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Showing 1-30 of 419 results for "778672" within Papers

Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.

L Zhang et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(9), 1274-1281 (2015-06-20)

The aim of the present study was to investigate whether the synthesis of endogenous hydrogen sulfide (H2 S) was altered in achalasia patients and to determine the effects of H2 S on esophageal motility. (1) Tissue samples in lower esophageal

A Simple and Green Route for Room-Temperature Synthesis of Gold Nanoparticles and Selective Colorimetric Detection of Cysteine.

Pelin Onsekizoglu Bagci et al.

Journal of food science, 80(9), N2071-N2078 (2015-08-05)

Gold nanoparticles (AuNPs) were synthesized at room temperature following a simple, rapid, and green route using fresh-squeezed apple juice as a reducing reagent. The optimal AuNPs, based on the particle color, stability, and color change suitable for colorimetric detection of

Promoting thiol expression increases the durability of antitumor T-cell functions.

Pravin Kesarwani et al.

Cancer research, 74(21), 6036-6047 (2014-08-29)

Ex vivo-expanded CD8(+) T cells used for adoptive immunotherapy generally acquire an effector memory-like phenotype (TEM cells). With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited persistence and reduced antitumor efficacy, relative to CD8(+)

Targeting tumor-initiating cells: eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction.

Rebecca Lamb et al.

Oncotarget, 6(7), 4585-4601 (2015-02-12)

We have used an unbiased proteomic profiling strategy to identify new potential therapeutic targets in tumor-initiating cells (TICs), a.k.a., cancer stem cells (CSCs). Towards this end, the proteomes of mammospheres from two breast cancer cell lines were directly compared to

Essential role for polymerase specialization in cellular nonhomologous end joining.

John M Pryor et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(33), E4537-E4545 (2015-08-05)

Nonhomologous end joining (NHEJ) repairs chromosome breaks and must remain effective in the face of extensive diversity in broken end structures. We show here that this flexibility is often reliant on the ability to direct DNA synthesis across strand breaks

Metabolic pathways and biotechnological production of L-cysteine.

Masaru Wada et al.

Applied microbiology and biotechnology, 73(1), 48-54 (2006-10-06)

L-Cysteine is an important amino acid both biologically and commercially. Although most amino acids are commercially produced by fermentation, cysteine is mainly produced by protein hydrolysis. However, synthetic or biotechnological products have been preferred in the market. Biotechnological processes for

Synthesis of L-cysteine in Salmonella typhimurium.

N M Kredich et al.

Ciba Foundation symposium, (72)(72), 87-99 (1979-01-01)

In Salmonella typhimurium and Escherichia coli the biosynthesis of L-cysteine from L-serine and inorganic sulphate proceeds along a branched convergent pathway along one arm of which sulphate is reduced to sulphide, while on the other L-serine is acetylated to O-acetyl-L-serine.

L-cysteine-capped core/shell/shell quantum dot-graphene oxide nanocomposite fluorescence probe for polycyclic aromatic hydrocarbon detection.

Oluwasesan Adegoke et al.

Talanta, 146, 780-788 (2015-12-24)

Environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), become widely distributed in the environment after emission from a range of sources, and they have potential biological effects, including toxicity and carcinogenity. In this work, we have demonstrated the analytical

Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis.

Jin-Ting Zhang et al.

Oncology reports, 14(6), 1519-1522 (2005-11-08)

Particularly interesting new cysteine-histidine rich protein (PINCH), an adapter protein involved in integrin and growth factor signalling, is up-regulated in the stroma of colorectal, breast, prostate, lung and skin cancer. Strong stromal immunostaining for PINCH is an independent prognostic indicator

Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.

Marta Siernicka et al.

Immunology, 146(1), 173-183 (2015-06-23)

Natural killer (NK) cells are considered critical components of the innate and adaptive immune responses. Deficiencies in NK cell activity are common, such as those that occur in cancer patients, and they can be responsible for dysfunctional immune surveillance. Persistent

Homogeneous enzymatic assay for L-cysteine with betaC-S lyase.

Yoshiaki Nishiya et al.

Bioscience, biotechnology, and biochemistry, 69(11), 2244-2246 (2005-11-25)

We have developed a new enzymatic assay for determining L-cysteine concentration. The method involves the use of betaC-S lyase from Streptococcus anginosus, which catalyzes the alpha,beta-elimination of L-cysteine to hydrogen sulfide, pyruvate, and ammonia. The production of pyruvate is measured

Biomarkers of one-carbon metabolism are associated with biomarkers of inflammation in women.

Clare Abbenhardt et al.

The Journal of nutrition, 144(5), 714-721 (2014-03-22)

Folate-mediated one-carbon metabolism is essential for DNA synthesis, repair, and methylation. Perturbations in one-carbon metabolism have been implicated in increased risk of some cancers and may also affect inflammatory processes. We investigated these interrelated pathways to understand their relation. The

Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.

Veronika Seiberlich et al.

Glia, 63(9), 1621-1635 (2015-04-08)

Oligodendrocytes, the myelin forming cells of the CNS, are characterized by their numerous membranous extensions, which enwrap neuronal axons and form myelin sheaths. During differentiation oligodendrocytes pass different morphological stages, downregulate the expression of the proteoglycan NG2, and acquire major

Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells.

Sujoy Dutta et al.

PloS one, 9(5), e97580-e97580 (2014-05-17)

Exosomes are nanovesicles originating from multivesicular bodies and are released by all cell types. They contain proteins, lipids, microRNAs, mRNAs and DNA fragments, which act as mediators of intercellular communications by inducing phenotypic changes in recipient cells. Tumor-derived exosomes have

[Targeted effect profile - proven effectiveness].

MMW Fortschritte der Medizin, 155(5), 70-71 (2013-05-10)

Glycoprotein 130 polymorphism predicts soluble glycoprotein 130 levels.

Anna Wonnerth et al.

Metabolism: clinical and experimental, 63(5), 647-653 (2014-03-19)

Interleukin-6 (IL-6) is a key cytokine in inflammatory diseases. It exerts its biological function via binding to a homodimer of its signal transducer glycoprotein 130 (gp130). Soluble gp130 (sgp130) is the natural inhibitor of IL-6 trans-signalling. The aim of this

Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.

Jason S McLellan et al.

Science (New York, N.Y.), 342(6158), 592-598 (2013-11-02)

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable

In Vivo Collagen Remodeling in the Vascular Wall of Decellularized Stented Tissue-Engineered Heart Valves.

Samaneh Ghazanfari et al.

Tissue engineering. Part A, 21(15-16), 2206-2215 (2015-06-02)

Decellularized tissue-engineered heart valves (TEHVs) are under investigation as alternative for current heart valve prostheses with the potential to rapidly repopulate with cells within the body. Ideally, these valves are stented for transapical or minimally invasive delivery. It is unclear

Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes.

M Allen McAlexander et al.

The Journal of pharmacology and experimental therapeutics, 349(1), 118-125 (2014-02-08)

Prior studies have demonstrated that the ion channel transient receptor potential vanilloid 4 (TRPV4) is functionally expressed in airway smooth muscle cells and that TRPV4 single nucleotide polymorphisms are associated with airflow obstruction in patients with chronic obstructive pulmonary disease.

In vivo evaluation of anionic thiolated polymers as oral delivery systems for efflux pump inhibition.

Thomas F Palmberger et al.

International journal of pharmaceutics, 491(1-2), 318-322 (2015-06-23)

Recently, the cationic polymer thiolated chitosan has been reported to modulate drug absorption by inhibition of intestinal efflux pumps. The objective of this study was to evaluate in vitro and in vivo whether thiolated anionic biopolymers also show an efflux

Diversity and enumeration of halophilic and alkaliphilic bacteria in Spanish-style green table-olive fermentations.

Helena Lucena-Padrós et al.

Food microbiology, 53(Pt B), 53-62 (2015-12-19)

The presence and enumeration of halophilic and alkaliphilic bacteria in Spanish-style table-olive fermentations was studied. Twenty 10-tonne fermenters at two large manufacturing companies in Spain, previously studied through both culture dependent and independent (PCR-DGGE) methodologies, were selected. Virtually all this

Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly.

Alok Pandey et al.

The Journal of biological chemistry, 288(52), 36773-36786 (2013-11-13)

For iron-sulfur (Fe-S) cluster synthesis in mitochondria, the sulfur is derived from the amino acid cysteine by the cysteine desulfurase activity of Nfs1. The enzyme binds the substrate cysteine in the pyridoxal phosphate-containing site, and a persulfide is formed on

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Shaun M Cote et al.

Biochemistry, 52(51), 9141-9154 (2013-11-26)

NEMO (NF-κB essential modulator) associates with catalytic subunits IKKα and IKKβ to form the IκB kinase (IKK) complex and is a key regulator of NF-κB pathway signaling. Biochemical and structural characterization of NEMO has been challenging, however, leading to conflicting

The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats.

Shangchun Li et al.

Environmental toxicology, 30(12), 1470-1480 (2014-06-26)

In the present study, we investigated the role of glutathione (GSH) and its related enzymes in Sprague Dawley (SD) rats subjected to microcystin-leucine-arginine (MCLR)-induced hepatotoxicity. SD rats were intraperitoneally (i.p.) injected with MCLR after pretreating with or without buthionine-(S,R)-sulfoximine (BSO)

Fabrication of chiral amino acid ionic liquid modified magnetic multifunctional nanospheres for centrifugal chiral chromatography separation of racemates.

Yating Liu et al.

Journal of chromatography. A, 1400, 40-46 (2015-05-16)

As the rapid development of nanotechnology, the magnetic nanospheres modified with special chiral selective ligands show a great potentiality in enantiomeric separation. In this study, magnetic nanospheres modified with task-specific chiral ionic liquid were designed for the separation of chiral

Structure of an agonist-bound ionotropic glutamate receptor.

Maria V Yelshanskaya et al.

Science (New York, N.Y.), 345(6200), 1070-1074 (2014-08-12)

Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex

Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications.

Huifang Xu et al.

The Journal of biological chemistry, 289(19), 13565-13574 (2014-03-29)

The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by collagen. DDR activation does not appear to occur by the common mechanism of ligand-induced receptor dimerization: the DDRs form stable noncovalent dimers in the absence

Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status.

Jie Zhou et al.

Journal of pharmaceutical sciences, 104(8), 2619-2626 (2015-06-09)

There is an increasing interest in using N-acetylcysteine (NAC) as a treatment for neurodegenerative disorders to increase glutathione (GSH) levels and its redox status. The purpose of this study was to characterize the biosynthesis of NAC to GSH using a

Camphor modulates TRPV3 cation channels activity by interacting with critical pore-region cysteine residues.

Muhammad Azhar Sherkheli et al.

Pakistan journal of pharmaceutical sciences, 26(3), 431-438 (2013-04-30)

TRPV3 ion channels mediate thermo-transduction, nociception, inflammation and dermatitis in mammals. TRPV1-4 proteins have been shown to have conserved cysteine-residues in the pore-forming regions. These residues participate in channel activation via S-nitrosylation of channel proteins. Camphor is a commonly used

Rosmarinic acid inhibits chemical hypoxia-induced cytotoxicity in primary cultured rat hepatocytes.

Yu Jin Jeon et al.

Archives of pharmacal research, 37(7), 907-915 (2013-10-03)

We examine the effect of rosmarinic acid (RA) in chemical hypoxia-induced injury in rat hepatocytes. Cell viability was significantly decreased by cobalt chloride (CoCl2), a well-known hypoxia mimetic agent in a time- and dose- dependent manner. RA pretreatment before exposure

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