably damaged by radiation therapy resulting in xerostomia, which severely affects patient quality of
F Kazazi-Hyseni et al.
Acta biomaterialia, 22, 141-154 (2015-05-02)
Subcapsular renal injection is a novel administration method for local delivery of therapeutics for the treatment of kidney related diseases. The aim of this study was to investigate the feasibility of polymeric microspheres for sustained release of protein therapeutics in
Jayati Trivedi et al.
SpringerPlus, 4, 165-165 (2015-04-29)
In view of the rising global problems of environment pollution and degradation, the present process provides a 'green solution' to the synthesis of higher esters of lubricant range, more specifically in the range C12-C36, using different combinations of acids and
Pedro Pires Goulart Guimarães et al.
Molecules (Basel, Switzerland), 20(1), 879-899 (2015-01-13)
The aim of this work was to synthesize sulfadiazine-poly(lactide-co-glycolide) (SUL-PLGA) nanoparticles (NPs) for the efficient delivery of 5-fluorouracil to cancer cells. The SUL-PLGA conjugation was assessed using FTIR, 1H-NMR, 13C-NMR, elemental analysis and TG and DTA analysis. The SUL-PLGA NPs
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