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Showing 1-30 of 155 results for "73767" within Papers
Junjie Zhao et al.
Biochemistry, 53(15), 2474-2482 (2014-03-29)
Dehaloperoxidase hemoglobin A (DHP A) is a multifunctional hemoglobin that appears to have evolved oxidative pathways for the degradation of xenobiotics as a protective function that complements the oxygen transport function. DHP A possesses at least two internal binding sites
Junlei Sun et al.
Biochimica et biophysica acta, 1837(8), 1362-1375 (2014-04-22)
The axial ligands of the acceptor chlorophylls, A(0A) and A(0B), in Photosystem I are the Met sulfur atoms of M688(PsaA) and M668(PsaB). To determine the role of the Met, His variants were generated in Synechocystis sp. PCC 6803. Molecular dynamics
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Susanne Klumpp et al.
Science signaling, 2(61), pe13-pe13 (2009-03-13)
Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory mechanisms in mammalian cells, and research focused in this area is ongoing. We are just beginning to appreciate
Jiafeng Geng et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9639-9644 (2013-05-31)
The diheme enzyme MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor protein to generate a tryptophan tryptophylquinone cofactor. The MauG-catalyzed reaction proceeds via a bis-Fe(IV) intermediate in which one heme is present as Fe(IV)=O and the other as Fe(IV)
Leslie E Gentry et al.
Biochemistry, 52(35), 6085-6096 (2013-08-06)
Human frataxin has a vital role in the biosynthesis of iron-sulfur (Fe-S) clusters in mitochondria, and its deficiency causes the neurodegenerative disease Friedreich's ataxia. Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery
Thanutchaporn Kumrungsee et al.
Biochimica et biophysica acta, 1840(10), 3073-3078 (2014-08-06)
Tryptophan-histidine (Trp-His) was found to suppress the activity of the Ca²⁺/calmodulin (CaM)-dependent protein kinases II (CaMKII), which requires the Ca²⁺-CaM complex for an initial activation. In this study, we attempted to clarify whether Trp-His inhibits Ca²⁺-CaM complex formation, a CaMKII
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 17(5), 1336-1340 (2006-12-19)
The mitochondrial isozymes of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VA and hCA VB, were investigated for activation with a series of amino acids and amines. D-His, L-DOPA, histamine, dopamine, and 4-(2-aminoethyl)morpholine were excellent hCA VA activators, with KAs
Jiancheng Hu et al.
Molecular and cellular biology, 35(1), 264-276 (2014-10-29)
A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of
A T Da Poian et al.
Protein and peptide letters, 16(7), 779-785 (2009-07-16)
Membrane fusion is an essential step in the entry of enveloped viruses into their host cells, what makes it a potentially attractive target for viral inactivation approaches. Fusion is mediated by viral surface glycoproteins that undergo conformational changes triggered by
Yoo-Mi Kim et al.
Metabolism: clinical and experimental, 63(1), 42-49 (2013-10-22)
17α-hydroxylase/17,20-lyase deficiency is a rare form of congenital adrenal hyperplasia, characterized by hypertension and sexual infantilism and caused by loss-of-function mutations in CYP17A1. This study investigated the clinical and molecular characteristics of six adults with 17α-hydroxylase/17,20-lyase deficiency and the functional
Anas Al-Hussein et al.
Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)
The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both
Maarja-Liisa Oldekop et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 147-155 (2014-08-12)
For liquid chromatographic analysis of amino acids involving derivatization and mass-spectrometric detection, it becomes more important to evaluate the presence of matrix effects in complex samples. This is somewhat complicated for amino acid analysis where analyte free sample matrix is
Florian P Seebeck
Chimia, 67(5), 333-336 (2013-07-19)
Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis
Robert A Bender
Microbiology and molecular biology reviews : MMBR, 76(3), 565-584 (2012-08-31)
The ability to degrade the amino acid histidine to ammonia, glutamate, and a one-carbon compound (formate or formamide) is a property that is widely distributed among bacteria. The four or five enzymatic steps of the pathway are highly conserved, and
Sunanda Margrett Williams et al.
The Journal of biological chemistry, 289(16), 11042-11058 (2014-02-28)
Dps (DNA-binding protein from starved cells) are dodecameric assemblies belonging to the ferritin family that can bind DNA, carry out ferroxidation, and store iron in their shells. The ferritin-like trimeric pore harbors the channel for the entry and exit of
Xavier Brazzolotto et al.
The Biochemical journal, 460(1), 79-89 (2014-03-15)
Iron is an essential element for almost all organisms. In eukaryotes, it is mainly used in mitochondria for the biosynthesis of iron-sulfur clusters and haem group maturation. Iron is delivered into the mitochondrion by mitoferrins, members of the MCF (mitochondrial
Opening the black box: revealing the molecular basis of thyroid hormone transport.
Alexandro J Martagón et al.
Endocrinology, 154(7), 2266-2269 (2013-06-26)
Stefan Harjes et al.
Journal of virology, 87(12), 7008-7014 (2013-04-19)
APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd), can mutate viral cDNA and restrict infectivity. We used time-resolved nuclear magnetic resonance (NMR) spectroscopy
Chang-Hoon Choi et al.
The Journal of cell biology, 202(6), 849-859 (2013-09-18)
Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial
Doreen Braun et al.
Endocrinology, 154(7), 2553-2561 (2013-04-18)
Mutations in monocarboxylate transporter 8 (MCT8; SLC16A2) cause the Allan-Herndon-Dudley syndrome, a severe X-linked psychomotor retardation syndrome. MCT8 belongs to the major facilitator superfamily of 12 transmembrane-spanning proteins and transports thyroid hormones across the blood-brain barrier and into neurons. How
Ivan Anastassov et al.
Journal of neurochemistry, 129(2), 249-255 (2013-11-30)
Our recent studies have shown that endogenous zinc, co-released with glutamate from the synaptic terminals of vertebrate retinal photoreceptors, provides a feedback mechanism that reduces calcium entry and the concomitant vesicular release of glutamate. We hypothesized that zinc feedback may
Vishard Ragoonanan et al.
Pharmaceutical research, 31(6), 1512-1524 (2014-01-09)
We hypothesize that ultrasonication can accelerate solute crystallization in freeze-concentrates. Our objective is to demonstrate ultrasonication as a potential predictive tool for evaluating physical stability of excipients in frozen solutions. The crystallization tendencies of lyoprotectants (trehalose, sucrose), carboxylic acid buffers
Sai Prasad Pydi et al.
Biochimica et biophysica acta, 1838(1 Pt B), 231-236 (2013-09-03)
Bitter taste receptors (T2Rs) belong to the superfamily of G protein-coupled receptors (GPCRs). T2Rs are chemosensory receptors with important therapeutic potential. In humans, bitter taste is perceived by 25 T2Rs, which are distinct from the well-studied Class A GPCRs. The
Smriti Kala et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6022-6027 (2014-04-09)
The genome packaging reactions of tailed bacteriophages and herpes viruses require the activity of a terminase enzyme, which is comprised of large and small subunits. Phage genomes are replicated as linear concatemers composed of multiple copies of the genome joined
Seppo Parkkila et al.
Bioorganic & medicinal chemistry letters, 16(15), 3955-3959 (2006-05-30)
The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and
Christian Bamann et al.
Biochimica et biophysica acta, 1837(5), 614-625 (2013-09-26)
Proteorhodopsins are the most abundant retinal based photoreceptors and their phototrophic function might be relevant in marine ecosystems. Here, we describe their remarkable molecular properties with a special focus on the green absorbing variant. Its distinct features include a high
Shoji Yamada et al.
Biochimica et biophysica acta, 1840(1), 434-442 (2013-10-15)
Nα-Acetylhistidine (NAH) is present in very high concentrations exclusively in the brain and lens of ectothermic vertebrates, including ray-finned fishes, amphibians and reptiles, and not in those of endothermic birds and mammals. Although NAH is known to be synthesized from
Maryam Rezazadeh et al.
Analytica chimica acta, 773, 52-59 (2013-04-09)
In the present work, pulsed electromembrane extraction (PEME) was performed for the first time, as a new concept of electrically enhanced microextraction method, for extraction and quantification of histidine, phenylalanine and tryptophan in different matrices. PEME offers an alternative to
Jeffrey M Brown et al.
Journal of neurochemistry, 129(2), 275-283 (2013-11-26)
NMDA receptor hypofunction is hypothesized to contribute to cognitive deficits associated with schizophrenia. Since direct activation of NMDA receptors is associated with serious adverse effects, modulation of the NMDA co-agonists, glycine or D-serine, represents a viable alternative therapeutic approach. Indeed
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