CN
Search Within
810255P
Applied Filters:
Keyword:'810255P'
Showing 1-30 of 39 results for "810255P" within Papers
Jameson T Crowley et al.
PLoS pathogens, 9(1), e1003109-e1003109 (2013-01-18)
Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol
Kaoru Yamashita et al.
Biochemical and biophysical research communications, 524(1), 184-189 (2020-01-27)
Plasma aldosterone concentration increases in proportion to the severity of heart failure, even during treatment with renin-angiotensin system inhibitors. This study investigated alternative regulatory mechanisms of aldosterone production that are significant in heart failure. Dahl salt-sensitive rats on a high-salt
Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogens
Cockburn CL, et al.
Life science alliance, 2(2), e201800292-e201800292 (2019)
Zaiguo Li et al.
The Journal of organic chemistry, 72(22), 8376-8382 (2007-10-05)
Two analogues (1, 2) of free cholesterol and one analogue (3) of the immunosuppressive sphingolipid FTY720 containing a boron dipyrromethene chromophore (BODIPY) were synthesized. The synthetic routes involved preparation of boron dipyrromethene moieties (5, 11), bearing a phenylethynyl group at
Katarina Trajkovic et al.
Science (New York, N.Y.), 319(5867), 1244-1247 (2008-03-01)
Intraluminal vesicles of multivesicular endosomes are either sorted for cargo degradation into lysosomes or secreted as exosomes into the extracellular milieu. The mechanisms underlying the sorting of membrane into the different populations of intraluminal vesicles are unknown. Here, we find
Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure
Solanko LM, et al.
Biophysical Journal, 105(9), 2082-2092 (2013)
Robert M Littleton et al.
BMC complementary and alternative medicine, 12, 105-105 (2012-07-25)
Consumers are increasingly turning to plant-based complementary and alternative medicines to treat hypercholesterolemia. Many of these treatments are untested and their efficacy is unknown. This multitude of potential remedies necessitates a model system amenable to testing large numbers of organisms
Salvatore Chiantia et al.
Biochimica et biophysica acta, 1778(5), 1356-1364 (2008-03-19)
Ceramide-induced alterations in the lateral organization of membrane proteins can be involved in several biological contexts, ranging from apoptosis to viral infections. In order to investigate such alterations in a simple model, we used a combined approach of atomic force
Ali Khattib et al.
BioFactors (Oxford, England), 46(1), 146-157 (2019-10-30)
Many population studies have shown that blood concentrations of high-density lipoprotein (HDL) cholesterol are inversely correlated with risk of cardiovascular disease (CVD). However, in recent studies, increasing blood HDL cholesterol concentrations failed to reduce CVD events. On the other hand
Impaired Cholesterol-Uptake Capacity of HDL Might Promote Target-Lesion Revascularization by Inducing Neoatherosclerosis After Stent Implantation
Nagano Y, et al.
Journal of the American Heart Association, 8(9), e011975-e011975 (2019)
María Trinidad Soria-Florido et al.
Circulation, 141(6), 444-453 (2020-01-17)
Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date
Zaiguo Li et al.
The Journal of organic chemistry, 71(4), 1718-1721 (2006-02-14)
Analogues of cholesterol (compounds 1 and 2) and coprostanol (compound 3) containing the BODIPY fluorophore in the aliphatic tail of the free sterol have been synthesized starting with bisnorcholenic acid, cholenic acid 3beta-acetate, and lithocholic acid, respectively. An ester linkage
Janus Liposomes: Gel-Assisted Formation and Bioaffinity-Directed Clustering
Wang M, et al.
Langmuir, 34(25), 7509-7518 (2018)
Silvia Scolari et al.
Biochemistry, 49(42), 9027-9031 (2010-09-25)
Seminal plasma proteins of the fibronectin type II (Fn2) family modulate mammalian spermatogenesis by triggering the release of the lipids phosphatidylcholine and cholesterol from sperm cells. Whereas the specific interaction of these proteins with phosphatidylcholine is well-understood, their selectivity for
Michele R Plewes et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5299-5316 (2020-02-23)
The corpus luteum is an endocrine gland that synthesizes and secretes progesterone. Luteinizing hormone (LH) activates protein kinase A (PKA) signaling in luteal cells, increasing delivery of substrate to mitochondria for progesterone production. Mitochondria maintain a highly regulated equilibrium between
James E Shaw et al.
Biophysical journal, 90(6), 2170-2178 (2005-12-20)
Coupling atomic force microscopy (AFM) with high-resolution fluorescence microscopy is an attractive means of identifying membrane domains by both physical topography and fluorescence. We have used this approach to study the ability of a suite of fluorescent molecules to probe
Jeremias Sibold et al.
Physical chemistry chemical physics : PCCP, 22(17), 9308-9315 (2020-04-21)
Lipid domains in plasma membranes act as molecular sorting platforms for e.g., signalling processes. In model membranes, such as freestanding or supported bilayers, some lipid domains with defined chemical composition, lipid packing and physical behaviour can be reproduced. However, in
Hyeon Young Kim et al.
Journal of nanobiotechnology, 18(1), 17-17 (2020-01-23)
This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid vesicles. Budesonide (Bud), an anti-inflammatory drug was chosen as a model drug and encapsulated into
Ma Feng et al.
European journal of preventive cardiology, 2047487319894114-2047487319894114 (2019-12-17)
Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are
Florly S Ariola et al.
Biophysical journal, 96(7), 2696-2708 (2009-04-08)
Cholesterol-rich, liquid-ordered (L(o)) domains are believed to be biologically relevant, and yet detailed knowledge about them, especially in live cells under physiological conditions, is elusive. Although these domains have been observed in model membranes, understanding cholesterol-lipid interactions at the molecular
Iván Ferraz-Amaro et al.
Clinical rheumatology (2020-01-30)
Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages. CEC is linked to cardiovascular events in the general population, and it has been shown to be disrupted in inflammatory states. The aim
James E Shaw et al.
Journal of structural biology, 155(3), 458-469 (2006-08-08)
Elucidating the role that charged membrane proteins play in determining cell membrane structure and dynamics is an area of active study. We have applied in situ correlated atomic force and confocal microscopies to characterize the interaction of the NAP-22 peptide
Elina Shrestha et al.
The Journal of biological chemistry, 291(21), 11172-11184 (2016-03-31)
Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in reverse cholesterol transport through up-regulation of ATP-binding cassette transporters (ABCA1 and ABCG1) that mediate cellular cholesterol efflux. Mouse models of atherosclerosis exhibit reduced atherosclerosis and enhanced
Bo Y Baker et al.
The Journal of biological chemistry, 282(14), 10223-10232 (2007-02-16)
Steroidogenic acute regulatory protein (StAR) stimulates adrenal and gonadal steroidogenesis by increasing the influx of cholesterol into mitochondria, where it is converted to pregnenolone to initiate steroidogenesis. StAR acts on the outer mitochondrial membrane where each molecule stimulates the mitochondrial
Daniel Wüstner et al.
Chemistry and physics of lipids, 164(3), 221-235 (2011-02-05)
Cholesterol with BODIPY at carbon-24 of the side chain (BCh2) has recently been introduced as new cholesterol probe with superior fluorescence properties. We compare BCh2 with the intrinsically fluorescent dehydroergosterol (DHE), a well-established marker for cholesterol, by introducing simultaneous imaging
Sandhya Sankaranarayanan et al.
Journal of lipid research, 52(12), 2332-2340 (2011-10-01)
Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [(3)H]cholesterol and measuring release of the labeled sterol. Using [(3)H]cholesterol is not ideal for the
Eri H Hayakawa et al.
Scientific reports, 10(1), 2794-2794 (2020-02-19)
Cholesterol, a necessary component of animal cell membranes, is also needed by the lethal human malaria parasite Plasmodium falciparum. Because P. falciparum lacks a cholesterol synthesis pathway and malaria patients have low blood cholesterol, we speculated that it scavenges cholesterol
David L Marks et al.
Histochemistry and cell biology, 130(5), 819-832 (2008-09-30)
Much evidence has accumulated to show that cellular membranes such as the plasma membrane, contain multiple "microdomains" of differing lipid and protein composition and function. These domains are sometimes enriched in cholesterol and sphingolipids and are believed to be important
Mingming Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(25), 7509-7518 (2018-06-01)
This article reports a high-yield procedure for preparing microsized (giant) Janus liposomes via gel-assisted lipid swelling and clustering behavior of these liposomes directed by biotin-avidin affinity binding. Confocal fluorescence microscopy reveals in detail that these new lipid colloidal particles display
María de Las Mercedes Carro et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183357-183357 (2020-05-18)
Ram sperm are particularly sensitive to freeze-thawing mainly due to their lipid composition, limiting their use in artificial insemination programs. We evaluated the extent of cholesterol and desmosterol incorporation into ram sperm through incubation with increasing concentrations of methyl-β-cyclodextrin (MβCD)-sterol
Page 1 of 2