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Showing 1-30 of 30 results for "703478" within Papers
S Mandruzzato et al.
The Journal of experimental medicine, 186(5), 785-793 (1997-08-29)
Of the antigens recognized on human tumors by autologous cytolytic T lymphocytes, all those defined thus far have been identified on melanoma or renal cell carcinoma. We report here the identification of an antigen recognized by autologous cytolytic T lymphocytes
Florencia Paula Madorsky Rowdo et al.
International journal of oncology, 56(6), 1429-1441 (2020-04-03)
It is estimated that ~50% of patients with melanoma harbour B‑Raf (BRAF)V600 driver mutations, with the most common of these being BRAFV600E, which leads to the activation of mitogen‑activated protein kinase proliferative and survival pathways. BRAF inhibitors are used extensively
Ricardo T Fujiwara et al.
PLoS neglected tropical diseases, 3(3), e399-e399 (2009-03-25)
Hookworms survive for several years (5 to 7 years) in the host lumen, inducing a robust but largely ineffective immune response. Among the most striking aspects of the immune response to hookworm (as with many other helminths) is the ablation
Kouta Niizuma et al.
The Journal of biological chemistry, 290(36), 22298-22308 (2015-07-30)
Recruitment of circulating monocytes and neutrophils to infection sites is essential for host defense against infections. Here, we identified a previously unannotated gene that encodes an immunoglobulin-like receptor, designated CD300H, which is located in the CD300 gene cluster. CD300H has
Faizan A Sadiq et al.
International journal of food microbiology, 262, 89-98 (2017-10-03)
Biofilms on the surface of dairy manufacturing plants are potential reservoirs of microbial contamination. These microbial aggregates may harbour pathogenic and spoilage organisms which contaminate dairy products. The biofilm forming capacity of many spore forming isolates of dairy origin has
Giulia Pavarelli et al.
ChemSusChem, 8(13), 2250-2259 (2015-06-16)
We investigated the synthesis of maleic anhydride by oxidehydration of a bio-alcohol, 1-butanol, as a possible alternative to the classical process of n-butane oxidation. A vanadyl pyrophosphate catalyst was used to explore the one-pot reaction, which involved two sequential steps:
Irene Tom et al.
Analytical biochemistry, 479, 1-5 (2015-03-24)
When used in conjunction with multivalent protein probes, protein microarrays offer a robust technology for discovery of low-affinity extracellular protein-protein interactions. Probes for receptor-matching screens generally consist of purified extracellular domains fused to affinity tags. Given that approximately two-thirds of
M Rescigno et al.
The Journal of experimental medicine, 192(11), 1661-1668 (2000-12-06)
Ligation of the Fas (CD95) receptor leads to an apoptotic death signal in T cells, B cells, and macrophages. However, human CD34(+)-derived dendritic cells (DCs) and mouse DCs, regardless of their maturation state, are not susceptible to Fas-induced cell death.
Nicole M Mackey-Lawrence et al.
BMC microbiology, 9, 61-61 (2009-03-28)
Staphylococcus aureus immunodominant surface antigen B (IsaB) elicits an immune response during septicemia and is generally classified as a virulence factor, but its biological function remains completely undefined. In an attempt to identify staphylococcal RNA-binding proteins, we designed an RNA
Elisabetta Agea et al.
The Journal of experimental medicine, 202(2), 295-308 (2005-07-13)
Plant pollens are an important source of environmental antigens that stimulate allergic responses. In addition to acting as vehicles for foreign protein antigens, they contain lipids that incorporate saturated and unsaturated fatty acids, which are necessary in the reproduction of
I Hwang et al.
The Journal of experimental medicine, 191(7), 1137-1148 (2000-04-05)
At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)-peptide-major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting
Bahareh Rasaeifar et al.
Pharmaceuticals (Basel, Switzerland), 13(8) (2020-08-23)
Members of the family of bombesinlike peptides exert a wide range of biological activities both at the central nervous system and in peripheral tissues through at least three G-Protein Coupled Receptors: BB1, BB2 and BB3. Despite the number of peptide
Yvette Garbe et al.
BMC cancer, 11, 410-410 (2011-09-29)
Various strategies have been developed to transfer tumor-specific antigens into antigen presenting cells in order to induce cytotoxic T cell responses against tumor cells. One approach uses cellular vaccines based on fusions of autologous antigen presenting cells and allogeneic tumor
Bin-Zhi Qian et al.
The Journal of experimental medicine, 212(9), 1433-1448 (2015-08-12)
Although the link between inflammation and cancer initiation is well established, its role in metastatic diseases, the primary cause of cancer deaths, has been poorly explored. Our previous studies identified a population of metastasis-associated macrophages (MAMs) recruited to the lung
Sarah Al-Maawi et al.
Acta biomaterialia, 121, 621-636 (2020-11-30)
Evaporation of phosphate species during thermal treatment (> 400 °C) of calcium phosphates leads to the formation of an alkaline layer on their surface. The aim of this study was to evaluate the hypothesis that the biological response of thermally treated
Roland Prielhofer et al.
BMC systems biology, 11(1), 123-123 (2017-12-10)
State-of-the-art strain engineering techniques for the host Pichia pastoris (syn. Komagataella spp.) include overexpression of homologous and heterologous genes, and deletion of host genes. For metabolic and cell engineering purposes the simultaneous overexpression of more than one gene would often
Yuan-Lin Chou et al.
PLoS pathogens, 9(6), e1003405-e1003405 (2013-06-12)
The triple-gene-block protein 3 (TGBp3) of Bamboo mosaic virus (BaMV) is an integral endoplasmic reticulum (ER) membrane protein which is assumed to form a membrane complex to deliver the virus intracellularly. However, the virus entity that is delivered to plasmodesmata
Luís H Franco et al.
Genetic vaccines and therapy, 6, 3-3 (2008-01-23)
A number of reports have demonstrated that rodents immunized with DNA vaccines can produce antibodies and cellular immune responses presenting a long-lasting protective immunity. These findings have attracted considerable interest in the field of DNA vaccination. We have previously described
Ching-Chung Tsai et al.
Scientific reports, 5, 15879-15879 (2015-11-03)
Gastroesophageal reflux disease (GERD) is a disorder that is related to an incompetent lower esophageal sphincter (LES). Previous studies showed that bombesin could increase LES pressure in humans and opossums. The aim of the present study was to characterize the
S Landmann et al.
The Journal of experimental medicine, 194(4), 379-391 (2001-08-22)
Cell surface expression of major histocompatibility complex class II (MHCII) molecules is increased during the maturation of dendritic cells (DCs). This enhances their ability to present antigen and activate naive CD4(+) T cells. In contrast to increased cell surface MHCII
Gabriela Kucerova et al.
Chirality, 29(6), 239-246 (2017-04-25)
The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. The chiral selectors immobilized on 2.5 μm silica particles were tris-(3,5-dimethylphenylcarmabate)
I M Barbash et al.
Gene therapy, 20(3), 274-282 (2012-05-04)
Duchenne muscular dystrophy (DMD) cardiomyopathy patients currently have no therapeutic options. We evaluated catheter-based transendocardial delivery of a recombinant adeno-associated virus (rAAV) expressing a small nuclear U7 RNA (U7smOPT) complementary to specific cis-acting splicing signals. Eliminating specific exons restores the
H Ito et al.
Journal of viral hepatitis, 24(2), 155-162 (2016-11-04)
A persistent hepatitis B virus (HBV) infection is characterized by a lack of or a weak immune response to HBV, which may be reflective of tolerance to HBV. Efficient induction of HBV-specific immune response leads to the clearance of HBV
Shanjana Awasthi et al.
Immunology and cell biology, 87(5), 419-427 (2009-02-19)
Dendritic cells (DCs) are the most potent antigen-presenting cells, but the ontogeny and functions of lung DCs are not known during prenatal period. Here, we isolated lung DC population from fetal (125-175 days of gestation age) and adult baboons. The
Anne Lisa Mitter et al.
Autophagy, 15(6), 1031-1050 (2019-01-29)
Macroautophagy/autophagy is a highly conserved intracellular vesicle transport pathway that prevents accumulation of harmful materials within cells. The dynamic assembly and disassembly of the different autophagic protein complexes at the so-called phagophore assembly site (PAS) is strictly regulated. Rab GTPases
Cristina Marchini et al.
PloS one, 5(11), e14131-e14131 (2010-12-15)
Mounting clinical and experimental evidence suggests that the shift of carcinomas towards a mesenchymal phenotype is a common paradigm for both resistance to therapy and tumor recurrence. However, the mesenchymalization of carcinomas has not yet entered clinical practice as a
Carmela Corso et al.
Nucleic acids research, 39(16), 7263-7275 (2011-06-01)
Major histocompatibility complex class II mRNAs encode heterodimeric proteins involved in the presentation of exogenous antigens during an immune response. Their 3'UTRs bind a protein complex in which we identified two factors: EBP1, an ErbB3 receptor-binding protein and DRBP76, a
N Iwakura et al.
Alimentary pharmacology & therapeutics, 41(8), 776-784 (2015-02-20)
The features of proton pump inhibitor-responsive oesophageal eosinophilia (PPI-REE) are similar to those of eosinophilic oesophagitis (EoE), but PPI-REE demonstrates symptomatic and histological responses to PPI therapy. Several studies have shown that basophils play a crucial role in the pathogenesis
Klaudia Kuranda et al.
Molecular therapy. Methods & clinical development, 13, 112-120 (2019-02-12)
Hematopoietic stem cell transplantation (HSCT) using unrelated cord blood (CB) donors is a suitable approach when an HLA-matched donor is not available. However, one important drawback is the risk of life-threatening viral infections prior to immune reconstitution, particularly from adenoviruses (AdVs).
Kerstin Schneider et al.
PloS one, 3(10), e3482-e3482 (2008-10-23)
Human dendritic cells (DCs) are the main antigen presenting cells (APC) and can be divided into two main populations, myeloid and plasmacytoid DCs (pDCs), the latter being the main producers of Type I Interferon. The vast majority of pDCs can
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