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Showing 1-11 of 11 results for "81300" within Papers

Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.

Oliver J Harrison et al.

Cell reports, 30(8), 2655-2671 (2020-02-27)

Non-clustered δ1- and δ2-protocadherins, close relatives of clustered protocadherins, function in cell adhesion and motility and play essential roles in neural patterning. To understand the molecular interactions underlying these functions, we used solution biophysics to characterize binding of δ1- and

Ultrasound monitoring of cartilaginous matrix evolution in degradable PEG hydrogels.

Mark A Rice et al.

Acta biomaterialia, 5(1), 152-161 (2008-09-17)

Ultrasound has potential as a non-destructive analytical technique to provide real-time online assessments of matrix evolution in cell-hydrogel constructs used in tissue engineering. In these studies, chondrocytes were encapsulated in poly(ethylene glycol) hydrogels, and gel degradation was manipulated to provide

Design and in vitro evaluation of a novel vaginal drug delivery system based on gelucire.

M Patel Geeta et al.

Current drug delivery, 6(2), 159-165 (2009-05-20)

Carbamazepine indicated for the control of epilepsy, undergoes extensive hepatic first-pass metabolism after oral administration. A vaginal dosage form of carbamazepine is not commercially available. Conventional suppository having poor retention in the vaginal tract, as they are removed in a

Drag-reducing polymers: a novel class of diuretic and natriuretic compounds.

D D Smyth et al.

Cardiovascular drugs and therapy, 4(1), 297-300 (1990-02-01)

Previous studies have demonstrated that Separan AP-30, a drag-reducing polymer, significantly decreased the formation of atherosclerotic plaques in rabbits fed a high-cholesterol diet. Furthermore, Separan AP-273, a polymer similar to but longer than Separan AP-30, markedly increased cardiac output in

Cell-matrix interactions and dynamic mechanical loading influence chondrocyte gene expression and bioactivity in PEG-RGD hydrogels.

Idalis Villanueva et al.

Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)

The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene

Collective dynamics of microtubule-based 3D active fluids from single microtubules.

Teagan E Bate et al.

Soft matter, 15(25), 5006-5016 (2019-06-06)

Self-organization of kinesin-driven, microtubule-based 3D active fluids relies on the collective dynamics of single microtubules. However, the connection between macroscopic fluid flows and microscopic motion of microtubules remains unclear. In this work, the motion of single microtubules was characterized by

Elaboration of the Corticosteroid Synthesis Pathway in Primates through a Multistep Enzyme.

Carrie F Olson-Manning

Molecular biology and evolution, 37(8), 2257-2267 (2020-03-21)

Metabolic networks are complex cellular systems dependent on the interactions among, and regulation of, the enzymes in the network. Although there is great diversity of types of enzymes that make up metabolic networks, the models meant to understand the possible

PEG hydrogels formed by thiol-ene photo-click chemistry and their effect on the formation and recovery of insulin-secreting cell spheroids.

Chien-Chi Lin et al.

Biomaterials, 32(36), 9685-9695 (2011-09-20)

Hydrogels provide three-dimensional frameworks with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. While recent research efforts have created diverse macromer chemistry to form hydrogels, the mechanisms of hydrogel polymerization for in situ cell encapsulation remain

Hemodynamic effects of a poly(ethylene oxide) drag-reducing polymer, Polyox WSR N-60K, in the open-chest rat.

P I Polimeni et al.

Journal of cardiovascular pharmacology, 14(3), 374-380 (1989-09-01)

The acute hemodynamic effects of an intravenously (i.v.) injected poly(ethylene oxide), Polyox WSR N-60K (dose 50 mg/kg), were studied in the open-chest rat anesthetized with sodium pentobarbital. The injectate is one of four drag-reducing polymers known to augment in vitro

[The prevention of the development of the collagen-induced microembolic syndrome by decreasing the hydrodynamic resistance of the blood with special polymers under flow].

I L Konorova et al.

Patologicheskaia fiziologiia i eksperimental'naia terapiia, (4)(4), 7-9 (1991-07-01)

The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced

Effects of polyethylene glycol on DNA adsorption and hybridization on gold nanoparticles and graphene oxide.

Xu Zhang et al.

Langmuir : the ACS journal of surfaces and colloids, 28(40), 14330-14337 (2012-09-20)

Understanding the interface between DNA and nanomaterials is crucial for rational design and optimization of biosensors and drug delivery systems. For detection and delivery into cells, where high concentrations of cellular proteins are present, another layer of complexity is added.

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