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Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.

Takeshi Minashima et al.

The Journal of biological chemistry, 287(18), 14803-14815 (2012-03-09)

Annexin A6 (AnxA6) is highly expressed in hypertrophic and terminally differentiated growth plate chondrocytes. Rib chondrocytes isolated from newborn AnxA6-/- mice showed delayed terminal differentiation as indicated by reduced terminal differentiation markers, including alkaline phosphatase, matrix metalloproteases-13, osteocalcin, and runx2

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