71631

Applied Filters:

Keyword:'71631'

Showing 1-30 of 799 results for "71631" within Papers

Enhancement of electrophoretic mobility of microparticles near a solid wall--experimental verification.

Qian Liang et al.

Electrophoresis, 36(5), 731-736 (2014-11-26)

Although the existing theories have predicted enhancement of electrophoretic mobility of microparticles near a solid wall, the relevant experimental studies are rare. This is mainly due to difficulties in experimentally controlling and measuring particle-wall separations under dynamic electrophoretic conditions. This

The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis.

Jenni Lahtela et al.

Disease models & mechanisms, 8(4), 393-401 (2015-02-26)

Treatment of non-small cell lung cancer (NSCLC) is based on histological analysis and molecular profiling of targetable driver oncogenes. Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a

Using mass spectrometry to detect, differentiate, and semiquantitate closely related peptide hormones in complex milieu: measurement of IGF-II and vesiculin.

Kate L Lee et al.

Endocrinology, 156(3), 1194-1199 (2014-12-30)

The search for an islet β-cell growth factor has been a key objective in recent diabetes research, because the ability to regenerate and/or protect the functioning β-cell population in patients could result in a great advancement for diabetes treatment. IGF-I

Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malaria.

Lester H Lambert et al.

Infection and immunity, 82(11), 4842-4853 (2014-08-27)

Clinical immunity to pregnancy associated-malaria (PAM) in multigravida women has been attributed to antibodies that recognize VAR2CSA on the infected erythrocyte (IE) surface. The size and complexity of VAR2CSA have focused efforts on selecting one or more of its six

Binary mixtures of diclofenac with paracetamol, ibuprofen, naproxen, and acetylsalicylic acid and these pharmaceuticals in isolated form induce oxidative stress on Hyalella azteca.

Leobardo Manuel Gómez-Oliván et al.

Environmental monitoring and assessment, 186(11), 7259-7271 (2014-07-10)

Toxicity in natural ecosystems is usually not due to exposure to a single substance, but is rather the result of exposure to mixtures of toxic substances. Knowing the effects of contaminants as a mixture compared to their effects in isolated

Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages.

Girish Ramachandran et al.

PLoS neglected tropical diseases, 9(1), e3394-e3394 (2015-01-09)

Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 313) circulating in this geographic

Increase in insulin-induced relaxation of consecutive arterial segments toward the periphery: Role of vascular oxidative state.

I A Szijártó et al.

Free radical research, 48(7), 749-757 (2014-03-19)

The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the

Sodium bicarbonate--the swings and roundabouts will not stop without randomized evidence.

Burkhard Simma et al.

Critical care medicine, 41(9), 2242-2243 (2013-08-28)

Activation of muscarinic acetylcholine receptors elevates intracellular Ca(2+) concentrations in accessory lobe neurons of the chick.

Keita Takahashi et al.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 201(4), 385-394 (2014-12-08)

Accessory lobes are protrusions located at the lateral sides of the spinal cord of chicks and it has been proposed that they play a role as a sensory organ for equilibrium during walking. We have reported that functional neurons exist

Repertoire of virus-derived small RNAs produced by mosquito and mammalian cells in response to dengue virus infection.

Erin E Schirtzinger et al.

Virology, 476, 54-60 (2014-12-22)

RNA interference (RNAi) is the major defense of many arthropods against arthropod-borne RNA viruses (arboviruses), but the role of RNAi in vertebrate immunity to arboviruses is not clear. RNA viruses can trigger RNAi in vertebrate cells, but the vertebrate interferon

Contractions reverse stress softening in rat esophagus.

Hongbo Jiang et al.

Annals of biomedical engineering, 42(8), 1717-1728 (2014-04-30)

Strain/stress induced tissue softening is usually referred to irreversible softening. The aim of this study was to investigate whether stress softening in rat esophagus is reversible after potassium chloride (KCl) induced contraction. Three series of inflation-deflation loadings were carried out

Impact of environmentally based chemical hardness on uranium speciation and toxicity in six aquatic species.

Richard R Goulet et al.

Environmental toxicology and chemistry, 34(3), 562-574 (2014-12-06)

Treated effluent discharge from uranium (U) mines and mills elevates the concentrations of U, calcium (Ca), magnesium (Mg), and sulfate (SO4 (2-) ) above natural levels in receiving waters. Many investigations on the effect of hardness on U toxicity have

3-O-galloylated procyanidins from Rumex acetosa L. inhibit the attachment of influenza A virus.

Andrea Derksen et al.

PloS one, 9(10), e110089-e110089 (2014-10-11)

Infections by influenza A viruses (IAV) are a major health burden to mankind. The current antiviral arsenal against IAV is limited and novel drugs are urgently required. Medicinal plants are known as an abundant source for bioactive compounds, including antiviral

Tocotrienol-rich fraction (TRF) suppresses the growth of human colon cancer xenografts in Balb/C nude mice by the Wnt pathway.

Jing-Shu Zhang et al.

PloS one, 10(3), e0122175-e0122175 (2015-03-26)

Tocotrienols have been shown many biologic functions such as antioxidant, anti-cancer, maintaining fertility and regulating the immune system and so on. In this study, after feeding with tocotrienol-rich fraction from palm oil (TRF) for 2 weeks, Balb/c nude mice were

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.

Marie R Webster et al.

Pigment cell & melanoma research, 28(2), 184-195 (2014-11-20)

We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond

Nanomagnetic levitation three-dimensional cultures of breast and colorectal cancers.

Harvey L Bumpers et al.

The Journal of surgical research, 194(2), 319-326 (2015-01-27)

Innovative technologies for drug discovery and development, cancer models, stem cell research, tissue engineering, and drug testing in various cell-based platforms require an application similar to the in vivo system. We developed for the first time nanomagnetically levitated three-dimensional (3-D) cultures

ADAMTS expression in colorectal cancer.

Serafula Filou et al.

PloS one, 10(3), e0121209-e0121209 (2015-03-19)

ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of extracellular substrates, they control several cell functions such as fusion, adhesion, proliferation and migration. Through their thrombospondin

Determination of bisphenol A, triclosan and their metabolites in human urine using isotope-dilution liquid chromatography-tandem mass spectrometry.

Gilles Provencher et al.

Journal of chromatography. A, 1348, 97-104 (2014-05-20)

Bisphenol A (BPA) and triclosan (TCS) are ubiquitous environmental phenols exhibiting endocrine disrupting activities that may be involved in various health disorders in humans. There is a need to measure separately free forms and conjugated metabolites because only the former

Isolation of Enterococcus faecium NM113, Enterococcus faecium NM213 and Lactobacillus casei NM512 as novel probiotics with immunomodulatory properties.

Nahla M Mansour et al.

Microbiology and immunology, 58(10), 559-569 (2014-08-19)

Probiotics, defined as living bacteria that are beneficial for human health, mainly function through their immunomodulatory abilities. Hence, these microorganisms have proven successful for treating diseases resulting from immune deregulation. The aim of this study was to find novel candidates

Forecasting cell death dose-response from early signal transduction responses in vitro.

Julie A Vrana et al.

Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 338-351 (2014-05-16)

The rapid pharmacodynamic response of cells to toxic xenobiotics is primarily coordinated by signal transduction networks, which follow a simple framework: the phosphorylation/dephosphorylation cycle mediated by kinases and phosphatases. However, the time course from initial pharmacodynamic response(s) to cell death

Upregulation of glycolytic enzymes, mitochondrial dysfunction and increased cytotoxicity in glial cells treated with Alzheimer's disease plasma.

Tharusha Jayasena et al.

PloS one, 10(3), e0116092-e0116092 (2015-03-19)

Alzheimer's disease (AD) is a neurodegenerative disorder associated with increased oxidative stress and neuroinflammation. Markers of increased protein, lipid and nucleic acid oxidation and reduced activities of antioxidant enzymes have been reported in AD plasma. Amyloid plaques in the AD

Cytoplasmic HuR expression: correlation with cellular inhibitors of apoptosis protein-2 expression and clinicopathologic factors in oral squamous cell carcinoma cells.

Jeong-Dan Cha et al.

Head & neck, 36(8), 1168-1175 (2013-07-16)

HuR expression has been noted in several cancer types, in which it may contribute to increased expression of cellular inhibitors of apoptosis protein-2 (cIAP2) observed during tumorigenesis. To assess the correlation between cIAP2 and HuR in cases of oral squamous

Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise.

Yuan Z Feng et al.

American journal of physiology. Cell physiology, 308(7), C548-C556 (2015-01-23)

Exercise improves insulin sensitivity and oxidative capacity in skeletal muscles. However, the effect of exercise on substrate oxidation is less clear in obese and type 2 diabetic subjects than in lean subjects. We investigated glucose and lipid metabolism and gene

Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia.

Isabel Saez et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(6), 945-955 (2014-02-27)

Glycogen is present in the brain, where it has been found mainly in glial cells but not in neurons. Therefore, all physiologic roles of brain glycogen have been attributed exclusively to astrocytic glycogen. Working with primary cultured neurons, as well

Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.

Aline Rideau Batista Novais et al.

PloS one, 9(9), e106302-e106302 (2014-09-04)

Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are respectively involved

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice.

Byung Hee Han et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(8), E881-E890 (2015-02-13)

Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid β peptide (Aβ) within walls of cerebral arteries and is an important cause of intracerebral hemorrhage, ischemic stroke, and cognitive dysfunction in elderly patients with and without Alzheimer's Disease (AD).

Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells.

Sajad Salehi et al.

Endocrinology, 156(4), 1514-1522 (2015-01-31)

Kisspeptin, encoded by the Kiss1 gene, binds to a specific G protein-coupled receptor (kisspeptin1 receptor) to regulate the central reproductive axis. Kisspeptin has also been reported to be expressed in peripheral tissues, including the testes. However, factors regulating testicular kisspeptin

Chih-Jen Cheng et al.

American journal of physiology. Renal physiology, 308(5), F437-F443 (2014-12-06)

SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase] kinase consists of a full-length (FL-) and an alternatively spliced kidney-specific (KS-) isoform. SPAK regulates the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). The relative abundance and role of FL- vs. KS-SPAK

Legumain expression, activity and secretion are increased during monocyte-to-macrophage differentiation and inhibited by atorvastatin.

Rigmor Solberg et al.

Biological chemistry, 396(1), 71-80 (2014-09-11)

Macrophages express several lysosomal cysteine proteases such as cathepsins and legumain. In this study, we assessed the expression, activity and secretion of legumain in cellular models of monocytes/macrophages. Macrophages were derived from M-CSF- or GM-CSF/IFNγ-stimulated human primary monocytes (M2 and

N-acetylcysteine plus intravenous fluids versus intravenous fluids alone to prevent contrast-induced nephropathy in emergency computed tomography.

Stephen J Traub et al.

Annals of emergency medicine, 62(5), 511-520 (2013-06-19)

We test the hypothesis that N-acetylcysteine plus normal saline solution is more effective than normal saline solution alone in the prevention of contrast-induced nephropathy. The design was a randomized, double blind, 2-center, placebo-controlled interventional trial. Inclusion criteria were patients undergoing

Page 1 of 27