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Showing 31-60 of 4556 results for "71387" within Papers
Li Li et al.
Molecular pharmacology, 86(6), 760-772 (2014-10-01)
4-Aminopyridine (4-AP, fampridine) is used clinically to improve neuromuscular function in patients with multiple sclerosis, spinal cord injury, and myasthenia gravis. 4-AP can increase neuromuscular and synaptic transmission by directly stimulating high voltage-activated (HVA) Ca(2+) channels independent of its blocking
Fen Hu et al.
PloS one, 9(9), e107217-e107217 (2014-09-26)
The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of
Katanchalee Mai-Ngam et al.
Carbohydrate polymers, 112, 440-447 (2014-08-19)
The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm)
Miaomiao Tian et al.
International journal of molecular sciences, 16(2), 4209-4225 (2015-02-19)
Invasion and metastasis of hepatocellular carcinoma (HCC) is a major cause for lethal liver cancer. Signaling pathways associated with cancer progression are frequently reconfigured by aberrant phosphorylation of key proteins. To capture the key phosphorylation events in HCC metastasis, we
Mahdy Ranjbar et al.
Ophthalmic research, 53(3), 136-140 (2015-02-28)
Disease-modifying antirheumatic drugs (DMARDs) have been suggested in the treatment of inflammatory ophthalmological diseases. The aim of the present study was to investigate the effects of these DMARDs on bovine retinal function. Bovine retina preparations were perfused with a standard
Tamara Muñoz-Caro et al.
Parasitology research, 113(11), 4189-4197 (2014-09-07)
Extracellular trap (ET) formation has been demonstrated as an important novel effector mechanism of polymorphonuclear neutrophils (PMN), eosinophils, mast cells and macrophages acting extracellularly against pathogens. In the present study, we show that tachyzoites of the emerging apicomplexan parasite Besnoitia
Adam Khader et al.
The Journal of surgical research, 193(2), 807-815 (2014-09-13)
Renal ischemia-reperfusion (I/R) is a severe clinical complication with no specific treatment. Resveratrol has been shown as a promising experimental agent in renal I/R due to its effect on cellular energy metabolism, oxidative stress, and inflammation. Recently, we identified two
Kensuke Sakuma et al.
PloS one, 10(2), e0118510-e0118510 (2015-02-19)
Various types of antipsychotics have been developed for the treatment of schizophrenia since the accidental discovery of the antipsychotic activity of chlorpromazine. Although all clinically effective antipsychotic agents have common properties to interact with the dopamine D2 receptor (D2R) activation
Elena Rodriguez et al.
Pulmonary pharmacology & therapeutics, 30, 22-31 (2014-12-03)
Mice with Plp1 gene duplication model the most common form of Pelizaeus-Merzbacher disease (PMD), a CNS disease in which patients may suffer respiratory complications. We hypothesized that affected mice would lack airway responsiveness compared to wild-type and carrier mice during
Bokun Cheng et al.
PloS one, 10(3), e0120022-e0120022 (2015-03-24)
Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Yana Dautova et al.
PloS one, 9(5), e97565-e97565 (2014-05-23)
Calcification is a detrimental process in vascular ageing and in diseases such as atherosclerosis and arthritis. In particular, small calcium phosphate (CaP) crystal deposits are associated with inflammation and atherosclerotic plaque de-stabilisation. We previously reported that CaP particles caused human
Toshitsugu Fujita et al.
PloS one, 10(1), e0116579-e0116579 (2015-01-22)
Accumulating evidence suggests that Pax5 plays essential roles in B cell lineage commitment. However, molecular mechanisms of B cell-specific expression of Pax5 are not fully understood. Here, we applied insertional chromatin immunoprecipitation (iChIP) combined with stable isotope labeling using amino
Valeria Velasco et al.
PloS one, 9(5), e97617-e97617 (2014-05-23)
The aim of this study was to compare a real-time PCR assay, with a conventional culture/PCR method, to detect S. aureus, mecA and Panton-Valentine Leukocidin (PVL) genes in animals and retail meat, using a two-step selective enrichment protocol. A total
Diverse expression pattern of wheat transcription factors against abiotic stresses in wheat species.
Mehmet Cengiz Baloglu et al.
Gene, 550(1), 117-122 (2014-08-19)
Abiotic stress including drought and salinity affects quality and yield of wheat varieties used for the production of both bread and pasta flour. bZIP, MBF1, WRKY, MYB and NAC transcription factor (TF) genes are the largest transcriptional regulators which are
Wan H Fan et al.
Journal of virology, 89(3), 1502-1511 (2014-11-21)
Herpesviruses have a characteristic particle structure comprising an icosahedral capsid, which contains the DNA genome and is, in turn, surrounded by a proteinaceous tegument layer and a lipid envelope. In herpes simplex virus, the interaction between the capsid and tegument
A Wiegering et al.
Hernia : the journal of hernias and abdominal wall surgery, 18(5), 691-700 (2014-08-13)
Mesh infection is a severe complication after incisional hernia repair and occurs in 1-3 % of all open mesh implantations. For this reason, topical antimicrobial agent applied directly to the mesh is often used procedure. So far, however, this procedure lacks
Mélanie Bonizec et al.
Nucleic acids research, 42(17), 10975-10986 (2014-09-04)
Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a broad array of cellular functions due to its ability to associate with multiple cofactors. Aside from its role in removing RNA polymerase II from chromatin after DNA damage, little is
Michael B Gill et al.
The EMBO journal, 34(4), 448-465 (2014-12-05)
Paradoxically, the thymidine kinase (TK) encoded by Kaposi sarcoma-associated herpesvirus (KSHV) is an extremely inefficient nucleoside kinase, when compared to TKs from related herpesviruses. We now show that KSHV-TK, in contrast to HSV1-TK, associates with the actin cytoskeleton and induces
Cláudia Maria da Silva et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(7), 899-904 (2014-09-15)
The aim of this study was to evaluate the presence of myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), tumor necrosis factor alpha (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral and menstrual blood in women with (n=10) and without (n=7) endometriosis. NAG
Cong Li et al.
Journal of experimental botany, 65(18), 5415-5427 (2014-07-30)
The DREB (dehydration-responsive element binding)-type transcription factors regulate the expression of stress-inducible genes by binding the DRE/CRT cis-elements in promoter regions. The upstream transcription factors that regulate the transcription of DREB transcription factors have not been clearly defined, although the
Tie Yi Kiew et al.
International journal of pharmaceutics, 484(1-2), 115-123 (2015-03-01)
While the supersaturation generation capability of amorphous nanopharmaceuticals (NPs) in their aqueous suspension form has been well established, their supersaturation generation is adversely affected after drying. Herein we investigated the effects of freeze drying on the supersaturation generation capability of
Christine L Hsieh et al.
Journal of neurotrauma, 31(20), 1677-1688 (2014-05-09)
Traumatic brain injury (TBI) provokes inflammatory responses, including a dramatic rise in brain macrophages in the area of injury. The pathway(s) responsible for macrophage infiltration of the traumatically injured brain and the effects of macrophages on functional outcomes are not
Yang Chen et al.
PloS one, 9(11), e113340-e113340 (2014-11-27)
Plants are constantly under attack from a variety of microorganisms, and rely on a series of complex detection and response systems to protect themselves from infection. Here, we found that a by-product of glutamate fermentation triggered defense responses in grapevine
Andrea Delekate et al.
Nature communications, 5, 5422-5422 (2014-11-20)
Astrocytic network alterations have been reported in Alzheimer's disease (AD), but the underlying pathways have remained undefined. Here we measure astrocytic calcium, cerebral blood flow and amyloid-β plaques in vivo in a mouse model of AD using multiphoton microscopy. We
Tao G Dong et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(7), 2181-2186 (2015-02-04)
Whether antibiotics induce the production of reactive oxygen species (ROS) that contribute to cell death is an important yet controversial topic. Here, we report that lethal attacks from bacterial and viral species also result in ROS production in target cells.
Jinhui Xu et al.
European journal of drug metabolism and pharmacokinetics, 39(4), 301-310 (2013-12-24)
The extended use of doxorubicin (DOX) could be limited due to the emergence of drug resistance and cardiotoxicity associated with its treatment. Conjugates of DOX with transferrin (DOX-TRF) can effectively alleviate these side effects, thereby leading to a better treatment.
Marta Nocella et al.
American journal of physiology. Cell physiology, 307(12), C1123-C1129 (2014-10-10)
Stretching of activated skeletal muscles induces a force increase above the isometric level persisting after stretch, known as residual force enhancement (RFE). RFE has been extensively studied; nevertheless, its mechanism remains debated. Unlike previous RFE studies, here the excess of
Elisabetta Moratti et al.
PloS one, 10(3), e0119110-e0119110 (2015-03-17)
PTPRG is a widely expressed protein tyrosine phosphatase present in various isoforms. Peptides from its extracellular domain have been detected in plasma by proteomic techniques. We aim at characterizing the plasmatic PTPRG (sPTPRG) form and to identify its source. The
Sarah L Tansley et al.
Rheumatology (Oxford, England), 53(12), 2204-2208 (2014-07-06)
Calcinosis is a major cause of morbidity in JDM and has previously been linked to anti-NXP2 autoantibodies, younger age at disease onset and more persistent disease activity. This study aimed to investigate the clinical associations of anti-NXP2 autoantibodies in patients
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