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Showing 1-30 of 106 results for "59060" within Papers
Julie Bolcaen et al.
Nuclear medicine and biology, 42(1), 38-45 (2014-09-15)
Discrimination between (high-grade) brain tumor recurrence and radiation necrosis (RN) remains a diagnostic challenge because both entities have similar imaging characteristics on conventional magnetic resonance imaging (MRI). Metabolic imaging, such as positron emission tomography (PET) could overcome this diagnostic dilemma.
Dorottya Czövek et al.
Respiratory research, 15, 81-81 (2014-08-15)
Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able
Chang Seok Lee et al.
The Journal of biological chemistry, 289(37), 25556-25570 (2014-07-24)
Rapamycin at high doses (2-10 mg/kg body weight) inhibits mammalian target of rapamycin complex 1 (mTORC1) and protein synthesis in mice. In contrast, low doses of rapamycin (10 μg/kg) increase mTORC1 activity and protein synthesis in skeletal muscle. Similar changes
Cécile Philippe et al.
European journal of pharmacology, 735, 177-183 (2014-05-02)
The MCHR1 is an interesting pharmacological and pharmaceutical target, due to its involvement in pathologies as diabetes, gut inflammation and adiposity. in vivo PET-studies of the MCHR1 in energy homeostasis and diabetes could be of great value for deeper understanding
G Tan et al.
Scandinavian journal of rheumatology, 44(2), 150-156 (2014-12-03)
To investigate whether serum anti-high mobility group box 1 (anti-HMGB1) antibodies are related to the development of skin lesions in systemic lupus erythematosus (SLE). This study involved 21 SLE patients with skin lesions, 18 without skin lesions, and 22 healthy
Martina Seifert et al.
The Journal of surgical research, 193(2), 933-941 (2014-12-03)
Undesirable processes of inflammation, calcification, or immune-mediated reactions are limiting factors in long-term survival of heart valves in patients. In this study, we target the modulatory effects of ice-free cryopreservation (IFC) of xenogeneic heart valve leaflet matrices, without decellularization, on
Emmanuelle Charrin et al.
British journal of haematology, 168(5), 747-756 (2014-11-11)
Oxidative stress plays a crucial role in sickle cell disease (SCD) physiopathology. Given that chronic physical activity is known to decrease reactive oxygen species (ROS) and increase nitric oxide (NO) bioavailability in healthy subjects and in patients with cardiovascular or
Behnia S Lashkari et al.
Journal of reproductive immunology, 107, 43-51 (2014-12-04)
Pelvic infections and sexually transmitted diseases place a burden on health resources and may be associated with premature birth. The mechanisms by which the female reproductive tract (FRT) combats these infections remain ill understood, but are likely to involve the
Javier Morán et al.
Experimental gerontology, 58, 104-112 (2014-08-03)
Menopause leads to a decrease in estrogen production that increases central insulin resistance, contributing to the development of neurodegenerative diseases. We have evaluated the influence of aging and estradiol or genistein treatments on some key stages of the insulin signaling
M Quiviger et al.
Gene therapy, 21(12), 1001-1007 (2014-08-22)
Mucopolysaccharidosis type IIIA (MPS-IIIA) or Sanfilippo A syndrome is a lysosomal storage genetic disease that results from the deficiency of the N-sulfoglucosamine sulfohydrolase (SGSH) protein, a sulfamidase required for the degradation of heparan sulfate glycosaminoglycans (GAGs). The accumulation of these
Katrina L Paumier et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-883 (2014-10-01)
In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effects in Parkinson's disease. The present study investigated whether chronic treatment with a frequently prescribed tricyclic antidepressant
Chengcao Sun et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(2), 224-237 (2015-01-17)
Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as
Craig M McKittrick et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(4), 638-647 (2015-01-08)
Blood brain barrier (BBB) breakdown and neuroinflammation are key events in ischemic stroke morbidity and mortality. The present study investigated the effects of mast cell deficiency and stabilization on BBB breakdown and neutrophil infiltration in mice after transient middle cerebral
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Angèle Nalbandian et al.
Human gene therapy methods, 26(1), 13-24 (2014-12-30)
Inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia is attributed to mutations in the valosin-containing protein (VCP) gene, mapped to chromosomal region 9p13.3-12. Affected individuals exhibit scapular winging and die from progressive muscle weakness and
David Van Mater et al.
Cancer research, 75(3), 605-614 (2014-12-17)
Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation.
Javier Catalán
The journal of physical chemistry. A, 114(2), 811-816 (2009-12-19)
A photophysical study of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indole dissolved in 2-methylbutane at decreasing temperatures from 293 to 93 K revealed the presence of two different fluorescence emissions due to doubly hydrogen-bonded dimers of the monomer species. One of the emissions is assigned to
Sara A Olenich et al.
The Journal of physiology, 592(15), 3325-3338 (2014-06-22)
Temporal expression of positive and negative angiogenic factors in response to detraining is poorly understood. We report the protein expression of anti-angiogenic peptides (thrombospondin-1, TSP-1; and endostatin) as well as pro-angiogenic factors (vascular endothelial growth factor, VEGF; matrix metalloproteinases-2 and
Anna K Kopec et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 288-297 (2014-08-21)
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic syndrome. Robust coagulation cascade activation is common in obese patients with NAFLD. We identified a critical temporal relationship between thrombin generation and the manifestation of hepatic steatosis
Benedikt Galliker et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(25), 6161-6168 (2009-05-14)
We have identified two intermediates in the autoxidation of NO*: ONOO*, which was detected by EPR spectroscopy at 295 K and atmospheric pressure in the gas phase, and ONOONO, a red substance produced at 113 K in 2-methylbutane. The red
Fernando Eduardo Padovan-Neto et al.
Neuropharmacology, 89, 87-99 (2014-09-10)
It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID). Here, we investigated the ability of
Nicolas Goffart et al.
Neuro-oncology, 17(1), 81-94 (2014-08-03)
Patients with glioblastoma multiforme (GBM) have an overall median survival of 15 months. This catastrophic survival rate is the consequence of systematic relapses that could arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. We previously demonstrated that
Dorota Haznar-Garbacz et al.
AAPS PharmSciTech, 12(4), 1183-1185 (2011-09-16)
A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an
B Auffinger et al.
Cell death and differentiation, 21(7), 1119-1131 (2014-03-13)
Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells known as glioma stem cells (GSCs). This hypothesis states that only
Shailaja Kesaraju et al.
Journal of neurochemistry, 109(5), 1413-1426 (2009-05-30)
Freshwater turtles survive prolonged anoxia and reoxygenation without overt brain damage by well-described physiological processes, but little work has been done to investigate the molecular changes associated with anoxic survival. We examined stress proteins and apoptotic regulators in the turtle
Christian Giordano et al.
Human molecular genetics, 24(8), 2147-2162 (2015-01-02)
Toll-like receptor 4 (TLR4) recognizes specific structural motifs associated with microbial pathogens and also responds to certain endogenous host molecules associated with tissue damage. In Duchenne muscular dystrophy (DMD), inflammation plays an important role in determining the ultimate fate of
David Santos et al.
American journal of dentistry, 22(5), 315-320 (2010-03-17)
To compare the effects of a new gel-to-foam dentifrice to two standard fluoride control dentifrices on foam generation, levels of total viable anaerobes and total viable volatile sulfur compound (VSC)-producing bacteria in expectorate after brushing. 36 subjects participated in this
Heidi Tran et al.
The European journal of neuroscience, 41(1), 55-68 (2014-11-19)
The striatum is the key input nucleus of the basal ganglia, and is implicated in motor control and learning. Despite the importance of striatal circuits, the mechanisms associated with their development are not well established. Previously, Ten-m3, a member of
Georg F Weber et al.
The Journal of experimental medicine, 211(6), 1243-1256 (2014-05-14)
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B
Y C Hsu et al.
Chemosphere, 42(3), 227-234 (2000-12-02)
Motor vehicle emission factors of carbon monoxide (CO) and non-methane volatile organic compounds (NMVOCs) were calculated inside the Chung-Cheng Tunnel of Kaohsiung in Taiwan. The results were compared with those model predictions from the Mobile Taiwan 2.0 model. Individual concentrations
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