778966

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Showing 1-13 of 13 results for "778966" within Papers

Synthesis of 2-hydroxypropyl-$\beta$-cyclodextrin/pluronic-based polyrotaxanes via heterogeneous reaction as potential Niemann-Pick type C therapeutics

Yawo MA,et al.

Biomacromolecules, 14, 4189-4197 (2013)

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

Rachel J Smith et al.

The European journal of neuroscience, 30(3), 493-503 (2009-08-07)

The orexin/hypocretin system has recently been implicated in reward-processing and addiction. We examined the involvement of the orexin system in cue-induced reinstatement of extinguished cocaine-seeking by administering the orexin 1 receptor antagonist SB-334867 (SB) or the orexin 2 receptor antagonist

Progesterone administration modulates cortical TLR4/NF-κB signaling pathway after subarachnoid hemorrhage in male rats.

Zhong Wang et al.

Mediators of inflammation, 2011, 848309-848309 (2011-03-16)

Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI)

?Back to the future?: a new look at hydroxypropyl beta-cyclodextrins.

Malanga M, et al.

Journal of Pharmaceutical Sciences, 105(9), 2921-2931 (2016)

A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.

Weijin Wang et al.

Theranostics, 11(11), 5279-5295 (2021-04-17)

Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the related tauopathies, thus targeting tau could be promising for drug development. Proteolysis Targeting Chimera (PROTAC) is a novel drug discovery strategy for selective protein degradation from

Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™.

Jagdishbhai L Italia et al.

PloS one, 6(10), e25744-e25744 (2011-10-15)

Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but

When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists.

D E Rusyniak et al.

Neuroscience, 154(4), 1619-1626 (2008-06-07)

When given in a warm environment MDMA (3,4-methylenedioxymethamphetamine, ecstasy) causes hyperthermia by increasing interscapular brown adipose tissue (iBAT) heat production and decreasing heat loss via cutaneous vasoconstriction. When given in a cold environment, however, MDMA causes hypothermia by an unknown

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease.

Shuhua Chen et al.

PloS one, 6(8), e24293-e24293 (2011-09-16)

Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning and memory deficits in the male triple

2-Hydroxypropyl-?-cyclodextrin acts as a novel anticancer agent.

Yokoo M, et al.

PLoS ONE, 10(11), e0141946-e0141946 (2015)

2-Hydroxypropyl-?-cyclodextrin (HP-?-CD): a toxicology review.

Gould S & Scott RC.

Food And Chemical Toxicology, 43(10), 1451-1459 (2005)

Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.

Dmitri R Davydov et al.

Biochemistry, 47(43), 11348-11359 (2008-10-04)

To establish a direct method for monitoring substrate binding in cytochrome P450eryF applicable at elevated hydrostatic pressures, we introduce a laser dye Fluorol-7GA (F7GA) as a novel fluorescent ligand. The high intensity of fluorescence and the reasonable resolution of the

Hydroxypropyl-$\beta$-cyclodextrin-based solid dispersed granules: A prospective alternative to conventional solid dispersion

Jung Suk K,et al.

International Journal of Pharmaceutics, 628, 122286-122286 (2022)

Hydroxypropyl-$\beta$-cyclodextrin as a versatile additive for the formation of metastable tetragonal zirconia exhibiting high thermal stability

Lei B,et al.

CrystEngComm, 15, 2076-2083 (2013)

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