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Showing 1-30 of 32 results for "64947" within Papers
Malin C Celander et al.
Environmental toxicology and chemistry, 30(1), 52-63 (2010-10-22)
Safety factors are used in ecological risk assessments to extrapolate from the toxic responses of laboratory test species to all species representing that group in the environment. More accurate extrapolation of species responses is important. Advances in understanding the mechanistic
Eva M Mateo et al.
International journal of food microbiology, 151(3), 289-298 (2011-10-22)
Fusarium langsethiae has been isolated from infected cereals in central and northern Europe where it has been identified in the last decade as the main species involved in the occurrence of high levels of T-2 and HT-2 toxins, mainly in
Ivana Haluzova et al.
Neuro endocrinology letters, 31 Suppl 2, 105-113 (2010-12-29)
The aim of the study was to investigate effects of the fungicide formulation Spartakus (prochloraz 450 g.L-1) on common carp Cyprinus carpio through biometric, biochemical, haematological and antioxidant indices, induction of xenobiotic metabolizing enzymes and histological examination of selected tissues.
Manuel Tejada et al.
Ecotoxicology and environmental safety, 74(6), 1708-1714 (2011-05-21)
We studied in the laboratory the effect of Prochloraz fungicide on the biological properties (soil enzymatic activities and soil bacterial communities) of a Plaggic Anthrosol. Five hundred grams of soil (<2mm) was mixed with three dosages of Prochloraz (1, 2
P R Jacobsen et al.
International journal of andrology, 33(2), 434-442 (2010-05-22)
Risk assessment is currently based on the no observed adverse effect levels (NOAELs) for single compounds. Humans are exposed to a mixture of chemicals and recent studies in our laboratory have shown that combined exposure to endocrine disrupters can cause
Antonio F Hernández et al.
Toxicology, 307, 136-145 (2012-06-26)
Pesticides almost always occur in mixtures with other ones. The toxicological effects of low-dose pesticide mixtures on the human health are largely unknown, although there are growing concerns about their safety. The combined toxicological effects of two or more components
Hongbo Li et al.
Talanta, 83(2), 591-595 (2010-11-30)
A ultrasensitive, simple and convenient electrochemical method was firstly developed for the determination of prochloraz and its metabolites as 2,4,6-trichlorophenol (2,4,6-TCP) using nano-aperture medical stone. Compared with the undoped disposable electrode (UDE), nano-aperture medical stone doped disposable electrode (MSDDE) not
Karen L Thorpe et al.
Aquatic toxicology (Amsterdam, Netherlands), 105(3-4), 412-420 (2011-08-13)
Exogenous treatment of fish with natural sex hormones and their mimics has been shown to influence gonadal differentiation resulting in biased phenotypic sex-ratios. This has lead to the development of the Fish Sexual Development Test (FSDT) as a method for
Christina N Robitaille et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 126-135 (2014-10-18)
Several pesticides suspected or known to have endocrine disrupting effects were screened for pro- or antiandrogenic properties by determining their effects on proliferation, prostatic-specific antigen (PSA) secretion and androgen receptor (AR) expression, and AR phosphorylation in androgen-dependent LNCaP human prostate
Hélène Rime et al.
Toxicological sciences : an official journal of the Society of Toxicology, 118(1), 61-70 (2010-09-02)
In the present study, we aimed at characterizing the effect of prochloraz, an imidazole fungicide, on the oocyte meiotic maturation process in a freshwater teleost species, the rainbow trout (Oncorhynchus mykiss). Full-grown post-vitellogenic ovarian follicles were incubated in vitro with
Adam D Biales et al.
Aquatic toxicology (Amsterdam, Netherlands), 105(3-4), 618-628 (2011-10-04)
The hypothalamus-pituitary-gonadal (HPG) axis plays a central role in the maintenance of homeostasis and disruptions in its function can have important implications for reproduction and other critical biological processes. A number of compounds found in aquatic environments are known to
Frederik Knud Nielsen et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(2), 343-350 (2011-12-27)
The effects of three model endocrine disruptors, prochloraz, ketoconazole and genistein on steroidogenesis were tested in the adrenocortical H295R cell line to demonstrate that a broader mechanistic understanding can be achieved in one assay by applying chemical analysis to the
Ana Masiá et al.
Journal of chromatography. A, 1345, 86-97 (2014-05-06)
Ultra-high pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QqTOF-MS) acquiring full scan MS data for quantification, and automatic data dependent information product ion spectra (IDA-MS/MS) without any predefinition of the ions by the user was checked for identifying organic contaminants in
Kasper Skov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 83-88 (2014-12-23)
Blood plasma is a well-known body fluid often analyzed in studies on the effects of toxic compounds as physiological or chemical induced changes in the mammalian body are reflected in the plasma metabolome. Sample preparation prior to LC-MS based analysis
Henrik Holbech et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 155(2), 407-415 (2011-11-26)
Results are presented from a validation (with 5 laboratories) of the Fish Sexual Development Test (FSDT) developed to detect endocrine disrupters (EDs) and included in the OECD (Organisation for Economic Co-operation and Development) working program. The aromatase-inhibiting fungicide prochloraz was
Synergy in microcosms with environmentally realistic concentrations of prochloraz and esfenvalerate.
Maj-Britt A Bjergager et al.
Aquatic toxicology (Amsterdam, Netherlands), 101(2), 412-422 (2011-01-11)
Laboratory experiments have shown that azole fungicides enhance the toxic effect of pyrethroid insecticides towards the aquatic crustacean Daphnia magna. Due to their sorptive properties the pesticides may, however, be less bioavailable in natural environments, possibly rendering them less toxic
Katrine Banke Nørgaard et al.
Environmental science and pollution research international, 17(4), 957-967 (2010-01-16)
The ergosterol biosynthesis-inhibiting (EBI) fungicide prochloraz can enhance the effect of other pesticides in a range of animal species. Approximately 50% of the fungicides used in Denmark are EBI fungicides. Hence, if they all have synergising potential, a risk assessment
Hyowook Gil et al.
Blood purification, 34(3-4), 344-348 (2013-01-12)
We treated a patient with critical manganese intoxication with vigorous extracorporeal elimination. In this article, we describe the clinical characteristics and treatment modalities of the patient. A 65-year-old man was brought to the emergency room (ER) 5.5 h after ingesting
Pernille Rosenskjold Jacobsen et al.
Reproductive toxicology (Elmsford, N.Y.), 34(2), 237-250 (2012-06-09)
There is growing concern of permanent damage to the endocrine and nervous systems after developmental exposure to endocrine disrupting chemicals. In this study the permanent reproductive and neurobehavioral effects of combined exposure to five endocrine disrupting pesticides, epoxiconazole, mancozeb, prochloraz
Maj-Britt A Bjergager et al.
Aquatic toxicology (Amsterdam, Netherlands), 110-111, 17-24 (2012-01-17)
Azole fungicides can enhance the toxicity of pyrethroid insecticides on aquatic species. It is, however, unknown to what extend the synergy found under laboratory conditions for strongly sorbing compounds (Azole logK(ow): 3-4, pyrethroid logK(ow): 6-7) will also take place in
Chunsheng Liu et al.
Environmental science & technology, 45(2), 769-775 (2010-12-17)
The objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary-adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes of fish. Adult female zebrafish were exposed to 300 μg/L prochloraz (PCZ) or 100 mg/L propylthiouracil (PTU), and
Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz
Vinggaard MA, et al.
Toxicological Sciences, 69(2), 344-353 (2002)
C V Rider et al.
International journal of andrology, 33(2), 443-462 (2010-05-22)
Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act required the US Environmental Protection Agency to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end, we
Inês Domingues et al.
Environmental toxicology, 28(3), 155-163 (2011-06-10)
Zebrafish early life stages (ELS) assays have been increasingly used to assess the toxicity of chemicals and waste waters, showing a great potential due to the wide variety of endpoints that can be incorporated in the test. Moreover, zebrafish ELS
Sarah Y Skolness et al.
Aquatic toxicology (Amsterdam, Netherlands), 103(3-4), 170-178 (2011-04-08)
Prochloraz is a fungicide known to cause endocrine disruption through effects on the hypothalamic-pituitary-gonadal (HPG) axis. To determine the short-term impacts of prochloraz on gene expression and steroid production, adult female fathead minnows (Pimephales promelas) were exposed to the chemical
M L a Marca Pereira et al.
Aquatic toxicology (Amsterdam, Netherlands), 101(3-4), 500-511 (2011-02-01)
A variety of natural and synthetic environmental substances have been shown to disrupt vertebrate reproduction through mimicking or modifying the regulation of the endocrine system. Tests to screen for any such chemicals that directly interact with the steroid hormone receptors
Sofie Christiansen et al.
Environmental health perspectives, 117(12), 1839-1846 (2010-01-06)
By disrupting the action of androgens during gestation, certain chemicals present in food, consumer products, and the environment can induce irreversible demasculinization and malformations of sex organs among male offspring. However, the consequences of simultaneous exposure to such chemicals are
Sandra Halwachs et al.
Toxicological sciences : an official journal of the Society of Toxicology, 131(2), 491-501 (2012-10-20)
The molecular mechanisms by which environmental pollutants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or widely used imidazole fungicide prochloraz display their toxic effects in vertebrates are still not well understood. Using computer analysis, we recently identified nuclear aryl hydrocarbon receptor (AhR) binding sites
Anne Marie Vinggaard et al.
International journal of andrology, 29(1), 186-192 (2006-02-10)
Prochloraz is an imidazole fungicide that is widely used in Europe, Australia, Asia and South America within gardening and agriculture. Screening studies have shown that prochloraz elicits multiple mechanisms of action in vitro, as it antagonizes the androgen and the
Jonathan G L Mullins et al.
PloS one, 6(6), e20973-e20973 (2011-07-09)
A structural rationale for recent emergence of azole (imidazole and triazole) resistance associated with CYP51 mutations in the wheat pathogen Mycosphaerella graminicola is presented, attained by homology modelling of the wild type protein and 13 variant proteins. The novel molecular
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