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Showing 1-30 of 168 results for "850355P" within Papers
Paulo F Almeida et al.
Langmuir : the ACS journal of surfaces and colloids, 34(33), 9798-9809 (2018-08-09)
The excess heat capacity (Δ C p) of mixtures of dipalmitoylphosphatidylcholine (DPPC) and cholesterol (Chol) is examined in detail in large unilamellar vesicles (LUVs), both experimentally, using differential scanning calorimetry (DSC), and theoretically, using a three-state Ising model. The model
Simon Becher et al.
Analytical chemistry, 90(19), 11486-11494 (2018-09-11)
Phosphatidylcholines are the major phospholipid component of most eukaryotic cell membranes. Phosphatidylcholines have been shown to actively participate in regulatory and metabolic processes. Dysfunctional metabolic processes have been linked to human disease and can result in altered phosphatidylcholine structural features
Benjamin J Peters et al.
Langmuir : the ACS journal of surfaces and colloids, 34(30), 8939-8951 (2018-07-01)
Pyridine-based small-molecule drugs, vitamins, and cofactors are vital for many cellular processes, but little is known about their interactions with membrane interfaces. These specific membrane interactions of these small molecules or ions can assist in diffusion across membranes or reach
Łukasz Syga et al.
Chembiochem : a European journal of chemical biology, 21(9), 1320-1328 (2019-12-10)
Attachment of lipophilic groups is an important post-translational modification of proteins, which involves the coupling of one or more anchors such as fatty acids, isoprenoids, phospholipids, or glycosylphosphatidyl inositols. To study its impact on the membrane partitioning of hydrophobic peptides
Sana Ahmed et al.
Langmuir : the ACS journal of surfaces and colloids (2018-06-26)
Nanomedicine relies on the effective internalization of nanoparticles combined with polymeric nanocarriers into living cells. Thus, exploration of internalization is essential for improving the efficacy of nanoparticle-based strategies in clinical practice. Here, we investigated the physicochemical internalization of gold nanoparticles
Philippe Calvez et al.
Journal of the American Chemical Society (2016-10-01)
Recoverin undergoes a calcium-myristoyl switch during visual phototransduction. Indeed, calcium binding by recoverin results in the extrusion of its myristoyl group, which allows its membrane binding. However, the contribution of particular lipids and of specific amino acids of recoverin in
Ommolbanin Asadpour et al.
Cell journal, 22(1), 30-39 (2019-10-14)
The purpose of this study was to develop multivalent antibody constructs via grafting anti-HER2 antibodies, including Herceptin and oligoclonal-variable domain of heavy chain antibodies (VHHs), onto liposome membranes to enhance antibody activity and compare their effect on phospholipase C (PLC)
A A Anosov et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183147-183147 (2019-12-10)
Most researchers associate the increase in the permeability of lipid bilayers of artificial and biological membranes observed in various experiments with the formation of hypothetical hydrophobic and hydrophilic pores. Although the existence of hydrophobic defects, as the first stage of
John M Harrington et al.
The Journal of biological chemistry, 289(36), 24811-24820 (2014-07-20)
Haptoglobin-related protein (Hpr) is a component of a minor subspecies of high density lipoproteins (HDL) that function in innate immunity. Here we show that assembly of Hpr into HDL is mediated by its retained N-terminal signal peptide, an unusual feature
Thais A Enoki et al.
Langmuir : the ACS journal of surfaces and colloids, 34(5), 2014-2025 (2017-12-29)
Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed of phosphatidylcholine
Konstantin A Okotrub et al.
The Analyst, 145(4), 1466-1472 (2019-12-24)
The orientation of lipid molecules is an essential characteristic of supported phospholipid layers, synthetic lipid structures, and biological specimens. Here, we perform Raman spectroscopy to analyze the orientation order in lipid structures. For this purpose, we studied dry oriented planar
André C Machado et al.
Colloids and surfaces. B, Biointerfaces, 188, 110794-110794 (2020-01-24)
Knowing how a drug interacts with cell membranes is important to understand and predict its effects at the molecular level. Therefore, we aimed to study the interaction of nitrofurantoin (NFT), a compound with potential antibiotic and antitumor properties, with lipidic
DeeAnn K Asamoto et al.
Biophysical journal, 118(2), 403-414 (2019-12-18)
Nanodiscs (NDs) are an excellent alternative to small unilamellar vesicles (SUVs) for studies of membrane protein structure, but it has not yet been shown that membrane proteins are able to spontaneously fold and insert into a solution of freely diffusing
Lucas H Hofmeister et al.
ACS nano, 9(4), 4435-4446 (2015-03-15)
In regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points, and regions distal to stenoses, blood flow becomes disturbed. Atherosclerosis preferentially develops in these regions
Warren G Hill et al.
American journal of physiology. Cell physiology, 289(1), C33-C41 (2005-02-25)
Caveolae are invaginated membrane structures with high levels of cholesterol, sphingomyelin, and caveolin protein that are predicted to exist as liquid-ordered domains with low water permeability. We isolated a caveolae-enriched membrane fraction without detergents from rat lung and characterized its
Phenotypic basis for matrix stiffness-dependent chemoresistance of breast cancer cells to doxorubicin
Joyce MH, et al.
Frontiers in Oncology, 8, 203-208 (2018)
Poonam Nigam
Chemistry and physics of lipids, 228, 104888-104888 (2020-02-08)
Interaction of Pluronic F-68 with monolayers composed of DPPC (1,2-Dipalmytoyl-sn-glycero-3-phosphocholine), POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) and their mixture have been studied. A series of isotherms were obtained by compressing mixed PF-68/lipid monolayers over subphase containing varying concentrations of PF-68. Results obtained were analyzed
Tatsuya Fujii et al.
Analytica chimica acta, 1119, 35-40 (2020-05-23)
Exosomes are expected to be biomarkers of cancer since they contain information about the cells that excrete them. In this study we developed a method to count the exosomes secreted from cancer cells in a culture medium without the need
Li-Juan Zhao et al.
Journal of ethnopharmacology, 260, 112943-112943 (2020-05-19)
Arenobufagin (ArBu) is an important anti-tumor ingredient of Chan'su which has long been used as traditional Chinese medicine in clinic for tumor therapy in China. The purpose of our study is to investigate the lipid homeostasis regulation effects of ArBu
Da Shi et al.
Langmuir : the ACS journal of surfaces and colloids (2018-12-15)
Although most phospholipid-shelled microbubbles (MBs) investigated for medical applications are stabilized by a fluorocarbon (FC) gas, information on the interactions between phospholipid and FC molecules at the gas/water interface remains scarce. We report that the procedure of introduction of perfluorohexane
Huamei He et al.
Journal of controlled release : official journal of the Controlled Release Society, 323, 387-397 (2020-04-25)
Chemotherapy is an important modality available for cancer treatment. However, the present chemotherapy is still far from being satisfactory mainly owing to the severe side effects of the chemotherapeutic agents and drug resistance of cancer cells. Thus, reversing drug resistance
Cornelia A Hermann et al.
Analytical and bioanalytical chemistry (2020-02-20)
Magnetized liposome (magnetosomes) labels can overcome diffusion limitations in bioassays through fast and easy magnetic attraction. Our aim therefore was to advance the understanding of factors influencing their synthesis focusing on encapsulation strategies and synthesis parameters. Magnetosome synthesis is governed
Qiying Shen et al.
International journal of pharmaceutics, 576, 119001-119001 (2020-01-02)
The conventional medications are still facing a huge challenge for the treatment of rheumatoid arthritis (RA). Thus, looking for an effective therapy of RA has became an urgent issue nowadays. In this study, a novel thermosensitive liposome loaded with sinomenine
Chung-Yin Lin et al.
Journal of controlled release : official journal of the Controlled Release Society, 321, 519-528 (2020-03-01)
Ultrasound-targeted microbubble destruction (UTMD) in conjunction with neurotrophic factors (NFs) gene delivery has the potential to facilitate the penetration of therapeutic genes into the brain for neuroprotective therapy against neurodegenerative diseases. We previously presented a gene delivery system that conjugates
Qing Wang et al.
Biophysical journal, 115(4), 664-678 (2018-08-08)
Using Förster resonance energy transfer, raft/liquid-ordered-domain formation was assessed in asymmetric vesicles containing outer leaflets composed of high-Tm (melting temperature) saturated phosphatidylcholines (diC18:0PC, diC16:0PC, diC15:0PC, or diC14:0PC), low-Tm unsaturated dioleoylphosphatidylcholine (DOPC) and cholesterol, and inner leaflets composed of lipids that
H M H N Bandara et al.
International journal of pharmaceutics, 578, 119096-119096 (2020-02-02)
In contrast to the plethora of antibacterial agents, only a handful of antifungals are currently available to treat Candida albicans biofilm-associated infections. Additional novel antibiofilm strategies to eliminate C. albicans biofilm infections are needed. This study aims to improve the
Arif M Siddiquee et al.
Biomedical optics express, 10(12), 6569-6579 (2019-12-20)
Here we report the results of shear-mode thicknesses and absorption coefficient measurements made on neat membranes using scanning near-field optical microscopy (SNOM). Biomimic neat membranes composed of two different types of phoshpholipid molecules: 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2- dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were
Regina Adão et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183314-183314 (2020-04-19)
α-Synuclein (αsyn) is a cytosolic intrinsically disordered protein (IDP) known to fold into an α-helical structure when binding to membrane lipids, decreasing protein aggregation. Model membrane enable elucidation of factors critically affecting protein folding/aggregation, mostly using either small unilamellar vesicles
Norbert Kučerka et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 3134-3141 (2017-03-10)
Interactions of calcium (Ca2+) and zinc (Zn2+) cations with biomimetic membranes made of dipalmitoylphosphatidylcholine (DPPC) were studied by small angle neutron diffraction (SAND). Experiments show that the structure of these lipid bilayers is differentially affected by the two divalent cations.
L Bakás et al.
Biophysical journal, 71(4), 1869-1876 (1996-10-01)
Alpha-Hemolysin is an extracellular protein toxin (107 kDa) produced by some pathogenic strains of Escherichia coli. Although stable in aqueous medium, it can bind to lipid bilayers and produce membrane disruption in model and cell membranes. Previous studies had shown
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