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Showing 1-30 of 144 results for "62285" within Papers
Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene.
A Takagi et al.
Molecular and cellular probes, 10(4), 313-314 (1996-08-01)
Amélie Berton et al.
Molecular nutrition & food research, 53(12), 1592-1602 (2009-10-14)
Pancreatic lipase (PL) and pancreatic lipase-related proteins 1 and 2 (PLRP1 and PLRP2) display different functional properties, despite close structures. The aim of the study was to compare the kinetic properties of recombinant human PLRP1, PLRP2, and PL on a
J Gras
Drugs of today (Barcelona, Spain : 1998), 49(12), 755-759 (2014-02-14)
Obesity is a modern plague in industrialized and developing countries, and currently overweight and obesity cause more deaths worldwide than underweight. Cetilistat is a novel, orally active, gastrointestinal and pancreatic lipase inhibitor. In in vitro studies cetilistat inhibited human pancreatic
Serum TAG analysis differentiates between genetic and obesity-associated NAFLD.
Douglas G Mashek et al.
Diabetes, 63(1), 42-44 (2013-12-21)
J Nilsson et al.
European journal of biochemistry, 192(2), 543-550 (1990-09-11)
We have isolated and sequenced cDNA clones covering the entire coding sequence of human-milk bile-salt-stimulated lipase, as well as 996 nucleotides of the 3' end of the pancreatic enzyme carboxylic ester hydrolase. The deduced amino acid sequence of the lipase
F K Winkler et al.
Nature, 343(6260), 771-774 (1990-02-22)
Pancreatic lipase (triacylglycerol acyl hydrolase) fulfills a key function in dietary fat absorption by hydrolysing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. We have determined the three-dimensional structure of the human enzyme, a single-chain glycoprotein of
Michael C Zody et al.
Nature, 440(7084), 671-675 (2006-03-31)
Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of
[Actions of pancreatic lipase on esters in emulsions].
L SARDA et al.
Biochimica et biophysica acta, 30(3), 513-521 (1958-12-01)
Susumu Saito et al.
Journal of human genetics, 48(5), 249-270 (2003-05-02)
We screened DNAs from 48 Japanese individuals for single-nucleotide polymorphisms (SNPs) in eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes by directly sequencing the relevant genomic regions in their entirety except for repetitive elements. This
A M van Bennekum et al.
Biochemistry, 39(16), 4900-4906 (2000-04-19)
Previously [van Bennekum, A. M., et al. (1999) Biochemistry 38, 4150-4156] we showed that carboxyl ester lipase (CEL)-deficient (CELKO) mice have normal levels of pancreatic, bile salt-dependent retinyl ester hydrolase (REH) activity. In the present study, we further investigated this
Dafang Wan et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(44), 15724-15729 (2004-10-23)
A large-scale assay was performed by transfecting 29,910 individual cDNA clones derived from human placenta, fetus, and normal liver tissues into human hepatoma cells and 22,926 cDNA clones into mouse NIH 3T3 cells. Based on the results of colony formation
A Roussel et al.
The Journal of biological chemistry, 274(24), 16995-17002 (1999-06-08)
Fat digestion in humans requires not only the classical pancreatic lipase but also gastric lipase, which is stable and active despite the highly acidic stomach environment. We report here the structure of recombinant human gastric lipase at 3.0-A resolution, the
Silvia Sookoian et al.
Journal of lipid research, 50(10), 2111-2116 (2009-09-10)
We explored the role of the adiponutrin (PNPLA3) nonsynonymous-rs738409 single nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and whether this SNP contributes to the severity of histological disease. Two hundred sixty-six individuals were evaluated in
Dai Rui-Wu et al.
The journal of trauma and acute care surgery, 76(3), 784-790 (2014-02-21)
In our previous study, we established a small animal model that mimicked the pathophysiology of isolated pancreatic trauma. To gain further insights into the relationships between tissue damage and the ability of the pancreatic cells to regenerate, we induced pancreatic
Dilip Kumar et al.
Natural product communications, 8(2), 195-198 (2013-03-22)
In continuation towards the discovery of potential antiobesity lead(s) from natural products, we have screened n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc) and methanol (MeOH) extracts of 33 Indian medicinal plants (200 extracts) for in vitro pancreatic lipase inhibitory activity. Of
Yanhui Lin et al.
Biochemical and biophysical research communications, 434(3), 534-540 (2013-04-16)
The alteration of triglyceride (TG) metabolism in vascular smooth muscle cells (SMC) is likely to be correlated with certain phenotype, though this has not been elucidated. Adipose triglyceride lipase (ATGL) exerts major TG catalytic activity in both adipotic and non-adipotic
Lovisa E Johansson et al.
European journal of endocrinology, 159(5), 577-583 (2008-08-30)
The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis. This study aimed to replicate the association between PNPLA3 variants and obesity, and to investigate their effect on insulin
Xueyan Dong et al.
Diagnostic pathology, 8, 45-45 (2013-03-21)
Gastric cancer is one of the most common malignant tumors in the world. Finding effective diagnostic biomarkers in urine or serum would represent the most ideal solution to detecting gastric cancer during annual physical examination. This study was to evaluate
Purification and characterization of lipase produced by Aspergillus oryzae CJLU-31 isolated from waste cooking oily soil
Zhou J, et al.
American Journal of Food Technology, 7(10), 596-608 (2012)
S J Humphray et al.
Nature, 429(6990), 369-374 (2004-05-28)
Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises
V V Petrushenko et al.
Klinichna khirurhiia, (12)(12), 69-72 (2014-02-08)
Impact of rofecoxib on progressing of pancreatic fibrous changes in the rats in experimental chronic pancreatitis, caused by L-arginine, was studied up. In 60 male rats chronic pancreatitis was simulated, using intraabdominal L-arginine introduction (100 mg/100 g) through 21 days.
Nathan A Ungerleider et al.
Endocrinology, 154(6), 2025-2033 (2013-03-28)
The development of insulin resistance is tightly linked to fatty liver disease and is considered a major health concern worldwide, although their mechanistic relationship remains controversial. Activin has emerging roles in nutrient homeostasis, but its metabolic effects on hepatocytes remain
M Kulka et al.
Polish journal of veterinary sciences, 17(1), 143-147 (2014-04-15)
The objective of this study was to investigate paraoxonase-1 (PON-1) activity in different lactation stages. The study was conducted on Holstein--Friesian dairy cows in 2nd and 3rd lactation. A significant decrease in paraoxonase activity was found in the postpartum period
Pensri Saelee et al.
Asian Pacific journal of cancer prevention : APJCP, 10(3), 501-506 (2009-07-31)
Our previous study of gene alterations in 29 hepatocellular carcinoma (HCC) using AP-PCR amplified with 59 different 10-mer arbitrary primers and gene cloning, indicated DNA alterations by DNA fingerprints from 34 primers. Among these, the altered DNA fragment from primer
Kathrin A Zierler et al.
The Journal of biological chemistry, 288(14), 9892-9904 (2013-02-16)
Efficient catabolism of cellular triacylglycerol (TG) stores requires the TG hydrolytic activity of adipose triglyceride lipase (ATGL). The presence of comparative gene identification-58 (CGI-58) strongly increased ATGL-mediated TG catabolism in cell culture experiments. Mutations in the genes coding for ATGL
Sawsan Amara et al.
Biochimica et biophysica acta, 1801(4), 508-516 (2010-01-20)
Monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) are the most abundant lipids in nature, mainly as important components of plant leaves and chloroplast membranes. Pancreatic lipase-related protein 2 (PLRP2) was previously found to express galactolipase activity, and it is assumed to be
D Y Hui et al.
FEBS letters, 276(1-2), 131-134 (1990-12-10)
Three overlapping cDNA clones covering the entire primary sequence of the bile salt stimulated lipase in human milk were isolated from a human breast lambda gt10 cDNA library by screening with the rat pancreatic cholesterol esterase cDNA. Nucleotide sequencing of
M Cargill et al.
Nature genetics, 22(3), 231-238 (1999-07-03)
A major goal in human genetics is to understand the role of common genetic variants in susceptibility to common diseases. This will require characterizing the nature of gene variation in human populations, assembling an extensive catalogue of single-nucleotide polymorphisms (SNPs)
Elena Larrieta-Carrasco et al.
Gene, 520(2), 185-188 (2013-03-21)
Non-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. The
Lipoprotein lipase of chicken adipose tissue.
E D KORN et al.
The Journal of biological chemistry, 226(2), 833-839 (1957-06-01)
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