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Showing 1-30 of 174 results for "87921" within Papers
Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.
Liying Tang et al.
Phytochemistry, 107, 102-110 (2014-08-26)
Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for
Gunnar Bergström et al.
Lab on a chip, 15(15), 3242-3249 (2015-07-03)
Beating in vivo-like human cardiac bodies (CBs) were used in a microfluidic device for testing cardiotoxicity. The CBs, cardiomyocyte cell clusters derived from induced pluripotent stem cells, exhibited typical structural and functional properties of the native human myocardium. The CBs
Kazutaka Shibatomi et al.
Chemistry, an Asian journal, 3(8-9), 1581-1584 (2008-06-21)
The Lewis acid catalyzed bromination of aromatic side chains was achieved efficiently by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as the bromination reagent under mild conditions. Zirconium(IV) chloride showed the highest catalytic activity for this benzylic bromination. It was revealed that the present
Heath D Watts et al.
The journal of physical chemistry. B, 115(9), 1958-1970 (2011-02-16)
Coniferyl alcohol is a monomeric building block of lignin, the second most abundant biopolymer. During lignification, the monomer forms a variety of linkages through free radical additions. A large NMR database has been constructed that reports the (1)H and (13)C
Anastasia De Luca et al.
Oncotarget, 6(6), 4126-4143 (2015-01-18)
We designed and synthesized two novel nitrobenzoxadiazole (NBD) analogues of the anticancer agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX). The new compounds, namely MC3165 and MC3181, bear one and two oxygen atoms within the hydroxy-containing alkyl chain at the C4 position of the NBD
Ruijian Zhong et al.
Fitoterapia, 102, 23-26 (2015-01-20)
Three new labdane-type diterpene glycosides, 15,18-di-O-β-d-glucopyranosyl-13(E)-ent-labda-7(8),13(14)-diene-3β,15,18-triol (1), 15,18-di-O-β-d-glucopyranosyl-13(E)-ent-labda-8(9),13(14)-diene-3β,15,18-triol (2), and 15-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranosyl-18-O-β-d-glucopyranosyl-13(E)-ent-labda-8(9),13(14)-diene-3β,15,18-triol (3), were isolated from the fruits of Rubus chingii. Their structures were elucidated on the basis of spectroscopic data and chemical methods. The cytotoxic activities of compounds 1-3 were
August Andersson et al.
FEBS letters, 545(2-3), 139-143 (2003-06-14)
The interaction between the peptide hormone motilin and bicelles has been investigated by pulsed field gradient-nuclear magnetic resonance methods and by the use of paramagnetic probes. Diffusion coefficients were measured for motilin, the phospholipids with and without motilin, and for
Ahmed Kamal et al.
Bioorganic chemistry, 59, 23-30 (2015-02-11)
A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo[2,1-c][1,4]benzodiazepine conjugates (5a-c, 6a,b) have been synthesized and evaluated for their cytotoxic potential and DNA-binding ability. The representative conjugates 5a and 5b have been screened for their cytotoxicity against a panel of 60
Hong-Mei Li et al.
Journal of Asian natural products research, 17(7), 761-766 (2015-01-16)
Two new abietane diterpene glycosides, wilfordosides A (1) and B (2), were isolated from the roots of Tripterygium wilfordii. The structures of compounds 1 and 2 were established using spectroscopic methods including extensive 1D and 2D NMR analysis, in combination
Yonghe Fei et al.
Food chemistry, 187, 385-390 (2015-05-16)
Three new monoterpene glycosides (1-3) and eleven known compounds (4-14) were isolated from seeds of Helianthus annuus L. (sunflower). Their structures were determined by spectroscopic and chemical methods. All the compounds were isolated from sunflower seeds for the first time.
Elise Ivarsen et al.
Journal of AOAC International, 97(5), 1282-1290 (2015-04-24)
Clostridium perfringens is the causative agent of necrotic enteritis leading to significant losses in the poultry industry. Dichloromethane and n-hexane extracts of aerial parts of Artemisia annua (Asteraceae) exhibited activity against C. perfringens with minimum inhibitory concentrations (MIC) of 185
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine
Yan-Ling Zhang et al.
Journal of Asian natural products research, 17(7), 717-723 (2015-01-07)
Two new capsaicin analogs, N-(3-methoxy-4-hydroxyphenethyl)-tetracosanamide (1) and N-(3,4-dihydroxyphenethyl)-tetracosanamide (2), along with one new flavonoidal glycoside pinnatifin E (3) were isolated from the ethanolic extract of the seeds of Vaccaria segetalis. Their structures were elucidated on the basis of spectroscopic methods
Thuy Nguyen et al.
Bioorganic & medicinal chemistry, 23(9), 2195-2203 (2015-03-24)
A series of substituted 1H-indole-2-carboxamides structurally related to compounds Org27569 (1), Org29647 (2) and Org27759 (3) were synthesized and evaluated for CB1 allosteric modulating activity in calcium mobilization assays. Structure-activity relationship studies showed that the modulation potency of this series
Jinping Jia et al.
Molecules (Basel, Switzerland), 20(6), 10065-10081 (2015-06-04)
Forsythiae Fructus (FF), the dried fruit of Forsythia suspensa, has been widely used as a heat-clearing and detoxifying herbal medicine in China. Green FF (GF) and ripe FF (RF) are fruits of Forsythia suspensa at different maturity stages collected about
Xiu-Rong Zhang et al.
Drug development and industrial pharmacy, 41(6), 916-926 (2014-05-03)
Mitomycin C (MTC) was incorporated to a micelle system preparing from a polymer named deoxycholic acid chitosan-grafted poly(ethylene glycol) methyl ether (mPEG-CS-DA). mPEG-CS-DA was synthesized and characterized by (1)H nuclear magnetic resonance ((1)H-NMR) and Fourier transform infrared spectroscopy. mPEG-CS-DA formed
Dong Gu Lee et al.
Chemical & pharmaceutical bulletin, 63(11), 927-934 (2015-11-03)
Four phytochemical constituents were isolated from Panax ginseng root by repeated column chromatography (CC), medium pressure liquid chromatography (MPLC), high-speed counter current chromatography (HSCCC), and semi-preparative HPLC. Their structures were elucidated as the dammarane-type triterpene saponins ginsenoside-Rg18 (1), 6-acetyl ginsenoside-Rg3
Zhuhua Yao et al.
Chirality, 27(12), 936-943 (2015-10-02)
Rivaroxaban is an oral direct factor Xa (FXa) inhibitor clinically used to prevent and treat thromboembolic disorders. Drug-drug interaction (DDI) exist for rivaroxaban and the inhibitors of CYP3A4/5. This study aims to investigate the inhibition of rivaroxaban and its derivatives
Alicia J Sawdon et al.
Colloids and surfaces. B, Biointerfaces, 122, 738-745 (2014-09-07)
Polymeric prodrug micelles for delivery of acyclovir (ACV) were synthesized. First, ACV was used directly to initiate ring-opening polymerization of ɛ-caprolactone to form ACV-polycaprolactone (ACV-PCL). Through conjugation of hydrophobic ACV-PCL with hydrophilic methoxy poly(ethylene glycol) (MPEG) or chitosan, polymeric micelles
Sandeep Gawaskar et al.
Bioorganic & medicinal chemistry, 22(23), 6638-6646 (2014-12-03)
Due to their beneficial side effect profile, NMDA receptor antagonists interacting selectively with the allosteric ifenprodil binding site of the GluN2B subunit are of major interest for the treatment of neurological and neurodegenerative disorders. A series of benzo[7]annulen-7-amines 6 was
Nicolás Ubero-Pascal et al.
Microscopy research and technique, 68(5), 264-271 (2005-11-30)
Hexamethyldisilizane (HMDS) and tetramethylsilane are organic compounds that are volatile at ambient temperature and which can therefore be used for air-drying biological samples for SEM studies. The techniques using these compounds provide results that are comparable with those obtained by
Seong Su Hong et al.
Fitoterapia, 99, 347-351 (2014-12-03)
The ethanolic extract of the needles of Pinus thunbergii was found to suppress antigen mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. A new neolignan glycoside, named pinusthunbergiside A (1), as well as six known neolignan glycosides (2-7) were isolated
Xijuan Chen et al.
The Science of the total environment, 505, 39-46 (2014-10-13)
Aerobic degradation experiments of Triclosan were performed in activated sludge to identify possible transformation products for this compound. During 7 days, the formation of biotransformation products such as 2,4-Dichlorophenol, 4-Chlorocatechol, 5-Hydroxy-Triclosan and other Monohydroxy-Triclosan derivatives as well as Dihydroxy-Triclosan-derivatives were
Tameryn Stringer et al.
Dalton transactions (Cambridge, England : 2003), 44(33), 14906-14917 (2015-08-01)
A series of mono- and bis-salicylaldimine ligands and their corresponding Rh(i) complexes were prepared. The compounds were characterised using standard spectroscopic techniques including NMR, IR spectroscopy and mass spectrometry. The salicylaldimine ligands and complexes were screened for antiparasitic activity against
M B Avinash et al.
Scientific reports, 5, 16070-16070 (2015-11-04)
A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was utilized to synthesize molecular crystals of cyclic dipeptides (CDPs), whose molecular weights (~0.2 kDa) are nearly three orders of magnitude smaller
Sangjun Lee et al.
Carbohydrate polymers, 121, 284-294 (2015-02-11)
In this study, we synthesized dimer acid (DA) esters, having short to long alkyl chains, (DA-Cn) by the Diels-Alder reaction and subsequent esterification reaction of fatty acids that were prepared by the hydrolysis of waste vegetable oil. It was found
Cai-Hua Jia et al.
Journal of agricultural and food chemistry, 63(47), 10280-10286 (2015-10-23)
Caffeic acid phenethyl ester (CAPE) and 4-vinylcatechol (4-VC) were prepared for studying their antioxidative activities in emulsion. Oil-in-water emulsions of stripped soybean oil containing 200 ppm of CAPE, 4-VC, or α-tocopherol were stored at 40 °C in the dark for
Anita Cohen et al.
European journal of medicinal chemistry, 95, 16-28 (2015-03-21)
A preliminary in vitro screening of compounds belonging to various chemical families from our library revealed the thieno[3,2-d]pyrimidin-4(3H)-one scaffold displayed a promising profile against Plasmodium falciparum. Then, 120 new derivatives were synthesized and evaluated in vitro; compared to drug references, 40 showed
Philippe C Gros et al.
Organic & biomolecular chemistry, 4(23), 4331-4335 (2006-11-15)
The first regioselective C-4 lithiation of (S)-nicotine has been realized using TMSCH2Li as basic reagent in toluene. The reaction proceeded under mild conditions with a small excess of electrophile. The 4-chloro derivative was subsequently metallated at C-5 with the same
Giampietro Frison et al.
Rapid communications in mass spectrometry : RCM, 29(13), 1196-1204 (2015-09-24)
We describe the analytical characterization of the designer drug bk-2C-B, a cathinone derivative, contained in a seized tablet, in the absence of an analytical standard. The analytical techniques employed include gas chromatography/mass spectrometry (GC/MS), without and with derivatization with 2,2,2-trichloroethyl
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