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Showing 1-30 of 182 results for "71950" within Papers
Kenjiro Bandow et al.
Bone, 74, 125-133 (2014-12-17)
Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been
Jung Jin Lim et al.
Scientific reports, 7(1), 10272-10272 (2017-09-02)
Although chronic hyperandrogenism suppresses antral follicular development, a phenomenon often observed in polycystic ovarian syndrome (PCOS), whether and how deregulation of androgen receptor (AR) signaling is involved, is not well understood. In the present study, we examined the role of
Quan Zhou et al.
Journal of cellular and molecular medicine, 19(3), 521-534 (2014-10-30)
Spermatogonial stem cells (SSCs) are undifferentiated cells that are required to maintain spermatogenesis throughout the reproductive life of mammals. Although SSC transplantation and culture provide a powerful tool to identify the mechanisms regulating SSC function, the precise signalling mechanisms governing
DE-Geng Zhang et al.
Oncology letters, 9(1), 47-54 (2014-12-02)
Recently, an increasing number of studies have demonstrated that lung cancer is a stem cell disease. However, ideal cell surface markers for isolating stem cells in lung cancer are yet to be identified. In the present study, a cell population
Tamara Winkler et al.
PloS one, 9(6), e98444-e98444 (2014-06-04)
Intervertebral discs (IVDs) are strong fibrocartilaginous joints that connect adjacent vertebrae of the spine. As discs age they become prone to failure, with neurological consequences that are often severe. Surgical repair of discs treats the result of the disease, which
M Mathieu et al.
European cells & materials, 28, 82-96 (2014-09-03)
Because of poor self-healing ability, joint cartilage can undergo irreversible degradation in the course of various diseases or after injury. A promising approach for cartilage engineering consists of using of mesenchymal stem cells (MSC) and a differentiation factor combined with
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional
Celine Thiry et al.
Biological trace element research, 152(1), 152-160 (2013-02-12)
Most European people have selenium (Se) intake inferior to recommended values that are considered necessary to ensure the beneficial action of antioxidant selenoproteins. People could therefore tend to have recourse to Se-enriched food supplements (FS) aiming to increase their Se
Kang Sun et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 36-41 (2012-11-10)
Selenium, an essential trace element, can also be toxic at higher levels of exposure. Several lines of evidence show epigallocatechin-3-gallate (EGCG), a predominant component of green tea catechins with numerous health benefits, can ameliorate the toxicity of many agents. A
Ulrike Fischer et al.
Oncotarget, 6(9), 7023-7039 (2015-03-12)
In development of amphibians and flies, gene amplification is one of mechanisms to increase gene expression. In mammalian cells, gene amplification seems to be restricted to tumorigenesis and acquiring of drug-resistance in cancer cells. Here, we report a complex gene
Valerie L Flax et al.
The American journal of clinical nutrition, 99(4), 950-956 (2014-02-07)
Selenium is found in soils and is essential for human antioxidant defense and immune function. In Malawi, low soil selenium and dietary intakes coupled with low plasma selenium concentrations in HIV infection could have negative consequences for the health of
Saeed Salman et al.
Archives of animal nutrition, 67(1), 48-61 (2013-01-10)
Dietary selenium (Se) can be supplemented from organic or inorganic sources and this may affect Se metabolism and functional outcome such as antioxidative status and immune functions in dairy cows. A feeding trial was performed with 16 Holstein-Friesian dairy cows
P S P Gupta et al.
PloS one, 9(6), e100201-e100201 (2014-06-18)
Follicular development occurs in wave like patterns in monotocous species such as cattle and humans and is regulated by a complex interaction of gonadotropins with local intrafollicular regulatory molecules. To further elucidate potential mechanisms controlling dominant follicle selection, granulosa cell
Pamela B Cassidy et al.
Nutrients, 5(3), 725-749 (2013-03-09)
The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in
Alper Yazici et al.
International journal of ophthalmology, 8(2), 263-268 (2015-05-06)
To investigate the effects of selenium in rat retinal ischemia reperfusion (IR) model and compare pre-treatment and post-treatment use. Selenium pre-treatment group (n=8) was treated with intraperitoneal (i.p.) selenium 0.5 mg/kg for 7d and terminated 24h after the IR injury.
Takuya Kitamura et al.
Molecular carcinogenesis, 54(6), 459-472 (2014-05-20)
Although very few studies have addressed the molecular and cellular mechanisms underlying the development of biliary tract cancer (BTC), several lines of evidence suggest a role for the erbB receptor family. Overexpression and activation of erbB2 has been reported in
Erqun Song et al.
Life sciences, 109(1), 37-43 (2014-06-17)
This study was designed to investigate the protective effects of selenium supplementation on patulin-induced neurotoxicity. Mice were subjected to patulin for 8 weeks. Sodium selenite (Na2SeO3) and selenium-methionine (Se-Met) were supplemented with the diet, and we investigated the effects of
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Periyasamy Palsamy et al.
Biochimica et biophysica acta, 1842(9), 1794-1805 (2014-07-06)
Cataract-induced by sodium selenite in suckling rats is one of the suitable animal models to study the basic mechanism of human cataract formation. The aim of this present investigation is to study the endoplasmic reticulum (ER) stress-mediated activation of unfolded
Prashant S Daundkar et al.
Environmental toxicology and pharmacology, 38(3), 711-719 (2014-10-10)
In the present investigation, ameliorative effect of selenium on carbendazim induced oral sub chronic toxicity in bucks was assessed by studying various indices of antioxidant defense system. Bucks were randomly divided into four groups of four animals each. Group I
Emil Rudolf et al.
Toxicology letters, 231(1), 29-37 (2014-09-11)
Effects of chronic exposure to supranutritional sodium selenite (Se) were investigated in colonic fibroblasts. Initially, Se did not produce any gross changes in exposed cells; however, basal levels of autophagy were transiently increased and p38 activity was stimulated. From the
Yu-Chi Chen et al.
International journal of cancer, 133(9), 2054-2064 (2013-04-25)
The survival rate for breast cancer drops dramatically once the disease progresses to the metastatic stage. Selenium (Se) is an essential micronutrient credited with having high anticancer and chemopreventive properties. In our study, we investigated if dietary Se supplementation modified
Yuxuan Wu et al.
Cell research, 25(1), 67-79 (2014-12-06)
Spermatogonial stem cells (SSCs) can produce numerous male gametes after transplantation into recipient testes, presenting a valuable approach for gene therapy and continuous production of gene-modified animals. However, successful genetic manipulation of SSCs has been limited, partially due to complexity
Jorrit De Waele et al.
Biomaterials, 41, 122-131 (2014-12-20)
Transplantation of neural stem cells (NSC) in diseased or injured brain tissue is widely studied as a potential treatment for various neurological pathologies. However, effective cell replacement therapy relies on the intrinsic capacity of cellular grafts to overcome hypoxic and/or
Zhushi Li et al.
Oncology research, 21(6), 325-331 (2013-01-01)
It was revealed by our previous research that sodium selenite repressed autophagy accompanied by the induction of apoptosis in human leukemia NB4 cells. The inhibition of autophagy exerted a facilitative effect on apoptosis. In the present study, we further explored
Kaiyan Hui et al.
Cancer letters, 354(1), 189-199 (2014-08-17)
Supranutritional selenite has anti-cancer therapeutic effects in vivo; however, the detailed mechanisms underlying these effects are not clearly understood. Further studies would broaden our understanding of the anti-cancer effects of this compound and provide a theoretical basis for its clinical
Eun Hui Bae et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 348-361 (2013-02-20)
This study aimed to examine the protective effects of aliskiren on gentamicin-induced nephropathy. Rats were injected with gentamicin (100 mg/kg per day) for 14 days. Aliskiren was infused for two weeks. Human proximal tubular epithelial cell lines (HK-2) were cultured
New method for bis (methylmercuric) selenide synthesis from methylmercuric chloride, sodium selenite and reduced glutathione
Naganuma A and Imura N
Chemosphere, 10(4), 441-443 (1981)
Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.
D A McCreedy et al.
Biomaterials science, 2(11), 1672-1682 (2014-10-28)
Embryonic stem (ES) cells can be differentiated into many neural cell types that hold great potential as cell replacement therapies following spinal cord injury (SCI). Coupling stem cell transplantation with biomaterial scaffolds can produce a unified combination therapy with several
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