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Reymond Barreto
Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 34(4), 417-421 (2007-09-26)
The incidence of contrast-induced nephropathy (CIN) is increasing due to the growing number of patients undergoing radiocontrast studies. CIN is associated with a mortality rate as high as 34%. The purpose of this article is to review the strategies for
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of
Rita Salánki et al.
PloS one, 9(10), e111450-e111450 (2014-10-25)
Cell adhesion is a fundamental phenomenon vital for all multicellular organisms. Recognition of and adhesion to specific macromolecules is a crucial task of leukocytes to initiate the immune response. To gain statistically reliable information of cell adhesion, large numbers of
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of
Shuying Huo et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15328-15336 (2014-07-31)
L-Selenomethionine (SeMet), the predominant form of selenium acquired from the diet by humans, has been used as a supplement, and exhibit some important functions like cancer prevention and antioxidative defense. Its interactions with Pt(II) anticancer drugs have been characterized, but
Catherine Jackson et al.
PloS one, 9(8), e105808-e105808 (2014-08-30)
Cultured epidermal cell sheets (CECS) are used in regenerative medicine in patients with burns, and have potential to treat limbal stem cell deficiency (LSCD), as demonstrated in animal models. Despite widespread use, short-term storage options for CECS are limited. Advantages
Fu-Chen Kung et al.
Materials science & engineering. C, Materials for biological applications, 45, 578-588 (2014-12-11)
Electrospun fiber sheets with various orientations (random, partially aligned, and aligned) and smooth and roughened casted membranes were prepared. Hydroxyapatite (HA) crystals were in situ formed on these material surfaces via immersion in 10× simulated body fluid solution. The size
Kasper Klein et al.
Journal of microbiological methods, 109, 110-116 (2014-12-30)
Several rod-shaped pathogens including Escherichia coli, Salmonella spp. and Klebsiella pneumonia are capable of adopting highly filamentous cell shapes under certain circumstances. This phenomenon occurs as a result of continued cell elongation during growth without the usual septation into single
Divyabharathi Chepyala et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 48-54 (2015-01-16)
Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the safety and efficacy of colistin and to improve clinical outcomes. This study developed an
Kohji Abe et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(12), 1907-1913 (2014-09-18)
To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential of the hydroethidine derivative as a radiotracer to measure in vivo brain ROS
Sabine Buhner et al.
Experimental physiology, 99(10), 1299-1311 (2014-06-22)
Based on the discomfort/pain threshold during rectal distension, irritable bowel syndrome (IBS) patients may be subtyped as normo- or hypersensitive. We previously showed that mucosal biopsy supernatants from IBS patients activated enteric and visceral afferent neurons. We tested the hypothesis
Angela Schlipp et al.
Cardiovascular research, 104(2), 245-257 (2014-09-13)
We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. We studied intercalated discs
Edyta Bajak et al.
Toxicology letters, 233(2), 187-199 (2014-12-20)
Higher efficacy and safety of nano gold therapeutics require examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells exposed to AuNP (5 and 30nm). Cellular
Christof Kaltenmeier et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3768-3777 (2015-03-18)
IL-21 can induce both plasma cells and regulatory B cells. In this article, we demonstrate that untreated HIV patients display CD4(+) T cells with enhanced IL-21 expression and high in vivo frequencies of regulatory B cells overexpressing the serine protease
Timothy R DeGrado et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we
Michael S Nastasie et al.
BMC cancer, 15, 76-76 (2015-04-18)
There is an urgent need for new approaches to deliver bioactive molecules to cancer cells efficiently and specifically. Here we fuse the cancer cell nuclear targeting module of the Chicken Anaemia Virus Apoptin protein to the core histones H2B and
Adam Fekete et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(42), 14032-14045 (2014-10-17)
Mitral cells express low-voltage activated Cav3.3 channels on their distal apical tuft dendrites (McKay et al., 2006; Johnston and Delaney, 2010). They also discharge Na(+)-dependent dendritic action potentials and release glutamate from these dendrites. Around resting membrane potentials, between -65
Dongmei Shi et al.
Immunologic research, 61(3), 206-218 (2014-11-10)
Dendritic cells (DCs) are known to play an important role in initiating and orchestrating antimicrobial immunity. Given the fact that candidiasis appears often in immunocompromised patients, it seems plausible that DCs hold the key to new antifungal strategies. One possibility
Carmela Guido et al.
Reproduction (Cambridge, England), 147(5), 589-598 (2014-01-17)
The study of androgens involved in male reproduction has been object of intense efforts, while their reported action on human male gametes is limited. We previously described the presence of androgen receptor (AR) in sperm with a role related to
Shijie Song et al.
Journal of neuroscience research, 92(8), 975-980 (2014-03-26)
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic cytokine that also possesses neurotrophic and antiapoptotic properties. G-CSF has been reported to decrease amyloid burden significantly, promote hippocampal neurogenesis, and improve spatial learning in a mouse model of Alzheimer's disease. To understand
Tatiele Katzer et al.
Journal of microencapsulation, 31(6), 519-528 (2014-04-05)
To develop non-toxic aqueous ocular drug delivery systems containing prednisolone by means of its nanoencapsulation. Nanocapsules were prepared by interfacial deposition of preformed polymer [poly(ε-caprolactone) or Eudragit® RS100]. Particle size distribution was determined by laser diffractometry, photon correlation spectroscopy and
Qiong Dai et al.
ACS nano, 9(3), 2876-2885 (2015-02-26)
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona". Coronas, in particular the protein corona, play an important role in determining the surface properties of particles and their targeting abilities.
U Thormann et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 92-106 (2014-12-06)
The purpose of this work was to investigate the role of bioconjugation and carrier mediated efflux of conjugation products in the absorption mechanism of the sesquiterpene lactone nobilin in the Caco-2 model in vitro and to elucidate the impact of
Jon R Eidet et al.
Current eye research, 40(1), 30-39 (2014-04-23)
To evaluate the effect of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelial cells (HCjEs). Three-day cultured HCjEs were stored at nine different temperatures between 4 °C and 37 °C for four and seven days.
Yukie Yoshii et al.
Biomaterials, 51, 278-289 (2015-03-17)
Anti-cancer drug development typically utilizes high-throughput screening with two-dimensional (2D) cell culture. However, 2D culture induces cellular characteristics different from tumors in vivo, resulting in inefficient drug development. Here, we report an innovative high-throughput screening system using nanoimprinting 3D culture
Zhixiang Wu et al.
Molecular & cellular proteomics : MCP, 14(2), 329-339 (2014-12-17)
Methylation of lysine residues on histone proteins is known to play an important role in chromatin structure and function. However, non-histone protein substrates of this modification remain largely unknown. An effective approach for system-wide analysis of protein lysine methylation, particularly
Yolanda Corbett et al.
Microbes and infection, 17(3), 184-194 (2014-12-03)
In malaria, the evidence concerning the nucleotide-binding, oligomerization domain (NOD) 2 (NOD2) receptor is fragmented and the stimuli that might activate NOD2 are not well characterized. We investigated the role of NOD2 in vitro in the response of macrophages to Plasmodium
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Prasad Dasari et al.
Medical microbiology and immunology, 203(6), 383-393 (2014-07-06)
The digestive vacuole (DV) of Plasmodium falciparum, which is released into the bloodstream upon rupture of each parasitized red blood cell (RBC), was recently discovered to activate the alternative complement pathway. In the present work, we show that C3- and
Moshe Ben-Sasson et al.
Water research, 62, 260-270 (2014-06-26)
The potential to incorporate silver nanoparticles (Ag-NPs) as biocides in membranes for water purification has gained much interest in recent years. However, a viable strategy for loading the Ag-NPs on the membrane remains challenging. This paper presents a novel, facile
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