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Showing 1-30 of 54 results for "59510" within Papers
Heath D Schmidt et al.
Addiction biology, 20(2), 285-296 (2014-02-11)
Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of accumbens core mGluR1, mGluR5 and protein kinase C (PKC) in
Beibei Chen et al.
Journal of chromatography. A, 1363, 62-70 (2014-08-19)
In this paper, the "state of the art" of chiral speciation of selenoamino acids (SeAAs) in biological samples is critically reviewed. The significance and the features of such studies are highlighted. A special focus lies on chiral speciation of SeAAs
Kay O Johswich et al.
Infection and immunity, 83(1), 354-363 (2014-11-05)
Neisseria meningitidis asymptomatically colonizes the human upper respiratory tract but is also the cause of meningitis and severe septicemia. Carriage or disease evokes an immune response against the infecting strain. Hitherto, we have known little about the breadth of immunity
Glenn A Jacobson et al.
Journal of pharmaceutical and biomedical analysis, 94, 54-57 (2014-02-20)
Pergolide, an ergot-derived dopamine D2 receptor agonist, is used extensively as an orally administered treatment for pituitary pars intermedia dysfunction (PPID) in horses. One of the barriers associated with pergolide determinations in plasma for pharmacokinetic applications has been the technically
Robert Hiessl et al.
Analytical methods : advancing methods and applications, 12(24), 3137-3144 (2020-09-16)
In this study, an inline analytical method was designed and applied in process characterisation and development. The model reaction is the two-step diesterification of 3-methylphthalic anhydride with 2-ethylhexanol consisting of alcoholysis as the first step, followed by an acid-catalysed, second
Chris Twelves et al.
Breast cancer research and treatment, 148(3), 553-561 (2014-11-09)
Data from two phase 3 studies of eribulin were pooled in analyses initially requested by the European Medicines Agency to assess whether specific patient subgroups, previously treated with an anthracycline and a taxane, benefited from eribulin. Study 305/EMBRACE included women
Cinzia Martinengo et al.
Cancer research, 74(21), 6094-6106 (2014-09-07)
Rearrangements involving the anaplastic lymphoma kinase (ALK) gene are defining events in several tumors, including anaplastic large-cell lymphoma (ALCL) and non-small cell lung carcinoma (NSCLC). In such cancers, the oncogenic activity of ALK stimulates signaling pathways that induce cell transformation
Tânia E Sintra et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 20(5), 727-735 (2019-01-24)
Twelve surface-active ionic liquids (SAILs) and surface-active derivatives, based on imidazolium, ammonium, and phosphonium cations and containing one, or more, long alkyl chains in the cation and/or the anion, were synthetized and characterized. The aggregation behavior of these SAILs in
Adnan H Mahmood et al.
International journal of pharmaceutics, 481(1-2), 71-78 (2015-02-01)
To introduce better antibiotics for the treatment of some infectious diseases in sheep and to expand the range of antibiotics available for veterinary medicine, pharmacokinetics of two antibiotics marbofloxacin (MBX) and trovafloxacin (TVX) were investigated in sheep after intramuscular injection.
Gaotong Lin et al.
Drug development and industrial pharmacy, 40(12), 1616-1622 (2013-09-24)
The aim of the study was to develop a high performance liquid chromatography method for simultaneous determination of imatinib and CGP74588 in rat serum and study the inhibition effects of ketoconazole, itraconazole and voriconazole on pharmacokinetics of imatinib and CGP74588
Gabriel Nowak et al.
Neuropharmacology, 84, 46-51 (2014-05-07)
Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies, along with the antidepressant-like activities of negative allosteric modulators (NAMs) of mGlu5, led us
Petri A Turhanen et al.
Scientific reports, 5, 8992-8992 (2015-03-12)
A Novel approach to remove metals from aqueous solutions has been developed. The method is based on a resin free, solid, non-toxic, microcrystalline bisphosphonate material, which has very low solubility in water (59 mg/l to ion free Milli-Q water and 13 mg/l
Franziska Roth-Walter et al.
PloS one, 9(8), e104803-e104803 (2014-08-15)
The mechanisms of allergic sensitization to milk are still elusive. The major allergen Bos d 5 belongs to the lipocalin-family and thus is able to transport numerous ligands. In this study we investigated its ability to bind to iron-siderophore complexes
Chanhun Park et al.
Journal of chromatography. A, 1365, 106-114 (2014-09-23)
The economically-efficient separation of formic acid from acetic acid and succinic acid has been a key issue in the production of formic acid with the Actinobacillus bacteria fermentation. To address this issue, an optimal three-zone simulated moving bed (SMB) chromatography
Varahenage R Perera et al.
Biochimica et biophysica acta, 1840(9), 2851-2861 (2014-05-14)
Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis was identified as a new member of the recently discovered DinB/YfiT-like Superfamily. Based on structural
Pablo Manfredi et al.
Infection and immunity, 83(1), 300-310 (2014-11-05)
Capnocytophaga canimorsus, a dog mouth commensal and a member of the Bacteroidetes phylum, causes rare but often fatal septicemia in humans that have been in contact with a dog. Here, we show that C. canimorsus strains isolated from human infections
Michael A Malfatti et al.
Antimicrobial agents and chemotherapy, 58(11), 6477-6483 (2014-08-20)
Determining the pharmacokinetics (PKs) of drug candidates is essential for understanding their biological fate. The ability to obtain human PK information early in the drug development process can help determine if future development is warranted. Microdosing was developed to assess
Stanisław Stanosz et al.
The Journal of clinical endocrinology and metabolism, 99(12), E2472-E2476 (2014-08-27)
This report presents original, combined mode of treatment of preinvasive endometrial cancer (IA/G1) in young women with polycystic ovarian syndrome. The objective of the study was the assessment of treatment with natural female sexual hormones in combination with antidiabetic, antioxidative
Anne-Charlotte Dubbelman et al.
Investigational new drugs, 33(1), 233-240 (2014-11-08)
Lenvatinib is an orally available multi-targeted tyrosine kinase inhibitor with anti-angiogenic and antitumor activity. To get more insight into the disposition of lenvatinib, a mass balance study was performed in patients with advanced solid tumors. A single oral 24 mg
Dayong Wang et al.
Journal of Alzheimer's disease : JAD, 43(2), 519-534 (2014-08-13)
The stress protein heme oxygenase-1 (HO-1) is upregulated and co-localizes to pathological features, including tauopathies in the brains of individuals with Alzheimer's disease. However, the relationship between HO-1 and Alzheimer's disease remains unclear. In our previous research, the long-term overexpression
Jinhui Yang et al.
Neuropharmacology, 86, 353-361 (2014-09-10)
Increasing evidence demonstrates that different opioids, while acting μ opioid receptors, can activate distinct downstream responses, a phenomenon termed functional selectivity or biased agonism. The present study designed experiments to test whether the μ receptor agonist morphine and D-Ala(2), N-Me-Phe(4)
Robert C Shumaker et al.
Clinical drug investigation, 34(9), 651-659 (2014-07-16)
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor under clinical investigation in solid tumours. This study evaluated the influence of P-glycoprotein (P-gp) inhibition (single-dose rifampicin) and simultaneous cytochrome P450 3A4 (CYP3A4)/P-gp induction (multiple-dose rifampicin) on lenvatinib pharmacokinetics. This Phase I
Roberta Venè et al.
Neoplasia (New York, N.Y.), 16(9), 710-722 (2014-09-24)
Targeting tumor-specific metabolic adaptations is a promising anticancer strategy when tumor defense mechanisms are restrained. Here, we show that redox-modulating drugs including the retinoid N-(4-hydroxyphenyl)retinamide (4HPR), the synthetic triterpenoid bardoxolone (2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester), arsenic trioxide (As2O3), and phenylethyl isothiocyanate
M Koczywas et al.
British journal of cancer, 111(12), 2268-2274 (2014-10-29)
Eribulin mesylate is a synthetic macrocyclic ketone analogue of Halichondrin B that has demonstrated high antitumor activity in preclinical and clinical settings. This phase I study aimed to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetics in
Mingna Li et al.
Drug delivery, 21(4), 293-301 (2013-10-26)
Two novel polymer-drug conjugates norcantharidin-poly(vinyl alcohol) and norcantharidin-chitosan (NCTD-PVA and NCTD-CS) were synthesized via alcoholysis reaction and characterized by (1)H-NMR and FTIR. NCTD was released from the conjugates via hydrolysis, faster in PBS (pH 5.0) than that in PBS (pH
Rosuany N Vélez Acevedo et al.
Journal of bacteriology, 196(15), 2762-2774 (2014-05-20)
Iron is an essential nutrient for survival and establishment of infection by Neisseria gonorrhoeae. The neisserial transferrin binding proteins (Tbps) comprise a bipartite system for iron acquisition from human transferrin. TbpA is the TonB-dependent transporter that accomplishes iron internalization. TbpB
André R S Colla et al.
Pharmacology, biochemistry, and behavior, 124, 108-116 (2014-06-03)
Ursolic acid (UA) is a natural pentacyclic triterpenoid carboxylic acid that exerts antidepressant-like effects in the tail suspension test (TST) and in the forced swimming test, and this effect was reported to be mediated by the dopaminergic system. Many studies
R M Meyer et al.
Molecular psychiatry, 19(12), 1284-1294 (2013-10-16)
Hormones in the hypothalamus-pituitary-adrenal (HPA) axis mediate many of the bodily responses to stressors, yet there is no clear relationship between the levels of these hormones and stress-associated mental illnesses such as posttraumatic stress disorder (PTSD). Therefore, other hormones are
Mohammad M Fares et al.
Biomaterials science, 6(11), 2938-2950 (2018-09-25)
The design of new hydrogel-based biomaterials with tunable physical and biological properties is essential for the advancement of applications related to tissue engineering and regenerative medicine. For instance, interpenetrating polymer network (IPN) and semi-IPN hydrogels have been widely explored to
P Tauber et al.
Endocrinology, 155(4), 1353-1362 (2014-02-11)
Somatic mutations of the potassium channel KCNJ5 are found in 40% of aldosterone producing adenomas (APAs). APA-related mutations of KCNJ5 lead to a pathological Na(+) permeability and a rise in cytosolic Ca(2+), the latter presumably by depolarizing the membrane and
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