Search Within
700000P
Applied Filters:
Keyword:'700000P'
Showing 1-30 of 141 results for "700000P" within Papers
Antti H Rantamäki et al.
Scientific reports, 9(1), 18349-18349 (2019-12-05)
Understanding the toxicity of ionic liquids (ILs) is crucial in the search of greener chemicals. By comparing in vivo toxicity and in vitro interactions determined between compounds and biomimetic lipid membranes, more detailed toxicity vs. structure relation can be obtained.
Tomas Sabirovas et al.
Biochimica et biophysica acta. Biomembranes, 1862(6), 183232-183232 (2020-03-03)
Mixed self-assembled monolayers of octadecyltrichlorosilane (OTS) and methyltrichlorosilane (MTS) were deposited via simple silanization procedure on a mechanically polished titanium surface. The monolayers act as molecular anchors for mixed hybrid bilayer lipid membranes (mhBLM) which were accomplished via vesicle fusion.
Yanjuan Huang et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 119-134 (2019-12-29)
Current therapeutic strategies for the treatment of bone metastases are often limited by the lack of selectivity, severe systemic toxicity and suboptimal efficacy. Nanomedicine meditated chemo-photodynamic therapy provides a promising therapeutic opportunity for enhanced cancer therapy. Herein, we constructed an
Carola Hofmann et al.
Analytical and bioanalytical chemistry, 412(14), 3383-3393 (2020-04-07)
Liposomes have been widely applied in bioanalytical assays. Most liposomes used bare negative charges to prevent non-specific binding and increase colloidal stability. Here, in contrast, highly stable, positively charged liposomes entrapping the fluorescent dye sulforhodamine B (SRB) were developed to
Kevin A Carter et al.
Nature communications, 5, 3546-3546 (2014-04-05)
The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we describe liposomes doped with porphyrin-phospholipid that are permeabilized directly by near-infrared
Jianjun Pan et al.
The journal of physical chemistry. B, 116(51), 14829-14838 (2012-12-04)
Cholesterol and ether lipids are ubiquitous in mammalian cell membranes, and their interactions are crucial in ether lipid mediated cholesterol trafficking. We report on cholesterol's molecular interactions with ether lipids as determined using a combination of small-angle neutron and X-ray
Yui Suzuki et al.
Langmuir : the ACS journal of surfaces and colloids, 33(10), 2671-2676 (2017-02-14)
We have developed a novel system for photocontrol of the fusion of lipid vesicles through the use of a photosensitive surfactant containing an azobenzene moiety (AzoTAB). Real-time microscopic observations clarified a change in both the surface area and internal volume
Nicolas Puff et al.
Langmuir : the ACS journal of surfaces and colloids, 36(16), 4347-4356 (2020-04-03)
The study of biomimetic model membrane systems undergoing liquid-ordered (Lo)-liquid-disordered (Ld) phase separation using spectroscopic methods has played an important role in understanding the properties of lipid rafts in plasma membranes. In particular, the membrane-associated fluorescence probe Laurdan has proved
Guangtao Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(49), 14025-14030 (2016-11-23)
Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid
Graham J Taylor et al.
Langmuir : the ACS journal of surfaces and colloids, 33(38), 10016-10026 (2017-08-16)
In-plane lipid organization and phase separation in natural membranes play key roles in regulating many cellular processes. Highly cooperative, first-order phase transitions in model membranes consisting of few lipid components are well understood and readily detectable via calorimetry, densitometry, and
Xue-Tao Li et al.
Journal of liposome research, 1-13 (2020-04-01)
Tumour metastasis is a major cause of cancer treatment failure and death, and chemotherapy efficiency for gastric cancer patients is usually unsatisfactory due to tumour cell metastasis, poor targeting and serious adverse reactions. In this study, a kind of R8GD-modified
Hungyen Lee et al.
Molecular pharmaceutics, 17(6), 2165-2174 (2020-04-22)
Trojan horse liposomes (THLs) are a form of ligand-targeted nanomedicine, where a plasmid DNA is encapsulated in the interior of a 100-150 nm pegylated liposome, and the tips of a fraction of the surface pegylated strands are covalently linked to
Valerija Vezočnik et al.
Langmuir : the ACS journal of surfaces and colloids, 34(30), 8983-8993 (2018-07-10)
Understanding of the interactions between proteins and natural and artificially prepared lipid membrane surfaces and embedded nonpolar cores is important in studies of physiological processes and their pathologies and is applicable to nanotechnologies. In particular, rapidly growing interest in cellular
Benjamin R Coyac et al.
Journal of periodontology (2020-04-13)
Autologous bone can be harvested from the flutes of a conventional drill or from a bone scraper; here we compared whether autologous bone chips generated by a new slow-speed instrument were more osteogenic than the bone chips generated by conventional
Brandt Bertrand et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183105-183105 (2019-11-05)
The aim of this study was to investigate the factors that govern the activity and selectivity of two potent antimicrobial peptides (AMPs) using lipid membrane models of bacterial, erythrocyte and fungal cells. These models were used in calcein liposome leakage
Orrin Shindell et al.
Langmuir : the ACS journal of surfaces and colloids, 34(15), 4673-4680 (2018-01-25)
Artificial lipid membranes incorporating proteins have frequently been used as models for the dynamic organization of biological structures in living cells as well as in the development of biology-inspired technologies. We report here on the experimental demonstration and characterization of
Peter J N Kett et al.
The journal of physical chemistry. B, 117(21), 6455-6465 (2013-05-21)
The assignment of the vibrational spectrum of cholesterol is surprisingly incomplete for such a fundamental molecule. To improve our understanding, a new investigation of the spectra of cholesterol in the C-H stretching region has been undertaken using the surface specific
James Kurniawan et al.
Langmuir : the ACS journal of surfaces and colloids, 33(1), 382-387 (2016-12-22)
Cellular membranes containing sphingolipids and cholesterol have been shown to self-organize into lipid rafts-specialized domains that host integral membrane proteins and modulate the bioactivity of cells. In this work, force-distance profiles between raft membranes in the liquid-ordered phase consisting of
Milan Gautam et al.
Expert opinion on drug delivery, 17(3), 423-434 (2020-02-08)
Background: Phytosterols significantly reduce the risk of cancer by directly inhibiting tumor growth, inducing apoptosis, and inhibiting tumor metastasis. Stigmasterol (STS), a phytosterol, exhibits anticancer effects against various cancers, including breast cancer. Chemotherapeutics, including doxorubicin (DOX), might act synergistically with
Interaction of imidazolium-based lipids with phospholipid bilayer membranes of different complexity.
Steffen Bornemann et al.
Physical chemistry chemical physics : PCCP, 22(17), 9775-9788 (2020-04-28)
In recent years, alkylated imidazolium salts have been shown to affect lipid membranes and exhibit general cytotoxicity as well as significant anti-tumor activity. Here, we examined the interactions of a sterically demanding, biophysically unexplored imidazolium salt, 1,3-bis(2,6-diisopropylphenyl)-4,5-diundecylimidazolium bromide (C11IPr), on
Meygal Kahana et al.
Molecular psychiatry (2020-05-07)
Delivery of drugs into the brain is poor due to the blood brain barrier (BBB). This study describes the development of a novel liposome-based brain-targeting drug delivery system. The liposomes incorporate a diacylglycerol moiety coupled through a linker to a
Heegon Kim et al.
ACS nano, 14(6), 6519-6531 (2020-04-29)
Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are not only the main components of the plaques but also key inflammation-triggering sources. However, no existing therapeutics can achieve effective removal of both components within the plaques. Here, we
Megan B Miller et al.
The Journal of biological chemistry, 290(21), 13541-13555 (2015-04-12)
Previous studies revealed an essential role for the lipid-binding Sec14 domain of kalirin (KalSec14), but its mechanism of action is not well understood. Because alternative promoter usage appends unique N-terminal peptides to the KalSec14 domain, we used biophysical, biochemical, and
Nobuto Arashiki et al.
Biochemistry, 55(25), 3504-3513 (2016-06-09)
An asymmetric distribution of phospholipids in the membrane bilayer is inseparable from physiological functions, including shape preservation and survival of erythrocytes, and by implication other cells. Aminophospholipids, notably phosphatidylserine (PS), are confined to the inner leaflet of the erythrocyte membrane
Michael Lorenz et al.
The Journal of biological chemistry, 290(11), 6962-6974 (2015-01-22)
Herpesviruses assemble capsids in the nucleus and egress by unconventional vesicle-mediated trafficking through the nuclear envelope. Capsids bud at the inner nuclear membrane into the nuclear envelope lumen. The resulting intralumenal vesicles fuse with the outer nuclear membrane, delivering the
Simon Matoori et al.
Small (Weinheim an der Bergstrasse, Germany), 16(20), e2000369-e2000369 (2020-04-25)
In emergency medicine, blood lactate levels are commonly measured to assess the severity and response to treatment of hypoperfusion-related diseases (e.g., sepsis, trauma, cardiac arrest). Clinical blood lactate testing is conducted with laboratory analyzers, leading to a delay of 3
Shuai Shao et al.
Nature chemistry, 7(5), 438-446 (2015-04-23)
Methods to attach polypeptides to lipid bilayers are often indirect and ineffective, and can represent a substantial bottleneck in the formation of functionalized lipid-based materials. Although the polyhistidine tag (his-tag) has been transformative in its simplicity and efficacy in binding
Yuanqing Ma et al.
Biophysical journal, 115(8), 1498-1508 (2018-10-03)
Membrane viscosity and hydration levels characterize the biophysical properties of biological membranes and are reflected in the rate and extent of solvent relaxation, respectively, of environmentally sensitive fluorophores such as Laurdan. Here, we first developed a method for a time-resolved
Vicente Castro-Castillo et al.
Journal of materials chemistry. B, 8(1), 88-99 (2019-11-27)
We synthesized an anthracene derivative with solvatochromic properties to be used as a molecular probe for membrane dynamics and supramolecular organization. A nine carbon atom acyl chain and a dimethylamino substitution were introduced at positions 2 and 6 of the
Yuanmo Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 36(1), 37-46 (2019-12-24)
Enzymes conjugated to nanomaterials are used in the design of various biotechnologies. In the development of biosensors, surface modifications with the enzyme glucose oxidase (GOx) serve to aid the detection of blood glucose. In order to optimize sensor effectiveness, the
Page 1 of 5