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Showing 31-60 of 106 results for "59-49-4" within Papers
M Bajzová et al.
Physiological research, 57(6), 927-934 (2007-12-07)
Retinol binding protein 4 (RBP4) is a novel adipokine which might be involved in the development of insulin resistance. The aim of the study was to investigate the expression of RBP4 mRNA in subcutaneous and visceral fat depots and the
Alex Lin et al.
Journal of neuropathology and experimental neurology, 71(1), 66-72 (2011-12-14)
Recent studies highlight the importance of BRAF alterations resulting in mitogen activated protein kinase (MAK/ERK) pathway activation in low-grade CNS tumors. We studied 106 low-grade CNS neoplasms in a cohort of primarily pediatric patients to identify the prevalence and clinicopathologic
Leon Alexander Danyel et al.
Ultrasound in medicine & biology, 46(8), 1889-1895 (2020-05-23)
Transcranial color-coded duplex sonography (TCCS) and computed tomography angiography (CTA) are widely used to identify intracranial stenoses (ISs). We assessed concordance of IS grading between TCCS and CTA and proposed new TCCS criteria for severe IS ≥70%. One hundred two
W Shen et al.
Human & experimental toxicology, 15(5), 428-434 (1996-05-01)
1. Nitrofurantoin is an antimicrobial agent which produces hepatotoxicity caused by the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2. Our goal was
Alexander S McLawhorn et al.
Clinical orthopaedics and related research, 473(10), 3183-3189 (2015-06-07)
The enhanced posterior soft tissue repair has reduced the frequency of dislocation after primary THA performed through the posterolateral approach. However, the long-term integrity of the repair is unknown and could influence surgeon choice regarding surgical technique and THA approach.
Hans F A Vasen et al.
Gastroenterology, 140(3), 850-856 (2010-12-07)
Surveillance of high-risk groups for pancreatic cancer might increase early detection and treatment outcomes. Individuals with germline mutations in p16-Leiden have a lifetime risk of 15% to 20% of developing pancreatic cancer. We assessed the feasibility of detecting pancreatic cancer
M Attanasio et al.
Clinical genetics, 74(1), 39-46 (2008-04-26)
Fibrillin-1 gene (FBN1) mutations cause Marfan syndrome (MFS), an inherited connective tissue disorder with autosomal dominant transmission. Major clinical manifestations affect cardiovascular and skeletal apparatuses and ocular and central nervous systems. We analyzed FBN1 gene in 99 patients referred to
Vincenzo Belcastro et al.
Epilepsia, 48(10), 1990-1994 (2007-06-15)
The influence of antiepileptic drugs (AEDs) and/or common polymorphisms (677C --> T, 1298A --> C) of the methylene-tetrahydrofolate-reductase (MTHFR) gene on the recurrence time of hyper-total-homocysteinemia (tHcy > 13 micromol/L) was investigated in 59 hyper-homocysteinemic patients (34M/25F, 20-49 years). Plasma
Karen O Klein et al.
The Journal of clinical endocrinology and metabolism, 105(10) (2020-08-02)
Gonadotropin-releasing hormone agonists (GnRHas) are standard of care for central precocious puberty (CPP). A 6-month subcutaneous injection has recently been approved by the Food and Drug Administration. Determine efficacy, pharmacokinetics, and safety of 6-month 45-mg subcutaneous leuprolide acetate for CPP.
D Martijn O Pruissen et al.
Blood, 111(3), 1282-1286 (2007-11-17)
Prothrombotic conditions are associated with ischemic stroke in young women. In particular, the combination of oral contraceptive use and prothrombotic genetic variants appears to increase the risk of ischemic stroke. We performed a population-based case-control study in 190 women aged
Khaldon Bodoor et al.
Cancer epidemiology, 34(6), 724-732 (2010-06-15)
Bladder cancer accounts for nearly 5% of all newly diagnosed cancers in Jordan, with a much higher frequency in males. Recent studies have shown that activating mutations in FGFR3 are the most common findings in non-invasive low grade bladder tumors.
Dan Wang et al.
Zhonghua yi xue za zhi, 91(30), 2129-2131 (2011-11-19)
To study the STAT5 phosphorylation levels of erythropoietin receptor (EPOR) and thrombopoietin receptor (TPOR) in CD34(+)CD59(-) and CD34(+)CD59(+) bone marrow cells of the patients with paroxysmal nocturnal hemoglobinuria (PNH). The bone marrow mononuclear cells (BMMNC) were extracted from 23 PNH
Jane Shearer et al.
Diabetes, 54(11), 3133-3139 (2005-10-27)
The aim of this study was to determine the contribution of heart-type fatty acid-binding protein (H-FABP) to glucose and long-chain fatty acid (LCFA) utilization in dietary-induced insulin resistance. We tested the hypothesis that H-FABP facilitates increases in LCFA flux present
L P Pan et al.
Pharmacogenetics, 8(5), 383-389 (1998-11-24)
In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of reduced haloperidol were assessed by measuring
James R McMillan et al.
The Journal of investigative dermatology, 121(1), 96-103 (2003-07-04)
Recessive mutations in the desmosomal plaque protein plakophilin 1 (PkP1) underlie ectodermal dysplasia/skin fragility syndrome (MIM 604536). We undertook an immunohistochemical and quantitative electron microscopic examination of suprabasal desmosomes from 4 skin samples from 3 PkP1 deficient patients, an unaffected
Natalia Acosta-Baena et al.
The Lancet. Neurology, 10(3), 213-220 (2011-02-08)
Mild cognitive impairment (MCI) and pre-MCI have been proposed as stages preceding Alzheimer's disease (AD) dementia. We assessed descendants of individuals with a mutation in presenilin 1 (PSEN1) that causes familial AD, with the aim of identifying distinct stages of
Cyril Cuffel et al.
International journal of cancer, 128(11), 2625-2634 (2010-08-18)
Cancer-testis (CT) antigens comprise families of tumor-associated antigens that are immunogenic in patients with various cancers. Their restricted expression makes them attractive targets for immunotherapy. The aim of this study was to determine the expression of several CT genes and
Mudassar Mohiuddin et al.
Toxins, 12(10) (2020-10-18)
Clostridium perfringens poses a serious threat to small ruminants by causing moderate to severe enterotoxaemia. Due to its ability to produce a wide arsenal of toxins, it is ranked among the most prevalent and important pathogens in livestock. This study
N Ranta et al.
Scandinavian journal of immunology, 82(6), 539-546 (2015-09-09)
There is an increasing need for novel biomarkers that enable better diagnostic and prognostic stratification of patients with suspected infection. A proprotein convertase enzyme FURIN is upregulated upon immune cell activation, and it promotes infectivity by cleaving and activating pathogens.
Catherine E Bond et al.
BMC cancer, 15, 20-20 (2015-01-24)
PRDM5 is an epigenetic regulator that has been recognized as an important tumour suppressor gene. Silencing of PRDM5 by promoter hypermethylation has been demonstrated in several cancer types and PRDM5 loss results in upregulation of the Wnt pathway and increased
Dengfeng Cao et al.
Human pathology, 42(5), 710-718 (2011-02-04)
LIN28 is an RNA-binding protein involved in maintaining the pluripotency of embryonic stem cells. Using formalin-fixed, paraffin-embedded tissue blocks, we performed immunohistochemical staining of LIN28 in 103 primary and 81 metastatic testicular germ cell tumors (54 intratubular germ cell neoplasias
A Rivera-Sagredo et al.
European journal of biochemistry, 197(1), 217-228 (1991-04-10)
The binding of methyl beta-lactoside and of all possible monodeoxy derivatives of methyl beta-lactoside to the galactose-specific highly cytotoxin lectin ricin, has been investigated. The distribution of low-energy conformers of the disaccharide structures has been first determined using molecular-mechanics calculations
Tomoo Kuge et al.
Clinical therapeutics, 26(10), 1644-1651 (2004-12-16)
Seirogan, an herbal medication containing wood creosote, a mixture of simple phenolic (single-ring)compounds, has been marketed in Asia for the past century as an antidiarrheal and antispasmodic medication. This was the first randomized, double-blind study of this herbal medication in
Selvizhi Subramanian et al.
The Cochrane database of systematic reviews, (10)(10), CD006628-CD006628 (2010-10-12)
In many parts of the world, particularly in industrialised countries, second generation (atypical) antipsychotic drugs have become first line treatment for people suffering from schizophrenia. The question as to whether the effects of various second generation antipsychotic drugs differ is
Jia Xu et al.
Analytical and bioanalytical chemistry, 409(19), 4559-4569 (2017-05-26)
A hexafluoroisopropanol (HFIP)-mediated cloud point extraction (CPE) system was established. A small amount of HFIP (even 1%, v/v) can dramatically reduce the cloud point of Triton X-100 (TX-100) aqueous solution (even to 1 °C) and make liquid-liquid two-phase separation (coacervate phase
Silvia Pizzi et al.
Endocrine-related cancer, 15(4), 1013-1024 (2008-07-18)
The role of Wnt pathway in digestive endocrine tumours is debated. The aim of this work is to investigate key players in Wnt pathway by a multimodal approach. Sixty cases (49 well-differentiated and 11 poorly differentiated) were investigated for methylation
Takeji Umemura et al.
The American journal of gastroenterology, 103(3), 588-594 (2008-03-18)
Autoimmune pancreatitis (AIP) is characterized by high serum IgG4 concentrations, lymphoplasmacytic inflammation, and a favorable response to corticosteroid treatment. Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors
D G Evans et al.
Journal of medical genetics, 46(9), 593-597 (2008-04-17)
To assess the effectiveness of annual ovarian cancer screening (transvaginal ultrasound and serum CA125 estimation) in reducing mortality from ovarian cancer in women at increased genetic risk. A cohort of 3532 women at increased risk of ovarian cancer was screened
Ghalia Boubaker et al.
PLoS neglected tropical diseases, 9(6), e0003795-e0003795 (2015-06-09)
Alveolar echinococcosis (AE) is caused by infection with the larval stage of the tapeworm Echinococcus multilocularis. An increasing understanding of immunological events that account for the metacestode survival in human and murine AE infection prompted us to undertake explorative experiments
Lutz Bünger et al.
Genetical research, 84(3), 161-173 (2005-04-13)
Myostatin is a negative regulator of muscle growth and mutations in its gene lead to muscular hypertrophy and reduced fat. In cattle, this is seen in 'double muscled' breeds. We have used marker-assisted introgression to introduce a murine myostatin mutation
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