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Showing 1-30 of 6976 results for "717975" within Papers
Daniel J Spade et al.
Biology of reproduction, 93(5), 110-110 (2015-09-25)
In utero exposure to some phthalate esters adversely affects the development of the rat seminiferous cord, causing germ cell loss and increasing the number of multinucleated germ cells (MNGs). To understand the timing of MNG formation and determine whether it
Jie Ma et al.
Pharmacology, 93(5-6), 220-224 (2014-07-12)
It is significant for patients with traumatic brain injury (TBI) to receive prehospital emergency treatment as early as possible to reduce mortality. Therefore, a new prefilled multi-drug injector was developed to improve the treatment of TBI. Here, we studied the
Katherine A Rempe et al.
mBio, 6(4) (2015-08-27)
Glycosylation is a widespread mechanism employed by both eukaryotes and bacteria to increase the functional diversity of their proteomes. The nontypeable Haemophilus influenzae glycosyltransferase HMW1C mediates unconventional N-linked glycosylation of the adhesive protein HMW1, which is encoded in a two-partner
Nobuyuki Asai et al.
Biochemical and biophysical research communications, 451(2), 302-307 (2014-08-06)
Endochondral ossification is an essential step for skeletal development, which requires chondrocyte differentiation in growth cartilage. The low-density lipoprotein receptor-related protein 4 (LRP4), a member of LDLR family, is an inhibitor for Wnt signaling, but its roles in chondrocyte differentiation
Zofia Olszowy et al.
Archiwum medycyny sadowej i kryminologii, 53(1), 3-7 (2003-12-13)
In the paper the authors have presented a possible use of formic acid detection in biological specimens in the diagnosis of methanol poisonings. Formic acid was determined as a volatile methyl formate ester by the gas chromatographic head-space method. Based
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Morten P Oksvold et al.
Experimental hematology, 43(5), 352-363 (2015-02-03)
Dasatinib inhibits B-cell receptor-Abelson murine leukemia viral oncogene homologue 1, Src, and other tyrosine kinases. Few studies have addressed the impact of dasatinib on normal blood cells, especially in vivo. Here we show that dasatinib leads to a reduced number
Mitsuru Tanaka et al.
Molecular nutrition & food research, 59(8), 1541-1549 (2015-03-27)
The basic dipeptide, Trp-His, was found to show an in vivo anti-atherosclerotic effect when orally administered to apo E-deficient mice. In addition, this dipeptide causes vasorelaxation in contracted rat aorta via suppression of intracellular Ca(2+) signaling cascades. In this study
Hye Jeong Yang et al.
European journal of nutrition, 54(1), 77-88 (2014-04-05)
Brain insulin resistance is related to both diabetes and Alzheimer's disease. We investigated whether both chungkookjangs, soybeans fermented in a traditional method (TFC) and with Bacillus lichenifomis (SFC), can protect against cognitive dysfunction and glucose dysregulation in rats with Alzheimer's
M Serrano et al.
Talanta, 143, 71-76 (2015-06-17)
In the last decades, the assessment of polycyclic aromatic hydrocarbons' exposure has generated great interest and 1-hydroxypyrene (1-OHP) has been commonly used as a biological indicator of exposure to PAHs in many studies in environmental and occupational health. In this
Qingnian Goh et al.
Experimental cell research, 331(2), 292-308 (2014-10-05)
We previously demonstrated that the expression of intercellular adhesion molecule-1 (ICAM-1) by skeletal muscle cells after muscle overload contributes to ensuing regenerative and hypertrophic processes in skeletal muscle. The objective of the present study is to reveal mechanisms through which
Ugo Bussy et al.
Analytical and bioanalytical chemistry, 406(28), 7253-7260 (2014-09-23)
Electrochemistry combined with (liquid chromatography) high resolution mass spectrometry was used to simulate the general reductive metabolism of three biologically important nitro aromatic molecules: 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide, and nilutamide. TFM is a pesticide used in the Laurential Great Lakes while
Jef Stappaerts et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 1-7 (2015-01-17)
The aim of this study was to evaluate the intestinal disposition of abiraterone acetate, an ester prodrug of the anticancer agent abiraterone. Stability of the prodrug and solubility and dissolution characteristics of both abiraterone and abiraterone acetate were monitored in
Zeynep Altintas et al.
Biosensors & bioelectronics, 74, 996-1004 (2015-08-13)
Comparative and comprehensive investigations for adenovirus recognition and detection were conducted using plastic and natural antibodies to compare three different strategies. The implementation of molecularly imprinted polymer (MIP) technology for specific and sensitive recognition of viruses with the combination of
Taissia G Popova et al.
Nanomaterials (Basel, Switzerland), 5(1), 298-320 (2015-04-17)
Chemokines (CKs) secreted by the host cells into surrounding tissue establish concentration gradients directing the migration of leukocytes. We propose an
Charles Awortwe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(3), 218-229 (2014-11-08)
1.This study investigated the mechanism underlying Echinacea-mediated induction of CYP1A2, CYP3A4 and MDR1 in terms of human pregnane X receptor (PXR) activation. 2.Crude extracts and fractions of Echinacea purpurea were tested for PXR activation in HepG2 cells by a reporter
Ayşe Ufuk et al.
Pharmaceutical research, 32(12), 3937-3951 (2015-08-01)
To assess accumulation and lysosomal sequestration of 9 drugs used in respiratory indications (plus imipramine as positive control) in the alveolar macrophage (AM) cell line NR8383. For all drugs, uptake at 5 μM was investigated at 37 and 4°C to delineate
Iain M McIntyre et al.
Forensic science international, 251, 195-201 (2015-04-29)
Non-toxic postmortem trazodone tissue (liver) concentrations have not been previously described. Liver trazodone concentrations were compared to peripheral blood and central blood concentrations in 19 medical examiner cases. Postmortem blood specimens were initially screened for alcohol and simple volatiles, drugs
Roman Řemínek et al.
Electrophoresis, 36(11-12), 1349-1357 (2014-11-11)
Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of candidate compounds have to be assessed prior to clinical testing. Since biotransformation significantly influences drug
Rumi Tanoue et al.
Journal of chromatography. A, 1355, 193-205 (2014-06-25)
In the present study, a sensitive and accurate isotope dilution method was developed for the simultaneous determination of 17 polar pharmaceutical and personal care product (PPCP) residues (logKow=1.40-5.74), including 14 pharmaceuticals and 3 personal care products, in biological organs and
Ran Sun et al.
Journal of environmental sciences (China), 33, 45-59 (2015-07-05)
Biodegradation of polycyclic aromatic hydrocarbons (PAHs) is normally limited by their low solubility and poor bioavailability. Prior research suggests that biosurfactants are synthesized as intermediates during the production of mucilage at the root tip. To date the effects of mucilage
Stijn Palmers et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(2), 161-169 (2014-12-20)
To this day, research for furan mitigation has mostly targeted the levels of food production and handling of prepared foods by the consumer. However, part of the furan concentrations found in commercially available food products might originate from chemical deterioration
Argo Aug et al.
PloS one, 10(11), e0142053-e0142053 (2015-11-05)
E-cigarettes are widely believed to be safer than conventional cigarettes and have been even suggested as aids for smoking cessation. However, while reasonable with some regards, this judgment is not yet supported by adequate biomedical research data. Since bronchial epithelial
Ahmed M Zaher et al.
The Journal of antibiotics, 68(3), 197-200 (2014-10-16)
Enniatins (ENs), a group of antibiotics commonly produced by various strains of Fusarium, are six-membered cyclic depsipeptides formed by the union of three molecules of D-α-hydroxyisovaleric acid and three N-methyl-L-amino acids. The endophyte Fusarium tricinctum Corda was isolated from the
Małgorzata Sztanke et al.
Bioorganic & medicinal chemistry, 23(13), 3448-3456 (2015-05-16)
The straightforward and practical synthesis route and remarkable antitumour activities in vitro of a novel class of thiophene bioisosteres (10-18) are disclosed. These molecules were obtained with good overall yields via the reaction of 1-aryl-2-hydrazonoimidazolidine hydroiodides with ethyl 2-oxo-2-(2-thienyl)acetate in
Ezzat Naddaf et al.
Journal of separation science, 38(13), 2348-2356 (2015-05-02)
A sensitive technique to determinate naproxen in hair samples was developed using hollow-fiber micro-solid-phase combined with fluorescence spectrophotometry. The incorporation of multi-walled carbon nanotubes modified with a Keggin polyoxometalate into a silica matrix prepared by the sol-gel method was reported.
Fadi M Awadallah et al.
European journal of medicinal chemistry, 96, 425-435 (2015-04-29)
Four series of sulfonamides incorporating chromone moieties were synthesized and assessed for their cytotoxic activity against MCF-7 and A-549 cell lines, considering the fact that some of these tumors overexpress isoforms of carbonic anhydrase (CA, EC 4.2.1.1) which is inhibited
Hadi Tabani et al.
Journal of chromatography. A, 1407, 21-29 (2015-07-15)
Introducing new sorbents is an interesting and debatable issue in the field of sample preparation. In this study, for the first time, a pH-sensitive magnetic nanoparticles microgel, Fe3O4-SiO2-oly(4-vinylpyridine), was introduced as a new sorbent. The operating mechanism of this sorbent
Balint Z Kacsoh et al.
eLife, 4 (2015-05-15)
Behavioral adaptation to environmental threats and subsequent social transmission of adaptive behavior has evolutionary implications. In Drosophila, exposure to parasitoid wasps leads to a sharp decline in oviposition. We show that exposure to predator elicits both an acute and learned
Hiroya Yurimoto
Bioscience, biotechnology, and biochemistry, 73(4), 793-800 (2009-04-09)
Methanol is a promising feedstock for biotechnological and chemical processes as well as a primary source of energy to replace coal and petroleum. Methylotrophic yeasts, that can utilize methanol as the sole source of carbon and energy, have been studied
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