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Showing 1-30 of 228 results for "850375C" within Papers
Keni Yang et al.
Acta biomaterialia, 106, 314-327 (2020-02-23)
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context
Han-Yuan Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 36(26), 7325-7331 (2020-05-12)
Transmembrane proteins (TMPs) regulate processes occurring at the cell surface and are essential gatekeepers of information flow across the membrane. TMPs are difficult to study, given the complex environment of the membrane and its influence on protein conformation, mobility, biomolecule
Madhabi Lata Shuma et al.
Biochemistry, 59(18), 1780-1790 (2020-04-15)
The entry of cell-penetrating peptides (CPPs) into live cells and lipid vesicles has been monitored using probe (e.g., fluorescent dye)-labeled CPPs. However, probe labeling may alter the interaction of CPPs with membranes. We have developed a new method to detect
Véronique Yvette Ntsogo Enguéné et al.
Frontiers in microbiology, 6, 541-541 (2015-06-18)
Efflux pumps are membrane transporters that actively extrude various substrates, leading to multidrug resistance (MDR). In this study, we have designed a new test that allows investigating the assembly of the MexA-MexB-OprM efflux pump from the Gram negative bacteria Pseudomonas
Yogi Kurniawan et al.
Langmuir : the ACS journal of surfaces and colloids, 29(34), 10817-10823 (2013-07-31)
Cellular adaptation to elevated alcohol concentration involves altering membrane lipid composition to counteract fluidization. However, few studies have examined the biophysical response of biologically relevant heterogeneous membranes. Lipid phase behavior, molecular packing, and elasticity have been examined by surface pressure-area
Keishi Suga et al.
Langmuir : the ACS journal of surfaces and colloids, 29(15), 4830-4838 (2013-03-20)
Nanosized ordered domains formed in 1,2-dioleoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DOPC/DPPC) and DOPC/cholesterol (Ch) liposomes were characterized using a newly developed (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) quenching method. The membrane fluidity of the DOPC/DPPC liposomes, evaluated by the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), increased significantly above their phase-transition
Lucrecia Alberdi et al.
Journal of cell science, 133(9) (2020-05-16)
Salmonella enterica is an intracellular bacterial pathogen. The formation of its replication niche, which is composed of a vacuole associated with a network of membrane tubules, depends on the secretion of a set of bacterial effector proteins whose activities deeply
An Ghysels et al.
Nature communications, 10(1), 5616-5616 (2019-12-11)
The functional significance of ordered nanodomains (or rafts) in cholesterol rich eukaryotic cell membranes has only begun to be explored. This study exploits the correspondence of cellular rafts and liquid ordered (Lo) phases of three-component lipid bilayers to examine permeability.
Lei Li et al.
Langmuir : the ACS journal of surfaces and colloids, 36(21), 5944-5953 (2020-05-12)
Activation of Raf kinases by the membrane-anchored protein K-Ras4B is a key step of cellular signal regulation. As a predominant variant of the Ras family, K-Ras4B has been considered to be a major drug target in cancer therapy. Therefore, an
Chaohong Liu et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3237-3246 (2012-03-06)
B cells encounter both soluble Ag (sAg) and membrane-associated Ag (mAg) in the secondary lymphoid tissue, yet how the physical form of Ag modulates B cell activation remains unclear. This study compares actin reorganization and its role in BCR signalosome
Zehui Xia et al.
Journal of colloid and interface science, 568, 1-7 (2020-02-20)
To maintain osmotic balance, cells usually produce neutral solutes (i.e., osmolytes), together with charged species to cope with salinity stress. Osmolytes are known to be important in stabilizing/destabilizing macromolecules (e.g., proteins) via depletion /accumulation around their surfaces. To better understand
Sigalit Meker et al.
Langmuir : the ACS journal of surfaces and colloids, 34(32), 9548-9560 (2018-07-19)
Amyloid-β (Aβ) peptide has been implicated in Alzheimer's disease, which is a leading cause of death worldwide. The interaction of Aβ peptides with the lipid bilayers of neuronal cells is a critical step in disease pathogenesis. Recent evidence indicates that
Günther H Peters et al.
Journal of the American Chemical Society, 135(6), 2164-2171 (2013-01-15)
Serotonin (5-hydroxytryptamine, 5-HT) is a prevalent neurotransmitter throughout the animal kingdom. It exerts its effect through the specific binding to the serotonin receptor, but recent research has suggested that neural transmission may also be affected by its nonspecific interactions with
Shadai Salazar Vazquez et al.
Biochimie, 170, 26-35 (2019-12-16)
Type 2 diabetes mellitus is a disease characterized by the formation of amyloid fibrillar deposits consisting mainly in human islet amyloid polypeptide (hIAPP), a peptide co-produced and co-secreted with insulin. hIAPP and insulin are synthesized by pancreatic β cells initially
Photo-Oxidation of Unilamellar Vesicles by a Lipophilic Pterin: Deciphering Biomembrane Photodamage.
Mariana Vignoni et al.
Langmuir : the ACS journal of surfaces and colloids, 34(50), 15578-15586 (2018-11-21)
Pterins are natural products that can photosensitize the oxidation of DNA, proteins, and phospholipids. Recently, a new series of decyl-chain (i.e., lipophilic) pterins were synthesized and their photophysical properties were investigated. These decyl-pterins led to efficient intercalation in large unilamellar
N'Goundo Magassa et al.
EMBO reports, 11(5), 400-405 (2010-03-27)
Bacterial toxin injection into the host cell is required for the virulence of numerous pathogenic bacteria. Cytolysin-mediated translocation (CMT) of Streptococcus pyogenes uses streptolysin O (SLO) to translocate the S. pyogenes nicotinamide adenine dinucleotide-glycohydrolase (SPN) into the host cell cytosol
Seong-Eun Kim et al.
Colloids and surfaces. B, Biointerfaces, 185, 110595-110595 (2019-11-19)
The interaction between the cinnamycin and the biomimetic membranes was studied using the atomic force microscope(AFM). The bilayer was composed of the monolayer tethered on the gold surface and the outer layer fused with the vesicles on the monolayer. The
Badri P Maliwal et al.
PloS one, 8(5), e63043-e63043 (2013-05-15)
The fluorescence lifetimes of most red emitting organic probes are under 4 nanoseconds, which is a limiting factor in studying interactions and conformational dynamics of macromolecules. In addition, the nanosecond background autofluorescence is a significant interference during fluorescence measurements in
Max Piffoux et al.
ACS nano, 12(7), 6830-6842 (2018-07-06)
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery. However, efficient and reproducible loading of EVs with therapeutic or imaging agents
Han-Yuan Liu et al.
Analytical and bioanalytical chemistry (2020-02-06)
We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted lipid bilayer formation method. These supported bilayers present protein recognition elements that are mobile, critical for multivalent
Mahsa Kheradmandi et al.
Cellular and molecular bioengineering, 13(3), 189-199 (2020-05-20)
Atherosclerosis (ATH), the build up of fat in the arteries, is a principal cause of heart attack and stroke. Drug instability and lack of target specificity are major drawbacks of current clinical therapeutics. These undesirable effects can be eliminated by
Md Zahidul Islam et al.
Langmuir : the ACS journal of surfaces and colloids, 33(9), 2433-2443 (2017-02-07)
The translocation of cell-penetrating peptides (CPPs) through plasma membranes of living cells is an important physiological phenomenon in biomembranes. To reveal the mechanism underlying the translocation of a CPP, transportan 10 (TP10), through lipid bilayers, we examined the effects of
Peter J Beltramo et al.
Langmuir : the ACS journal of surfaces and colloids, 34(20), 5880-5888 (2018-05-02)
Capacitance measurements provide unique insights into the thickness, compressibility, and composition of large-area membrane bilayers and are used here in addition to demonstrate the successful incorporation of model ion channels. The simultaneous ability to control the bilayer size, manipulate tension
Mohammad Abu Sayem Karal et al.
Chemistry and physics of lipids, 230, 104916-104916 (2020-05-15)
The interaction of anionic magnetite nanoparticles (MNPs) of size 18 nm with negatively charged giant unilamellar vesicles (GUVs) formed from a mixture of neutral dioleoylphosphatidylcholine (DOPC) and negatively charged dioleoylphosphatidylglycerol (DOPG) lipids has been investigated. It has been obtained that
Kenneth K Y Ho et al.
PloS one, 12(3), e0174689-e0174689 (2017-03-31)
Development of artificial cell models requires encapsulation of biomolecules within membrane-bound compartments. There have been limited studies of using mammalian cell-free expression (CFE) system as the 'cytosol' of artificial cells. We exploit glass capillary droplet microfluidics for the encapsulation of
Mengting Yang et al.
Langmuir : the ACS journal of surfaces and colloids, 34(28), 8408-8414 (2018-06-22)
Plasma membranes in the human brain can interact with amyloid β-peptide (1-42; Aβ42) and induce Aβ42 fibrillation, which is considered to be a crucial process underlying the neurotoxicity of Aβ42 and the pathogenesis of Alzheimer's disease (AD). However, the mechanism
Enamul Haque Mojumdar et al.
International journal of molecular sciences, 21(1) (2019-12-22)
Ganglioside lipids have been associated with several physiological processes, including cell signaling. They have also been associated with amyloid aggregation in Parkinson's and Alzheimer's disease. In biological systems, gangliosides are present in a mix with other lipid species, and the
Imelda J Galván Márquez et al.
Canadian journal of microbiology, 66(2), 161-168 (2019-11-20)
Nisin is a class I polycyclic bacteriocin produced by the bacterium Lactococcus lactis, which is used extensively as a food additive to inhibit the growth of foodborne Gram-positive bacteria. Nisin also inhibits growth of Gram-negative bacteria when combined with membrane-disrupting
Hanna Brzeska et al.
The Journal of biological chemistry, 283(46), 32014-32023 (2008-09-06)
The tail of Acanthamoeba myosin IC (AMIC) has a basic region (BR), which contains a putative pleckstrin homology (PH) domain, followed by two Gly/Pro/Ala (GPA)-rich regions separated by a Src homology 3 (SH3) domain. Cryoelectron microscopy had shown that the
Yachong Guo et al.
ACS nano (2018-11-20)
Increasing awareness of bioeffects and toxicity of nanomaterials interacting with cells puts in focus the mechanisms by which nanomaterials can cross lipid membranes. Apart from well-discussed energy-dependent endocytosis for large objects and passive diffusion through membranes by solute molecules, other
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