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Showing 31-60 of 6982 results for "644374" within Papers
Bouchra Ghazi et al.
The Journal of investigative dermatology, 135(1), 229-237 (2014-07-10)
We previously identified the NK cell receptor KIR3DL2 as a valuable diagnostic and prognostic marker for the detection of the tumoral T cell burden of Sézary syndrome (SS) patients. However, the function of this receptor on the malignant T lymphocyte
Zoran S Ilić et al.
Journal of the science of food and agriculture, 95(13), 2660-2667 (2014-11-13)
The concept of photo-selective netting using commercial cultivation practices was studied in a tomato (Solanum lycopersicum 'Vedetta') summer cultivation in south Serbia (under high solar radiation 910 W m(-2) , with a photosynthetic photon flux density of 1661 µmol m(-2)
Jacqueline Jones et al.
Clinical & experimental metastasis, 31(5), 497-510 (2014-02-27)
The expression and biological consequences of Kaiso, a novel bi-modal transcription factor, in infiltrating ductal carcinomas (IDCs) have not been widely investigated. In the present study, we determined Kaiso expression and subcellular localization in 146 normal tissues, 376 IDCs, and
Li Jiao et al.
Digestive diseases and sciences, 60(12), 3590-3602 (2015-07-18)
Inflammatory bowel disease results from a combination of dysfunction of intestinal epithelial barrier and dysregulation of mucosal immune system. iPLA2β has multiple homeostatic functions and shown to play a role in membrane remodeling, cell proliferation, monocyte chemotaxis, and apoptosis. The
Kristoffer Sahlholm et al.
Psychopharmacology, 232(18), 3443-3453 (2015-07-15)
Dopamine stabilizers have stimulatory actions under low dopamine tone and inhibitory actions under high dopamine tone without eliciting catalepsy. These compounds are dopamine D2 receptor (D2R) antagonists or weak partial agonists and may have pro-mnemonic and neuroprotective effects. The mechanism
Thomas Zweckmair et al.
Journal of chromatographic science, 52(2), 169-175 (2013-02-05)
This study presents a liquid chromatography-ultraviolet (LC-UV) method for the accurate analysis of formose reaction products with regard to sum parameters. Limitations encountered in gas chromatography (e.g., thermal stability of analytes) were overcome. First, alditols are O-benzoylated and subjected to
Ping Du et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 28-35 (2014-07-27)
Docetaxel lipid microsphere (DT-LM) is a novel formulation of docetaxel without Tween-80. A sensitive, robust and reproducible ultrafiltration (UF) followed by UPLC-MS/MS method was developed and validated for the quantification of unbound docetaxel in human plasma using paclitaxel as IS.
François Versace et al.
Bioanalysis, 6(15), 2043-2055 (2014-10-18)
Direct-infusion ESI-MS/MS is a powerful approach for the identification of substances in complex mixtures. The aim of this work was to investigate its applicability to the toxicological screening of blood samples. A simple protein precipitation was used, followed by a
Haruka Oda et al.
Biomaterials, 56, 86-91 (2015-05-03)
A large number of lineage-committed progenitor cells are required for advanced regenerative medicine based on cell engineering. Due to their ability to differentiate into multiple cells lines, multipotent stem cells have emerged as a vital source for generating transplantable cells
Antonina Gucciardi et al.
Biomedical chromatography : BMC, 28(8), 1131-1139 (2014-01-23)
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained
Dave Singh et al.
European journal of clinical pharmacology, 71(10), 1175-1184 (2015-08-13)
Inhaled LPS causes neutrophilic airway inflammation in healthy subjects. We compared the effects of p38 MAPK inhibitors and fluticasone propionate on the LPS response. Three randomised, double-blind, placebo-controlled, single dose crossover studies were performed. Active treatments were the oral p38
Lucas H Hofmeister et al.
ACS nano, 9(4), 4435-4446 (2015-03-15)
In regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points, and regions distal to stenoses, blood flow becomes disturbed. Atherosclerosis preferentially develops in these regions
Catarine Massucato Nishijima et al.
International journal of molecular sciences, 16(6), 12454-12466 (2015-06-05)
Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work
Elodie Alinat et al.
Journal of chromatography. A, 1387, 134-143 (2015-02-24)
Fine characterization of nitrocellulose (NC) remains a challenge, especially in forensic analysis, and a strategy consisting in obtaining representative fingerprints by a separation technique, as for proteins, is of prime interest. In this work, we first established that NCs (especially
Dong Dong et al.
PloS one, 10(6), e0131806-e0131806 (2015-07-01)
Staphylococcus aureus and Pseudomonas aeruginosa are major pathogens in chronic rhinosinusitis (CRS) and their biofilms have been associated with poorer postsurgical outcomes. This study investigated the distribution and anti-biofilm effect of cationic (+) and anionic (-) phospholipid liposomes with different
E Canellas et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 75, 79-87 (2014-12-03)
Adhesives are used to manufacture multilayer materials, where their components pass through the layers and migrate to the food. Nine different adhesives (acrylic, vinyl and hotmelt) and their migration in 21 laminates for future use as market samples have been
Parthasarathy Seshacharyulu et al.
Oncotarget, 6(7), 5164-5181 (2015-02-18)
Transmembrane proteins MUC4, EGFR and HER2 are shown to be critical in invasion and metastasis of pancreatic cancer. Besides, we and others have demonstrated de novo expression of MUC4 in ~70-90% of pancreatic cancer patients and its stabilizing effects on
Jing Zhao et al.
Acta biomaterialia, 16, 94-102 (2015-02-01)
Polymeric micelles with cell outer membrane mimetic structure were prepared in water from amphiphilic random copolymers bearing both the hydrophilic phosphorylcholine zwitterions and hydrophobic octadecyl side chains of cell outer membrane. The polymeric micelles showed sizes ranging from 80 nm
Slawomir Mandziuk et al.
Drug and chemical toxicology, 38(1), 1-8 (2014-03-04)
The delayed cardiomyopathy caused by doxorubicin - an chemotherapeutic drug with broad spectrum of anticancer activity - is mainly triggered by oxidative stress. The aim of this study was to assess an effect of Mutellina purpurea methanolic extract fraction and
Roland Rad et al.
Nature genetics, 47(1), 47-56 (2014-12-09)
Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1 as an oncogenic transcription factor that drives pancreatic cancer invasion
Andrea Speltini et al.
Journal of chromatography. A, 1379, 9-15 (2015-01-07)
This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer
Michelle Goritzka et al.
The Journal of experimental medicine, 212(5), 699-714 (2015-04-22)
Type I interferons (IFNs) are important for host defense from viral infections, acting to restrict viral production in infected cells and to promote antiviral immune responses. However, the type I IFN system has also been associated with severe lung inflammatory
Jinyeong Kim et al.
Protein expression and purification, 116, 90-97 (2015-08-16)
A novel gene encoding a thermostable esterase (designated as Est-gela) was isolated from the moderate thermophile Bacillus gelatini KACC 12197. The open reading frame of this gene (1170 bp) encodes 389 amino acid residues, and the molecular weight of Est-gela
Iwona Kowalska et al.
Journal of agricultural and food chemistry, 62(46), 11200-11208 (2014-10-31)
Fourteen phenolic compounds (flavonoids and phenolic acids) were isolated and 19 were identified in the aerial parts of Triticum aestivum L. The structures of these compounds were established on the basis of the data obtained by electrospray ionization-mass spectrometry (ESI-MS)
Hongxin Cao et al.
Proteomics, 15(21), 3699-3710 (2015-08-11)
Kidney fibrosis (KF) is a common process that leads to the progression of various types of kidney disease including kidney-yang deficiency syndrome, however, little is known regarding the underlying biology of this disorder. Fortunately, integrated omics approaches provide the molecule
Yuta Morishige et al.
Biological & pharmaceutical bulletin, 38(9), 1255-1264 (2015-06-30)
A simple and rapid assay method for analysis of the metabolic activity of viable but non-culturable (VBNC) Salmonella was established. An environmental isolate of Salmonella Enteritidis (SE), grown to the logarithmic phase, rapidly lost its culturability during incubation with 1-10 mM
Elena Marangon et al.
PloS one, 10(2), e0118194-e0118194 (2015-02-18)
Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC). This drug has a narrow therapeutic range and treatment can lead to side effects, mainly neutropenia and diarrhea, frequently requiring discontinuing or lowering the drug dose. A
B W Sykes et al.
Journal of veterinary pharmacology and therapeutics, 38(2), 130-136 (2014-10-02)
The objectives were to document the pharmacokinetics of intravenous, enteric-coated oral and plain oral omeprazole in fasted horses and to investigate the impact of feeding on the bioavailability of an enteric-coated omeprazole. Twelve horses received four treatments: intravenous omeprazole (0.5 mg/kg)
Anna Vallverdú-Queralt et al.
International journal of molecular sciences, 16(5), 9588-9599 (2015-05-01)
The consumption of carotenoid-rich vegetables such as tomatoes and tomato sauces is associated with reduced risk of several chronic diseases. The predominant carotenoids in tomato products are in the (all-E) configuration, but (Z) isomers can be formed during thermal processing.
Atsuki Matsubara et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 199-204 (2014-09-03)
The potential of supercritical fluid extraction (SFE) as a preparation method for mass spectrometry of dried blood spots (DBS) was examined. SFE is generally used for the extraction of hydrophobic compounds, but hydrophilic metabolites such as amino acids, amines, and
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