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Showing 1-30 of 103 results for "850725p" within Papers
Shuai Zhen et al.
Human gene therapy (2020-01-25)
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) technology enables targeted gene editing, but cancer gene therapy with this approach requires improvements to enable safe and efficient delivery of CRISPR/Cas9 to tumors. We developed and evaluated a self-assembled
Jürgen Kreiter et al.
Biomolecules, 10(5) (2020-05-06)
Several mitochondrial proteins, such as adenine nucleotide translocase (ANT), aspartate/glutamate carrier, dicarboxylate carrier, and uncoupling proteins 2 and 3, are suggested to have dual transport functions. While the transport of charge (protons and anions) is characterized by an alteration in
Sanjay Arora et al.
ACS chemical neuroscience, 11(11), 1620-1633 (2020-05-01)
Alzheimer's disease (AD), the most common cause of dementia, inflicts enormous suffering to patients and their family members. It is the third deadliest disease, affecting 46.8 million people worldwide. Brain-derived neurotrophic factor (BDNF) is involved in the development, maintenance, and
Parvin Zamani et al.
Life sciences, 252, 117646-117646 (2020-04-10)
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells causing resistance to immunotherapies in cancer tumors. In the current study, various immunogenic and therapeutic features of the combination therapies with non-liposomal Doxorubicin (Dox) and the E75 immunogenic peptide (Pep), derived from the
Wei Jin et al.
Journal of the American Society for Mass Spectrometry, 31(2), 366-378 (2020-01-11)
Gemini surfactants are a class of lipid molecules that have been successfully used in vitro and in vivo as nonviral gene delivery vectors. However, the biological fate of gemini surfactants has not been well investigated. In particular, the metabolism of
Max Piffoux et al.
ACS nano, 12(7), 6830-6842 (2018-07-06)
Extracellular vesicles (EVs) are recognized as nature's own carriers to transport macromolecules throughout the body. Hijacking this endogenous communication system represents an attractive strategy for advanced drug delivery. However, efficient and reproducible loading of EVs with therapeutic or imaging agents
Keni Yang et al.
Acta biomaterialia, 106, 314-327 (2020-02-23)
Nano-sized objects such as liposomes are modified by adsorption of biomolecules in biological fluids. The resulting corona critically changes nanoparticle behavior at cellular level. A better control of corona composition could allow to modulate uptake by cells. Within this context
Exploring the correlation between lipid packaging in lipoplexes and their transfection efficacy
Moghaddam B, et al.
Pharmaceutics, 3(4), 848-864 (2011)
Armando Tripodi et al.
Thrombosis research, 185, 96-101 (2019-12-02)
Preterm newborns are considered at risk of acquired coagulopathy and are often prophylactically infused with fresh frozen plasma (FFP) even in the absence of bleeding. To assess the coagulation asset of preterm neonates and the biological plausibility of such infusions
Madlen Hubert et al.
eLife, 9 (2020-05-05)
Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids. However, the influence of lipid composition on caveolae surface stability is not well described or understood.
Mariya Chavarha et al.
Biophysical journal, 104(3), 594-603 (2013-02-28)
The hydrophobic surfactant proteins, SP-B and SP-C, greatly accelerate the adsorption of the surfactant lipids to an air/water interface. Previous studies of factors that affect curvature suggest that vesicles may adsorb via a rate-limiting structure with prominent negative curvature, in
Debasis Das et al.
Nature communications, 11(1), 231-231 (2020-01-15)
The opening of a fusion pore during exocytosis creates the first aqueous connection between the lumen of a vesicle and the extracellular space. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) mediate the formation of these dynamic structures, and their kinetic
Amandine Rovini et al.
Cellular and molecular life sciences : CMLS, 77(18), 3611-3626 (2019-11-25)
An intrinsically disordered neuronal protein α-synuclein (αSyn) is known to cause mitochondrial dysfunction, contributing to loss of dopaminergic neurons in Parkinson's disease. Through yet poorly defined mechanisms, αSyn crosses mitochondrial outer membrane and targets respiratory complexes leading to bioenergetics defects.
Jiajun Xu et al.
Molecular pharmaceutics, 17(1), 301-315 (2019-11-26)
The controversy surrounding the use of diphtheria toxin (DT) as a therapeutic agent against tumor cells arises mainly from its unexpected harmfulness to healthy tissues. We encoded the cytotoxic fragment A of DT (DTA) as an objective gene in the
Rashik Ahmed et al.
Chemical science, 10(24), 6072-6082 (2019-07-31)
Soluble amyloid beta assemblies (Aβ n
Michael Margolis et al.
Biochimie, 108, 133-139 (2014-12-03)
Obesity, an established risk factor for breast cancer (BC), is associated with systemic inflammation. The breast contains adipose tissue (bAT), yet whether it plays a role in BC progression in obese females is being intensively studied. There is scarce knowledge
Jordi H Borrell et al.
The journal of physical chemistry. B, 121(28), 6882-6889 (2017-06-22)
Because transmembrane proteins (TMPs) can be obtained with sufficient purity for X-ray diffraction studies more frequently than decades ago, their mechanisms of action may now be elucidated. One of the pending issues is the actual interplay between transmembrane proteins and
Yuma Yamada et al.
Mitochondrion, 52, 67-74 (2020-02-26)
The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human
Stephen A Pearson et al.
Metallomics : integrated biometal science, 12(6), 902-915 (2020-04-28)
Iron-sulfur cluster proteins play key roles in a multitude of physiological processes; including gene expression, nitrogen and oxygen sensing, electron transfer, and DNA repair. Biosynthesis of iron-sulfur clusters occurs in mitochondria on iron-sulfur cluster scaffold proteins in the form of
Jinju Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 321, 184-197 (2020-02-09)
Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance
Non Miyata et al.
The Journal of cell biology, 214(1), 77-88 (2016-06-30)
Phosphatidylethanolamine (PE) is an essential phospholipid for mitochondrial functions and is synthesized mainly by phosphatidylserine (PS) decarboxylase at the mitochondrial inner membrane. In Saccharomyces cerevisiae, PS is synthesized in the endoplasmic reticulum (ER), such that mitochondrial PE synthesis requires PS
Stuart A Whitehead et al.
Bioconjugate chemistry, 28(4), 923-932 (2017-03-02)
Artificial systems for controlled membrane fusion applicable for drug delivery would ideally use triggers that are orthogonal to biology. To apply the strain-promoted alkyne-azide cycloaddition (SPAAC) to drive membrane fusion, oxo-dibenzocyclooctyne (ODIBO)-lipid 1 was designed, synthesized, and studied alongside azadibenzocyclooctyne
Takao Hanada et al.
The Journal of biological chemistry, 282(52), 37298-37302 (2007-11-08)
Autophagy is a bulk degradation process in eukaryotic cells; autophagosomes enclose cytoplasmic components for degradation in the lysosome/vacuole. Autophagosome formation requires two ubiquitin-like conjugation systems, the Atg12 and Atg8 systems, which are tightly associated with expansion of autophagosomal membrane. Previous
Jayesh A Kulkarni et al.
Nanoscale, 11(45), 21733-21739 (2019-11-13)
Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells (hepatocytes) following intravenous (i.v.) administration. These LNP-siRNA systems consist of four lipid components
Yu-Qing Wang et al.
International journal of pharmaceutics, 582, 119331-119331 (2020-04-15)
The major drawbacks of the cytotoxin like DM1 are the off-target effects. Here, the targeting nanovesicles were developed by synthesizing tocopherol-SS-DM1 and conjugating a pH low insertion peptide (pHLIP) to PEGylated phospholipids, in which tocopherol-SS-DM1 improves the drug loading and
Katyayini Aribindi et al.
Investigative ophthalmology & visual science, 54(4), 3037-3044 (2013-04-06)
We compared phospholipid (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidylinositol) profiles of control and glaucomatous trabecular meshwork (TM) derived from human donors. Control TM and most primary open angle glaucoma (POAG) TM were collected from cadaver donors. A select subset of POAG
Katherine N Liu et al.
Biophysical journal, 118(10), 2426-2433 (2020-04-17)
Host lipid composition influences many stages of the influenza A virus (IAV) entry process, including initial binding of IAV to sialylated glycans, fusion between the viral envelope and the host membrane, and the formation of a fusion pore through which
Jürgen Kreiter et al.
Biophysical journal, 117(10), 1845-1857 (2019-11-11)
Genipin, a natural compound from Gardenia jasminoides, is a well-known compound in Chinese medicine that is used for the treatment of cancer, inflammation, and diabetes. The use of genipin in classical medicine is hindered because of its unknown molecular mechanisms
Christopher Janich et al.
Langmuir : the ACS journal of surfaces and colloids, 33(39), 10172-10183 (2017-09-06)
Four different binary lipid mixtures composed of a cationic lipid and the zwitterionic colipids DOPE or DPPC, which show different DNA transfer activities in cell culture models, were investigated at the soft air/water interface to identify transfection efficiency determining characteristics.
Catharina Husteden et al.
ACS applied materials & interfaces, 12(8), 8963-8977 (2020-02-01)
Biomaterials, which release active compounds after implantation, are an essential tool for targeted regenerative medicine. In this study, thin multilayer films loaded with lipid/DNA complexes (lipoplexes) were designed as surface coatings for in situ transfection applicable in tissue engineering and
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