78069

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Showing 1-30 of 88 results for "78069" within Papers

Relationships between degree of polymerization and antioxidant activities: a study on proanthocyanidins from the leaves of a medicinal mangrove plant Ceriops tagal.

Hai-Chao Zhou et al.

PloS one, 9(10), e107606-e107606 (2014-10-15)

Tannins from the leaves of a medicinal mangrove plant, Ceriops tagal, were purified and fractionated on Sephadex LH-20 columns. 13C nuclear magnetic resonance (13C-NMR), reversed/normal high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI MS) and matrix-assisted laser desorption/ionization time-of-flight

Modification of sialylation is associated with multidrug resistance in human acute myeloid leukemia.

H Ma et al.

Oncogene, 34(6), 726-740 (2014-02-18)

Aberrant cell surface sialylation patterns have been shown to correlate with tumor progression and metastasis. However, the role of sialylation regulation of cancer multidrug resistance (MDR) remains poorly understood. This study investigated sialylation in modification on MDR in acute myeloid

Ingredients in fruit juices interact with dasatinib through inhibition of BCRP: a new mechanism of beverage-drug interaction.

Brett Fleisher et al.

Journal of pharmaceutical sciences, 104(1), 266-275 (2014-11-25)

Small molecule tyrosine kinase inhibitors (TKIs) are a group of highly novel and target-specific anticancer drugs. Recently, most TKIs are found to be substrates of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). However, little information is available regarding the

An automated mass spectrometry-based screening method for analysis of sulfated glycosaminoglycans.

Nadezda Kiselova et al.

Biochemical and biophysical research communications, 450(1), 598-603 (2014-06-15)

Glycosaminoglycans (GAGs) are linear polysaccharides, consisting of repeated disaccharide units, attached to core proteins in all multicellular organisms. Chondroitin sulfate (CS) and dermatan sulfate (DS) constitute a subgroup of sulfated GAGs for which the degree of sulfation varies between species

The RimL transacetylase provides resistance to translation inhibitor microcin C.

Teymur Kazakov et al.

Journal of bacteriology, 196(19), 3377-3385 (2014-07-09)

Peptide-nucleotide antibiotic microcin C (McC) is produced by some Escherichia coli strains. Inside a sensitive cell, McC is processed, releasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase. The product of mccE, a gene from the plasmid-borne McC biosynthetic

Detection and quantitation of low abundance oligosaccharides in recombinant monoclonal antibodies.

Gomathinayagam Ponniah et al.

Analytical chemistry, 87(5), 2718-2726 (2015-02-04)

Oligosaccharides are critical for structural integrity, stability, and biological functions of recombinant monoclonal antibodies. It is relatively easy to characterize, quantify, and determine the impact of major glycoforms. While challenging to detect and quantify, certain low abundance oligosaccharides are highly

Coformer screening using thermal analysis based on binary phase diagrams.

Hiroyuki Yamashita et al.

Pharmaceutical research, 31(8), 1946-1957 (2014-02-14)

The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams

Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2009-2010.

David J Harvey

Mass spectrometry reviews, 34(3), 268-422 (2014-05-28)

This review is the sixth update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2010. General aspects

Fatty acid synthesis and oxidation in cumulus cells support oocyte maturation in bovine.

Laura Sanchez-Lazo et al.

Molecular endocrinology (Baltimore, Md.), 28(9), 1502-1521 (2014-07-25)

Oocyte meiotic maturation requires energy from various substrates including glucose, amino acids, and lipids. Mitochondrial fatty acid (FA) β-oxidation (FAO) in the oocyte is required for meiotic maturation, which is accompanied by differential expression of numerous genes involved in FAs

Mycobacterial envelope lipids fingerprint from direct MALDI-TOF MS analysis of intact bacilli.

Gérald Larrouy-Maumus et al.

Tuberculosis (Edinburgh, Scotland), 95(1), 75-85 (2014-12-10)

Mycobacterium tuberculosis (Mtb) lipids including glycolipids and lipoglycans play a crucial role in the modulation of the host immune response by targeting the innate receptors C-type lectins, TLRs and the CD1 proteins of class 1. Glycolipids have been shown to

In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.

Jose Castro-Perez et al.

Rapid communications in mass spectrometry : RCM, 28(22), 2471-2479 (2014-10-11)

The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a stable isotope labeled tracer protocol with matrix-assisted

Electrospun highly ordered mesoporous silica-carbon composite nanofibers for rapid extraction and prefractionation of endogenous peptides.

Gang-Tian Zhu et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 21(11), 4450-4456 (2015-02-03)

A simple method was developed for the preparation of ordered mesoporous silica-carbon composite nanofibers (OMSCFs). The OMSCFs exhibited high carbon content, continuously long fibrous properties, uniform accessible mesopores, and a large surface area. The OMSCFs were also found to have

Mass imaging of ketamine in a single scalp hair by MALDI-FTMS.

Min Shen et al.

Analytical and bioanalytical chemistry, 406(19), 4611-4616 (2014-06-08)

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) coupled with mass spectrometry imaging (MSI) is a rapidly emerging technology that produces distribution maps of small pharmaceutical molecules in situ in tissue sections. Segmental hair analysis provides useful information regarding the state and

N-glycans: phenotypic homology and structural differences between myocardial cells and induced pluripotent stem cell-derived cardiomyocytes.

Takuji Kawamura et al.

PloS one, 9(10), e111064-e111064 (2014-10-31)

Cell surface glycans vary widely, depending on cell properties. We hypothesized that glycan expression on induced pluripotent stem cells (iPSCs) might change during cardiomyogenic differentiation toward the myocardial phenotype. N-glycans were isolated from iPSCs, iPSC-derived cardiomyocytes (iPSC-CM), and original C57BL/6

In vivo enzyme inhibition improves the targeting of [177Lu]DOTA-GRP(13-27) in GRPR-positive tumors in mice.

Panteleimon J Marsouvanidis et al.

Cancer biotherapy & radiopharmaceuticals, 29(9), 359-367 (2014-10-07)

Gastrin-releasing peptide receptors (GRPR) and GRP-derived analogs have attracted attention due to high receptor expression in frequently occurring human neoplasia. The authors recently synthesized a series of GRPR-affine peptide analogs based on the 27-mer GRP and derivatized with the DOTA

Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.

Saleh Rachidi et al.

Journal of hepatology, 62(4), 879-888 (2014-12-03)

gp96, or grp94, is an endoplasmic reticulum (ER)-localized heat shock protein 90 paralog that acts as a protein chaperone and plays an important role for example in ER homeostasis, ER stress, Wnt and integrin signaling, and calcium homeostasis, which are

How subtle is the "terroir" effect? Chemistry-related signatures of two "climats de Bourgogne".

Chloé Roullier-Gall et al.

PloS one, 9(5), e97615-e97615 (2014-05-27)

The chemical composition of grape berries is influenced by various environmental conditions often considered to be representative of a "terroir". If grapes from a given terroir are assumed to reflect this origin in their chemical compositions, the corresponding wine should

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Janique Vandal et al.

Pharmaceutical biology, 53(6), 800-806 (2015-02-24)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only a few antimicrobial agents left that can be used against MDR

A protective chimeric antibody to tick-borne encephalitis virus.

Ivan K Baykov et al.

Vaccine, 32(29), 3589-3594 (2014-05-20)

The efficiency of several mouse monoclonal antibodies (mAbs) specific to the tick-borne encephalitis virus (TBEV) glycoprotein E in post-exposure prophylaxis was assessed, and mAb14D5 was shown to be the most active of all those studied. It was proven that the

Perovskite for the highly selective enrichment of phosphopeptides.

Xiao-Shui Li et al.

Journal of chromatography. A, 1376, 143-148 (2014-12-30)

Selective and effective enrichment of phosphopeptides from complex samples is essential in phosphoproteome study by mass spectrometry (MS). In this work, we compared perovskites (MgTiO3, CaTiO3, SrTiO3, BaTiO3 and CaZrO3) with metal oxides (ZrO2 and TiO2) in their capability for

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.

Maximiliano J Jiménez-Dalmaroni et al.

Innate immunity, 21(2), 175-193 (2014-03-05)

TLRs are key innate immune receptors that recognize conserved features of biological molecules that are found in microbes. In particular, TLR2 has been reported to be activated by different kinds of microbial ligands. To advance our understanding of the interaction

Investigation of minor species Candida africana, Candida stellatoidea and Candida dubliniensis in the Candida albicans complex among Yaoundé (Cameroon) HIV-infected patients.

Thierry K Ngouana et al.

Mycoses, 58(1), 33-39 (2014-10-08)

Minor species of the Candida albicans complex may cause overestimation of the epidemiology of C. albicans, and misidentifications could mask their implication in human pathology. Authors determined the occurrence of minor species of the C. albicans complex (C. africana, C.

Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor.

Junichi Taira et al.

Journal of biochemistry, 155(6), 353-360 (2014-02-19)

Growth factor receptor-bound protein 14 (Grb14) interacts with insulin receptor (IR) through the between PH and SH2 (BPS) domain. Grb14-IR complex formation is initiated by insulin stimulation, and the binding event results in the inhibition of insulin signalling. Thus, Grb14

Phosphoproteome of Cryptococcus neoformans.

Lakshmi Dhevi N Selvan et al.

Journal of proteomics, 97, 287-295 (2013-07-16)

Cryptococcus neoformans is an encapsulated pathogenic yeast, which causes life threatening meningitis in immunocompromised individuals. C. neoformans var. grubii is the most prevalent and virulent form among the two varieties of C. neoformans - C. neoformans var. grubii and C.

LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.

Rasha H Alghamdi et al.

European journal of medicinal chemistry, 92, 890-907 (2015-02-14)

High level of Low Density Lipoprotein-Cholesterol (LDL-C) in circulation in the blood is associated with an elevated risk of cardiovascular disease (CVD) and stroke. Currently the statin drugs which inhibit the enzyme HMG-CoA reductase responsible for cholesterol synthesis in the

Gaucher disease due to saposin C deficiency is an inherited lysosomal disease caused by rapidly degraded mutant proteins.

Marialetizia Motta et al.

Human molecular genetics, 23(21), 5814-5826 (2014-06-14)

Saposin (Sap) C is an essential cofactor for the lysosomal degradation of glucosylceramide (GC) by glucosylceramidase (GCase) and its functional impairment underlies a rare variant form of Gaucher disease (GD). Sap C promotes rearrangement of lipid organization in lysosomal membranes

Metabolite localization by atmospheric pressure high-resolution scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging in whole-body sections and individual organs of the rove beetle Paederus riparius.

Dhaka Ram Bhandari et al.

Analytical and bioanalytical chemistry, 407(8), 2189-2201 (2014-11-27)

Mass spectrometry imaging provides for non-targeted, label-free chemical imaging. In this study, atmospheric pressure high-resolution scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging (AP-SMALDI MSI) was used for the first time to describe the chemical distribution of the defensive compounds

Capillary electrophoresis fingerprinting of 8-aminopyrene-1,3,6-trisulfonate derivatized nitrocellulose after partial acid depolymerization.

Elodie Alinat et al.

Journal of chromatography. A, 1387, 134-143 (2015-02-24)

Fine characterization of nitrocellulose (NC) remains a challenge, especially in forensic analysis, and a strategy consisting in obtaining representative fingerprints by a separation technique, as for proteins, is of prime interest. In this work, we first established that NCs (especially

Protective immunity against enteral stages of Trichinella spiralis elicited in mice by live attenuated Salmonella vaccine that secretes a 30-mer parasite epitope fused to the molecular adjuvant C3d-P28.

Ericka N Pompa-Mera et al.

Research in veterinary science, 97(3), 533-545 (2014-10-15)

The development of a veterinary vaccine against T. spiralis infection is an alternative strategy to control trichinellosis. In an effort to develop an efficient vaccine, BALB/c mice were immunized with attenuated Salmonella enterica serovar Typhimurium SL3261 that expresses a 30-mer

Desulfovibrio desulfuricans isolates from the gut of a single individual: structural and biological lipid A characterization.

Wei Zhang-Sun et al.

FEBS letters, 589(1), 165-171 (2014-12-06)

The levels of sulfate-reducing bacteria (SRB), including Desulfovibrionaceae, in the gut increase following a fat-enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae

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