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Showing 1-30 of 144 results for "62285" within Papers
Serum TAG analysis differentiates between genetic and obesity-associated NAFLD.
Douglas G Mashek et al.
Diabetes, 63(1), 42-44 (2013-12-21)
S J Humphray et al.
Nature, 429(6990), 369-374 (2004-05-28)
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises
Dai Rui-Wu et al.
The journal of trauma and acute care surgery, 76(3), 784-790 (2014-02-21)
In our previous study, we established a small animal model that mimicked the pathophysiology of isolated pancreatic trauma. To gain further insights into the relationships between tissue damage and the ability of the pancreatic cells to regenerate, we induced pancreatic
V V Petrushenko et al.
Klinichna khirurhiia, (12)(12), 69-72 (2014-02-08)
Impact of rofecoxib on progressing of pancreatic fibrous changes in the rats in experimental chronic pancreatitis, caused by L-arginine, was studied up. In 60 male rats chronic pancreatitis was simulated, using intraabdominal L-arginine introduction (100 mg/100 g) through 21 days.
Dilip Kumar et al.
Natural product communications, 8(2), 195-198 (2013-03-22)
In continuation towards the discovery of potential antiobesity lead(s) from natural products, we have screened n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH) extracts of 33 Indian medicinal plants (200 extracts) for in vitro pancreatic lipase inhibitory activity. Of
Yanhui Lin et al.
Biochemical and biophysical research communications, 434(3), 534-540 (2013-04-16)
The alteration of triglyceride (TG) metabolism in vascular smooth muscle cells (SMC) is likely to be correlated with certain phenotype, though this has not been elucidated. Adipose triglyceride lipase (ATGL) exerts major TG catalytic activity in both adipotic and non-adipotic
Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene.
A Takagi et al.
Molecular and cellular probes, 10(4), 313-314 (1996-08-01)
Amélie Berton et al.
Molecular nutrition & food research, 53(12), 1592-1602 (2009-10-14)
Pancreatic lipase (PL) and pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2) display different functional properties, despite close structures. The aim of the study was to compare the kinetic properties of recombinant human PLRP1, PLRP2, and PL on a
Lovisa E Johansson et al.
European journal of endocrinology, 159(5), 577-583 (2008-08-30)
The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis. This study aimed to replicate the association between PNPLA3 variants and obesity, and to investigate their effect on insulin
Silvia Sookoian et al.
Journal of lipid research, 50(10), 2111-2116 (2009-09-10)
We explored the role of the adiponutrin (PNPLA3) nonsynonymous-rs738409 single nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and whether this SNP contributes to the severity of histological disease. Two hundred sixty-six individuals were evaluated in
Nathan A Ungerleider et al.
Endocrinology, 154(6), 2025-2033 (2013-03-28)
The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial. Activin has emerging roles in nutrient homeostasis, but its metabolic effects on hepatocytes remain
Susumu Saito et al.
Journal of human genetics, 48(5), 249-270 (2003-05-02)
We screened DNAs from 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes by directly sequencing the relevant genomic regions in their entirety except for repetitive elements. This
[Actions of pancreatic lipase on esters in emulsions].
L SARDA et al.
Biochimica et biophysica acta, 30(3), 513-521 (1958-12-01)
A M van Bennekum et al.
Biochemistry, 39(16), 4900-4906 (2000-04-19)
Previously [van Bennekum, A. M., et al. (1999) Biochemistry 38, 4150-4156] we showed that carboxyl ester lipase (CEL)-deficient (CELKO) mice have normal levels of pancreatic, bile salt-dependent retinyl ester hydrolase (REH) activity. In the present study, we further investigated this
Lipoprotein lipase of chicken adipose tissue.
E D KORN et al.
The Journal of biological chemistry, 226(2), 833-839 (1957-06-01)
M Kulka et al.
Polish journal of veterinary sciences, 17(1), 143-147 (2014-04-15)
The objective of this study was to investigate paraoxonase-1 (PON-1) activity in different lactation stages. The study was conducted on Holstein--Friesian dairy cows in 2nd and 3rd lactation. A significant decrease in paraoxonase activity was found in the postpartum period
S Bernbäck et al.
European journal of biochemistry, 182(3), 495-499 (1989-07-01)
Human gastric lipase subjected to limited tryptic proteolysis lost its ability to hydrolyze emulsified long-chain triacylglycerol. Activity against a water-soluble substrate was however retained, indicating that proteolysis did not affect the active site. Sequence analysis revealed that trypsin specifically cleaved
Donna M Muzny et al.
Nature, 440(7088), 1194-1198 (2006-04-28)
After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome
M E Lowe et al.
The Journal of biological chemistry, 264(33), 20042-20048 (1989-11-25)
Pancreatic lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) hydrolyzes dietary long chain triacylglycerol to free fatty acids and monoacylglycerols in the intestinal lumen. In the presence of bile acids, the activity of lipase is stimulated by colipase. As a prelude to studying
M Cargill et al.
Nature genetics, 22(3), 231-238 (1999-07-03)
A major goal in human genetics is to understand the role of common genetic variants in susceptibility to common diseases. This will require characterizing the nature of gene variation in human populations, assembling an extensive catalogue of single-nucleotide polymorphisms (SNPs)
Judith Fischer et al.
Nature genetics, 39(1), 28-30 (2006-12-26)
Neutral lipid storage disease comprises a heterogeneous group of autosomal recessive disorders characterized by systemic accumulation of triglycerides in cytoplasmic droplets. Here we report a neutral lipid storage disease subgroup characterized by mild myopathy, absence of ichthyosis and mutations in
W C Lee et al.
Genomics, 22(2), 372-376 (1994-07-15)
A gene, GS2 (DXS1283E), was isolated from a CpG island located approximately midway between the steroid sulfatase (STS) and the Kallmann syndrome (KAL1) loci on the distal short arm of the human X chromosome. DNA sequencing of a GS2 cDNA
Dafang Wan et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(44), 15724-15729 (2004-10-23)
A large-scale assay was performed by transfecting 29,910 individual cDNA clones derived from human placenta, fetus, and normal liver tissues into human hepatoma cells and 22,926 cDNA clones into mouse NIH 3T3 cells. Based on the results of colony formation
Effects of bezafibrate treatment in a patient and a carrier with mutations in the PNPLA2 gene, causing neutral lipid storage disease with myopathy.
Tineke van de Weijer et al.
Circulation research, 112(5), e51-e54 (2013-03-02)
Pensri Saelee et al.
Asian Pacific journal of cancer prevention : APJCP, 10(3), 501-506 (2009-07-31)
Our previous study of gene alterations in 29 hepatocellular carcinoma (HCC) using AP-PCR amplified with 59 different 10-mer arbitrary primers and gene cloning, indicated DNA alterations by DNA fingerprints from 34 primers. Among these, the altered DNA fragment from primer
Kathrin A Zierler et al.
The Journal of biological chemistry, 288(14), 9892-9904 (2013-02-16)
Efficient catabolism of cellular triacylglycerol (TG) stores requires the TG hydrolytic activity of adipose triglyceride lipase (ATGL). The presence of comparative gene identification-58 (CGI-58) strongly increased ATGL-mediated TG catabolism in cell culture experiments. Mutations in the genes coding for ATGL
Sawsan Amara et al.
Biochimica et biophysica acta, 1801(4), 508-516 (2010-01-20)
Monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) are the most abundant lipids in nature, mainly as important components of plant leaves and chloroplast membranes. Pancreatic lipase-related protein 2 (PLRP2) was previously found to express galactolipase activity, and it is assumed to be
D Y Hui et al.
FEBS letters, 276(1-2), 131-134 (1990-12-10)
Three overlapping cDNA clones covering the entire primary sequence of the bile salt stimulated lipase in human milk were isolated from a human breast lambda gt10 cDNA library by screening with the rat pancreatic cholesterol esterase cDNA. Nucleotide sequencing of
Elena Larrieta-Carrasco et al.
Gene, 520(2), 185-188 (2013-03-21)
Non-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. The
A Roussel et al.
The Journal of biological chemistry, 274(24), 16995-17002 (1999-06-08)
Fat digestion in humans requires not only the classical pancreatic lipase but also gastric lipase, which is stable and active despite the highly acidic stomach environment. We report here the structure of recombinant human gastric lipase at 3.0-A resolution, the
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