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Showing 1-30 of 75 results for "84532" within Papers
Patrick A Mayes et al.
International journal of cancer, 132(3), E149-E157 (2012-09-06)
Inhibition of centromere-associated protein-E (CENP-E) has demonstrated preclinical anti-tumor activity in a number of tumor types including neuroblastoma. A potent small molecule inhibitor of the kinesin motor activity of CENP-E has recently been developed (GSK923295). To identify an effective drug
Sílvia Fernàndez-Roig et al.
The American journal of clinical nutrition, 97(6), 1252-1259 (2013-04-19)
Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy. The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy. Fasting plasma folate, cobalamin, free choline, betaine, dimethylglycine
Jonathan E McDunn et al.
The Prostate, 73(14), 1547-1560 (2013-07-05)
Current diagnostic techniques have increased the detection of prostate cancer; however, these tools inadequately stratify patients to minimize mortality. Recent studies have identified a biochemical signature of prostate cancer metastasis, including increased sarcosine abundance. This study examined the association of
Brian Tf Wu et al.
The American journal of clinical nutrition, 98(5), 1209-1217 (2013-09-06)
Choline needs are increased in pregnancy. Choline can be used as a source of methyl for homocysteine remethylation to methionine, but choline synthesis requires methyls from methionine. Vitamin B-12 deficiency increases choline use for homocysteine methylation. We investigated whether poor
[Sarcosine dehydrogenase deficiency].
K Hiraga
Ryoikibetsu shokogun shirizu, (18 Pt 1)(18 Pt 1), 221-223 (1998-05-20)
Mohammad Mahdi Moein et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 168-173 (2014-08-12)
In situ monolithic molecularly imprinted polymer sol-gel packed tips (MMSTs) were prepared and evaluated for the extraction of lung cancer biomarker L-tyrosine (Tyr) from human plasma and urine samples. Several extraction parameters such as the conditioning, washing and elution solutions
R S Lanigan
International journal of toxicology, 20 Suppl 1, 1-14 (2001-05-19)
This safety assessment addresses cosmetic ingredients that are N-acyl derivatives of sarcosine and are generally referred to as acyl sarcosines, and those that are salts, known generally as acyl sarcosinates. Previous assessments have addressed the safety of each of the
Natalia Cernei et al.
International journal of molecular sciences, 14(7), 13893-13908 (2013-07-25)
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there
Ryan O Walters et al.
Cell reports, 25(3), 663-676 (2018-10-18)
A hallmark of aging is a decline in metabolic homeostasis, which is attenuated by dietary restriction (DR). However, the interaction of aging and DR with the metabolome is not well understood. We report that DR is a stronger modulator of
Laszlo G Harsing et al.
Brain research bulletin, 93, 110-119 (2012-12-26)
Glycine is an amino acid neurotransmitter that is involved in both inhibitory and excitatory neurochemical transmission in the central nervous system. The role of glycine in excitatory neurotransmission is related to its coagonist action at glutamatergic N-methyl-D-aspartate receptors. The glycine
Scott E Wolkenberg et al.
Current topics in medicinal chemistry, 10(2), 170-186 (2010-02-20)
The simple amino acid glycine is implicated in both inhibitory and excitatory neurotransmission in mammalian central nervous system, and it modulates excitatory neurotransmission through its role as a necessary co-agonist for glutamatergic N-methyl-D-aspartate (NMDA) receptors. Given the involvement of NMDA
Stefan de Vogel et al.
International journal of cancer, 134(1), 197-206 (2013-06-26)
Methyl group donors and intermediates of one-carbon metabolism affect DNA synthesis and DNA methylation, and may thereby affect prostate carcinogenesis. Choline, the precursor of betaine, and the one-carbon metabolite sarcosine have been associated with increased prostate cancer risk. Within JANUS
H L Levy et al.
Pediatrics, 74(4), 509-513 (1984-10-01)
Sarcosinemia has been detected by routine screening of urine for metabolic and transport disorders in Massachusetts. Three infants who had sarcosinemia were detected through the neonatal urine specimen, an observed incidence of 1:350,000. A fourth child had sarcosinemia detected through
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Sandeep Akare et al.
Biochimica et biophysica acta, 1735(1), 59-67 (2005-06-14)
Elevated concentrations of fecal bile acids are a known risk factor for colon cancer, owing to alterations in cellular signaling. In colonic cells, where bile acid uptake is minimal, the hydrophobicity-induced membrane perturbation and alterations have been proposed, but these
Zigmund Luka et al.
Biochemical and biophysical research communications, 449(4), 392-398 (2014-05-27)
Dimethylglycine dehydrogenase (DMGDH) is a mammalian mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline. DMGDH is a flavin containing enzyme which catalyzes the oxidative demethylation of dimethylglycine in vitro with the formation
Rima Obeid et al.
Molecular nutrition & food research, 56(10), 1582-1589 (2012-08-30)
The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors. We measured concentrations of the metabolites related to the methylation cycle
Ondrej Zitka et al.
Electrophoresis, 34(18), 2639-2647 (2013-06-19)
Carcinoma of prostate (CaP) is the second most frequent malignant tumor occurring in men in Europe. Currently there is discussion on a wide range of potential CaP markers.One of them—nonprotein amino acid sarcosine, also known as N-methylglycine was chosen as
Marin Barisic et al.
Nature cell biology, 16(12), 1249-1256 (2014-11-11)
Accurate chromosome segregation during cell division in metazoans relies on proper chromosome congression at the equator. Chromosome congression is achieved after bi-orientation to both spindle poles shortly after nuclear envelope breakdown, or by the coordinated action of motor proteins that
Donna Vanhauteghem et al.
PloS one, 8(3), e60328-e60328 (2013-04-02)
Our previous work described a clear loss of Escherichia coli (E. coli) membrane integrity after incubation with glycine or its N-methylated derivatives N-methylglycine (sarcosine) and N,N-dimethylglycine (DMG), but not N,N,N-trimethylglycine (betaine), under alkaline stress conditions. The current study offers a
Gopal Jee Gopal et al.
Biochemical and biophysical research communications, 456(1), 98-103 (2014-12-03)
Helicobacter pylori are the well known human pathogen associated with gastric cancer and peptic ulcer. Pathogenesis is mainly due to the presence of 40 kb cagPAI (cag Pathogenicity Island) region that encodes the type IV secretion system (TFSS) consisting of
E Nna
Nigerian journal of clinical practice, 16(4), 407-417 (2013-08-27)
Many candidate biomarkers for diagnosis of prostate cancer have been investigated, but prostate-specific antigen (PSA) testing remains the frontline test for both mass screening and individual clinical testing. Although the PSA test is cost-effective, analytically reliable, and flexibly high throughput
J J Strain et al.
The British journal of nutrition, 110(2), 330-336 (2013-01-10)
Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on
Ken J Hampel et al.
Journal of bacteriology, 196(1), 7-15 (2013-10-08)
Pseudomonas aeruginosa displays tremendous metabolic diversity, controlled in part by the abundance of transcription regulators in the genome. We have been investigating P. aeruginosa's response to the host, particularly changes regulated by the host-derived quaternary amines choline and glycine betaine
King Hang Aaron Lau et al.
Langmuir : the ACS journal of surfaces and colloids, 28(46), 16099-16107 (2012-10-30)
Poly(N-substituted glycine) "peptoids" are a class of peptidomimetic molecules receiving significant interest as engineered biomolecules. Sarcosine (i.e., poly(N-methyl glycine)) has the simplest side chain chemical structure of this family. In this Article, we demonstrate that surface-grafted polysarcosine (PSAR) brushes exhibit
J R Bales et al.
Clinical chemistry, 30(10), 1631-1636 (1984-10-01)
Acetaminophen and its glucuronide, sulfate, N-acetyl-L-cysteinyl, and L-cysteinyl metabolites can be rapidly detected by 1H NMR spectroscopy of intact, untreated human urine. Study of the time course of excretion of these metabolites in five clinically normal men after ingestion of
Zhibin Huang et al.
Molecules (Basel, Switzerland), 17(11), 12704-12717 (2012-10-30)
A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction
Narendra Kumar et al.
Biophysical chemistry, 171, 9-15 (2012-12-26)
Sarcosine is one of the most important protecting osmolytes which is also known to counteract the denaturing effect of urea. We used molecular dynamics simulation methods to investigate the mechanism of protein stabilization and counteraction of urea by sarcosine. We
S Umair et al.
Experimental parasitology, 134(1), 1-6 (2013-02-05)
Sarcosine (N-methylglycine) is an intermediate in glycine degradation and can also be synthesised from glycine in mammals. Sarcosine metabolism in Haemonchus contortus and Teladorsagia circumcincta differed from that of mammals in that creatinase activity was present and sarcosine was demethylated
Gard Frodahl Tveitevåg Svingen et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 2041-2048 (2013-06-01)
Dimethylglycine is linked to lipid metabolism, and increased plasma levels may be associated with adverse prognosis in patients with coronary artery disease. We evaluated the relationship between plasma dimethylglycine and risk of incident acute myocardial infarction in a large prospective
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