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Showing 1-30 of 48 results for "810150c" within Papers
Wajih Anwer et al.
Biophysical journal, 118(5), 1032-1043 (2020-02-07)
Excessive accumulation of acylcarnitines (ACs), often caused by metabolic disorders, has been associated with obesity, arrhythmias, cardiac ischemia, insulin resistance, etc. Mechanisms whereby elevated ACs might contribute to pathophysiological effects remain largely unexplored. We have aimed to gain insight into
Laure Gibot et al.
Cancers, 12(2) (2020-02-13)
The use of nanocarriers for hydrophobic photosensitizers, in the context of photodynamic therapy (PDT) to improve pharmacokinetics and bio-distribution, is well-established. However, the mechanisms at play in the internalization of nanocarriers are not well-elucidated, despite its importance in nanocarrier design.
A triple chain polycationic peptide-mimicking amphiphile - efficient DNA-transfer without co-lipids.
Shashank Reddy Pinnapireddy et al.
Biomaterials science, 8(1), 232-249 (2019-11-05)
Non-viral gene delivery in its current form is largely dependent upon the ability of a delivery vehicle to protect its cargo in the extracellular environment and release it efficiently inside the target cell. Also a simple delivery system is required
Margrethe A Boyd et al.
Biophysical journal, 115(7), 1307-1315 (2018-09-17)
Cells dynamically regulate their membrane surface area during a variety of processes critical to their survival. Recent studies with model membranes have pointed to a general mechanism for surface area regulation under tension in which cell membranes unfold or take
Qing Wang et al.
Biophysical journal, 115(4), 664-678 (2018-08-08)
Using Förster resonance energy transfer, raft/liquid-ordered-domain formation was assessed in asymmetric vesicles containing outer leaflets composed of high-Tm (melting temperature) saturated phosphatidylcholines (diC18:0PC, diC16:0PC, diC15:0PC, or diC14:0PC), low-Tm unsaturated dioleoylphosphatidylcholine (DOPC) and cholesterol, and inner leaflets composed of lipids that
Spatiotemporal control of coacervate formation within liposomes
Deshpande S, et al.
Nature Communications, 10(1), 1800-1800 (2019)
Yang Liu et al.
Nature communications, 10(1), 5108-5108 (2019-11-11)
Mounting evidence suggests that the tumor microenvironment is profoundly immunosuppressive. Thus, mitigating tumor immunosuppression is crucial for inducing sustained antitumor immunity. Whereas previous studies involved intratumoral injection, we report here an inhalable nanoparticle-immunotherapy system targeting pulmonary antigen presenting cells (APCs)
Mart G F Last et al.
ACS nano, 14(4), 4487-4498 (2020-04-03)
Membraneless organelles formed by liquid-liquid phase separation are dynamic structures that are employed by cells to spatiotemporally regulate their interior. Indeed, complex coacervation-based phase separation is involved in a multitude of biological tasks ranging from photosynthesis to cell division to
Sathish Ramakrishnan et al.
Langmuir : the ACS journal of surfaces and colloids, 34(20), 5849-5859 (2018-04-26)
In vivo membrane fusion primarily occurs between highly curved vesicles and planar membranes. A better understanding of fusion entails an accurate in vitro reproduction of the process. To date, supported bilayers have been commonly used to mimic the planar membranes.
Yasunori Watanabe et al.
The Journal of biological chemistry, 295(10), 3257-3268 (2020-02-02)
Eukaryotic cells are compartmentalized to form organelles, whose functions rely on proper phospholipid and protein transport. Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transfer phosphatidylserine, at 2.2 Å resolution. We
Mingming Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(25), 7509-7518 (2018-06-01)
This article reports a high-yield procedure for preparing microsized (giant) Janus liposomes via gel-assisted lipid swelling and clustering behavior of these liposomes directed by biotin-avidin affinity binding. Confocal fluorescence microscopy reveals in detail that these new lipid colloidal particles display
Megan B Miller et al.
The Journal of biological chemistry, 290(21), 13541-13555 (2015-04-12)
Previous studies revealed an essential role for the lipid-binding Sec14 domain of kalirin (KalSec14), but its mechanism of action is not well understood. Because alternative promoter usage appends unique N-terminal peptides to the KalSec14 domain, we used biophysical, biochemical, and
Hudson P Pace et al.
Analytical chemistry, 90(21), 13065-13072 (2018-10-24)
Over the last two decades, supported lipid bilayers (SLBs) have been extensively used as model systems to study cell membrane structure and function. While SLBs have been traditionally produced from simple lipid mixtures, there has been a recent surge in
Samuel T Hess et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(44), 17370-17375 (2007-10-26)
Organization in biological membranes spans many orders of magnitude in length scale, but limited resolution in far-field light microscopy has impeded distinction between numerous biomembrane models. One canonical example of a heterogeneously distributed membrane protein is hemagglutinin (HA) from influenza
A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim W, et al.
Nature, 556(7699), 103-103 (2018)
Erdem Karatekin et al.
Nature protocols, 7(5), 903-920 (2012-04-21)
Many biological processes rely on membrane fusion, and therefore assays to study its mechanisms are necessary. Here we report an assay with sensitivity to single-vesicle, and even to single-molecule events using fluorescently labeled vesicle-associated v-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein
Huan Bao et al.
Nature, 554(7691), 260-263 (2018-02-09)
The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known about the mechanisms that determine the size and kinetic properties of these transient structures. Here, we reduced the number of available SNAREs (proteins that mediate
Ghazi Ben Messaoud et al.
Soft matter, 16(10), 2540-2551 (2020-02-26)
Lipid lamellar hydrogels are a class of soft materials composed of a defectuous lipid lamellar phase, where defects are classically stabilized by polymer or surfactant inclusions in lipid membranes. We have recently shown that bolaform microbial glucolipids, composed of a
Mudassar Mumtaz Virk et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 395-405 (2017-12-13)
Hybrid vesicles, comprising blends of amphiphilic block copolymers and phospholipids, have attracted significant attention recently because of their unique combination of chemical and physical properties. We report a method to make unilamellar hybrid vesicles with diameters of 100 nm by
Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids
Vance JE
Journal of Lipid Research, 49(7), 1377-1387 (2008)
Naoki Yoshikawa et al.
Pharmaceutics, 12(4) (2020-04-16)
Understanding the in vivo fate of lipoplex, which is composed of cationic liposomes and DNA, is an important issue toward gene therapy. In disease conditions, the fate of lipoplex might change compared with the normal condition. Here, we examined the
Sigalit Meker et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9548-9560 (2018-07-19)
Amyloid-β (Aβ) peptide has been implicated in Alzheimer's disease, which is a leading cause of death worldwide. The interaction of Aβ peptides with the lipid bilayers of neuronal cells is a critical step in disease pathogenesis. Recent evidence indicates that
Max Piffoux et al.
ACS nano, 12(7), 6830-6842 (2018-07-06)
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery. However, efficient and reproducible loading of EVs with therapeutic or imaging agents
Non Miyata et al.
The Journal of cell biology, 214(1), 77-88 (2016-06-30)
Phosphatidylethanolamine (PE) is an essential phospholipid for mitochondrial functions and is synthesized mainly by phosphatidylserine (PS) decarboxylase at the mitochondrial inner membrane. In Saccharomyces cerevisiae, PS is synthesized in the endoplasmic reticulum (ER), such that mitochondrial PE synthesis requires PS
Ataru Seimei et al.
Journal of colloid and interface science, 569, 211-218 (2020-03-01)
We investigated the formation behavior of supported lipid bilayers (SLBs) on polyelectrolyte multilayers (PEMs) prepared using the layer-by-layer method. The SLBs were formed using the liposome fusion method, which was driven by electrostatic interactions. We used three types of cationic
Stuart A Whitehead et al.
Bioconjugate chemistry, 28(4), 923-932 (2017-03-02)
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion, oxo-dibenzocyclooctyne (ODIBO)-lipid 1 was designed, synthesized, and studied alongside azadibenzocyclooctyne
Yachong Guo et al.
ACS nano (2018-11-20)
Increasing awareness of bioeffects and toxicity of nanomaterials interacting with cells puts in focus the mechanisms by which nanomaterials can cross lipid membranes. Apart from well-discussed energy-dependent endocytosis for large objects and passive diffusion through membranes by solute molecules, other
Kenta Okuno et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183377-183377 (2020-05-29)
Photopolymerizable lipids, such as diacetylene lipids have attracted much attention for their ability to stabilize lipid bilayer structure. In this study, we investigated the phase separation behavior of a lipid bilayer containing 1,2‑bis(10,12‑tricosadiynoyl)‑sn‑glycero‑3‑phosphocholine (DiynePC). The phase separation behavior of liposomes
Hanna M G Barriga et al.
Langmuir : the ACS journal of surfaces and colloids, 35(50), 16521-16527 (2019-11-09)
Dispersions of nonlamellar lipid membrane assemblies are gaining increasing interest for drug delivery and protein therapeutic application. A key bottleneck has been the lack of rational design rules for these systems linking different lipid species and conditions to defined lattice
Ming-Tao Lee et al.
Biochemistry, 57(38), 5629-5639 (2018-08-29)
Daptomycin is a phosphatidylglycerol specific, calcium-dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A recent Bacillus subtilis study found that daptomycin clustered into fluid lipid domains of bacterial membranes and the membrane binding was correlated
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