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Showing 1-30 of 494 results for "644544" within Papers
P T Clayton et al.
The Journal of clinical investigation, 79(4), 1031-1038 (1987-04-01)
Urinary bile acids from a 3-mo-old boy with cholestatic jaundice were analyzed by ion exchange chromatography and gas chromatography-mass spectrometry (GC-MS). This suggested the presence of labile sulfated cholenoic acids with an allylic hydroxyl group, a conclusion supported by analysis
Hsiang-Yu Chang et al.
Colloids and surfaces. B, Biointerfaces, 130, 157-163 (2015-04-22)
In this study, we employed HgTe nanostructure-based matrices (nanomartrices; NMs) for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) for the analyses of polyethylene glycol (PEG) derivatives as well as thiol-PEG-modified gold nanoparticles (PEG-Au NPs). Relative to common organic matrices, the use
Divya Singhal et al.
Materials science & engineering. C, Materials for biological applications, 58, 548-557 (2015-10-20)
A novel hydrazone, 1,3-bis (2-formylphenoxy) propane bis (2,4-dinitrophenyl hydrazine) (S) has been synthesized and characterized by the NMR, IR, CHNS, UV-Vis, Raman, TEM and XPS analysis. Upon the addition of monohydrogen phosphate (MHP) ion, sudden color change from light yellow
Linge Wang et al.
Macromolecular rapid communications, 36(15), 1437-1443 (2015-06-04)
Polymer beads have attracted considerable interest for use in catalysis, drug delivery, and photonics due to their particular shape and surface morphology. Electrospinning, typically used for producing nanofibers, can also be used to fabricate polymer beads if the solution has
Dominika Wrobel et al.
Biochimica et biophysica acta, 1848(7), 1490-1501 (2015-04-07)
The influence of maltose-modified poly(propylene imine) (PPI) dendrimers on dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (DMPC/DMPG) (3%) liposomes was studied. Fourth generation (G4) PPI dendrimers with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers
Qi Lai et al.
Chirality, 27(12), 979-988 (2015-10-03)
Several novel chiral bifunctional L-thiazoline-thiourea derivatives were easily synthesized from commercially available L-cysteine in high yield. These catalysts were subsequently applied to the enantioselective Michael addition of acetylacetone to β-nitrostyrenes. The products with S configuration were obtained in 98% enantiomeric
Courtney A Ober et al.
AAPS PharmSciTech, 13(4), 1396-1406 (2012-10-12)
Cocrystals of itraconazole, an antifungal drug with poor bioavailability, and succinic acid, a water-soluble dicarboxylic acid, were formed by gas antisolvent (GAS) cocrystallization using pressurized CO(2) to improve itraconazole dissolution. In this study, itraconazole and succinic acid were simultaneously dissolved
Clément Falaise et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16654-16664 (2015-09-30)
The ex-situ qualitative study of the kinetic formation of the poly-oxo cluster U38 , has been investigated after the solvothermal reaction. The resulting products have been characterized by means of powder XRD and scanning electron microscopy (SEM) for the solid
Johannes Bertsch et al.
Journal of bacteriology, 197(9), 1681-1689 (2015-03-04)
The methylenetetrahydrofolate reductase (MTHFR) of acetogenic bacteria catalyzes the reduction of methylene-THF, which is highly exergonic with NADH as the reductant. Therefore, the enzyme was suggested to be involved in energy conservation by reducing ferredoxin via electron bifurcation, followed by
Michael C Hill et al.
Advanced healthcare materials, 4(5), 714-722 (2014-12-23)
The extracellular environment exposes cells to numerous biochemical and physical signals that regulate their behavior. Strategies for generating continuous gradients of signals in biomaterials may allow for spatial control and patterning of cell behavior, and ultimately aid in the engineering
Zilan Zhou et al.
International journal of pharmaceutics, 487(1-2), 81-90 (2015-04-14)
A dual functional nano-scaled drug carrier, comprising of a targeting ligand and pH sensitivity, has been made in order to increase the specificity and efficacy of the drug delivery system. The nanoparticles are made of a tri-block copolymer, poly(d,l lactide-co-glycolide)
Jiang-Feng Song et al.
Ultrasonics sonochemistry, 27, 602-608 (2015-05-03)
Ultrasound treatment has been widely applied in the extraction of biologically active compounds including carotenoids. However, there are few reports on their effects on the stability of these compounds. In the present study, the stability of all-trans lutein, one of
Brittany K Casey et al.
European journal of mass spectrometry (Chichester, England), 21(5), 747-752 (2015-11-19)
In order to ensure accurate mass determinations, MALDI-TOF mass spectrometers must be calibrated regularly. While peptides and proteins represent the most widely used calibration standards due to their monodispersity, known masses and availability, their limited shelf-life complicates their use. Recently
Ángel Benito et al.
Molecules (Basel, Switzerland), 20(6), 9510-9523 (2015-05-29)
Most red wines commercialized in the market use the malolactic fermentation process in order to ensure stability from a microbiological point of view. In this second fermentation, malic acid is converted into L-lactic acid under controlled setups. However this process
Lionel Tortolano et al.
Journal of biomedical materials research. Part A, 103(12), 3843-3851 (2015-06-27)
The aim of this study is to investigate in vitro interactions between hydrophobic acrylate intraocular lenses (IOLs) and their biological environment. The influence of lens chemical composition and aging on fibronectin (FN) adsorption and on IOLs cytotoxicity on human lens
A Starobrat et al.
Dalton transactions (Cambridge, England : 2003), 44(45), 19469-19477 (2015-08-06)
We report the most recent results related to application of a metathetic pathway towards mixed-metal borohydrides. The synthetic protocol utilizes highly-fluorinated weakly coordinating anion salts as precursors. We discuss the technicalities related to the use of fluorine-rich anions as well
Yuanhong Shan et al.
Journal of chromatography. A, 1375, 101-109 (2014-12-17)
To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhedral-oligomeric-silsesquioxane-type (POSS) cross-linking agent and the home-made
S M El-Ashry et al.
Luminescence : the journal of biological and chemical luminescence, 30(6), 891-897 (2015-01-27)
Two simple, rapid, sensitive and precise spectrophotometric and spectrofluorimetric methods were developed for the determination of indacaterol maleate in bulk powder and capsules. Both methods were based on the direct measurement of the drug in methanol. In the spectrophotometric method
Kwan Wee Tan et al.
ACS nano, 8(5), 4730-4739 (2014-04-02)
Structure control in solution-processed hybrid perovskites is crucial to design and fabricate highly efficient solar cells. Here, we utilize in situ grazing incidence wide-angle X-ray scattering and scanning electron microscopy to investigate the structural evolution and film morphologies of methylammonium
Arash Nikoubashman et al.
ACS nano, 8(8), 8015-8026 (2014-08-12)
We study thin films of homopolymers (PS) and monolayers of cylinder-forming diblock copolymers (PS–PHMA) under shear. To this end, we employed both experiments and computer simulations that correctly take into account hydrodynamic interactions and chain entanglements. Excellent quantitative agreement for
Dahai He et al.
The Journal of organic chemistry, 77(19), 8435-8443 (2012-09-06)
Fifteen new lignans, gymnothelignans A-O (1-15), bearing tetrahydrofuran with variable conformations belonging to three potentially related skeletons were isolated from Gymnotheca chinensis Decne. The structures were elucidated by means of detailed spectroscopic analysis. Absolute configurations were assigned using X-ray single-crystal
Laura E Blue et al.
Journal of chromatography. A, 1380, 71-80 (2015-01-13)
The predicted advantages of superficially porous particles over totally porous particles are decreased eddy dispersion, longitudinal diffusion, and resistance to mass transfer contributions to the theoretical plate height. While sub-2 micron superficially porous particles are commercially available, further improvements in
Aarti Sawant-Basak et al.
Journal of pharmaceutical sciences, 102(9), 3277-3293 (2013-04-17)
4-{4-[4-Tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (PF-4995274, TBPT) is a new agent that is a partial agonist of the human serotonin-4 (5-HT4) receptor and is under investigation for neurological disorders. Metabolism of TBPT was examined in vitro in human liver microsomes and human hepatocytes. Metabolites
Joyann A Marks et al.
Journal of pharmaceutical sciences, 103(9), 2871-2883 (2014-05-16)
Blends of polymers with complementary properties hold promise for addressing the diverse, demanding polymer performance requirements in amorphous solid dispersions (ASDs), but we lack comprehensive property understanding for blends of important ASD polymers. Herein, we prepare pairwise blends of commercially
Y Zhu et al.
Neurobiology of disease, 74, 114-125 (2014-12-03)
Spinal cord injury (SCI) leads to formation of a fibrotic scar that is inhibitory to axon regeneration. Recent evidence indicates that the fibrotic scar is formed by perivascular fibroblasts, but the mechanism by which they are recruited to the injury
Andreas Lauterbach et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 614-624 (2014-12-03)
A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion as a topical drug delivery system (TDDS) for follicular penetration has been introduced. The objective of the present study was to investigate the rheological properties, the follicular penetration with differential tape stripping
Yulia Kaluzhny et al.
Alternatives to laboratory animals : ATLA, 43(2), 101-127 (2015-05-23)
The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other
Xiao Zhang et al.
Angewandte Chemie (International ed. in English), 54(12), 3653-3657 (2015-02-05)
As a unique two-dimensional nanomaterial, layered black phosphorus (BP) nanosheets have shown promising applications in electronics. Although mechanical exfoliation was successfully used to prepare BP nanosheets, it is still a challenge to produce novel BP nanostructures in high yield. A
N Frančič et al.
The Analyst, 139(12), 3127-3136 (2014-05-03)
In this work we demonstrate the efficient immobilization of histidine 6-tagged organophosphate hydrolase (His6-OPH), an organophosphate-degrading enzyme, on mesoporous titania thin films. This permits the use of the biocatalyst films as efficient tools in the detection/detoxification of paraoxon. His6-OPH was
Sudipta Chatterjee et al.
Carbohydrate polymers, 123, 432-442 (2015-04-07)
Fish oil-loaded microcapsules were prepared from oil-in-water emulsions using N-stearoyl O-butylglyceryl chitosan as shell material. The emulsions were prepared by both membrane and ultrasonic emulsification processes under variable conditions to examine the effect of the emulsification process and encapsulation conditions
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