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Showing 1-30 of 75 results for "84532" within Papers
Ondrej Zitka et al.
Electrophoresis, 34(18), 2639-2647 (2013-06-19)
Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers.One of them—nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as
Donna Vanhauteghem et al.
PloS one, 8(3), e60328-e60328 (2013-04-02)
Our previous work described a clear loss of Escherichia coli (E. coli) membrane integrity after incubation with glycine or its N-methylated derivatives N-methylglycine (sarcosine) and N,N-dimethylglycine (DMG), but not N,N,N-trimethylglycine (betaine), under alkaline stress conditions. The current study offers a
Gopal Jee Gopal et al.
Biochemical and biophysical research communications, 456(1), 98-103 (2014-12-03)
Helicobacter pylori are the well known human pathogen associated with gastric cancer and peptic ulcer. Pathogenesis is mainly due to the presence of 40 kb cagPAI (cag Pathogenicity Island) region that encodes the type IV secretion system (TFSS) consisting of
E Nna
Nigerian journal of clinical practice, 16(4), 407-417 (2013-08-27)
Many candidate biomarkers for diagnosis of prostate cancer have been investigated, but prostate-specific antigen (PSA) testing remains the frontline test for both mass screening and individual clinical testing. Although the PSA test is cost-effective, analytically reliable, and flexibly high throughput
Zigmund Luka et al.
Biochemical and biophysical research communications, 449(4), 392-398 (2014-05-27)
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Rima Obeid et al.
Molecular nutrition & food research, 56(10), 1582-1589 (2012-08-30)
The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors. We measured concentrations of the metabolites related to the methylation cycle
Natalia Cernei et al.
International journal of molecular sciences, 14(7), 13893-13908 (2013-07-25)
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there
R S Lanigan
International journal of toxicology, 20 Suppl 1, 1-14 (2001-05-19)
This safety assessment addresses cosmetic ingredients that are N-acyl derivatives of sarcosine and are generally referred to as acyl sarcosines, and those that are salts, known generally as acyl sarcosinates. Previous assessments have addressed the safety of each of the
Ken J Hampel et al.
Journal of bacteriology, 196(1), 7-15 (2013-10-08)
Pseudomonas aeruginosa displays tremendous metabolic diversity, controlled in part by the abundance of transcription regulators in the genome. We have been investigating P. aeruginosa's response to the host, particularly changes regulated by the host-derived quaternary amines choline and glycine betaine
Ryan O Walters et al.
Cell reports, 25(3), 663-676 (2018-10-18)
A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of
H L Levy et al.
Pediatrics, 74(4), 509-513 (1984-10-01)
Sarcosinemia has been detected by routine screening of urine for metabolic and transport disorders in Massachusetts. Three infants who had sarcosinemia were detected through the neonatal urine specimen, an observed incidence of 1:350,000. A fourth child had sarcosinemia detected through
Marin Barisic et al.
Nature cell biology, 16(12), 1249-1256 (2014-11-11)
Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that
J J Strain et al.
The British journal of nutrition, 110(2), 330-336 (2013-01-10)
Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on
Sandeep Akare et al.
Biochimica et biophysica acta, 1735(1), 59-67 (2005-06-14)
Elevated concentrations of fecal bile acids are a known risk factor for colon cancer, owing to alterations in cellular signaling. In colonic cells, where bile acid uptake is minimal, the hydrophobicity-induced membrane perturbation and alterations have been proposed, but these
Laszlo G Harsing et al.
Brain research bulletin, 93, 110-119 (2012-12-26)
Glycine is an amino acid neurotransmitter that is involved in both inhibitory and excitatory neurochemical transmission in the central nervous system. The role of glycine in excitatory neurotransmission is related to its coagonist action at glutamatergic N-methyl-D-aspartate receptors. The glycine
Mohammad Mahdi Moein et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 168-173 (2014-08-12)
In situ monolithic molecularly imprinted polymer sol-gel packed tips (MMSTs) were prepared and evaluated for the extraction of lung cancer biomarker L-tyrosine (Tyr) from human plasma and urine samples. Several extraction parameters such as the conditioning, washing and elution solutions
[Sarcosine dehydrogenase deficiency].
K Hiraga
Ryoikibetsu shokogun shirizu, (18 Pt 1)(18 Pt 1), 221-223 (1998-05-20)
Scott E Wolkenberg et al.
Current topics in medicinal chemistry, 10(2), 170-186 (2010-02-20)
The simple amino acid glycine is implicated in both inhibitory and excitatory neurotransmission in mammalian central nervous system, and it modulates excitatory neurotransmission through its role as a necessary co-agonist for glutamatergic N-methyl-D-aspartate (NMDA) receptors. Given the involvement of NMDA
Brian Tf Wu et al.
The American journal of clinical nutrition, 98(5), 1209-1217 (2013-09-06)
Choline needs are increased in pregnancy. Choline can be used as a source of methyl for homocysteine remethylation to methionine, but choline synthesis requires methyls from methionine. Vitamin B-12 deficiency increases choline use for homocysteine methylation. We investigated whether poor
Sílvia Fernàndez-Roig et al.
The American journal of clinical nutrition, 97(6), 1252-1259 (2013-04-19)
Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy. The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy. Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine
Jonathan E McDunn et al.
The Prostate, 73(14), 1547-1560 (2013-07-05)
Current diagnostic techniques have increased the detection of prostate cancer; however, these tools inadequately stratify patients to minimize mortality. Recent studies have identified a biochemical signature of prostate cancer metastasis, including increased sarcosine abundance. This study examined the association of
Patrick A Mayes et al.
International journal of cancer, 132(3), E149-E157 (2012-09-06)
Inhibition of centromere-associated protein-E (CENP-E) has demonstrated preclinical anti-tumor activity in a number of tumor types including neuroblastoma. A potent small molecule inhibitor of the kinesin motor activity of CENP-E has recently been developed (GSK923295). To identify an effective drug
Stefan de Vogel et al.
International journal of cancer, 134(1), 197-206 (2013-06-26)
Methyl group donors and intermediates of one-carbon metabolism affect DNA synthesis and DNA methylation, and may thereby affect prostate carcinogenesis. Choline, the precursor of betaine, and the one-carbon metabolite sarcosine have been associated with increased prostate cancer risk. Within JANUS
M Heil et al.
Journal of chromatography. B, Biomedical sciences and applications, 739(2), 313-324 (2000-04-08)
Enantioselective multidimensional gas chromatography-mass spectrometry (enantio-MDGC-MS) is a valuable tool for the differentiation of enantiomers from complex matrices when present in trace amounts. The separation of chiral compounds provides further information on the diagnosis of diseases, and on normal and
Simone J P M Eussen et al.
The British journal of nutrition, 110(2), 363-374 (2012-12-12)
Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and
Yohei Sakaguchi et al.
The Analyst, 140(6), 1965-1973 (2015-02-12)
We have developed a novel amino acid analysis method using derivatization of multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups). The amino, carboxyl, and phenolic hydroxyl groups of the amino acids were derivatized with 1-bromobutane so that the hydrophobicities
Gábor L Kovács
Magyar onkologia, 58(4), 301-309 (2014-12-18)
Prostate cancer is usually a disease of elderly men, however, over 40 years of age the tumor can appear at any times. PSA is a protein molecule synthesized by prostate cells. Measurement of serum PSA has revolutionized the diagnosis and
Stella Koutros et al.
Carcinogenesis, 34(10), 2281-2285 (2013-05-24)
Metabolomic profiling has identified, sarcosine, a derivative of the amino acid glycine, as an important metabolite involved in the etiology or natural history of prostate cancer. We examined the association between serum sarcosine levels and risk of prostate cancer in
S N Kozlov et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (2)(2), 3-12 (2013-06-29)
Detection ofproteases in outer membranes (OM) of ompT+ and ompT- Vibrio cholerae strains of O1 and O139 serogroups. Specific sterile preparations of OM were obtained by lysis of live V. cholerae cells by 4.5 M urea solution with subsequent differential
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