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Showing 31-60 of 166 results for "62481" within Papers
Xi Chen et al.
Neurosciences (Riyadh, Saudi Arabia), 18(4), 356-362 (2013-10-22)
To investigate whether lithium modifies open-field and elevated plus maze behavior, and brain phospho-glycogen synthase kinase 3 (P-GSK3beta) expression in Fmr1 knockout mice. One hundred and eighty FVB mice, including knockout and wild type, with an age of 30 days
Linda A Parker et al.
Psychopharmacology, 232(3), 583-593 (2014-08-03)
To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting. We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MAGL) inhibitor, MJN110, which selectively elevates the endocannabinoid 2-AG, to suppress acute nausea
Nina Tsao et al.
Antimicrobial agents and chemotherapy, 59(3), 1525-1533 (2014-12-24)
Intragastric Klebsiella pneumoniae infections of mice can cause liver abscesses, necrosis of liver tissues, and bacteremia. Lithium chloride, a widely prescribed drug for bipolar mood disorder, has been reported to possess anti-inflammatory properties. Using an intragastric infection model, the effects
Erin M Rock et al.
Psychopharmacology, 231(16), 3207-3215 (2014-03-07)
The effectiveness of cannabidiolic acid (CBDA) was compared with other potential treatments for anticipatory nausea (AN), using a rat model of contextually elicited conditioned gaping reactions. The potential of ondansetron (OND), Δ(9)-tetrahydrocannabinol (THC), chlordiazepoxide (CDP), CBDA, and co-administration of CBDA
L M Harrison et al.
Neuroscience, 236, 21-30 (2013-02-06)
G protein-coupled receptors (GPCR) signal not only through heterotrimeric G proteins, but also through alternate pathways. Thus, dopamine D2 receptors in the striatum signal through Gαi/o and also by promoting formation of a multi-protein complex containing β-arrestin2, protein phosphatase 2A
H Kubová et al.
Neuroscience, 235, 232-249 (2013-01-12)
The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology similar to that seen in human temporal lobe epilepsy.
Morten B Ley et al.
Dalton transactions (Cambridge, England : 2003), 43(35), 13333-13342 (2014-07-26)
Rare earth metal borohydrides have been proposed as materials for solid-state hydrogen storage because of their reasonably low temperature of decomposition. New synthesis methods, which provide halide-free yttrium and gadolinium borohydride, are presented using dimethyl sulfide and new solvates as
Vitali Alexeev et al.
Molecular cancer therapeutics, 13(12), 2968-2977 (2014-11-16)
Normal tissue toxicity markedly reduces the therapeutic index of genotoxic anticancer agents, including ionizing radiation. Countermeasures against tissue damage caused by radiation are limited by their potential to also protect malignant cells and tissues. Here, we tested a panel of
N Wang et al.
Neuroscience, 287, 144-156 (2014-12-30)
Mounting evidence suggests that brain inflammation mediated by glial cells may contribute to epileptogenesis. Minocycline is a second-generation tetracycline and has potent antiinflammatory effects independent of its antimicrobial action. The present study aimed to investigate whether minocycline could exert antiepileptogenic
Zachary Kaminsky et al.
Bipolar disorders, 17(2), 150-159 (2014-07-22)
Accumulating evidence implicates the potassium voltage-gated channel, KQT-like subfamily, member 2 and 3 (KCNQ2 and KCNQ3) genes in the etiology of bipolar disorder (BPD). Reduced KCNQ2 or KCNQ3 gene expression might lead to a loss of inhibitory M-current and an
Xueyan Zheng et al.
Carbohydrate polymers, 111, 25-32 (2014-07-20)
Tetraalkylammonium hydroxides have been found to mediate regioselective deacylation of cellulose esters. This deacylation surprisingly shows substantial selectivity for the removal of the acyl groups at O-2/3, affording cellulose-6-O-esters by a simple, efficient one-step process. The mechanism for this deacylation
Chloé Boitard et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 4092-4103 (2015-03-06)
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence during adolescence is particularly alarming since recent evidence indicates that obesity can affect hippocampal function during this developmental period. Adolescence is
Hung-Li Tsai et al.
PloS one, 9(8), e104937-e104937 (2014-08-30)
Wnts were previously shown to regulate the neurogenesis of neural stem or progenitor cells. Here, we explored the underlying molecular mechanisms through which Wnt signaling regulates neurotrophins (NTs) in the NT-induced neuronal differentiation of human mesenchymal stem cells (hMSCs). NTs
Gry Hulsart Billström et al.
Injury, 44 Suppl 1, S28-S33 (2013-02-13)
Scaffolds are extensively used in surgery to replace missing bone and to achieve bony union and fusion. An ideal scaffold should not only maintain, induce, and restore biological functions where cells, extracellular matrix, and growth factors are needed, but also
J R Liu et al.
British journal of anaesthesia, 110 Suppl 1, i3-i9 (2013-03-28)
Ketamine-induced neuroapoptosis has been attributed to diverse stress-related mechanisms. Glycogen synthase kinase-3β (GSK-3β) is a multifunctional kinase that is active in neuronal development and linked to neurodegenerative disorders. We hypothesized that ketamine would enhance GSK-3β-induced neuroapopotosis, and that lithium, an
Elke E E Noens et al.
Journal of bacteriology, 197(5), 951-958 (2014-12-24)
The serP1 and serP2 genes found adjacently on the chromosome of Lactococcus lactis strains encode two members of the amino acid-polyamine-organocation (APC) superfamily of secondary transporters that share 61% sequence identity. SerP1 transports L-serine, L-threonine, and L-cysteine with high affinity.
Nichola J Hawkins et al.
Molecular biology and evolution, 31(7), 1793-1802 (2014-04-16)
Evolution of resistance to drugs and pesticides poses a serious threat to human health and agricultural production. CYP51 encodes the target site of azole fungicides, widely used clinically and in agriculture. Azole resistance can evolve due to point mutations or
Munetaka Iwata et al.
Journal of cellular physiology, 230(1), 180-190 (2014-06-12)
Intervertebral disc degeneration (IVDD) greatly affects the quality of life. The nucleus pulposus (NP) of chondrodystrophic dog breeds (CDBs) is similar to the human NP because the cells disappear with age and are replaced by fibrochondrocyte-like cells. Because IVDD develops
X Chen et al.
Cell death & disease, 4, e510-e510 (2013-03-02)
Inflammation can influence multipotency and self-renewal of mesenchymal stem cells (MSCs), resulting in their awakened bone-regeneration ability. Human periodontal ligament tissue-derived MSCs (PDLSCs) have been isolated, and their differentiation potential was found to be defective due to β-catenin signaling indirectly
Muhammad Amir Yunus et al.
Journal of virology, 89(2), 1218-1229 (2014-11-14)
All members of the Caliciviridae family of viruses produce a subgenomic RNA during infection. The subgenomic RNA typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subgenomic RNA also encodes the VF1 protein, which
Sima Rahman et al.
PloS one, 7(12), e51746-e51746 (2012-12-29)
Lineage allocation of the marrow mesenchymal stem cells (MSCs) to osteoblasts and adipocytes is dependent on both Wnt signaling and PPARγ2 activity. Activation of PPARγ2, an essential regulator of energy metabolism and insulin sensitivity, stimulates adipocyte and suppresses osteoblast differentiation
J V Cockle et al.
British journal of cancer, 112(4), 693-703 (2015-01-30)
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour invasion are needed. Here, we examine the migratory
Lijuan Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 191(8), 4392-4398 (2013-09-18)
Lithium salt is a widely used glycogen synthase kinase-3β inhibitor and effective drug for the treatment of psychiatric diseases. However, the effects of lithium in innate immune responses, especially in cellular antiviral responses, are unknown. In this study, we show
Dan Wang et al.
PloS one, 9(12), e115801-e115801 (2014-12-24)
To explore the effects of neuronal Per-Arnt-Sim domain protein 4 (Npas4) on seizures in pilocarpine-induced epileptic rats, Npas4 expression was detected by double-label immunofluorescence, immunohistochemistry, and Western blotting in the brains of pilocarpine-induced epileptic model rats at 6 h, 24
Jaganathan Lakshmanan et al.
Journal of cellular biochemistry, 116(1), 133-141 (2014-08-28)
Excessive nitric oxide from the inducible nitric oxide synthase (iNOS) increases shock-induced hepatic injury, hepatic dysfunction, inflammation, and mortality in animal models. Cytokines increase the expression of iNOS in hepatocytes, but the signaling mechanisms involved are not completely understood. We
Zhiqian Yu et al.
Glia, 63(2), 257-270 (2014-09-03)
Evidence indicates that widely prescribed mood stabilizer, lithium (Li), mediates cellular functions of differentiated monocytic cells, including microglial migration, monocyte-derived dendritic cell (MoDC) differentiation, and amelioration of monocytic malfunctions observed in neuropsychiatric diseases. Here, we surveyed molecules which take major
Haq Nawaz et al.
Carbohydrate polymers, 92(2), 997-1005 (2013-02-13)
Cellulose acylation by anhydrides (ethanoic to hexanoic) plus tosyl chloride, TsCl, or imidazole in LiCl/N,N-dimethylacetamide solution has been studied. Contrary to a previous claim, TsCl does not catalyze acylation. For the diazole-catalyzed reaction, N-acylimidazole is the acylating agent. Third order
Amanjot Kaur Riar et al.
PloS one, 9(5), e98080-e98080 (2014-05-20)
Ingestion of ethanol (ETOH) during pregnancy induces grave abnormalities in developing fetal brain. We have previously reported that ETOH induces programmed cell death 4 (PDCD4), a critical regulator of cell growth, in cultured fetal cerebral cortical neurons (PCNs) and in
Y Leng et al.
Molecular psychiatry, 20(2), 215-223 (2014-01-29)
Fibroblast growth factor-21 (FGF-21) is a new member of the FGF super-family and an important endogenous regulator of glucose and lipid metabolism. It has been proposed as a therapeutic target for diabetes and obesity. Its function in the central nervous
Diego Ploper et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(5), E420-E429 (2015-01-22)
Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma
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