644544

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Kinetic and economic analysis of reactive capture of dilute carbon dioxide with Grignard reagents.

G R M Dowson et al.

Faraday discussions, 183, 47-65 (2015-09-16)

Carbon Dioxide Utilisation (CDU) processes face significant challenges, especially in the energetic cost of carbon capture from flue gas and the uphill energy gradient for CO2 reduction. Both of these stumbling blocks can be addressed by using alkaline earth metal

Ruthenium-Immobilized Periodic Mesoporous Organosilica: Synthesis, Characterization, and Catalytic Application for Selective Oxidation of Alkanes.

Nobuhiro Ishito et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15564-15569 (2015-09-04)

Periodic mesoporous organosilica (PMO) is a unique material that has a crystal-like wall structure with coordination sites for metal complexes. A Ru complex, [RuCl2 (CO)3 ]2 , is successfully immobilized onto 2,2'-bipyridine (BPy) units of PMO to form a single-site

Production of all trans-beta-carotene by using impinging flow of supercritical carbon dioxide anti-solvent pulverization.

Yi-Chen Shen et al.

Journal of chromatography. A, 1270, 1-8 (2012-11-28)

This work investigated column elution chromatography coupled with supercritical anti-solvent precipitation to produce carotenoid rich microsized particulates from microalgal Dunaliella salina species. The extract contained carotenoids ranging from 61.3 mg/g(salina) to 72.5 mg/g(salina) using ultrasonic stirred ethyl ether or tetrahydrofuran

Ionic complex of risedronate with positively charged deoxycholic acid derivative: evaluation of physicochemical properties and enhancement of intestinal absorption in rats.

Jin Woo Park et al.

Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)

Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect

Interstitial modification of palladium nanoparticles with boron atoms as a green catalyst for selective hydrogenation.

Chun Wong Aaron Chan et al.

Nature communications, 5, 5787-5787 (2014-12-20)

Lindlar catalysts comprising of palladium/calcium carbonate modified with lead acetate and quinoline are widely employed industrially for the partial hydrogenation of alkynes. However, their use is restricted, particularly for food, cosmetic and drug manufacture, due to the extremely toxic nature

Regulated bioanalysis of conformers - A case study with ASP2151 in dog plasma and urine.

Yoshiaki Ohtsu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 56-63 (2015-06-21)

We developed and validated bioanalytical methods for a potent helicase-primase inhibitor ASP2151 that has two conformers. These conformers elute as unseparated broad peaks under ordinary high-performance liquid chromatographic conditions, indicating discernable differences in hydrophobicity. We observed that column temperature and

A validated ultra-high-performance liquid chromatography-tandem mass spectrometry method for the selective analysis of free and total folate in plasma and red blood cells.

Filip Kiekens et al.

Journal of chromatography. A, 1398, 20-28 (2015-05-06)

A stable isotope dilution LC-MS/MS method is the method of choice for the selective quantitative determination of several folate species in clinical samples. By implementing an integrated approach to determine both the plasma and red blood cell (RBC) folate status

Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft.

Thomas J Raub et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1360-1371 (2015-07-08)

Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase inhibitor has potential for treating primary central nervous system tumors such as glioblastoma

Glucose and oxygen metabolism after penetrating ballistic-like brain injury.

Shyam Gajavelli et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(5), 773-780 (2015-02-12)

Traumatic brain injury (TBI) is a major cause of death and disability in all age groups. Among TBI, penetrating traumatic brain injuries (PTBI) have the worst prognosis and represent the leading cause of TBI-related morbidity and death. However, there are

Toward prediction of alkane/water partition coefficients.

Anita Toulmin et al.

Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literature

Study of the water structure in poly(methyl methacrylate-block-2-hydroxyethyl methacrylate) and its relationship to platelet adhesion on the copolymer surface.

Akira Mochizuki et al.

Journal of biomaterials science. Polymer edition, 26(12), 750-765 (2015-05-30)

The water structure and platelet compatibility of poly(methyl methacrylate (MMA)-block-2-hydroxyethyl methacrylate (HEMA)) were investigated. The molecular weight (Mn) of the polyHEMA segment was kept constant (average: 9600), while the Mn of the polyMMA segment was varied from 1340 to 7390.

Direct Production of 5-Hydroxymethylfurfural via Catalytic Conversion of Simple and Complex Sugars over Phosphated TiO2.

Luqman Atanda et al.

ChemSusChem, 8(17), 2907-2916 (2015-08-05)

A water-THF biphasic system containing N-methyl-2-pyrrolidone (NMP) was found to enable the efficient synthesis of 5-hydroxymethylfurfural (HMF) from a variety of sugars (simple to complex) using phosphated TiO2 as a catalyst. Fructose and glucose were selectively converted to HMF resulting

Performance of structured lipids incorporating selected phenolic and ascorbic acids.

Eliza Gruczynska et al.

Food chemistry, 173, 778-783 (2014-12-04)

Conditions applied during frying require antioxidant which is stable at these conditions and provides protection for frying oil and fried food. Novel structured lipids containing nutraceuticals and antioxidants were formed by enzymatic transesterification, exploring canola oil and naturally occurring antioxidants

Exciton delocalization drives rapid singlet fission in nanoparticles of acene derivatives.

Ryan D Pensack et al.

Journal of the American Chemical Society, 137(21), 6790-6803 (2015-05-07)

We compare the singlet fission dynamics of five pentacene derivatives precipitated to form nanoparticles. Two nanoparticle types were distinguished by differences in their solid-state order and kinetics of triplet formation. Nanoparticles that comprise primarily weakly coupled chromophores lack the bulk

Adsorption of water from aqueous acetonitrile on silica-based stationary phases in aqueous normal-phase liquid chromatography.

Jan Soukup et al.

Journal of chromatography. A, 1374, 102-111 (2014-12-30)

Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl

Determination of heptylphysostigmine in plasma by high-performance liquid chromatography with electrochemical detection.

L K Unni et al.

Journal of chromatography, 573(2), 275-281 (1992-01-17)

An analytical method was developed with sensitivity to detect clinically significant concentrations of heptylphysostigmine (HP), a new physostigmine derivative with potent and long-lasting inhibitory activity on cholinesterase. HP, an experimental drug for Alzheimer disease, was measured in human plasma by

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals.

Tristan Gollnest et al.

Nature communications, 6, 8716-8716 (2015-10-28)

The antiviral activity of nucleoside reverse transcriptase inhibitors is often limited by ineffective phosphorylation. We report on a nucleoside triphosphate (NTP) prodrug approach in which the γ-phosphate of NTPs is bioreversibly modified. A series of TriPPPro-compounds bearing two lipophilic masking

Metal and Metal Carbide Nanoparticle Synthesis Using Electrical Explosion of Wires Coupled with Epoxide Polymerization Capping.

Elseddik M Abdelkader et al.

Inorganic chemistry, 54(12), 5897-5906 (2015-05-27)

In this study, metal-containing nanoparticles (NPs) were produced using electrical explosion of wires (EEW) in organic solvents. The explosion chamber was constructed from Teflon to withstand the shockwave, allow growth and reaction of the incipient NPs in various organic solvents

HPMA-based polymeric micelles for curcumin solubilization and inhibition of cancer cell growth.

Ornchuma Naksuriya et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 501-512 (2015-07-03)

Curcumin (CM) has been reported as a potential anticancer agent. However, its pharmaceutical applications as therapeutic agent are hampered because of its poor aqueous solubility. The present study explores the advantages of polymeric micelles composed of block copolymers of methoxypoly(ethylene

Weak coordination of neutral S- and O-donor proximal ligands to a ferrous porphyrin nitrosyl. Characterization of 6-coordinate complexes at low T.

G G Martirosyan et al.

Journal of inorganic biochemistry, 121, 129-133 (2013-02-05)

The interaction of the S- and O-donor ligands tetrahydrothiophen (THT) and tetrahydrofuran (THF) with the ferrous nitrosyl complex Fe(TTP)(NO) (TTP(2-) is meso-tetra-p-tolyl-porphyrinatodianion) was studied at various temperatures both in solid state and solution using electronic and infrared absorption spectroscopy. Upon

Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury.

Simonetta Papa et al.

Biomaterials, 75, 13-24 (2015-10-17)

Many efforts have been performed in order to understand the role of recruited macrophages in the progression of spinal cord injury (SCI). Different studies revealed a pleiotropic effect played by these cells associated to distinct phenotypes (M1 and M2), showing

Galactosylated pullulan-curcumin conjugate micelles for site specific anticancer activity to hepatocarcinoma cells.

P R Sarika et al.

Colloids and surfaces. B, Biointerfaces, 133, 347-355 (2015-07-03)

Galactosylated pullulan-curcumin conjugate (LANH2-Pu Ald-Cur SA) is developed for target specific delivery of curcumin to hepatocarcinoma cells by five step synthetic strategy, which includes oxidation of pullulan (Pu Ald), introduction of amino group to the targeting ligand (LANH2), grafting of

Characterizing synthetic polymers and additives using new ionization methods for mass spectrometry.

Tarick J El-Baba et al.

Rapid communications in mass spectrometry : RCM, 28(11), 1175-1184 (2014-04-25)

New inlet and vacuum ionization methods provide advantages of specificity, simplicity and speed for the analysis of synthetic polymers and polymer additives directly from surfaces such as fibers using mass spectrometry (MS) on different commercial mass spectrometers (Waters SYNAPT G2

Effect of extrusion on phytochemical profiles in milled fractions of black rice.

Huihui Ti et al.

Food chemistry, 178, 186-194 (2015-02-24)

The phytochemical profile and antioxidant activities of unprocessed and extruded milled fractions of black rice were investigated. Extrusion increased the free phenolics, anthocyanins and oxygen radical absorbance capacity (ORAC) and decreased the bound forms. The total phenolics, anthocyanins and ORAC

Recognitive nano-thin-film composite beads for the enantiomeric resolution of the metastatic breast cancer drug aminoglutethimide.

Porkodi Kadhirvel et al.

Journal of chromatography. A, 1358, 93-101 (2014-07-22)

Straightforward crushing and sieving bulk polymeric R-aminoglutethimide-imprinted materials were prepared by classical free radical polymerization, whereas nano thin walled grafted imprinted materials were prepared using RAFT mediated control polymerization technique. A stoichiometric non-covalent approach based on a triply hydrogen bonding

Comparative method validation for closantel determination in cattle and sheep milk according to European Union Volume 8 and Veterinary International Conference on Harmonization guidelines.

Mathias Devreese et al.

Journal of chromatography. A, 1353, 106-113 (2014-03-25)

A specific and sensitive LC-MS/MS method was developed for quantitative determination of closantel in bovine and ovine colostrum and tank milk. Sample preparation consisted of extracting milk samples with acetonitrile/acetone (80/20, v/v) followed by SPE clean-up with Oasis mixed anion

Rectification of nanopores in aprotic solvents--transport properties of nanopores with surface dipoles.

Timothy Plett et al.

Nanoscale, 7(45), 19080-19091 (2015-11-03)

Nanopores have become a model system to understand transport properties at the nanoscale. We report experiments and modeling of ionic current in aprotic solvents with different dipole moments through conically shaped nanopores in a polycarbonate film and through glass nanopipettes.

Microcapsules for Enhanced Cargo Retention and Diversity.

Maximilian A Zieringer et al.

Small (Weinheim an der Bergstrasse, Germany), 11(24), 2903-2909 (2015-02-19)

Prevention of undesired leakage of encapsulated materials prior to triggered release presents a technological challenge for the practical application of microcapsule technologies in agriculture, drug delivery, and cosmetics. A microfluidic approach is reported to fabricate perfluoropolyether (PFPE)-based microcapsules with a

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

Shigeo Hayashi et al.

Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage

Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands.

Ibtissam Talhaoui et al.

Nucleic acids research, 42(10), 6300-6313 (2014-04-03)

The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved

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