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Showing 1-30 of 569 results for "63559" within Papers
Ai Ing Lim et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(10), 831-839 (2014-07-27)
Kidney injury molecule-1 (KIM-1) serves as a useful marker for monitoring tubular injury, and sustained KIM-1 expression may be implicated in chronic kidney fibrosis. In this study, we examine the kinetics and mechanisms of KIM-1 release in human proximal tubular
Shida Chen et al.
Acta ophthalmologica, 93(4), e261-e265 (2014-10-14)
Acute elevation of intraocular pressure (IOP) in acute primary angle closure (APAC) can cause huge damage to the variable cells in the eye; however, the mechanisms that connect the two processes still remain unclear. In this study, we aim to
Boubacar Coulibaly et al.
The Journal of infectious diseases, 211(5), 689-697 (2014-10-01)
Methylene blue (MB) has been shown to be safe and effective against falciparum malaria in Africa and to have pronounced gametocytocidal properties. Three days of treatment with artesunate (AS)-amodiaquine (AQ) combined with MB was compared with AS-AQ treatment in a
Angélica Maria de Sousa Leal et al.
BMC microbiology, 15, 115-115 (2015-06-07)
Violacein is a purple pigment from Chromobacterium violaceum that possesses diverse biological and pharmacological properties. Among these, pro-oxidant and antioxidant activities have been suggested. However, the cytotoxic mechanisms induced by violacein are poorly understood and the improvement in knowledge regarding
Ruth R Miller et al.
PloS one, 10(11), e0143472-e0143472 (2015-11-26)
Burkholderia cepacia complex bacteria are amongst the most feared of pathogens in cystic fibrosis (CF). The BCC comprises at least 20 distinct species that can cause chronic and unpredictable lung infections in CF. Historically the species B. cenocepacia has been
Kåre Håkansson et al.
American journal of rhinology & allergy, 28(5), 383-387 (2014-09-10)
Chronic rhinosinusitis (CRS) is a common health problem that is subclassified as CRS with nasal polyps (CRSwNPs) or CRS without NPs (CRSsNP). In accordance with the united airways concept, CRSwNPs frequently coexists with asthma but to date, this association remains
Yasuhisa Okamoto et al.
Masui. The Japanese journal of anesthesiology, 62(11), 1320-1325 (2013-12-25)
Chronic renal failure (CRF) is related to cardiac diseases. Cardiac surgery is also related to postoperative acute kidney injury (AKI). It means heart and kidney have close relationship. We analyzed recent published data to understand how to manage CRF patients
Jingsong Zeng et al.
Journal of neurosurgery, 119(5), 1228-1232 (2013-08-06)
The authors undertook this study to evaluate the effects of continuous intracranial pressure (ICP) monitoring-directed mannitol treatment on kidney function in patients with moderate or severe traumatic brain injury (TBI). One hundred sixty-eight patients with TBI were prospectively assigned to
Bote G Bruinsma et al.
Transplantation, 95(8), 1064-1069 (2013-02-16)
Bacterial contamination during cold organ preservation occurs without major complications. However, with organ preservation steering toward (sub)normothermic temperatures, bacterial contamination may be detrimental with limited evidence to support the choice of antibiotic. This study aimed to determine the effective antibiotic
M J de Grandmont et al.
Vox sanguinis, 107(3), 239-246 (2014-04-16)
Many international standards state that red blood cell (RBC) products should be discarded if left out of controlled temperature storage for longer than 30 min to reduce the risk of bacterial growth and RBC loss of viability. This study aimed to
Frederik B Pruijn et al.
Journal of medicinal chemistry, 48(4), 1079-1087 (2005-02-18)
The extravascular diffusion of antitumor agents is a key determinant of their therapeutic activity, but the relationships between physicochemical properties of drugs and their extravascular transport are poorly understood. It is well-known that drug lipophilicity plays an important role in
Haijiang Wu et al.
Molecular and cellular endocrinology, 417, 27-35 (2015-09-13)
Renal tubular epithelial cells (RTEC) apoptosis, which plays a key role in the pathogenesis and progression of diabetic nephropathy (DN), is believed to be contributive to the hyperglycemia-induced kidney failure, though the exact mechanisms remain elusive. In this study, we
Henry G Spratt et al.
Physiotherapy theory and practice, 30(7), 507-511 (2014-04-01)
A procedure commonly used in physical therapy (PT) clinics is therapeutic ultrasound (US). This equipment and associated gel comes in contact with patient skin, potentially serving as a reservoir for bacteria. In this study, we sampled US heads, gel bottle
Boyu Cui et al.
PloS one, 9(10), e107885-e107885 (2014-10-02)
The application of the luxCDABE operon of the bioluminescent bacterium Photorhabdus luminescens as a reporter has been published for bacteria, yeast and mammalian cells. We report here the optimization of fused luxAB (the bacterial luciferase heterodimeric enzyme) expression, quantum yield
Chinwe Duru et al.
Biologicals : journal of the International Association of Biological Standardization, 43(2), 110-116 (2015-01-24)
Lyophilized Influenza antigen reference reagents are a critical resource in the quality control of influenza vaccines. A standard formulation has been used successfully at NIBSC for many years however, following the unexpected occurrence of a collapsed appearance in a particular
Jun Jiang et al.
Journal of virology, 89(13), 6695-6710 (2015-04-17)
Positive-sense RNA viruses remodel host cell endomembranes to generate quasi-organelles known as "viral factories" to coordinate diverse viral processes, such as genome translation and replication. It is also becoming clear that enclosing viral RNA (vRNA) complexes within membranous structures is
Mercè Corominas et al.
International archives of allergy and immunology, 165(4), 244-246 (2015-01-31)
Immediate adverse reactions to glatiramer acetate (GA), a drug used in the treatment of patients with multiple sclerosis (MS), have been poorly investigated. We studied 3 MS patients who presented adverse reactions following GA administration. Two of them experienced severe
Sattar Mohammadi et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25, 152-158 (2014-06-10)
Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen of public health importance. The prevalence of MRSA and its antimicrobial resistance pattern, as well as SCCmec and spa types, remain unclear both in the community and in the hospitals of the western
Sebastian Koob et al.
Biochimica et biophysica acta, 1853(7), 1551-1563 (2015-03-15)
Mitochondrial membrane architecture is important for organelle function. Alterations thereof are linked to a number of human disorders including diabetes and cardiomyopathy. The MICOS complex was recently reported to be a central player determining cristae structure and formation of crista
Congwu He et al.
The New phytologist, 206(3), 1051-1062 (2015-01-24)
Silicon (Si) plays a large number of diverse roles in plants, but the structural and chemical mechanisms operating at the single-cell level remain unclear. We isolate the cell walls from suspension-cultured individual cells of rice (Oryza sativa) and fractionate them
Dana M LeMoine et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(3), 311-316 (2015-06-06)
Aseptic technique includes the use of sterile surgical gloves for survival surgeries in rodents to minimize the incidence of infections. Exam gloves are much less expensive than are surgical gloves and may represent a cost-effective, readily available option for use
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Noriaki Nagai et al.
Journal of oleo science, 64(7), 743-750 (2015-07-03)
We investigated the protective effects of mannitol on corneal damage caused by benzalkonium chloride (BAC), which is used as a preservative in commercially available timolol maleate eye drops, using rat debrided corneal epithelium and a human cornea epithelial cell line
Auemphon Mordmuang et al.
Nutrients, 7(10), 8503-8517 (2015-10-27)
Bovine mastitis is one of the most important infectious diseases in dairy herds, and staphylococci are the most important etiologic agents of this disease. Antibiotics and chemical agents used in livestock for prevention and cure of the disease can accumulate
Zhenlong Cheng et al.
PloS one, 10(3), e0122450-e0122450 (2015-04-01)
Potato common scab is an economically important crop disease that is characterized by the formation of superficial, raised or pitted lesions on the potato tuber surface. The most widely distributed causative agent of the disease is Streptomyces scabies, which produces
Oluwatomide Adeoye et al.
Acta poloniae pharmaceutica, 71(5), 803-811 (2014-11-05)
The study evaluated two novel coprocessed excipients (with two methods) as disintegrants in an orally disintegrating paracetamol tablet formulation. The tablets produced were assessed for mechanical properties with the use of friability and tensile strength while the release properties were
Hannah H Lee et al.
Molecular cancer therapeutics, 14(4), 994-1003 (2015-02-20)
The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an
Juliana Gjoerup et al.
Respirology (Carlton, Vic.), 17(6), 927-932 (2012-05-09)
Bronchiectasis is a chronic disorder characterized by impaired mucociliary clearance and a relentless cycle of infection, inflammation and bronchial wall injury, which has a debilitating impact on the patient's quality of life and results in increased morbidity and mortality. It
Gihan S Labib
Drug design, development and therapy, 9, 5135-5146 (2015-09-18)
Levocetirizine HCl, a second-generation piperazine derivative and H1-selective antihistaminic agent, possesses few side effects. The first objective of the study was to compare and evaluate the taste-masking effect of different ratios of 2-hydroxypropyl-β-cyclodextrin and mannitol on levocetirizine HCl using an
Maria D'Apolito et al.
Atherosclerosis, 239(2), 393-400 (2015-02-16)
The pathogenic events responsible for accelerated atherosclerosis in patients with chronic renal failure (CRF) are poorly understood. Here we investigate the hypothesis that concentrations of urea associated with CRF and increased ROS production in adipocytes might also increase ROS production
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