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Pheochromocytoma penetrance varies by RET mutation in MEN 2A.

Frank J Quayle et al.

Surgery, 142(6), 800-805 (2007-12-08)

The occurrence of pheochromocytoma in multiple endocrine neoplasia type 2A (MEN 2A) carriers varies greatly. This study aims to determine PC expression for specific MEN 2A RET mutations. Charts of MEN 2A patients enrolled in our multiple endocrine neoplasia program

The region adjacent to the highly immunogenic site and shielded by the middle domain is responsible for self-oligomerization/client binding of the HSP90 molecular chaperone.

Takayuki K Nemoto et al.

Biochemistry, 43(23), 7628-7636 (2004-06-09)

We here investigated the mechanism of self-oligomerization of the 90-kDa heat shock protein (HSP90) molecular chaperone, because it is known that this oligomerization reflects the client-binding activity. The transition temperatures for the self-oligomerization of the full-length forms of human HSP90alpha

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