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Showing 1-30 of 224 results for "697079" within Papers
Jun Guo et al.
Inflammation, 38(2), 664-671 (2014-07-13)
The aim of the study was to investigate the anti-apoptotic potency of TNFR:Fc gene in ischemia/reperfusion-induced myocardial cell injury and hypoxia/reoxygenation-induced H9c2 rat cardiomyocytes injury. Rats were randomly divided into the following groups (n=8): (1) sham operation group; (2) ischemia-reperfusion
Atsuhiko Toyoshima et al.
PloS one, 10(6), e0127302-e0127302 (2015-06-16)
Intra-arterial stem cell transplantation exerts neuroprotective effects for ischemic stroke. However, the optimal therapeutic time window and mechanisms have not been completely understood. In this study, we investigated the relationship between the timing of intra-arterial transplantation of allogeneic mesenchymal stem
Dan Wu et al.
Journal of molecular medicine (Berlin, Germany), 93(12), 1311-1325 (2015-07-04)
C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with modulation effects on metabolism, inflammation, and cardiovascular system. This study aimed to investigate the effect of CTRP3 on cardiac fibrosis and its underlying mechanism. The myocardial expression of CTRP3 was
Hong-Shuo Sun et al.
Experimental neurology, 263, 161-171 (2014-12-03)
Neonatal hypoxic-ischemic brain injury and its related illness hypoxic-ischemic encephalopathy (HIE) are major causes of nervous system damage and neurological morbidity in children. Hypoxic preconditioning (HPC) is known to be neuroprotective in cerebral ischemic brain injury. K(ATP) channels are involved
Rita Lh Yim et al.
Oncotarget, 5(20), 9770-9782 (2014-09-12)
Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin's lymphoma (NHL). In cancers, tumor suppressive microRNAs may be silenced by DNA hypermethylation. By microRNA profiling of representative EBV-negative MCL cell lines before and after demethylation treatment, miR-155-3p was found significantly
Yinghua Jiang et al.
Neuroscience letters, 602, 73-78 (2015-07-08)
We previously have shown that tissue type plasminogen activator (tPA) in combination with its receptor annexin A2 (rA2) protein significantly improved tPA thrombolytic efficacy. In this study we aimed to examine the therapeutic effects of the combination when treated at
Pei-Pei Zhai et al.
Neuropharmacology, 95, 1-11 (2015-03-10)
This study was designed to evaluate the neuroprotective effect of l-serine and the underlying mechanisms in mice after traumatic brain injury (TBI) induced using a weight drop model. The mice were intraperitoneally injected with l-serine 3 h after TBI and
Xiao-Hui Ma et al.
The International journal of neuroscience, 125(2), 140-146 (2014-04-16)
Hundreds of previous studies demonstrated the cytoprotective effect of trichostatin-A (TSA), a kind of histone deacetylases inhibitors (HDACIs), against cerebral ischemia/reperfusion insult. Meanwhile, phosphatidylinositol-3 kinase/Akt (PI3K/Akt) is a well-known, important signaling pathway that mediates neuroprotection. However, it should be remains
Jing Wang et al.
Environmental technology, 37(1), 39-45 (2015-06-27)
Bioreduced graphene oxide (BRGO) has been proven to be capable of accelerating nitrobenzene (NB) biotransformation by anaerobic sludge (AS). To realize its application, in the present study, two continuous anaerobic reactors (R1 with BRGO/AS composite; R2 with AS) were employed
Jeffrey A Kline et al.
Thrombosis research, 136(4), 769-774 (2015-09-05)
Pulmonary embolism (PE) can cause intracardiac hemolysis and increased plasma hemoglobin and arginase-1, which can worsen pulmonary vasoconstriction. We test the hypothesis that patients with PE that causes tricuspid regurgitation (TR), indicative of higher pulmonary arterial pressures, have decreased leukocyte
Xue Jiang et al.
Apoptosis : an international journal on programmed cell death, 20(8), 1033-1047 (2015-04-22)
sRAGE can protect cardiomyocytes from apoptosis induced by ischemia/reperfusion (I/R). However, the signaling mechanisms in cardioprotection by sRAGE are currently unknown. We investigated the cardioprotective effect and potential molecular mechanisms of sRAGE inhibition on apoptosis in the mouse myocardial I/R
Gulnaz Begum et al.
Stroke, 46(7), 1956-1965 (2015-06-13)
WNK kinases, including WNK3, and the associated downstream Ste20/SPS1-related proline-alanine-rich protein kinase (SPAK) and oxidative stress responsive 1 (OSR1) kinases, comprise an important signaling cascade that regulates the cation-chloride cotransporters. Ischemia-induced stimulation of the bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays an
Magdalena Stevanović et al.
Colloids and surfaces. B, Biointerfaces, 132, 208-215 (2015-06-07)
In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass(®)) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable
Bahman Khameneh et al.
Drug development and industrial pharmacy, 41(6), 989-994 (2014-05-21)
Antibiotic resistance has stimulated the research for developing novel strategies that can prevent bacterial growth. Methicillin-resistant Staphylococcus aureus (MRSA), regarded as one of the most serious antibiotic-resistant bacteria which has been conventionally recognized as a nosocomial pathogen. Nanoliposomal formulations of
Nam-Gyoon Kim
Perceptual and motor skills, 120(3), 906-927 (2015-05-20)
As an object approaches an observer, the visual angle subtended by any two texture elements on the object surface expands, as does the solid angle corresponding to the object's contour. The inverse of the relative rate of each of these
Ivan Kocic et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(1), 79-86 (2014-10-26)
This study evaluated the therapeutic potential of masitinib, an oral tyrosine kinase inhibitor with activity against c-Kit and platelet-derived growth factor receptors (PDGFR), to reduce ischemic brain area and neurological deficit. Using a well-established filament model of ischemic stroke in
Tao Luo et al.
Archives of biochemistry and biophysics, 586, 1-9 (2015-06-21)
Calpain plays an important role in myocardial ischemia/reperfusion (I/R) injury. PD150606, a nonpeptide, cell-permeable and noncompetitive calpain inhibitor, has been shown to have protective properties in ischemic disease. The aims of the present study were to investigate whether PD150606 could
Zhi Li et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(6), 1197-1206 (2015-05-23)
Recently, porous carbons have showed great potential in many areas. In this study, TiO2-doped mesoporous carbonaceous (TiO2@C) nanoparticles were obtained by a simple one-pot hydrothermal treatment, folic acid (FA) was conjugated to TiO2@C through an amide bond, then Mitoxantrone HCl
Mingbao Lin et al.
PloS one, 10(4), e0124558-e0124558 (2015-04-22)
Methylophiopogonanone A (MO-A), an active homoisoflavonoid of the Chinese herb Ophiopogon japonicus which has been shown to have protective effects on cerebral ischemia/reperfusion (I/R) injury, has been demonstrated to have anti-inflammatory and anti-oxidative properties. However, little is known about its
Fei Zhou et al.
Stem cell research & therapy, 6, 92-92 (2015-05-10)
Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental
Ying Li et al.
Toxicology and applied pharmacology, 286(1), 53-63 (2015-03-21)
Curcumin is a natural polyphenolic compound in Curcuma longa with beneficial effects on neuronal protection. This study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum
Li-Jun Xu et al.
Experimental neurology, 264, 1-7 (2014-11-30)
miR-181 has deleterious effects on stroke outcome, and reducing miR-181a levels prior to middle cerebral artery occlusion (MCAO) was shown previously to be protective. Here we tested the effect of post-ischemic treatment with miR-181a antagomir by intracerebroventricular and intravenous routes
Hua Dock et al.
Translational stroke research, 6(4), 296-300 (2015-04-01)
5-Aza-deoxycytidine (5-aza-dC) confers neuroprotection in ischemic mice by inhibiting DNA methylation. Zebularine is another DNA methylation inhibitor, less toxic and more stable in aqueous solutions and, therefore more biologically suitable. We investigated Zebularine's effects on brain ischemia in a rat
Jianjuan Ke et al.
Journal of cardiovascular pharmacology, 66(1), 25-34 (2015-02-24)
This study was undertaken to determine and confer the cardioprotective effects of the adenosine A2 receptor (A2AR) and its impact on myocardial autophagy in the setting of reperfusion. We established a rat ischemia model by subjecting rats to 30 minutes
A Vercelli et al.
Cell death & disease, 6, e1854-e1854 (2015-08-14)
Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We have previously shown that JNK inhibition by a specific cell-permeable peptide significantly reduces infarct size
Feng Gao et al.
Chemical & pharmaceutical bulletin, 60(3), 415-418 (2012-03-03)
A selective intramolecular transacylation from C-4 to C-5 of taxoids, which occurred simultaneously with the oxetane D-ring opening and was promoted by TiCl4, was presented. The optimal condition was found to be treatment of substrates in double dose of dichloromethane
Harri Heikkinen et al.
Solid state nuclear magnetic resonance, 43-44, 36-41 (2012-03-20)
In this study, solid state (13)C NMR spectroscopy was utilised to characterize and identify the metal-ester coordination in active fourth generation (phthalate) Ziegler-Natta catalysts. It is known that different donors affect the active species in ZN catalysts. However, there is
Bo Yang et al.
Neurotoxicity research, 28(1), 1-7 (2015-02-24)
Cystatin C (CysC) has been used as a renal function indicator and a strong predictor of cardiovascular events. In this study, we determined the prognostic value of serum CysC in patients with acute ischemic stroke (AIS) and examined its protective
Bo-ding Tong et al.
Molecular vision, 21, 324-334 (2015-04-16)
This study aimed to determine the role of miR-21 in orbital fibroblasts obtained from donors with thyroid-associated ophthalmopathy (TAO) and to elucidate the regulation of fibrosis by miR-21 in the pathological process of TAO. The expression of miR-21 was investigated
Y X Zhao et al.
Journal of hazardous materials, 187(1-3), 495-501 (2011-02-12)
The growth, breakage and regrowth nature of flocs formed by Titanium tetrachloride (TiCl(4)) and polyaluminum chloride (PACl) was comparatively evaluated with surface water treatment. A series of jar experiments were conducted to investigate the impacts of different operating parameters such
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