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Showing 1-30 of 10898 results for "71386" within Papers
Ling Lian et al.
Poultry science, 94(11), 2616-2621 (2015-10-27)
Marek's disease (MD), caused by Marek's disease virus (MDV), is a lymphoproliferative neoplastic disease of chickens and is characterized by MD lymphoma in multiple visceral organs of chicken. It causes great damage to poultry health. Recently, miRNA has been reported
Abaid Malik et al.
Basic & clinical pharmacology & toxicology, 116(1), 47-52 (2014-06-05)
The antifungal ionophore nystatin dissipates the Na(+) and K(+) gradients across the cell membrane, leading to cellular gain of Na(+) and cellular loss of K(+) . The increase of cellular Na(+) concentration may result in Ca(2+) accumulation in exchange for
Zhen-yi Xing et al.
Clinical neurology and neurosurgery, 131, 54-58 (2015-02-24)
The Notch signaling pathway has been well recognized as important adjuster in glioma tumorigenesis and could regulate the glioma cell proliferation through downstream factors such as epidermal growth factor receptor (EGFR). Our current study was aim to investigate the clinical
Raquel Ordoñez et al.
Journal of pineal research, 59(2), 178-189 (2015-05-16)
Autophagy is a process that maintains homeostasis during stress, although it also contributes to cell death under specific contexts. Ceramides have emerged as important effectors in the regulation of autophagy, mediating the crosstalk with apoptosis. Melatonin induces apoptosis of cancer
Sebastian Daum et al.
Biological chemistry, 395(7-8), 801-812 (2014-07-09)
As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not
Marina Campos Rocha et al.
PloS one, 10(8), e0135195-e0135195 (2015-08-22)
Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. In fungi, cell wall homeostasis is controlled by the conserved Cell Wall Integrity (CWI) pathway. In A. fumigatus this signaling cascade is partially characterized, but
K Crassina et al.
Journal of food science and technology, 52(9), 5922-5929 (2015-09-08)
Wheat flour was replaced with mango ginger powder (MGP) at 0, 5, 10 and 15 %. Influence of MGP on rheological and baking characteristics was studied. Farinograph was used to study the mixing profile of wheat flour-MGP blend. Pasting profile of
Laura K Vricella et al.
American journal of obstetrics and gynecology, 213(3), 408-408 (2015-05-20)
The impact of obesity on maternal blood volume in pregnancy has not been reported. We compared the blood volumes of obese and normal-weight gravidas using a validated hydroxyethyl starch (HES) dilution technique for blood volume estimation. Blood volumes were estimated
Fotios Tsopelas et al.
Journal of chromatography. A, 1396, 25-33 (2015-04-26)
The retention behavior of sixty structurally diverse drugs on two immobilized artificial membrane (IAM) columns, IAM.PC.MG and IAM.PC.DD2 types, at two pH values, 7.4 and 5.5, was established. Extrapolated to pure aqueous phase retention factors, logkw(IAM), were determined and the
Choong-Soo Yun et al.
Nature communications, 6, 8758-8758 (2015-10-28)
Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing
Weiqi Dai et al.
Oncotarget, 6(15), 13703-13717 (2015-05-06)
Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression
Eszter Németh et al.
Protein science : a publication of the Protein Society, 23(8), 1113-1122 (2014-06-05)
The nuclease domain of colicin E7 (NColE7) promotes the nonspecific cleavage of nucleic acids at its C-terminal HNH motif. Interestingly, the deletion of four N-terminal residues (446-449 NColE7 = KRNK) resulted in complete loss of the enzyme activity. R447A mutation was reported
Marika L Osterbur et al.
Human mutation, 36(8), 764-773 (2015-04-29)
Hereditary long QT syndrome is caused by deleterious mutation in one of several genetic loci, including locus LQT2 that contains the KCNH2 gene (or hERG, human ether-a-go-go related gene), causing faulty cardiac repolarization. Here, we describe and characterize a novel
António Pagarete et al.
Viruses, 7(7), 3937-3953 (2015-07-21)
Numbering in excess of 10 million per milliliter of water, it is now undisputed that aquatic viruses are one of the major factors shaping the ecology and evolution of Earth's microbial world. Nonetheless, environmental viral diversity and roles remain poorly
Shaken not stirred.
A Simpson et al.
Anaesthesia, 70(2), 228-228 (2015-01-15)
Malte Butzlaff et al.
Human molecular genetics, 24(13), 3623-3637 (2015-03-22)
The gene mapt codes for the microtubule-associated protein Tau. The R406W amino acid substitution in Tau is associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) characterized by Tau-positive filamentous inclusions. These filamentous Tau inclusions are present in
Siim Kukk et al.
The Journal of membrane biology, 248(4), 775-781 (2015-03-31)
The thermal stabilities of the rat and mouse dopamine transporter (DAT) proteins were studied within the temperature range of 0-37°C. The inactivation of the protein was followed by monitoring changes in radioligand-specific binding. We found that the process followed a
Bryan D Monesson-Olson et al.
PloS one, 9(5), e96641-e96641 (2014-05-06)
Vertebrate hair cells are responsible for the high fidelity encoding of mechanical stimuli into trains of action potentials (spikes) in afferent neurons. Here, we generated a transgenic zebrafish line expressing Channelrhodopsin-2 (ChR2) under the control of the hair-cell specific myo6b
Joanne E Mallinson et al.
The Journal of physiology, 593(5), 1239-1257 (2015-01-27)
Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that statin myalgia would be
A Sousa et al.
Journal of chromatography. A, 1355, 125-133 (2014-06-21)
Preparation of high quantities of supercoiled plasmid DNA of pharmaceutical grade purity is a research area where intensive investigation is being performed. From this standpoint, several downstream methods have been proposed, among them the monolithic chromatographic strategies owing to excellent
U M Fietzek et al.
European journal of neurology, 21(8), 1089-1095 (2014-04-24)
Spastic pes equinovarus is a frequent pathological posture of the lower extremity. Botulinum toxin (BoNT/A) has been successfully applied to treat lower limb spasticity. However, the best time to initiate treatment remains unclear. A beneficial effect of an early treatment
Bingnan Mu et al.
Bioresource technology, 196, 332-338 (2015-08-09)
In this work, kinetics of substitution accelerated cellulose hydrolysis with multiple reaction stages was investigated to lay foundation for mechanism study and molecular design of substituting compounds. High-efficiency hydrolysis of cellulose is critical for cellulose-based bioethanol production. It is known
Shiwei Wang et al.
Journal of bacteriology, 197(14), 2361-2373 (2015-05-06)
The Gram-positive spore-forming anaerobe Clostridium difficile is a leading cause of nosocomial diarrhea. Spores of C. difficile initiate infection when triggered to germinate by bile salts in the gastrointestinal tract. We analyzed germination kinetics of individual C. difficile spores using
Edward T Richardson et al.
Infection and immunity, 83(6), 2242-2254 (2015-03-18)
Mycobacterium tuberculosis survives within macrophages and employs immune evasion mechanisms to persist in the host. Protective T helper type 1 (Th1) responses are induced, and the immune response in most individuals is sufficient to restrict M. tuberculosis to latent infection
Zhenghui Li et al.
Bioorganic & medicinal chemistry, 22(24), 6735-6745 (2014-12-04)
A small molecule library of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives has been synthesized and evaluated as inhibitors of caspase-3 and -7, in which some of them showed nanomolar potency against caspase-3 and -7 in vitro. Meanwhile, in 10 lM concentration, both compounds
Filipe V Jacinto et al.
Genes & development, 29(12), 1224-1238 (2015-06-18)
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling
Yuzu Ikegaya et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 668-670 (2015-06-10)
HLTF is a pivotal protein in the template-switching pathway that allows DNA synthesis to continue even in the presence of DNA damage by utilizing a newly synthesized undamaged strand as a template. HLTF has a novel DNA-binding domain termed HIRAN
Deirdre R Ducken et al.
PloS one, 10(6), e0129309-e0129309 (2015-06-17)
Anaplasma marginale is a tick-borne rickettsial pathogen of cattle with a worldwide distribution. Currently a safe and efficacious vaccine is unavailable. Outer membrane protein (OMP) extracts or a defined surface protein complex reproducibly induce protective immunity. However, there are several
Christof Kaltenmeier et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3768-3777 (2015-03-18)
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine protease
Demin Cai et al.
PloS one, 9(8), e105504-e105504 (2014-08-26)
In this study, gestational sows were fed control or betaine-supplemented diets (3 g/kg) throughout the pregnancy, and the newborn piglets were used to elucidate whether maternal dietary betaine affected offspring hepatic gluconeogenic genes through epigenetic mechanisms. Neonatal piglets born to
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