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Showing 1-30 of 543 results for "66742" within Papers
T Bächi et al.
Scandinavian journal of immunology, 6(3), 241-246 (1977-01-01)
Protein A (pA) of Staphylococcus aureus, by virtue of its reactivity with the Fc portion of a variety of mammalian immumoglobulins (IgG), can be used for electron-microscopical immunoferritin techniques. The conjugation of pA with ferritin (pA-F) by means of bis(4-fluoro-3-nitrophenyl)
Sara Hosseininasab et al.
Chemical biology & drug design, 84(3), 307-315 (2014-04-02)
Therapeutic proteins and peptides are corresponding to a major area of research in biotechnology companies and current pharmaceutical. Because of their natural instability, the enormous majority of these drugs require parentéral administration. Oral insulin delivery would be a highly attractive
Long Ji et al.
Steroids, 78(9), 860-865 (2013-05-21)
In the present study, it was demonstrated that the dichloromethane extract of Physalis pubescens L. (DEPP) had weak potential quinone reductase (QR) inducing activity, but an UPLC-ESI-MS method with glutathione (GSH) as the substrate revealed that the DEPP had electrophiles
Yan Pan et al.
Journal of ethnopharmacology, 143(2), 586-591 (2012-08-14)
Labisa pumila (LP), popularly known with its local name, Kacip Fatimah, is a well known herb grown in Indochina and Southeast Asia and is traditionally used to regain energy after giving birth in women. The propensity of LP to cause
Małgorzata Kupczewska-Dobecka et al.
Medycyna pracy, 59(2), 187-195 (2008-07-26)
In 2007, a new maximum admissible concentration value of 88 mg/m3 was specified for dichloromethane (DCM) in the Polish list of admissible concentrations of harmful chemicals and dusts in the work environment atmosphere. The new value is four times higher
Rieuwert Hoppes et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 4803-4813 (2014-10-15)
Virus or tumor Ag-derived peptides that are displayed by MHC class I molecules are attractive starting points for vaccine development because they induce strong protective and therapeutic cytotoxic T cell responses. In thus study, we show that the MHC binding
Guo-Jyun Lai et al.
Carbohydrate polymers, 111, 288-297 (2014-07-20)
Nanofibrous membrane scaffolds of chitosan (CS), silk fibroin (SF) and CS/SF blend were prepared by electrospinning and studied for growth and osteogenic differentiation of human bone marrow mesenchymal stem cells (hMSCs). The morphology and physico-chemical properties of all membrane scaffolds
Rajesh Parikh et al.
Drug delivery, 21(6), 406-411 (2013-11-13)
Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance (MDR)-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar macrophages (AM). Pulmonary administration
Hoon Hur et al.
PloS one, 9(6), e98581-e98581 (2014-06-10)
The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous
Alberto De Petris et al.
The journal of physical chemistry. B, 119(5), 1919-1929 (2015-01-13)
The iron(III) protoporphyrin IX complex with imidazole, a biologically relevant ligand, occupying an axial position, has been studied by infrared multiple photon dissociation (IRMPD) spectroscopy. The complex has been delivered in gas-phase by electrospray ionization (ESI), mass selected in an
Leila Hejazi et al.
Rapid communications in mass spectrometry : RCM, 29(1), 91-99 (2014-12-03)
Mass spectrometric identification of compounds in chromatography can be obtained from molecular masses from soft ionization mass spectrometry techniques such as field ionization (FI) and fragmentation patterns from hard ionization techniques such as electron ionization (EI). Simultaneous detection by EI
Ziyi Yang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 897-908 (2014-08-12)
The focus of this study was to investigate the effect of processing on the surface crystallization of amorphous molecular dispersions and gain insight into the mechanisms underpinning this effect. The model systems, amorphous molecular dispersions of felodipine-EUDRAGIT® E PO, were
Anusuya Das et al.
PloS one, 9(7), e101276-e101276 (2014-08-01)
In this study, a microgel composed of chitosan and inorganic phosphates was used to deliver poly(lactic-co-glycolic acid) (PLAGA) microspheres loaded with sphingolipid growth factor FTY720 to critical size cranial defects in Sprague Dawley rats. We show that sustained release of
Hironobu Murata et al.
Biomacromolecules, 15(7), 2817-2823 (2014-06-24)
Atom transfer radical polymerization (ATRP)-based protein engineering of chymotrypsin with a cationic polymer was used to tune the substrate specificity and inhibitor binding. Poly(quaternary ammonium) was grown from the surface of the enzyme using ATRP after covalent attachment of a
Zhengyu Cao et al.
Marine drugs, 13(2), 903-919 (2015-02-13)
The frequent occurrence of Moorea producens (formerly Lyngbya majuscula) blooms has been associated with adverse effects on human health. Hoiamide A is a structurally unique cyclic depsipeptide isolated from an assemblage of the marine cyanobacteria M. producens and Phormidium gracile.
Salim Sioud et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2389-2397 (2014-10-11)
The formation of ions during atmospheric pressure photoionization (APPI) mass spectrometry in the positive mode usually provides radical cations and/or protonated species. Intriguingly, during the analysis of some N-alkyl-substituted thieno[3,4-c]pyrrole-4,6-dione (TPD) derivatives synthesized in our laboratory, unusual [M-H](+) ion peaks
Marzieh Rashidipour et al.
Journal of AOAC International, 97(4), 1109-1113 (2014-08-26)
Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with conventional maceration and Soxhlet extraction (SOXE) methods. Variables affecting MSPD, such as
Jing Ma et al.
Molecular medicine reports, 11(4), 2413-2420 (2014-12-17)
A combination of diagnostic and therapeutic ultrasound (US) techniques may be able to provide the basis of specific therapeutic protocols, particularly for the treatment of tumors. Nanotechnology may aid the progression towards the use of US for tumor diagnosis and
Joyann A Marks et al.
Journal of pharmaceutical sciences, 103(9), 2871-2883 (2014-05-16)
Blends of polymers with complementary properties hold promise for addressing the diverse, demanding polymer performance requirements in amorphous solid dispersions (ASDs), but we lack comprehensive property understanding for blends of important ASD polymers. Herein, we prepare pairwise blends of commercially
Rajesh Kumar et al.
Journal of chromatography. A, 1359, 16-25 (2014-08-02)
A simple, fast and sensitive analytical method using fabric phase sorptive extraction (FPSE) followed by high performance liquid chromatography with fluorescence detection (HPLC-FLD) has been developed for efficient quantification of biologically important molecules e.g., 17α-ethynylestradiol (EE2), β-estradiol (E2) and bisphenol
Julia E Vela-Ramirez et al.
The AAPS journal, 17(1), 256-267 (2014-11-26)
Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and dendritic cells, can be used to modulate immune responses. In this work, the in
N G R Dayan Elshan et al.
Bioorganic & medicinal chemistry, 23(8), 1841-1848 (2015-03-15)
The synthesis, characterization, and use of Eu-DTPA-PEGO-Trp-Nle-Asp-Phe-NH2 (Eu-DTPA-PEGO-CCK4), a luminescent probe targeted to cholecystokinin 2 receptor (CCK2R, aka CCKBR), are described. The probe was prepared by solid phase synthesis. A Kd value of 17±2nM was determined by means of saturation
Karine Rech Begnini et al.
Journal of medicinal food, 17(10), 1129-1133 (2014-09-18)
Cancer is a leading cause of death and is responsible for one in eight deaths worldwide. The use of herbs as complementary medicine for cancer, especially advanced cancer, has recently increased. The aim of this study was to evaluate in
Nikoleta Stoyanova et al.
Materials science & engineering. C, Materials for biological applications, 41, 119-126 (2014-06-09)
For the first time the preparation of defect-free fibers from immiscible blends of high molar mass poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) in the whole range of the polyester weight ratios is shown. Electrospinning using the solvent-nonsolvent approach proved
Rumi Tanoue et al.
Journal of chromatography. A, 1355, 193-205 (2014-06-25)
In the present study, a sensitive and accurate isotope dilution method was developed for the simultaneous determination of 17 polar pharmaceutical and personal care product (PPCP) residues (logKow=1.40-5.74), including 14 pharmaceuticals and 3 personal care products, in biological organs and
Glinda S Cooper et al.
International journal of environmental research and public health, 8(8), 3380-3398 (2011-09-13)
Dichloromethane (methylene chloride) is a widely used chlorinated solvent. We review the available epidemiology studies (five cohort studies, 13 case-control studies, including seven of hematopoietic cancers), focusing on specific cancer sites. There was little indication of an increased risk of
Michael H Abraham et al.
European journal of medicinal chemistry, 43(3), 478-485 (2007-06-05)
Values of in vitro gas to lung partition coefficients, K(lung), of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K(lung) yielded a correlation with R(2)=0.968 and S.D.=0.25 log units. Combination
Philipp Nuhn et al.
Pancreas, 42(2), 265-271 (2012-09-25)
The cytoprotective enzyme heme oxygenase 1 (HO-1) is highly up-regulated in acute pancreatitis (AP). In this study, we tested its metabolites as potential therapeutic agents for AP in rats. Acute necrotizing pancreatitis was induced by retrograde intraductal injection of sodium
N Domínguez-Morueco et al.
The Science of the total environment, 500-501, 139-146 (2014-09-14)
The aim of this study is to evaluate the presence and concentrations of the main phthalates in water from the Jarama and Manzanares rivers in the region of Madrid (RM, Central Spain), the most densely populated region of Spain, and
D N Nguyen et al.
International journal of pharmaceutics, 475(1-2), 214-226 (2014-09-03)
This study was the first investigation into the potential of a fixed dose combination of ritonavir and darunavir in the form of dispersible powders prepared by spray drying. A common polymer (hydroxypropyl methylcellulose, polyvinylpyrrolidone, and polyvinylpyrrolidone-vinyl acetate 64) was formulated
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