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Showing 1-30 of 182 results for "75-34-3" within Papers
Kyriacos N Felekkis et al.
Molecular cancer research : MCR, 3(1), 32-41 (2005-01-27)
AND-34, a 95-kDa protein with modest homology to Ras GDP exchange factors, associates with the focal adhesion protein p130Cas. Overexpression of AND-34 confers anti-estrogen resistance in breast cancer cell lines, a property linked to its ability to activate Rac. Here
Akinori Nishi et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(4), 1199-1204 (2005-01-20)
Dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) plays a central role in medium spiny neurons in the neostriatum in the integration of various neurotransmitter signaling pathways. In its Thr-34-phosphorylated form, it acts as a potent protein phosphatase-1 inhibitor, and
Jung-Hyuck Ahn et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(23), 9876-9881 (2007-05-31)
In dopaminoceptive neurons, dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) plays a central role in integrating the effects of dopamine and other neurotransmitters. Phosphorylation of DARPP-32 at Thr-34 by protein kinase A results in inhibition of protein phosphatase 1
Roula Albadine et al.
The American journal of surgical pathology, 34(7), 965-969 (2010-05-14)
Collecting duct carcinoma (CDC) is a relatively rare but aggressive type of renal malignancy with variable morphologic features. One of the World Health Organization diagnostic criteria for CDC is the exclusion of urothelial carcinoma of renal pelvis from the differential
N Nagai et al.
Biopharmaceutics & drug disposition, 17(5), 421-433 (1996-07-01)
The plasma concentration and cumulative urinary excretion over 34 h of dextromethorphan, free and conjugated dextrorphan, and 3-hydroxymorphinan were determined in seven healthy Japanese subjects after oral administration of 30 mg dextromethorphan hydrobromide. Conjugated metabolites were extensively present, whereas no
Anjali D Amarapurkar et al.
Annals of hepatology, 6(3), 170-173 (2007-09-06)
Chronic liver disease is characterized by inflammation and fibrosis. As a consequence angiogenesis leading to new vasculature may have prognostic value in disease progression. Interfering with angiogenesis may be a potential target to avoid progression of liver disease. Hence we
Paul Witkovsky et al.
The European journal of neuroscience, 25(11), 3233-3242 (2007-06-08)
The goal of the present study was to elucidate the role of DARPP-32 (dopamine- and cyclic adenosine 3'-5'-monophosphate-regulated phosphoprotein, 32 kDa) in retinal function. We examined mouse and rat retinas for the presence of DARPP-32 by immunocytochemistry. In both rodent
S M Pojda et al.
Klinika oczna, 94(1), 18-19 (1992-01-01)
21 patients (40 eyes) aged 27-84 years (15 women and 6 men) were treated orally with cavinton 3 x 5 mg, sadamine++ 3 X 75 mg, cinnarizine++ 3 X 40 mg, vit. A+E 3 X 1 caps. daily. Intramuscularly++ were
Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum.
I Saenz de Tejada et al.
The American journal of physiology, 261(4 Pt 2), H1078-H1085 (1991-10-01)
The localization, synthesis, and activity of endothelin and the receptor types mediating its effects in penile corpus cavernosum were investigated in whole tissue and in cultured cells derived from this tissue. With immunocytochemistry, utilizing an antiendothelin 1 (ET-1) monoclonal antibody
Lisa Polzien et al.
The Journal of biological chemistry, 284(41), 28004-28020 (2009-08-12)
BAD is a proapoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors. Although much attention has been devoted to the identification of phosphorylation sites in murine BAD, little data are available with
Jiucheng He et al.
Investigative ophthalmology & visual science, 56(6), 3505-3513 (2015-06-02)
To compare a 44-mer pigment epithelial-derived factor (PEDF) peptide with neurotrophic activity, and a 34-mer PEDF with antiangiogenic properties in association with docosahexaenoic acid (DHA) in corneal nerve regeneration after experimental surgery. A corneal stromal dissection was performed in rabbits.
Yangyang Feng et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 65(11), 1988-1993 (2012-05-18)
The anaerobic treatability of purified terephthalic acid (PTA) wastewater in a novel, rapid mass-transfer fluidized bed reactor using brick particles as porous carrier materials was investigated. The reactor operation was stable after a short 34 day start-up period, with chemical
John F Seymour et al.
British journal of haematology, 165(1), 49-56 (2014-01-29)
The efficacy and tolerance of azacitidine in higher-risk myelodysplasia with hypocellular bone marrow (BM) are unknown. This post hoc AZA-001 trial analysis assessed whether baseline BM cellularity affected the overall survival (OS) advantage demonstrated with azacitidine versus conventional care regimens
A Leyva et al.
Journal of cancer research and clinical oncology, 107(3), 211-216 (1984-01-01)
In a clinical study of high-dose thymidine (TdR) treatment, toxic effects, TdR metabolism, and the influence of TdR on pyrimidine and purine metabolism were examined. Ten patients with solid tumors were treated with continuous infusion of TdR at 34-75 g/m2/day
Anders Møller Andersen et al.
Pancreas, 39(1), 26-30 (2009-09-16)
In acute pancreatitis (AP), rapid diagnosis and early treatment are of importance for clinical outcome. Urinary trypsinogen-2 has been suggested as a promising diagnostic marker; however, studies using the urinary trypsinogen-2 dipstick test (UTDT) have provided varying results. The study
Alberto Deganello et al.
Oral oncology, 93, 29-38 (2019-05-22)
When amenable to radical excision, cancer involving the maxilla is typically treated with maxillectomy followed by adjuvant therapy. Posterior tumor extension beyond the maxillary box leads to the invasion of complex areas, where achieving clear margins may be challenging. Patients
A Sardi et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 39(11), 1207-1213 (2013-09-07)
Cytoreductive surgery (CRS)/hyperthermic intraperitoneal chemotherapy (HIPEC) is the procedure of choice in patients with peritoneal dissemination from appendiceal cancer. Although recurrence rates are 26%-44% after first CRS/HIPEC, the role of repeated CRS/HIPEC has not been well defined. We hypothesize that
Marc C Heinrich et al.
Radiology, 235(3), 843-849 (2005-04-23)
To compare the cytotoxic effects of dimeric and monomeric iodinated contrast media on renal tubular cells in vitro with regard to osmolality. LLC-PK1 cells were incubated with ioxithalamate, ioversol, iomeprol-300, iomeprol-150, iodixanol, iotrolan, and hyperosmolar mannitol solutions for 1-24 hours
Norma I Rallón et al.
AIDS (London, England), 24(8), F23-F29 (2010-04-15)
Given that peginterferon-ribavirin treatment is poorly tolerated, there is interest in the identification of predictors of response, particularly in HIV/hepatitis C virus (HCV)-coinfected patients that respond less than HCV-monoinfected individuals. A single nucleotide polymorphism (SNP) near the IL28B gene (rs12979860)
M Ito et al.
Biochimica et biophysica acta, 794(2), 183-193 (1984-07-06)
Acetoacetyl-CoA synthetase (acetoacetate:CoA ligase) was purified to electrophoretic homogeneity from a rat liver supernatant by ammonium sulfate fractionation and successive chromatographies on DEAE-Sepharose, Blue-Sepharose, Red-Sepharose, CoA-Sepharose, Ultrogel AcA-44, and DEAE-Sepharose once again. The purified enzyme had a specific activity of
Daniel Jackson et al.
Female pelvic medicine & reconstructive surgery, 19(3), 137-141 (2013-04-25)
Because of the reported high percentage of bladder infections after placement of a midurethral sling (8.9%-34%), this study was undertaken to determine if a 3-day postoperative course of a urinary antibiotic would significantly lower the incidence of urinary tract infection
Alessandra De Remigis et al.
International journal of cancer, 136(1), 127-137 (2014-05-17)
Cancer immunotherapy induces a variety of autoinflammatory responses, including those against the thyroid gland, which can be exploited to predict clinical outcomes. Considering the paucity of information about thyroid autoimmunity in patients receiving cancer vaccines, we designed our study to
K Kohno et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(14), 4978-4982 (1986-07-01)
Complementary DNA clones, pHEW1 and pRE2, coding for hamster and rat polypeptide chain elongation factor 2 (EF-2), respectively, were isolated and sequenced. It was shown that the cDNA insert in pHEW1 contains a 2574-base-pair open reading frame coding for an
J D Pelletier et al.
Bioorganic & medicinal chemistry, 4(10), 1617-1628 (1996-10-01)
To develop inhibitors of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) without residual estrogenic activity, the synthesis of 16 alpha-(bromoalkylamide) derivatives of estradiol was performed starting from a key intermediate aldehyde obtained from commercially available estrone. In addition, series of 16 alpha-(bromoalkyl)
M Piagnerelli et al.
Acta clinica Belgica, 68(1), 22-27 (2013-05-01)
Altered iron metabolism plays a central role in the development of anaemia in critically ill patients but the time course of iron status in septic and non-septic critically ill patients has not been well defined. Prospective study in a 34-bed
Z Zhang et al.
Tissue antigens, 80(2), 158-164 (2012-06-20)
Preeclampsia (PE), especially severe PE including early (before 34 weeks' gestation) and late (after 34 weeks' gestation) onset PE, is one of the leading causes of maternal and fetal mortality and morbidity. It is well known that abnormal human leukocyte
Anna Yemelyanova et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(2), 268-274 (2012-09-22)
While cervical cancer screening relies on cervical cytology and high-risk human papillomavirus (HPV) detection, the histologic diagnosis, and specifically lesion grade, is the main parameter that drives clinical management of screen-positive women. Morphologically diagnosed squamous intraepithelial lesions (SIL/CIN) regress spontaneously
Hiroshi Miyamoto et al.
The American journal of surgical pathology, 34(3), 418-422 (2010-02-16)
Studies predominantly performed on cystectomy specimens have shown that antibodies against smoothelin can distinguish between muscularis mucosae (MM) (negative or weak stain) and muscularis propria (MP) (strong stain). However, studies on diagnostically difficult (transurethral resection) specimens have not been performed.
N Ramnath et al.
Cancer chemotherapy and pharmacology, 71(5), 1173-1182 (2013-02-26)
Preclinical studies demonstrated antiproliferative synergy of 1,25-D3 (calcitriol) with cisplatin. The goals of this phase I/II study were to determine the recommended phase II dose (RP2D) of 1,25-D3 with cisplatin and docetaxel and its efficacy in metastatic non-small-cell lung cancer.
P Wanner et al.
European journal of biochemistry, 255(1), 271-278 (1998-08-06)
Two enone reductases catalyzing irreversibly the enantioselective reduction of alpha,beta-unsaturated carbonyls have been purified 165-fold and 257-fold, respectively, from the cytosolic fraction of Saccharomyces cerevisiae by means of streptomycin sulfate treatment, Sephadex G-25 filtration, DEAE-Sepharose CL-6B chromatography, blue Sepharose CL-6B
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