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Showing 1-30 of 228 results for "850375C" within Papers
Peter J Chung et al.
Langmuir : the ACS journal of surfaces and colloids, 34(43), 13000-13005 (2018-10-12)
Spherical nanoparticle-supported lipid bilayers (SSLBs) combine precision nanoparticle engineering with biocompatible interfaces for various applications, ranging from drug delivery platforms to structural probes for membrane proteins. Although the bulk, spontaneous assembly of vesicles and larger silica nanoparticles (>100 nm) robustly
Sobhan Roy et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(43), E4648-E4657 (2014-10-10)
CD1c is a member of the group 1 CD1 family of proteins that are specialized for lipid antigen presentation. Despite high cell surface expression of CD1c on key antigen-presenting cells and the discovery of its mycobacterial lipid antigen presentation capability
Jorge Larios et al.
The Journal of cell biology, 219(3) (2020-02-13)
The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling receptors and other proteins to lysosomes for degradation, but they also modulate intercellular communication when secreted as exosomes. The formation of ILVs requires four complexes, ESCRT-0, -I, -II
Kwahun Lee et al.
Langmuir : the ACS journal of surfaces and colloids, 34(41), 12387-12393 (2018-09-22)
Amphiphilic nanoparticles are known to cause defects in lipid bilayers. However, we have shown recently that their disruptive effects are significantly enhanced when surface charges and hydrophobic groups are spatially segregated on opposite hemispheres of a single particle. Using the
Tun Naw Sut et al.
Langmuir : the ACS journal of surfaces and colloids, 36(18), 5021-5029 (2020-04-21)
Supported lipid bilayers (SLBs) are versatile cell membrane-mimicking biointerfaces for various applications such as biosensors and drug delivery systems, and there is broad interest in developing simple, cost-effective methods to achieve SLB fabrication. One promising approach involves the deposition of
Hilal Yılmaz et al.
Protein expression and purification, 173, 105664-105664 (2020-05-08)
In this study, effect of affinity tags, Histidine (His) and Glutathione-S-Transferase (GST), on the activity of halophilic aquaporin was analyzed. The gene coding for H. elongata aquaporin was cloned into pET28a vector and expressed in E. coli BL21 successfully. Stopped
Jayesh A Kulkarni et al.
Nanoscale, 11(45), 21733-21739 (2019-11-13)
Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells (hepatocytes) following intravenous (i.v.) administration. These LNP-siRNA systems consist of four lipid components
Jürgen Kreiter et al.
Biophysical journal, 117(10), 1845-1857 (2019-11-11)
Genipin, a natural compound from Gardenia jasminoides, is a well-known compound in Chinese medicine that is used for the treatment of cancer, inflammation, and diabetes. The use of genipin in classical medicine is hindered because of its unknown molecular mechanisms
Molecular dynamics simulations of the interactions of DMSO with DPPC and DOPC phospholipid membranes
Hughes ZE, et al.
The Journal of Physical Chemistry B, 116(39), 11911-11923 (2012)
Feng Wang et al.
Journal of the American Chemical Society, 137(36), 11736-11742 (2015-08-25)
Zwitterionic phosphocholine (PC) lipids are highly biocompatible, representing a major component of the cell membrane. A simple mixing of PC liposomes and silica (SiO2) surface results in liposome fusion with the surface and formation of supported lipid bilayers. However, the
Alena Khmelinskaia et al.
Langmuir : the ACS journal of surfaces and colloids (2018-09-27)
DNA origami nanotechnology is being increasingly used to mimic membrane-associated biophysical phenomena. Although a variety of DNA origami nanostructures has already been produced to target lipid membranes, the requirements for membrane binding have so far not been systematically assessed. Here
Florian Schlosser et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 370(1661), 20140028-20140028 (2014-12-24)
Cells are sensitive to mechanical cues from their environment and at the same time generate and transmit forces to their surroundings. To test quantitatively forces generated by cells not attached to a substrate, we used a dual optical trap to
Juliana Kovalczuk de Oliveira et al.
Materials science & engineering. C, Materials for biological applications, 110, 110720-110720 (2020-03-25)
The use of nanocarriers for drug delivery is a strategy aimed to improve therapeutic indices through changes in their pharmacokinetic and pharmacodynamic characteristics. Liposomes are well-investigated nanocarriers for drug delivery to macrophage-targeted therapy, the main hosts of intracellular pathogens of
Jeremias Sibold et al.
Physical chemistry chemical physics : PCCP, 22(17), 9308-9315 (2020-04-21)
Lipid domains in plasma membranes act as molecular sorting platforms for e.g., signalling processes. In model membranes, such as freestanding or supported bilayers, some lipid domains with defined chemical composition, lipid packing and physical behaviour can be reproduced. However, in
Raya Sorkin et al.
Biophysical journal, 118(3), 643-656 (2020-01-19)
Synaptotagmin-1 (Syt1) is a calcium sensor protein that is critical for neurotransmission and is therefore extensively studied. Here, we use pairs of optically trapped beads coated with SNARE-free synthetic membranes to investigate Syt1-induced membrane remodeling. This activity is compared with
Md Mamun Or Rashid et al.
Biochimica et biophysica acta. Biomembranes, 1862(10), 183381-183381 (2020-06-07)
The effect of membrane potential on plasma membrane damage generated by antimicrobial peptides (AMPs) is an important, yet poorly characterized, process. Here, we studied the effect of membrane potential (φm) on pore formation by magainin 2 (Mag) in single giant
Jack Robinson et al.
Langmuir : the ACS journal of surfaces and colloids, 36(19), 5454-5465 (2020-04-25)
Annexins are soluble membrane-binding proteins that associate in a calcium dependent manner with anionic phospholipids. They play roles in membrane organization, signaling and vesicle transport and in several disease states including thrombosis and inflammation. Annexin V is believed to be
Honghong Sun et al.
Scientific reports, 10(1), 6617-6617 (2020-04-22)
Lymphocytes are some of the most motile cells of vertebrates, constantly navigating through various organ systems. Their specific positioning in the body is delicately controlled by site-specific directional cues such as chemokines. While it has long been suspected that an
Yelena Ugolev et al.
The Journal of biological chemistry, 283(32), 22257-22271 (2008-05-29)
Rac plays a pivotal role in the assembly of the superoxide-generating NADPH oxidase of phagocytes. In resting cells, Rac is found in the cytosol in complex with Rho GDP dissociation inhibitor (RhoGDI). NADPH oxidase assembly involves dissociation of the Rac.RhoGDI
Andrew A Bridges et al.
The Journal of cell biology, 213(1), 23-32 (2016-04-06)
Cells change shape in response to diverse environmental and developmental conditions, creating topologies with micron-scale features. Although individual proteins can sense nanometer-scale membrane curvature, it is unclear if a cell could also use nanometer-scale components to sense micron-scale contours, such
Ranit Pariary et al.
Biochimica et biophysica acta. Proteins and proteomics, 1868(5), 140378-140378 (2020-02-08)
Amyloidogenic disorders are currently rising as a global health issue, prompting more and more studies dedicated to the development of effective targeted therapeutics. The innate affinity of these amyloidogenic proteins towards the biomembranes adds further complexities to the systems. Our
Pablo Carravilla et al.
Biophysical journal, 118(1), 44-56 (2019-12-04)
Efficient engagement with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV). Developing an accommodation surface that engages with the viral lipid
Tjeerd Pols et al.
The FEBS journal, 288(1), 293-309 (2020-04-20)
In cells, the breakdown of arginine to ornithine and ammonium ion plus carbon dioxide is coupled to the generation of metabolic energy in the form of ATP. The arginine breakdown pathway is minimally composed of arginine deiminase, ornithine transcarbamoylase, carbamate
Imelda J Galván Márquez et al.
Canadian journal of microbiology, 66(2), 161-168 (2019-11-20)
Nisin is a class I polycyclic bacteriocin produced by the bacterium Lactococcus lactis, which is used extensively as a food additive to inhibit the growth of foodborne Gram-positive bacteria. Nisin also inhibits growth of Gram-negative bacteria when combined with membrane-disrupting
Serapion Pyrpassopoulos et al.
Biophysical journal, 118(1), 243-253 (2019-12-31)
Kinesin motors and their associated microtubule tracks are essential for long-distance transport of cellular cargos. Intracellular activity and proper recruitment of kinesins is regulated by biochemical signaling, cargo adaptors, microtubule-associated proteins, and mechanical forces. In this study, we found that
Md Hossen Ali et al.
Nanomaterials (Basel, Switzerland), 10(1) (2020-01-24)
Nanopriming has been shown to significantly improve seed germination and seedling vigor in several agricultural crops. However, this approach has not been applied to native upland boreal forest species with complex seed dormancy to improve propagation. Herein, we demonstrate the
Tadas Penkauskas et al.
Biochimica et biophysica acta. Biomembranes, 1862(9), 183306-183306 (2020-04-18)
Statins are effective inhibitors of cholesterol biosynthesis, largely used for prevention of cardiovascular diseases induced by hypercholesterolemia. However, their use in different clinical trials clearly indicate that the general benefits observed with statins are also related to effects beyond the
Halil I Okur et al.
The journal of physical chemistry. B, 121(13), 2808-2813 (2017-03-07)
Three-dimensional (3D) phospholipid monolayers at hydrophobic surfaces are ubiquitous and found in nature as adiposome organelles or in man-made materials such as drug delivery systems. However, the molecular level understanding of such monolayers remains elusive. Here, we investigate the molecular
Ming-Tao Lee et al.
Biochemistry, 57(38), 5629-5639 (2018-08-29)
Daptomycin is a phosphatidylglycerol specific, calcium-dependent membrane-active antibiotic that has been approved for the treatment of Gram-positive infections. A recent Bacillus subtilis study found that daptomycin clustered into fluid lipid domains of bacterial membranes and the membrane binding was correlated
Yun-Chieh Sung et al.
Nature nanotechnology, 14(12), 1160-1169 (2019-11-20)
Abnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to normalize tumour vasculature. However, a NO-delivery system with a prolonged half-life
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