75-27-4

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Showing 1-30 of 195 results for "75-27-4" within Papers

NTP Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in male F344/N rats and female B6C3F1 mice (Drinking Water Studies).

National Toxicology Program technical report series, (532)(532), 1-248 (2006-06-03)

Bromodichloromethane is a by-product of the chlorination of drinking water. It is formed by the halogen substitution and oxidation reactions of chlorine with naturally occurring organic matter (e.g., humic or fulvic acids) in water containing bromide. Bromodichloromethane has been shown

Toxicology studies of bromodichloromethane (CAS No. 75-27-4) in genetically modified (FVB Tg.AC Hemizygous) mice (dermal, drinking water, and gavage studies) and carcinogenicity studies of bromodichloromethane in genetically modified [B6.129-Trp53(tm1Brd) (N5) haploinsufficient] mice (drinking water and gavage studies).

National Toxicology Program genetically modified model report, (5)(5), 1-227 (2008-09-12)

Bromodichloromethane is a by-product of the chlorination of drinking water. It is formed by the halogen substitution and oxidation reactions of chlorine and naturally occurring organic matter (e.g., humic or fluvic acids) in water containing bromide. Bromodichloromethane was nominated to

Mitotic and nonmitotic multiple-layered perfusion cultures.

P F Kruse et al.

The Journal of cell biology, 42(1), 113-121 (1969-07-01)

Cell types in addition to those previously described (Kruse et al. 1963. J. Nat. Cancer Inst. 31:109; Kruse and Miedema. 1965. J. Cell Biol. 27:273) were found to form multiple-layered cultures by perfusion-culture technique. Dense populations containing 43 x 10(6)

ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas.

Sohei Yamamoto et al.

Histopathology, 60(7), 1073-1083 (2012-02-22)

Actinin-4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the actin cytoskeleton. We assessed how ACTN4/actinin-4 alterations contribute to the tumorigenesis of ovarian clear-cell adenocarcinomas (CCAs). Fluorescence in-situ hybridization analysis demonstrated that ACTN4 amplification

A simple, cheap and reliable method for control of 4-ethylphenol and 4-ethylguaiacol in red wines. Screening of fining agents for reducing volatile phenols levels in red wines.

Juliana Milheiro et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1041-1042, 183-190 (2016-11-18)

Brettanomyces/Dekkera produces 4-ethylphenol (4-EP) and 4-ethylguaiacol (4-EG) from hydroxycinnamic acids that affect the wine aroma and overall quality. A simple, cheap, fast and reliable quantitation method is needed for routine quality control of wines. In this work a simple method

Cochlear implantation and congenital deafness: perceptive and lexical results in 2 genetically pediatric identified population.

Wissame El Bakkouri et al.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 33(4), 539-544 (2012-05-10)

To evaluate the perceptive and linguistic results in 2 predefined genetic population of children with implants. Retrospective cohort study. Otolaryngology department of a tertiary referral hospital. Among 336 children with prelingual deafness who underwent implantation in our department between 1997

Susceptibility of last instar red flour beetles and confused flour beetles (Coleoptera: Tenebrionidae) to hydroprene.

F H Arthur

Journal of economic entomology, 94(3), 772-779 (2001-06-27)

Last instar larvae of the red flour beetle, Tribolium castaneum (Herbst), and the confused flour beetle, Tribolium confusum Jacquelin du Val, were either exposed for 8-144 h on concrete treated with 1.9 x 10(-3) mg(AI)/per cm2 hydroprene, or continually exposed

Characterization of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae from Riyadh, Saudi Arabia.

Ahmed A Al-Qahtani et al.

Journal of chemotherapy (Florence, Italy), 26(3), 139-145 (2013-10-05)

The objectives of this study were to determine the prevalences, genotypes, and clonal relationships of extended-spectrum beta-lactamase (ESBL)-producing strains in 98 Klebsiella pneumoniae isolates from Riyadh. The prevalence of ESBLs in these strains was 37·75%. All isolates that were confirmed

Sequences of taxol and cisplatin: a phase I and pharmacologic study.

E K Rowinsky et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 9(9), 1692-1703 (1991-09-01)

Untreated and minimally pretreated solid tumor patients received alternating sequences of taxol and cisplatin. Sequential dose escalation of each agent using taxol doses of 110 or 135 mg/m2 and cisplatin doses of 50 or 75 mg/m2 resulted in four dosage

Enzymatic activity of sperm proprotein convertase is important for mammalian fertilization.

Sitthichai Iamsaard et al.

Journal of cellular physiology, 226(11), 2817-2826 (2011-02-09)

Proprotein convertase subtilisin/kexin 4 (PCSK4) is implicated for sperm fertilizing ability, based on studies using Pcsk4-null mice. Herein we demonstrated proprotein convertase (PC) activity in intact sperm and acrosomal vesicles. To determine whether this activity was important for sperm fertilizing

Turnover of Se in adequately fed chickens using Se-75 as a tracer.

A Brandt-Kjelsen et al.

Journal of animal physiology and animal nutrition, 98(3), 547-558 (2013-09-17)

Inorganic selenium (Se) in the form of selenite is applied to livestock to avoid Se deficiency. Selenite is, however, an artificial Se source in diets of unsupplemented chickens. It is therefore hypothesized that organic Se sources, such as Se-enriched yeast

Potential application of Pistia stratiotes for the phytoremediation of mesotrione and its degradation products from water.

Hanna Barchanska et al.

International journal of phytoremediation, 21(11), 1090-1097 (2019-05-16)

The aim of the present work is to estimate remediation potential of Pistia stratiotes, its ability to uptake mesotrione (MES) - one of the most frequently used herbicides, and its main degradation products: 2-amino-4-methylsulfonyl benzoic acid (AMBA) and 4-methylsulfonyl-2-nitrobenzoic acid

The effects of laropiprant on the antiplatelet activity of co-administered clopidogrel and aspirin.

Pieter-Jan De Kam et al.

Platelets, 25(7), 480-487 (2013-11-12)

Laropiprant is an antagonist of the prostaglandin PGD2 receptor DP1. Laropiprant has a weak affinity for the thromboxane A2 receptor TP. Two double-blinded, randomized, placebo-controlled, crossover studies evaluated the effects of multiple-dose laropiprant at steady state on the antiplatelet effects

The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.

John Mach et al.

Fundamental & clinical pharmacology, 30(1), 23-34 (2015-10-11)

Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0

Endothelial nitric oxide synthase gene polymorphism and elite endurance athlete status: the Genathlete study.

B Wolfarth et al.

Scandinavian journal of medicine & science in sports, 18(4), 485-490 (2007-12-11)

In the Genathlete study, we examined the contribution of three polymorphisms in the endothelial nitric oxide synthase (NOS3) gene to discriminate elite endurance athletes (EEA) from sedentary controls (SC). The EEA group included a total of 316 Caucasian males with

Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene.

M Javier Herrero-Turrión et al.

Biochemical and biophysical research communications, 340(2), 386-394 (2005-12-27)

We have identified a new human gene coined sytdep (synaptotagmin XIV-derived protein) in human neutrophils. Sytdep encodes a 188-amino acid sequence with a 21.435kDa deduced molecular mass, showing 75% identity to human synaptotagmin (syt) XIV. Human neutrophils express sytdep, but

Comparison of segmental enhancement inversion on biphasic MDCT between small renal oncocytomas and chromophobe renal cell carcinomas.

Sungmin Woo et al.

AJR. American journal of roentgenology, 201(3), 598-604 (2013-08-27)

The purpose of this article is to assess the usefulness of segmental enhancement inversion on biphasic MDCT in differentiating small (<4 cm) renal oncocytomas from chromophobe renal cell carcinomas (CRCCs). Eighty-two patients (40 men and 42 women) with a mean

The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products.

Alessandra Bitto et al.

BioMed research international, 2013, 273498-273498 (2013-03-14)

An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg

Prevalence of pancreatic diabetes in patients carrying mutations or polymorphisms of the PRSS1 gene in the Han population.

Qi-cai Liu et al.

Diabetes technology & therapeutics, 11(12), 799-804 (2009-12-17)

This study updated the estimated prevalence of type 3c diabetes damage to the pancreas through different genotypes of PRSS1 and their clinical characteristics in the Han population. Cross-sectional analysis was performed of the most recent (2003-2007) patients with pancreatitis from

Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer.

Gerwin Heller et al.

Breast cancer research and treatment, 103(3), 283-291 (2007-01-30)

TSLC1 and DAL-1 are tumor suppressor genes involved in cell adhesion. In this study, we examined the expression and methylation pattern of these genes in breast cancer cell lines and primary breast carcinomas. TSLC1 expression was lost in 5 of

IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver.

Kristopher S Denby et al.

Applied immunohistochemistry & molecular morphology : AIMM, 20(6), 573-579 (2012-04-13)

Histopathologic distinction among small-cell carcinoma (SCC), pancreatic endocrine tumor (PET), and gastrointestinal carcinoids metastasized to the liver in needle core biopsies can be extremely challenging because of limited material, crush artifact, and lack of detailed clinical history. In this study

No significant impact of patient age and prior treatment profile with docetaxel on the efficacy of cabazitaxel in patient with castration-resistant prostate cancer.

Takeo Kosaka et al.

Cancer chemotherapy and pharmacology, 82(6), 1061-1066 (2018-10-05)

The correlation of the oncological outcomes of docetaxel and cabazitaxel in Japanese metastatic castration-resistant prostate cancer (mCRPC) patients has not been unclear. This study included a total of 47 consecutive Japanese mCRPC patients treated with cabazitaxel and assessed the prognostic

Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States.

Julia Tchou et al.

Clinical breast cancer, 7(8), 627-633 (2007-06-27)

Male breast cancer has been linked extensively to mutations of BRCA2 and, to a lesser extent, BRCA1. The aim of this study was to perform a comprehensive analysis of point mutations and genomic rearrangements in the BRCA1 and BRCA2 genes

Modular Enzymatic Cascade Synthesis of Nucleotides Using a (d)ATP Regeneration System.

Maryke Fehlau et al.

Frontiers in bioengineering and biotechnology, 8, 854-854 (2020-09-10)

Nucleoside-5'-triphosphates (NTPs) and their analogs are building blocks of DNA and are important compounds in both pharmaceutical and molecular biology applications. Currently, commercially available base or sugar modified NTPs are mainly synthesized chemically. Since the chemical production of NTPs is

Novel germline PALB2 truncating mutations in African American breast cancer patients.

Yonglan Zheng et al.

Cancer, 118(5), 1362-1370 (2011-09-21)

It has been demonstrated that the partner and localizer of breast cancer 2 (PALB2) acts as a bridging molecule between the breast cancer 1 (BRCA1) and BRCA2 proteins and is responsible for facilitating BRCA2-mediated DNA repair. Truncating mutations in the

Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells.

Christin Weise et al.

The Journal of nutritional biochemistry, 22(3), 269-275 (2010-06-26)

Nutrition can modify the onset or severity of diseases and recent changes in eating habits are supposed to promote immunoglobulin (Ig) E-dependent disorders. The n-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) possesses immunomodulatory properties and has been shown to influence

Colour stabilities of sour cherry juice concentrates enhanced with gallic acid and various plant extracts during storage.

Ayşe Navruz et al.

Food chemistry, 197(Pt A), 150-160 (2015-12-01)

Gallic acid (GA) and pomegranate rind extract (PRE), cherry stem extract (CSE) and green tea extract (GTE) were added to sour cherry juice concentrates (SCJCs) to enhance the colour. Effects of these copigment sources on anthocyanins, colour and turbidity were

Phase II trial to assess the safety and efficacy of clofarabine in combination with low-dose cytarabine in elderly patients with acute myeloid leukemia.

David Martínez-Cuadrón et al.

Annals of hematology, 93(1), 43-46 (2013-10-02)

Previous studies have shown that clofarabine plus low-dose cytarabine (LDAC) could induce roughly 60 % of complete remissions (CR) with acceptable toxicity and induction mortality in elderly acute myeloid leukemia (AML) patients not suitable for intensive chemotherapy. The Programa Español

Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells.

Marcia Godinho et al.

Journal of cellular physiology, 226(7), 1741-1749 (2011-04-21)

Resistance to the antiestrogen tamoxifen remains a major problem in the management of estrogen receptor-positive breast cancer. Knowledge on the resistance mechanisms is needed to develop more effective therapies. Breast cancer antiestrogen resistance 4 (BCAR4) was identified in a functional

Dose intensification of busulfan in the preparative regimen is associated with improved survival: a phase I/II controlled, randomized study.

Simrit Parmar et al.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 474-480 (2012-12-12)

Dose intensity is important for disease control in patients undergoing allogeneic stem cell transplantation. We conducted a phase I/II controlled, adoptive, randomized study to determine the optimal dosing schedule of i.v. busulfan. Patients aged ≤75 years with advanced hematologic malignancies

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