83702

Applied Filters:

Keyword:'83702'

Showing 1-30 of 308 results for "83702" within Papers

Effect of astragaloside IV against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial ATP-sensitive potassium channels.

Feng-Ying Guan et al.

Molecular medicine reports, 12(1), 371-376 (2015-03-05)

Astragaloside is one of the most common traditional Chinese medicines and is derived from Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of astragaloside. The current study investigated the protective effects of AsIV against hydrogen peroxide

Neuroprotective effects of Kukoamine B against hydrogen peroxide-induced apoptosis and potential mechanisms in SH-SY5Y cells.

Xiao-Long Hu et al.

Environmental toxicology and pharmacology, 40(1), 230-240 (2015-07-15)

Oxidative stress mediates the cell damage in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease (AD) and Parkinson's disease (PD). This study aimed at investigating the protective effects of Kukoamine B (KuB) against hydrogen peroxide (H2O2) induced cell injury and

Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine.

Chia-Chia Chao et al.

Pharmacological reports : PR, 66(4), 576-584 (2014-06-21)

Strong P2X7 receptor (P2X7R) activation causes Ca(2+) overload and consequent cell death. We previously showed that depletion of Ca(2+) stores and endoplasmic reticulum (ER) stress in differentiated NG108-15 neuronal cells contributed to P2X7R-mediated cytotoxicity. In this work, we assessed whether

Metformin plus sorafenib highly impacts temozolomide resistant glioblastoma stem-like cells.

Mihaela D Aldea et al.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(2), 502-511 (2014-06-27)

Glioblastoma stem cells (GSCs), responsible for the dismal disease prognosis after conventional treatments, are driven by overactive signaling pathways, such as PI3K/ AKT/mTOR and RAS/RAF/MAPK. The objective of our study was to target in vitro-GSCs by combining metformin (Met) as

Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes.

Ester Casanova et al.

Biochimica et biophysica acta, 1837(6), 783-791 (2014-02-04)

Skeletal muscle is a key organ of mammalian energy metabolism, and its mitochondria are multifunction organelles that are targets of dietary bioactive compounds. The goal of this work was to examine the regulation of mitochondrial dynamics, functionality and cell energy

Parallel damage in mitochondrial and lysosomal compartments promotes efficient cell death with autophagy: The case of the pentacyclic triterpenoids.

Waleska K Martins et al.

Scientific reports, 5, 12425-12425 (2015-07-28)

The role of autophagy in cell death is still controversial and a lot of debate has concerned the transition from its pro-survival to its pro-death roles. The similar structure of the triterpenoids Betulinic (BA) and Oleanolic (OA) acids allowed us

Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.

Jinghua Yu et al.

Molecular medicine reports, 12(5), 7195-7202 (2015-10-16)

Primary squamous cell carcinoma of the thyroid is a rare and aggressive type of neoplasm, which is routinely treated with surgery; however, despite this, survival time is not commonly more than six months. Thus, the aim of the present study

Stages of Cell Cannibalism--Entosis--in Normal Human Keratinocyte Culture.

A S Garanina et al.

Biochemistry. Biokhimiia, 80(11), 1469-1477 (2015-11-30)

Entosis is a type of cell cannibalism during which one cell penetrates into another cell and usually dies inside it. Researchers mainly pay attention to initial and final stages of entosis. Besides, tumor cells in suspension are the primary object

Diterpene Constituents of Euphorbia exigua L. and Multidrug Resistance Reversing Activity of the Isolated Diterpenes.

Dóra Rédei et al.

Chemistry & biodiversity, 12(8), 1214-1221 (2015-08-13)

Phytochemical investigation of the MeOH extract obtained from the aerial parts of the annual weed Euphorbia exigua L. resulted in the isolation of two novel (1, 2) and one known (3) jatrophane diterpenes. Their structures were established by extensive 1D-

Attenuated SAG expression exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy of H9c2 cardiomyocytes.

J H Park et al.

Free radical research, 49(8), 962-972 (2015-04-09)

Oxidative stress, associated with the accumulation of reactive oxygen species (ROS), results in numerous and detrimental effects on the myocardium such as the induction of apoptotic cell death, hypertrophy, fibrosis, dysfunction, and dilatation. The product of sensitive to apoptosis gene

Preparation and in vivo evaluation of solid lipid nanoparticles of griseofulvin for dermal use.

Nidhi Aggarwal et al.

Journal of biomedical nanotechnology, 9(4), 564-576 (2013-04-30)

Griseofulvin-loaded solid lipid nanoparticles (SLNs) were prepared by hot microemulsion technique and optimized for type and concentration of lipid and surfactant. The optimized SLN composition was characterized in terms of particle shape and size, drug entrapment efficiency, pH, stability, spreadability

Cytotoxic Activity and Antiproliferative Effects of Crude Skin Secretion from Physalaemus nattereri (Anura: Leptodactylidae) on in vitro Melanoma Cells.

Andréa Cruz e Carvalho et al.

Toxins, 7(10), 3989-4005 (2015-10-13)

Anuran secretions are rich sources of bioactive molecules, including antimicrobial and antitumoral compounds. The aims of this study were to investigate the therapeutic potential of Physalaemus nattereri skin secretion against skin cancer cells, and to assess its cytotoxic action mechanisms

Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations.

Yao-Tsung Yeh et al.

Free radical biology & medicine, 74, 1-13 (2014-06-22)

Phenethyl isothiocyanate (PEITC) is a naturally occurring cruciferous vegetable-derived compound that inhibits cell growth and induces apoptosis in oral cancer cells. However, the exact mechanism of PEITC action has not been fully elucidated. This study investigated the molecular mechanism and

Enhanced stability and permeation potential of nanoemulsion containing sefsol-218 oil for topical delivery of amphotericin B.

Afzal Hussain et al.

Drug development and industrial pharmacy, 41(5), 780-790 (2014-03-25)

To characterize the enhanced stability and permeation potential of amphotericin B nanoemulsion comprising sefsol-218 oil at varying pH and temperature of aqueous continuous phase. Several batches of amphotericin B loaded nanoemulsion were prepared and evaluated for their physical and chemical

Schisandrin B induces apoptosis and cell cycle arrest of gallbladder cancer cells.

Shan-Shan Xiang et al.

Molecules (Basel, Switzerland), 19(9), 13235-13250 (2014-08-29)

Gallbladder cancer, with high aggressivity and extremely poor prognosis, is the most common malignancy of the bile duct. The main objective of the paper was to investigate the effects of schisandrin B (Sch B) on gallbladder cancer cells and identify

Pseudolaric acid B exerts antitumor activity via suppression of the Akt signaling pathway in HeLa cervical cancer cells.

Mingqun Li et al.

Molecular medicine reports, 12(2), 2021-2026 (2015-04-22)

Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of the root and trunk of Pseudolarix kaempferi Gordon (Pinaceae), which has demonstrated cytotoxic effects against various types of cancer. However, the mechanisms underlying the anticancer effects of

Regulations of ABCB1 and ABCG2 expression through MAPK pathways in acute lymphoblastic leukemia cell lines.

Hirotaka Tomiyasu et al.

Anticancer research, 33(12), 5317-5323 (2013-12-11)

One of the major causes of failure in chemotherapy for patients with acute lymphoblastic leukemia (ALL) is the acquisition of multidrug resistance (MDR). Predominant mechanisms for MDR acquisition include the overexpression of efflux pumps. In the present study, the regulation

Compared flow cytometric analysis of mitochondria using 10-n-nonyl acridine orange and rhodamine 123.

L Benel et al.

Basic and applied histochemistry, 33(2), 71-80 (1989-01-01)

The use of the supravital mitochondrial-specific dye Rhodamine 123 (Rh 123) in combination with flow cytometry permits the monitoring of the changes in the mitochondrial transmembrane potential, reflecting the overall mitochondrial activity of the living cell. While this probe appears

Antioxidative and anticancer activities of various ethanolic extract fractions from crown-of-thorns starfish (Acanthaster planci).

Chi-Chiu Lee et al.

Environmental toxicology and pharmacology, 38(3), 761-773 (2014-10-13)

Many studies currently researching marine invertebrates to determine the therapeutic potential of their bioactive materials have been showing very promising results. The crown-of-thorns starfish Acanthaster planci, an Echinodermata of the class Asteroidea, is infamous as the unique venomous starfish and

Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis.

Chi-Yun Wang et al.

Molecular biology of the cell, 20(19), 4153-4161 (2009-08-07)

Annexin A2 is involved in multiple cellular processes, including cell survival, growth, division, and differentiation. A lack of annexin A2 makes cells more sensitive to apoptotic stimuli. Here, we demonstrate a potential mechanism for apoptotic stimuli-induced annexin A2 cleavage, which

Early cellular responses against tributyltin chloride exposure in primary cultures derived from various brain regions.

Sumonto Mitra et al.

Environmental toxicology and pharmacology, 37(3), 1048-1059 (2014-04-26)

Tributyltin (TBT) is a potent biocide and commonly used in various industrial sectors. Humans are mainly exposed through the food chain. We have previously demonstrated tin accumulation in brain following TBT-chloride (TBTC) exposure. In this study, effect of TBTC on

The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine

Pusch J, et al.

Biomaterials, 32(30), 7469-7478 (2011)

Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes.

Sun-Joo Oh et al.

Bioscience, biotechnology, and biochemistry, 79(7), 1075-1081 (2015-03-17)

Ginsenosides, also known as ginseng saponins, are the principal bioactive ingredients of ginseng, which are responsible for its diverse pharmacological activities. The present work aimed to assess skin anti-photoaging properties of ginsenoside Rb2 (Rb2), one of the predominant protopanaxadiol-type ginsenosides

Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts.

Hyo Hyun Yang et al.

Archives of pharmacal research, 38(5), 876-884 (2014-07-06)

Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (-)-loliolide

Quality by design approach for formulation, evaluation and statistical optimization of diclofenac-loaded ethosomes via transdermal route.

Shashank Jain et al.

Pharmaceutical development and technology, 20(4), 473-489 (2014-02-05)

The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging

Diorcinol D Exerts Fungicidal Action against Candida albicans through Cytoplasm Membrane Destruction and ROS Accumulation.

Ying Li et al.

PloS one, 10(6), e0128693-e0128693 (2015-06-06)

Candida albicans, which is the most common human fungal pathogen, causes high mortality among immunocompromised patients. Antifungal drug resistance becomes a major challenge for the management of Candida infection. Diorcinol D (DD), a diphenyl ether derivative isolated from an endolichenic

Pretreatment with Resveratrol Prevents Neuronal Injury and Cognitive Deficits Induced by Perinatal Hypoxia-Ischemia in Rats.

Olatz Arteaga et al.

PloS one, 10(11), e0142424-e0142424 (2015-11-07)

Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties

Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells.

Alessandra Capasso et al.

Oncotarget, 6(37), 40202-40222 (2015-10-17)

CDC25 phosphatases are important regulators of the cell cycle and represent promising targets for anticancer drug discovery. We recently identified NSC 119915 as a new quinonoid CDC25 inhibitor with potent anticancer activity. In order to discover more active analogs of

Sulforaphene Synergistically Sensitizes Cisplatin via Enhanced Mitochondrial Dysfunction and PI3K/PTEN Modulation in Ovarian Cancer Cells.

Raktim Biswas et al.

Anticancer research, 35(7), 3901-3908 (2015-07-01)

To explore if a natural isothiocyanate, sulforaphene (SFE), sensitizes ovarian cancer cells to the chemotherapy drug cisplatin (CDDP). We studied reactive oxygen species (ROS), mitochondrial membrane depolarization and cell-cycle distribution in two ovarian cancer cell lines SKOV3 and SNU 8

Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death.

Xuezhong Gong et al.

Archives of toxicology, 89(7), 1057-1070 (2014-06-26)

Although kidney is a target organ of arsenic cytotoxicity, the underlying mechanisms of arsenic-induced nephrotoxicity remain poorly understood. As tetramethylpyrazine (TMP) has recently been found to be a renal protectant in multiple kidney injuries, we hypothesize that TMP could suppress

Page 1 of 11