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Showing 31-60 of 178 results for "77515" within Papers
Shunji Hasegawa et al.
Cytokine, 69(2), 206-210 (2014-07-08)
Several studies support the role of viral infections in the pathogenesis of asthma exacerbation. However, several pediatricians believe that influenza virus infection does not exacerbate bronchial asthma, except for influenza A H1N1 2009 pandemic [A(H1N1)pdm09] virus infection. We previously reported
Oluwatoyin A Igbeneghu et al.
Journal of health, population, and nutrition, 32(2), 176-182 (2014-08-01)
Fluted pumpkin (Telfairia occidentalis) is a minimally-processed green leafy vegetable traditionally used for its antianaemic properties in the form of leaf juice without a heating or inactivation step before consumption. The aim of the study was to assess the presence
Judith Luiza Eisenbacher et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 6102-6110 (2014-05-06)
Simple stress or necrotic cell death with subsequent release of damage-associated molecular patterns (DAMPs) is a characteristic feature of most advanced tumors. DAMPs within the tumor microenvironment stimulate tumor-associated cells, including dendritic cells and mesenchymal stromal cells (MSCs). The presence
Gajalakshmi Dakshinamoorthy et al.
PloS one, 9(11), e112982-e112982 (2014-11-18)
Lymphatic filariasis affects 120 million people worldwide and another 1.2 billion people are at risk of acquiring the infection. Chemotherapy with mass drug administration is substantially reducing the incidence of the infection. Nevertheless, an effective vaccine is needed to prevent
Stephanie Supper et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 361-373 (2014-05-27)
Chitosan (CS)-based thermosensitive solutions that turn into semi-solid hydrogels upon injection at body temperature have increasingly drawn attention over the last decades as an attractive new type of in situ forming depot (ISFD) drug delivery system. Despite the great potential
Natalie Fekete et al.
Tissue engineering. Part C, Methods, 21(2), 112-122 (2014-06-12)
Cell therapy using multipotent mesenchymal stromal cells (MSCs) is of high interest in various indications. As the pleiotropic effects mediated by MSCs rely mostly on their unique secretory profile, long-term persistence of ex-vivo-expanded cells in the recipient may not always
Ching-Chi Lee et al.
The American journal of emergency medicine, 32(10), 1241-1247 (2014-08-31)
The objective of this study is to analyze the differences in clinical presentation and outcome of community-onset bacteremia between human immunodeficiency virus (HIV)-infected adults and HIV-uninfected adults visiting the emergency department (ED). A multicenter, case-control study with a ratio of
J Fisher et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 63-65 (2013-12-25)
Methylene blue inhibits the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, decreasing vasodilation and increasing responsiveness to vasopressors. It is reported to improve haemodynamics in distributive shock from various causes including septicaemia and post-cardiac surgery. Reports of use in overdose are
Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation.
Ivonne Brüstle et al.
Beilstein journal of nanotechnology, 6, 383-395 (2015-03-31)
The combination of stem cell therapy and nanoparticles promises to enhance the effect of cellular therapies by using nanocarriers as drug delivery devices to guide the further differentiation or homing of stem cells. The impact of nanoparticles on primary cell
Yuko Mitobe et al.
Regulatory toxicology and pharmacology : RTP, 71(3), 529-540 (2015-02-24)
Japanese cedar (JC) pollinosis is caused by Japanese cedar pollen (JCP) and most common seasonal allergic disease in Japan. Subcutaneous immunotherapy (SCIT) with allergen extract of JCP (JCP-allergen extract) is well established for JC pollinosis treatment with improvement of symptoms.
Nouruddin Wageih Ali et al.
Pakistan journal of pharmaceutical sciences, 26(3), 641-648 (2013-04-30)
Validated spectrophotometric and chemometric methods were developed for determination of Naphazoline Hydrochloride (NAP), Chlorpheniramine maleate (CLO) and Methylene blue (MB) in their ternary mixture. Method A was a spectrophotometric method, where NAP and MB were determined using second derivative (D²)
Methylene blue for refractory anaphylaxis--is it a magic bullet? The authors' response.
Cindy S Bauer et al.
The American journal of emergency medicine, 31(7), 1140-1141 (2013-05-18)
C Riccó et al.
The Veterinary record, 173(24), 608-608 (2013-10-26)
To compare different volumes of injectate using electrostimulator (ES)-guided and blind brachial plexus blockade (BPB) techniques in dogs. Prospective, randomised, blinded study. Fifty-eight healthy adult purpose-bred beagle dogs. Animals were randomised into 4 groups based on the volume of methylene
D C Riley et al.
Journal of neuroscience research, 93(4), 572-583 (2014-11-27)
Restoration of neuronal functions by outgrowths regenerating at ∼1 mm/day from the proximal stumps of severed peripheral nerves takes many weeks or months, if it occurs at all, especially after ablation of nerve segments. Distal segments of severed axons typically
N Waldschmitt et al.
Mucosal immunology, 7(6), 1452-1466 (2014-05-23)
Loss of intestinal epithelial cell (IEC) homeostasis and apoptosis negatively affect intestinal barrier function. Uncontrolled activation of the unfolded protein response (UPR) in IEC contributes to an impaired barrier and is implicated in the pathogenesis of inflammatory bowel diseases. However
Wolfgang Friebolin et al.
Journal of medicinal chemistry, 51(5), 1260-1277 (2008-02-12)
Plasmodium parasites are exposed to higher fluxes of reactive oxygen species and need high activities of intracellular antioxidant systems providing a steady glutathione flux. As a future generation of dual drugs, 18 naphthoquinones and phenols (or their reduced forms) containing
Allison Auchter et al.
Journal of Alzheimer's disease : JAD, 42 Suppl 4, S525-S535 (2014-08-01)
Chronic cerebral hypoperfusion, a risk factor for mild cognitive impairment and Alzheimer's disease, affects mitochondrial respiration and memory consolidation. Therefore, drugs that improve mitochondrial function may be appropriate cognitive treatments for cerebral hypoperfusion. Methylene blue (MB) crosses the blood-brain barrier
Ashok A Kumar et al.
American journal of hematology, 90(1), 31-36 (2014-09-30)
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood
Bo-Kuan Wu et al.
Cell cycle (Georgetown, Tex.), 13(20), 3222-3231 (2014-12-09)
Site-specific hypermethylation of tumor suppressor genes accompanied by genome-wide hypomethylation are epigenetic hallmarks of malignancy. However, the molecular mechanisms that drive these linked changes in DNA methylation remain obscure. DNA methyltransferase 1 (DNMT1), the principle enzyme responsible for maintaining methylation
Byung Hoon Kim et al.
Journal of nanoscience and nanotechnology, 13(3), 1966-1969 (2013-06-13)
The objective of this paper is to investigate the decomposition process of organic pollutants by liquid phase plasma. A bipolar pulsed power supply was used to generate discharges in the aqueous TiO2 nanoparticle dispersions. The applied voltage, pulse width, and
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Kang Kwang Lee et al.
Hepatology (Baltimore, Md.), 61(1), 326-336 (2014-08-22)
Acetaminophen (APAP) overdose is a frequent cause of drug-induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event
Xavier Bofill-De Ros et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1665-1677 (2014-06-05)
Oncolytic virotherapy shows promise for pancreatic ductal adenocarcinoma (PDAC) treatment, but there is the need to minimize associated-toxicities. In the current work, we engineered artificial target sites recognized by miR-216a and/or miR-148a to provide pancreatic tumor-selectivity to replication-competent adenoviruses (Ad-miRTs)
F Langner-Viviani et al.
Revue medicale suisse, 10(426), 876-880 (2014-05-20)
In medicine, vital blue dyes are mainly used for the evaluation of sentinel lymph nodes in oncologic surgery. Perioperative anaphylaxis to blue dyes is a rare but significant complication. Allergic reactions to blue dyes are supposedly IgE-mediated and mainly caused
Jennifer Malon et al.
Journal of neuroimmunology, 279, 64-70 (2015-02-12)
C57BL/6 (B6) mice develop peripheral neuropathy post-LP-BM5 infection, a murine model of HIV-1 infection, along with the up-regulation of select spinal cord cytokines. We investigated if calcitonin gene-related peptide (CGRP) contributed to the development of peripheral neuropathy by stimulating glial
Lei Guo et al.
Carbohydrate polymers, 93(2), 374-379 (2013-03-19)
Crosslinked porous starch (CPS) was prepared by two steps. Native starch was crosslinked with epichlorohydrin and then CPS was prepared by hydrolyzing the crosslinked starch with α-amylase. As a biodegradable and safe adsorbent, CPS was used to remove methylene blue
Xiaoqiang Cong et al.
Molecular medicine reports, 9(6), 2528-2532 (2014-04-01)
The role of resveratrol (Res) in inflammation induced by ischemia/reperfusion is not well understood. The aim of the present study was to investigate whether Res modulates neutrophil accumulation and tumor necrosis factor-α (TNF-α) induction in an ischemia/reperfusion-injured rat heart model.
Peijun Xu et al.
Advances in experimental medicine and biology, 827, 187-203 (2014-11-13)
Different quantum mechanic methods have been evaluated for the calculation of binding modes and interactions between intercalators with different DNA base pairs by comparing with the results of MP2, which is very expensive, indicating that WB97XD method under 6-311+G* basis
Pedro A Pereira et al.
Neurotoxicology and teratology, 44, 53-61 (2014-06-04)
Neuropeptide Y (NPY)- and acetylcholine-containing interneurons of the nucleus accumbens (NAc) seem to play a major role in the rewarding effects of alcohol. This study investigated the relationship between chronic alcohol consumption and subsequent withdrawal and the expression of NPY
Jordan R Jensen et al.
Bioorganic & medicinal chemistry, 19(17), 5147-5154 (2011-08-02)
Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggregates have been reported from high-throughput screens, but the affinity driving features common
Thomas C Baddeley et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 110-118 (2014-10-17)
Methylthioninium (MT) is a tau aggregation inhibitor with therapeutic potential in Alzheimer's disease (AD). MT exists in equilibrium between reduced [leucomethylthioninium (LMT)] and oxidized (MT(+)) forms; as a chloride salt [methylthioninium chloride (MTC), "methylene blue"], it is stabilized in its
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