Search Within
810255P
Applied Filters:
Keyword:'810255P'
Showing 1-30 of 39 results for "810255P" within Papers
Jeremias Sibold et al.
Physical chemistry chemical physics : PCCP, 22(17), 9308-9315 (2020-04-21)
Lipid domains in plasma membranes act as molecular sorting platforms for e.g., signalling processes. In model membranes, such as freestanding or supported bilayers, some lipid domains with defined chemical composition, lipid packing and physical behaviour can be reproduced. However, in
Hyeon Young Kim et al.
Journal of nanobiotechnology, 18(1), 17-17 (2020-01-23)
This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid vesicles. Budesonide (Bud), an anti-inflammatory drug was chosen as a model drug and encapsulated into
María Trinidad Soria-Florido et al.
Circulation, 141(6), 444-453 (2020-01-17)
Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date
Ali Khattib et al.
BioFactors (Oxford, England), 46(1), 146-157 (2019-10-30)
Many population studies have shown that blood concentrations of high-density lipoprotein (HDL) cholesterol are inversely correlated with risk of cardiovascular disease (CVD). However, in recent studies, increasing blood HDL cholesterol concentrations failed to reduce CVD events. On the other hand
Janus Liposomes: Gel-Assisted Formation and Bioaffinity-Directed Clustering
Wang M, et al.
Langmuir, 34(25), 7509-7518 (2018)
Salvatore Chiantia et al.
Biochimica et biophysica acta, 1778(5), 1356-1364 (2008-03-19)
Ceramide-induced alterations in the lateral organization of membrane proteins can be involved in several biological contexts, ranging from apoptosis to viral infections. In order to investigate such alterations in a simple model, we used a combined approach of atomic force
Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation
Nagano Y, et al.
Journal of the American Heart Association, 8(9), e011975-e011975 (2019)
Robert M Littleton et al.
BMC complementary and alternative medicine, 12, 105-105 (2012-07-25)
Consumers are increasingly turning to plant-based complementary and alternative medicines to treat hypercholesterolemia. Many of these treatments are untested and their efficacy is unknown. This multitude of potential remedies necessitates a model system amenable to testing large numbers of organisms
Silvia Scolari et al.
Biochemistry, 49(42), 9027-9031 (2010-09-25)
Seminal plasma proteins of the fibronectin type II (Fn2) family modulate mammalian spermatogenesis by triggering the release of the lipids phosphatidylcholine and cholesterol from sperm cells. Whereas the specific interaction of these proteins with phosphatidylcholine is well-understood, their selectivity for
Ma Feng et al.
European journal of preventive cardiology, 2047487319894114-2047487319894114 (2019-12-17)
Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are
Zaiguo Li et al.
The Journal of organic chemistry, 71(4), 1718-1721 (2006-02-14)
Analogues of cholesterol (compounds 1 and 2) and coprostanol (compound 3) containing the BODIPY fluorophore in the aliphatic tail of the free sterol have been synthesized starting with bisnorcholenic acid, cholenic acid 3beta-acetate, and lithocholic acid, respectively. An ester linkage
Jameson T Crowley et al.
PLoS pathogens, 9(1), e1003109-e1003109 (2013-01-18)
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol
Zaiguo Li et al.
The Journal of organic chemistry, 72(22), 8376-8382 (2007-10-05)
Two analogues (1, 2) of free cholesterol and one analogue (3) of the immunosuppressive sphingolipid FTY720 containing a boron dipyrromethene chromophore (BODIPY) were synthesized. The synthetic routes involved preparation of boron dipyrromethene moieties (5, 11), bearing a phenylethynyl group at
Kaoru Yamashita et al.
Biochemical and biophysical research communications, 524(1), 184-189 (2020-01-27)
Plasma aldosterone concentration increases in proportion to the severity of heart failure, even during treatment with renin-angiotensin system inhibitors. This study investigated alternative regulatory mechanisms of aldosterone production that are significant in heart failure. Dahl salt-sensitive rats on a high-salt
Michele R Plewes et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5299-5316 (2020-02-23)
The corpus luteum is an endocrine gland that synthesizes and secretes progesterone. Luteinizing hormone (LH) activates protein kinase A (PKA) signaling in luteal cells, increasing delivery of substrate to mitochondria for progesterone production. Mitochondria maintain a highly regulated equilibrium between
Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure
Solanko LM, et al.
Biophysical Journal, 105(9), 2082-2092 (2013)
Katarina Trajkovic et al.
Science (New York, N.Y.), 319(5867), 1244-1247 (2008-03-01)
Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find
James E Shaw et al.
Biophysical journal, 90(6), 2170-2178 (2005-12-20)
Coupling atomic force microscopy (AFM) with high-resolution fluorescence microscopy is an attractive means of identifying membrane domains by both physical topography and fluorescence. We have used this approach to study the ability of a suite of fluorescent molecules to probe
Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens
Cockburn CL, et al.
Life science alliance, 2(2), e201800292-e201800292 (2019)
Maarit Hölttä-Vuori et al.
Traffic (Copenhagen, Denmark), 9(11), 1839-1849 (2008-07-24)
Analysis of sterol distribution and transport in living cells has been hampered by the lack of bright, photostable fluorescent sterol derivatives that closely resemble cholesterol. In this study, we employed atomistic simulations and experiments to characterize a cholesterol compound with
Hye-Ra Lee et al.
International journal of molecular sciences, 21(3) (2020-02-06)
Hepatitis C virus (HCV) p7 is known to be a nonselective cation channel for HCV maturation. Because the interaction of HCV proteins with host lipids in the endoplasmic reticulum membrane is crucial for the budding process, the identification of p7-lipid
Toshihiko Oshita et al.
Clinica chimica acta; international journal of clinical chemistry, 503, 136-144 (2020-01-24)
Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity
Hye-Ra Lee et al.
mBio, 11(2) (2020-04-16)
To overcome increasing bacterial resistance to conventional antibiotics, many antimicrobial peptides (AMPs) derived from host defense proteins have been developed. However, there are considerable obstacles to their application to systemic infections because of their low bioavailability. In the present study
Clemens Röhrl et al.
Current pharmaceutical biotechnology, 13(2), 331-340 (2011-04-08)
Diaminobenzidine (DAB) photooxidation is a method for conversion of fluorescent signals into electron-dense precipitates that are visible in the electron microscope. Recently, we have applied this method to analyze organelles involved in holo-high density lipoprotein (HDL) particle uptake at the
Wendy Blay Puryear et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7475-7480 (2012-04-25)
The interaction between HIV and dendritic cells (DCs) is an important early event in HIV-1 pathogenesis that leads to efficient viral dissemination. Here we demonstrate a HIV gp120-independent DC capture mechanism that uses virion-incorporated host-derived gangliosides with terminal α2-3-linked sialic
Hiurma Sánchez-Pérez et al.
Rheumatology (Oxford, England) (2020-02-18)
Lipid profiles appear to be altered in SLE patients due to disease activity and inflammation. Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein cholesterol to accept cholesterol from macrophages. CEC has been linked to cardiovascular events in the
Frederik W Lund et al.
BMC biophysics, 5, 20-20 (2012-10-20)
Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking
Mingming Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(25), 7509-7518 (2018-06-01)
This article reports a high-yield procedure for preparing microsized (giant) Janus liposomes via gel-assisted lipid swelling and clustering behavior of these liposomes directed by biotin-avidin affinity binding. Confocal fluorescence microscopy reveals in detail that these new lipid colloidal particles display
Jannik Ruwisch et al.
American journal of respiratory cell and molecular biology (2020-01-11)
Surfactant protein C (SP-C) deficiency is found in samples from patients suffering idiopathic pulmonary fibrosis (IPF), especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling in aging mice and alveolar lipid homeostasis. For
Bo Y Baker et al.
The Journal of biological chemistry, 282(14), 10223-10232 (2007-02-16)
Steroidogenic acute regulatory protein (StAR) stimulates adrenal and gonadal steroidogenesis by increasing the influx of cholesterol into mitochondria, where it is converted to pregnenolone to initiate steroidogenesis. StAR acts on the outer mitochondrial membrane where each molecule stimulates the mitochondrial
Page 1 of 2