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Showing 1-30 of 308 results for "83702" within Papers
Kandikattu Hemanth Kumar et al.
Cytotechnology, 67(6), 955-967 (2014-08-15)
Identification, exploration and scientific validation of antioxidant rich herbal extracts to mitigate the radical induced cell damage provide new insights in the field of ayurvedic research/therapies. In the present study, we evaluated the anti-oxidant and anti-apoptotic potential of Celastrus paniculatus
Pankaj Kumar et al.
Biochimica et biophysica acta. Molecular cell research, 1867(8), 118728-118728 (2020-04-29)
Acquired multidrug resistance of cancer cells challenges the chemotherapeutic interventions. To understand the role of molecular chaperone, Hsp90 in drug adapted tumor cells, we have used in vitro drug adapted epidermoid tumor cells as a model system. We found that
Chu-I Lee et al.
Journal of cellular biochemistry, 116(9), 2074-2085 (2015-04-29)
Neuroblastoma is one of the most aggressive cancers and has a complex form of differentiation. We hypothesized that advanced cellular differentiation may alter the susceptibility of neuroblastoma to photodynamic treatment (PDT) and confer selective survival advantage. We demonstrated that hematoporphyrin
Awais A Mughal et al.
Molecular cancer, 14, 160-160 (2015-08-22)
Glioblastoma (GBM) is the most common primary brain malignancy and confers a dismal prognosis. GBMs harbor glioblastoma-initiating cells (GICs) that drive tumorigenesis and contribute to therapeutic resistance and tumor recurrence. Consequently, there is a strong rationale to target this cell
Hui Chen Pai et al.
PloS one, 10(4), e0123819-e0123819 (2015-04-16)
In this study, the anticancer mechanisms of MT-4 were examined in A2780 and multidrug-resistant NCI-ADR/res human ovarian cancer cell lines. To evaluate the activity of MT-4, we performed in vitro cell viability and cell cycle assays and in vivo xenograft
Jing Xiong et al.
Life sciences, 112(1-2), 41-48 (2014-07-30)
Altered drug disposition has been associated with inflammation and diabetes, leading to the alteration of drug efficacy and toxicity. Carboxylesterases are major hydrolytic enzymes in the liver, catalyzing the hydrolytic biotransformation of numerous therapeutic agents. Therefore, how glucose affects the
Alexandra Bernd et al.
Pharmaceutical research, 32(9), 2973-2982 (2015-05-20)
To characterize the human choroid plexus (CP) papilloma cell line HIBCPP with respect to ABC export protein expression and function in order to evaluate its use as an in vitro model to study carrier-mediated transport processes at the CP. Expression
ChunLing Dai et al.
Oncotarget, 6(19), 17738-17752 (2015-06-04)
Lapatinib has been used in combination with capecitabine or paclitaxel to treat patients with progressive HER2-overexpressing metastatic breast cancer (MBC). Unfortunately, an increased incidence of hepatotoxicity had been reported in the combinational therapy. The aim of this study was to
Elizandra Aparecida Britta et al.
Parasitology, 142(7), 978-988 (2015-02-26)
Trypanosoma cruzi is the causative agent of Chagas' disease, a parasitic disease that remains a serious health concern with unsatisfactory treatment. Drugs that are currently used to treat Chagas' disease are partially effective in the acute phase but ineffective in
Guodong Yao et al.
Archives of biochemistry and biophysics, 558, 51-60 (2014-06-15)
Pseudolaric acid B (PAB) is a diterpene acid, isolated from the root and trunk bark of Pseudolarix kaempferi Gordon (Pinaceae). Previous studies demonstrated that PAB induced G2/M arrest and apoptosis in several cancer cell lines, but the relationship between G2/M
Bo Ra You et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(3), 2087-2095 (2014-11-14)
PX-12 (1-methylpropyl 2-imidazolyl disulfide) as a thioredoxin (Trx) inhibitor has an anti-tumor effect. However, there is no report about the toxicological effect of PX-12 on lung cancer cells. Here, we investigated the anti-growth effects of PX-12 on Calu-6 lung cancer
Chengliang Luo et al.
Journal of molecular neuroscience : MN, 56(4), 988-998 (2015-05-15)
While the previous studies have shown poloxamer 188 (P188)'s neuroprotection in cultured HT22 cells under oxygen-glucose deprivation (OGD) insults, we investigated whether P188 is a potential neuroprotective agent in primary cortical neurons (PCNs) and in cerebral ischemia in vivo and
Fen Hu et al.
Scientific reports, 5, 14012-14012 (2015-09-12)
P2X7 receptor plays important roles in inflammation and immunity, and thereby it serves as a potential therapeutic target for inflammatory diseases. Rhein, an anthraquinone derivative, exhibits significant anti-inflammatory and immunosuppressive activities in therapy. However, the underlying mechanisms are largely unclear.
Raktim Biswas et al.
Journal of photochemistry and photobiology. B, Biology, 148, 118-127 (2015-04-26)
Phosphatidylinositol-3-kinase (PI3K) is one of the major activated pathways involved in the progression of anaplastic thyroid cancer. The activated PI3K pathway starts from the overexpression of epidermal growth-factor receptor (EGFR) which plays a key role in cancer development and metastasis.
Magdalena Frank et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1983-1995 (2015-01-16)
Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology remains to be clarified, and there is so far no successful therapeutic intervention.
Wei Chen et al.
Chemico-biological interactions, 219, 83-89 (2014-06-01)
Acrylamide (AA), a well-known toxicant, has attracted numerous attentions for its presumably carcinogenesis, neurotoxicity and cytotoxicity. Oxidative stress was considered to be associated with acrylamide cytotoxicity, but the link between oxidative stress and acrylamide cytotoxicity is still unclear. In the
Elizandra Aparecida Britta et al.
BMC microbiology, 14, 236-236 (2014-09-26)
The treatment of leishmaniasis with pentavalent antimonials is problematic because of their toxicity. Investigations of potentially active molecules are important to discover less toxic drugs that are viable economic alternatives for the treatment of leishmaniasis. Thiosemicarbazones are a group of
Shi-Jian Liu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(6), 5369-5374 (2014-02-08)
This study is the first to investigate the anticancer effect of Schisandra chinensis polysaccharide (SCP) in renal cell carcinoma (RCC) cells. The results revealed that SCP treatment showed high cytotoxic potency in Caki-1 cells by inducing apoptosis, which is associated
Flavio Alves Lara et al.
PloS one, 10(8), e0134779-e0134779 (2015-08-11)
In ticks, the digestion of blood occurs intracellularly and proteolytic digestion of hemoglobin takes place in a dedicated type of lysosome, the digest vesicle, followed by transfer of the heme moiety of hemoglobin to a specialized organelle that accumulates large
Ákos Csonka et al.
Anticancer research, 35(4), 2105-2112 (2015-04-12)
Resistance to chemotherapy is a main problem in cancer. The search for new effective compounds that can increase sensitivity of resistant cells to existing chemotherapeutics is an urgent need. In previous studies, it has been demonstrated that steroid derivatives showed
Madhulika Singh et al.
International journal of nanomedicine, 10, 6789-6809 (2015-11-21)
The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate
Saura C Sahu et al.
Journal of applied toxicology : JAT, 34(11), 1155-1166 (2014-02-14)
The use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics has increased significantly owing to their antibacterial and antifungal properties. As a consequence, the need for validated rapid screening methods to assess their toxicity is necessary
Inés Llaudó et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 15(3), 407-419 (2012-09-15)
P-glycoprotein (Pgp) is a member of the ABC-transporter family that transports substances across cellular membranes acting as an efflux pump extruding drugs out of the cells. Pgp plays a key role on the pharmacokinetics of several drugs. Herein, we have
Katarina Bolko Seljak et al.
Journal of pharmaceutical sciences, 103(11), 3491-3500 (2014-08-12)
A mixed lipid-mixed surfactant self-microemulsifying drug delivery system (SMEDDS) was developed to exploit the health benefits of resveratrol, a Biopharmaceutical Classification System Class 2 natural polyphenol, subject to extensive intestinal presystemic metabolism. SMEDDS with a mixed lipid phase (castor oil/Capmul
Naira Lígia Lima Giarola et al.
Experimental parasitology, 146, 25-33 (2014-09-02)
Leishmania amazonensis is a protozoan parasite that induces mucocutaneous and diffuse cutaneous lesions upon infection. An important component in treatment failure is the emergence of drug-resistant parasites. It is necessary to clarify the mechanism of resistance that occurs in these
Pratheeba Palasuberniam et al.
Scientific reports, 5, 13298-13298 (2015-08-19)
Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells and a panel of human breast cancer cells including estrogen receptor (ER) positive, human epidermal growth factor receptor
Lan Hong et al.
Acta pharmacologica Sinica, 35(12), 1577-1585 (2014-11-25)
Para-aminosalicylic acid (PAS) is effective in the treatment of manganism-induced neurotoxicity (manganism). In this study we investigated the roles of P-glycoprotein (MDR1a) and multidrug resistance protein (MRP) in transporting PAS and its N-acetylated metabolite AcPAS through blood-brain barrier. MDR1a-null or
Shang-Fan Yu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3298-3306 (2015-04-05)
We are interested in identifying mechanisms of resistance to the current generation of antibody-drug conjugates (ADC) and developing ADCs that can overcome this resistance. Pinatuzumab vedotin (anti-CD22-vc-MMAE) and polatuzumab vedotin (anti-CD79b-vc-MMAE) are ADCs that contain the microtubule inhibitor monomethyl auristatin
Haruka Minami et al.
PloS one, 10(6), e0128890-e0128890 (2015-06-11)
The blood brain barrier (BBB) is formed by brain microvascular endothelial cells (BMECs) and tightly regulates the transport of molecules from blood to neural tissues. In vitro BBB models from human pluripotent stem cell (PSCs)-derived BMECs would be useful not
Anshumali Awasthi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 710-721 (2013-10-26)
To develop naphthyridine derivatives as anticancer candidates, pharmacokinetic (PK) evaluations of 10 novel derivatives of 1,4-dihydro-4-oxo-1-proparagyl-1,8-naphthyridine-3-carboxamide, with potent anticancer activity were done using in vitro ADME (absorption, distribution, metabolism, excretion) and pharmacokinetic--pharmcodynamic (PK/PD) assays. Only derivatives 5, 6, 9 and
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