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Kaisu R Riihinen et al.
Fitoterapia, 97, 78-86 (2014-06-01)
The antimicrobial activity of lingonberry (Vaccinium vitis-idaea L.) was evaluated against two oral pathogens, Streptococcus mutans and Fusobacterium nucleatum. Long-bed gel permeation chromatography (GPC; Sephadex LH-20) yielded purified flavonoids, with the most efficient minimum inhibitory concentrations (MICs) against planktonic cells
María-Ángeles Del-Castillo-Alonso et al.
Journal of the science of food and agriculture, 95(2), 409-416 (2014-05-14)
Ultraviolet (UV) radiation induces adaptive responses that can be used for plant production improvement. The aim of this study was to assess the effect of solar UV exclusion on the physiology and phenolic compounds of leaves and berry skins of
Morshed A Chowdhury et al.
Bioorganic & medicinal chemistry letters, 19(24), 6855-6861 (2009-11-04)
A novel class of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-4 or C-5 position was designed for evaluation as anti-inflammatory (AI) agents. Replacement of the 2,4-difluorophenyl ring in diflunisal by the N-difluoromethyl-1,2-dihydropyrid-2-one moiety provided
Ekhtear Hossain et al.
Molecular and cellular biochemistry, 400(1-2), 29-40 (2014-10-29)
There is a growing body of evidence supporting an intimate association of immune activation with the pathogenesis of cardiovascular diseases, including atherosclerosis. Uptake of oxidized low-density lipoprotein (oxLDL) through scavenging receptors promotes the formation of mature lipid-laden macrophages, which subsequently
Liangmian Chen et al.
Journal of pharmaceutical and biomedical analysis, 95, 93-101 (2014-03-25)
A novel three-channel isocratic elution high performance liquid chromatography with electrochemical detection (3LC-ECD) system was developed for the simultaneous determination of various bioactive redox components in Shuang-Huang-Lian (SHL) preparations. This 3LC-ECD system consists of three isocratic elution flow ways, two
Alexandra Gaspar et al.
European journal of medicinal chemistry, 44(5), 2092-2099 (2008-12-09)
An interdisciplinary research project was developed combining the synthesis of a series of hydroxycinnamic acid derivatives and the evaluation of their physicochemical parameters (namely redox potentials and partition coefficients), along with the corresponding antioxidant activity. A structure-property-activity relationship (SPAR) approach
Yu Chen et al.
Nature chemical biology, 5(5), 358-364 (2009-03-24)
Fragment screens have successfully identified new scaffolds in drug discovery, often with relatively high hit rates (5%) using small screening libraries (1,000-10,000 compounds). This raises two questions: would other noteworthy chemotypes be found were one to screen all commercially available
Seon-Yeong Kwak et al.
Amino acids, 46(12), 2777-2785 (2014-09-15)
Caffeic acid (CA) is one of the antioxidants found in plants, which protects vascular cells against vascular injuries from oxidative stress. In our previous study, caffeoyl-prolyl-histidine amide (CA-L-Pro-L-His-NH2; CA-PH; a CA derivative) was synthesized, which exhibited a strong antioxidant activity
Koji Uwai et al.
Bioorganic & medicinal chemistry, 16(16), 7795-7803 (2008-08-01)
Caffeic acid esters, one of the components of propolis, are known to show a variety of biological effects such as anti-tumor, anti-oxidant, and anti-inflammatory activities. Although, the anti-inflammatory activities of caffeic acid esters have been studied by analyzing their structure
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry letters, 16(21), 5621-5624 (2006-08-16)
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their
Wendy R Russell et al.
Bioorganic & medicinal chemistry, 16(8), 4589-4593 (2008-03-04)
Elevated levels of phospholipases, prostaglandin synthases and lipoxygenases in colonic cells at various stages of malignancy indicate a strong link between dietary lipids and colon cancer. Lipoxygenase-catalysed arachidonic acid metabolism plays a key role in colorectal carcinogenesis and has the
Sung-Yong Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 92-99 (2013-01-12)
Perilla frutescens leaves are often used in East Asian gourmet food. In this study, we investigated the hepatoprotective effects of caffeic acid (CA), rosmarinic acid (RA), and their combination. P. frutescens contains 1.32μg CA/mg dry material (DM) and 26.84μg RA/mg
Ericsson David Coy et al.
Bioorganic & medicinal chemistry letters, 19(24), 6922-6925 (2009-11-03)
The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation
E Pontiki et al.
Bioorganic & medicinal chemistry, 15(17), 5819-5827 (2007-07-03)
Lipoxygenase catalyzes the first two steps of the transformation of arachidonic acid into leukotrienes which are implicated in host defense reactions. It is well known that many acids possess potent anti-inflammatory activity. Taking into account that compounds bearing a thienyl
Miriam Martínez-Huélamo et al.
Food chemistry, 173, 864-872 (2014-12-04)
Tomato sauce is the most commonly consumed processed tomato product worldwide, but very little is known about how the manufacturing process may affect the phenolic composition and bioavailability after consumption. In a prospective randomised, cross-over intervention study, we analysed the
Dongping Liu et al.
Bioorganic & medicinal chemistry letters, 21(22), 6833-6837 (2011-10-04)
Src homology-2 domain-containing protein tyrosine phosphatase (Shp2), a novel proto-oncogenic protein, is an important target in cancer therapy research. Approximately 2000 plant extracts were screened to find its natural specific inhibitors, with the ethyl acetate (EtOAc) active extract of the
Midori Soda et al.
European journal of medicinal chemistry, 48, 321-329 (2012-01-13)
Inhibitors of a human aldo-keto reductase, AKR1B10, are regarded as promising therapeutics for the treatment of cancer, but those with both high potency and selectivity compared to the structurally similar aldose reductase (AKR1B1) have not been reported. In this study
Bilal H Abbasi et al.
Applied biochemistry and biotechnology, 168(7), 2057-2066 (2012-10-19)
Gibberellic acid (GA(3)) is reported to have diverse effects on hairy root cultures of many plant species; therefore, the effects of GA(3) on the growth, secondary metabolite production (caffeic acid derivatives and lignin), phenylalanine ammonia lyase (PAL) activity, and free
Marienca Femenía-Ríos et al.
Bioorganic & medicinal chemistry letters, 16(22), 5836-5839 (2006-09-05)
A novel metabolite (-)-1 was isolated as its peracetylated derivative, (-)-2-(3',4'-diacetoxyphenyl)-3,4-diacetoxytetrahydrofuran (2), from a strain of the phytopathogenic fungus Colletotrichum gloeosporioides CECT 20122. The synthesis of (-)-1 was carried out by ring-closing metathesis of diene 6 and stereoselective dihydroxylation of
Amira S El Senousy et al.
Phytochemistry, 108, 67-76 (2014-10-11)
The metabolomic differences in phenolics from leaves derived from 3 artichoke cultivars (Cynara scolymus): American Green Globe, French Hyrious and Egyptian Baladi, collected at different developmental stages, were assessed using UHPLC-MS coupled to chemometrics. Ontogenic changes were considered as leaves
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry letters, 15(7), 1949-1953 (2005-03-23)
1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 microM. To clarify the structure-activity relationship of 1'S-1'-acetoxychavicol acetate, various natural and synthetic phenylpropanoids and synthetic
Miloš Ilić et al.
Bioorganic & medicinal chemistry letters, 21(16), 4705-4709 (2011-07-16)
Vascular oxidative stress, endothelial injury, and thrombosis are intertwined processes that display a synergistic pathological effect in many cardiovascular diseases. Antithrombotic therapy with anticoagulant and/or antiplatelet agents, combined with interventions against vascular oxidative stress and/or inflammation, both boosting endothelial antithrombotic
Hnin Thanda Aung et al.
Bioorganic & medicinal chemistry, 19(7), 2392-2396 (2011-03-11)
In our previous paper, we reported that rosmarinic acid (1) of Argusia argentea could neutralize snake venom induced hemorrhagic action. Rosmarinic acid (1) consists of two phenylpropanoids: caffeic acid (2) and 3-(3,4-dihydroxyphenyl)lactic acid (3). In this study, we investigated the
Cleverson Antonio Ferreira Martins et al.
Biomedical chromatography : BMC, 28(7), 986-993 (2014-01-10)
Malva sylvestris is a species used worldwide as an alternative to anti-inflammatory therapies; however, its mechanism of action remains unknown. In this paper, the anti-inflammatory effects of M. sylvestris alcoholic extracts were evaluated by measuring the pro-inflammatory mediators PGE₂ and
Giuseppe M Lombardo et al.
Dalton transactions (Cambridge, England : 2003), 41(47), 14337-14344 (2012-10-10)
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of the already published works deal with computational studies of these
Meltem Türkyılmaz et al.
Journal of the science of food and agriculture, 94(12), 2488-2496 (2014-01-22)
This study was conducted to determine the differences in some analytical properties of four apricot cultivars and to determine the changes in these analytical properties during sulfuring and sun-drying. There were significant differences in the contents of polyphenols, carotenoids and
Rosemary Vuković et al.
Plant science : an international journal of experimental plant biology, 199-200, 18-28 (2012-12-26)
The accumulation of phenolic compounds in plants is often part of the defense response against stress and pathogen attack, which can be triggered and activated by elicitors. Oomycetal proteinaceous elicitor, β-cryptogein, induces hypersensitive response and systemic acquired resistance against some
Verena Hess et al.
Applied and environmental microbiology, 79(6), 1942-1947 (2013-01-15)
The anaerobic acetogenic bacterium Acetobacterium woodii couples reduction of caffeate with electrons derived from molecular hydrogen to the synthesis of ATP by a chemiosmotic mechanism with sodium ions as coupling ions. Caffeate is activated to caffeyl coenzyme A (caffeyl-CoA) prior
Mao-Liang Chen et al.
Immunopharmacology and immunotoxicology, 36(6), 390-396 (2014-10-15)
Tournefortia sarmentosa, a Chinese herbal medicine, is considered an antioxidant or a detoxicating agent. Recently T. sarmentosa has received attention for its effects on the immune response. Here we provide evidence that aqueous extract of T. sarmentosa can induce increased
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry, 17(13), 4674-4680 (2009-05-20)
New p-terphenyls, curtisians R (1)-V (5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D-
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