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Showing 31-60 of 246 results for "88-14-2" within Papers
Olivier Kosmider et al.
Haematologica, 94(12), 1676-1681 (2009-10-03)
Acquired somatic deletions and loss-of-function mutations in one or several codons of the TET2 (Ten-Eleven Translocation-2) gene were recently identified in hematopoietic cells from patients with myeloid malignancies, including myeloproliferative disorders and myelodys-plastic syndromes. The present study was designed to
J V Cohen et al.
Familial cancer, 11(1), 69-75 (2011-09-08)
Risk-reducing salpingo-oophorectomy (RRSO) significantly reduces the risk of ovarian cancer and breast cancer in pre-menopausal women with BRCA1 and BRCA2 (B1/2) mutations. Despite its clear benefits, little is known about non-cancer endpoints in this population. Medical records were examined in
Shyam Sundar et al.
Tropical medicine & international health : TM & IH, 18(1), 96-100 (2012-11-10)
Standard treatment of Indian post-kala-azar dermal leishmaniasis (PKDL) is unsatisfactory because to achieve therapeutic effectiveness, heroic courses of parenteral and toxic agents have to be administered. Our objective was to evaluate oral miltefosine for its potential to provide effective as
Ingemarie R Berger et al.
Cancer genetics and cytogenetics, 159(2), 155-159 (2005-05-19)
Mitogen-activated protein kinases (MAPKs) are important regulators of a vast number of biological functions that affect life and death of eukaryotic cells and are tightly regulated by the concerted action of several phosphatases. Among these is the human homologue of
G W Hutchinson et al.
Veterinary parasitology, 162(3-4), 278-284 (2009-04-21)
The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nitroxynil, clorsulon and ivermectin with oral and pour-on combination formulations containing triclabendazole. Groups of
Stewart G Albert et al.
Intensive care medicine, 37(6), 901-910 (2011-03-05)
Although etomidate is a preferred anesthetic agent for rapid sequence intubation (RSI) in critical illness, as an inhibitor of cortisol synthesis (11β-hydroxylase), it may be associated with adrenal dysfunction. The objectives are to review the effects of etomidate versus comparator
Harold J Burstein et al.
Investigational new drugs, 25(2), 161-164 (2006-09-14)
Rebeccamycin analog (NSC 655649) is a synthetic antibiotic cytotoxic agent thought to inhibit topoisomerase function. We sought to determine the response rate to rebeccamycin analog among patients with refractory advanced breast cancer using two different treatment schedules. Eligible patients had
Muhammad Tayyab Ansari et al.
Pharmaceutical development and technology, 23(10), 1007-1015 (2016-11-26)
The purpose of this study was to investigate changes in the water solubility of artemether; a poorly soluble drug used for the treatment of malaria. Different solid dispersions (SDs) of artemether were prepared using artemether and polyethylene glycol 6000 at
P C Chong et al.
The Journal of biological chemistry, 257(19), 11667-11672 (1982-10-10)
The heterobifunctional photoaffinity probe, AGTC (N-(4-azidobenzoyl-[2-3H]glycyl)-S-(2-thiopyridyl) cysteine), was attached to cysteines 48 and 64 of troponin I to determine which component of rabbit skeletal troponin was in close proximity to these cysteines. The reconstituted troponin complex (AGC labeled CM-TnI, TnT
Luis A Diaz et al.
The Journal of investigative dermatology, 123(6), 1045-1051 (2004-12-22)
Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem (FS) are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought
José C Franque Mirembo et al.
International journal of occupational and environmental health, 19(2), 113-118 (2013-05-21)
Little is known about the potential for overexposure to respirable quartz in farming, in most parts of the world. To measure respirable dust and quartz exposure of tractor operators on two medium-sized dry climate farms. This is a descriptive cross-sectional
James A H Inkster et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(35), 11079-11087 (2012-07-19)
Nucleophilic incorporation of [(18)F]F(-) under aqueous conditions holds several advantages in radiopharmaceutical development, especially with the advent of complex biological pharmacophores. Sulfonyl fluorides can be prepared in water at room temperature, yet they have not been assayed as a potential
MSH-6: extending the reliability of immunohistochemistry as a screening tool in Muir-Torre syndrome.
Vishes Chhibber et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(2), 159-164 (2007-12-11)
The subtype of Muir-Torre syndrome, allelic to hereditary nonpolyposis colorectal cancer is typically associated with germline mutations in the mismatch repair proteins MSH-2 and/or MLH-1. More recently, mutation in an additional mismatch repair protein MSH-6 has been documented in a
Jamie Koo et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 25(6), 893-901 (2012-03-06)
Neuroendocrine tumors can present as liver metastases before discovery of the primary tumor. Islet 1 and PAX8 have recently been proposed as markers for neuroendocrine tumors of pancreatic origin. In this study, we compared the utility of Islet 1 and
H Sun et al.
American journal of clinical pathology, 115(1), 32-38 (2001-02-24)
To determine the potential role of PTEN in the process of endometrial carcinogenesis, we examined a series of endometrial carcinoma and hyperplasia of the uterine corpus for the presence of a PTEN mutation. The entire coding region of the gene
Rosalind F Sandell et al.
Human pathology, 46(9), 1390-1397 (2015-07-30)
Solitary (juvenile) xanthogranuloma (SXG) is an uncommon, benign lesion that usually occurs in children. The cell of origin of SXG has been the subject of debate, with hypotheses including endothelium, dermal dendrocytes, dermal indeterminate cells, and the plasmacytoid monocyte, among
M C Walsh et al.
Journal of animal science, 90(1), 261-271 (2011-08-16)
Pigs (n = 88) weaned at 19 ± 2 d of age were used in a 14-d study to evaluate the effects of water-delivered direct-fed microbials (DFM) or organic acids on growth, immune status, Salmonella infection and shedding, and intestinal
S Aho et al.
Nucleic acids research, 12(15), 6117-6125 (1984-08-10)
During the fine structural analysis of the 5' end of the 38 kb chicken pro alpha 2(I) collagen gene, we failed to locate an exon, only 11 bp in size, which had been predicted from the DNA sequence analysis of
Matthew Hoffmann et al.
Cancer chemotherapy and pharmacology, 71(2), 489-501 (2012-12-04)
To investigate the pharmacokinetics and disposition of [(14)C]pomalidomide following a single oral dose to healthy male subjects. Eight subjects were administered a single 2 mg oral suspension of [(14)C]pomalidomide. Blood (plasma), urine and feces were collected. Mass balance of radioactivity
Ankur Goyal et al.
World journal of gastroenterology, 12(29), 4721-4726 (2006-08-29)
To study whether CCR5Delta32 mutation was associated with viral infection and severity of liver disease. Two hundred and fifty two histologically proven, chronic HCV patients (mean age: 41 +/- 14 years; M/F: 164/88) were genotyped. PCR based genotyping of 32
José A Riancho et al.
Biogerontology, 8(2), 121-127 (2006-09-07)
Klotho gene codes for a protein with glucuronidase activity and is thought to influence bone and vascular homeostasis. We studied the relationship of a common T/G polymorphism, resulting in a phenylalanine (F) to valine (V) substitution at aminoacid position 352
Kevin K Hannawa et al.
Circulation, 112(2), 241-247 (2005-07-07)
This investigation tested the hypothesis that L-selectin is important in experimental abdominal aortic aneurysm (AAA) formation in rodents. Rat abdominal aortas were perfused with saline (control) or porcine pancreatic elastase and studied on postperfusion days 1, 2, 4, 7, and
Lidia Sabater et al.
Journal of neuroimmunology, 170(1-2), 186-190 (2005-09-17)
We describe a new antigen, BR serine/threonine kinase 2 (BRSK2), identified by an antibody present in the serum of a patient with limbic encephalitis and small-cell lung cancer (SCLC). Patient's serum immunolabeled the neuronal cytoplasm and, less intense, the neuropil
Guy Bertrand Djigoué et al.
Molecules (Basel, Switzerland), 18(1), 914-933 (2013-01-25)
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT) or epi-ADT. After the protection of the
R R West et al.
The Journal of biological chemistry, 266(32), 21886-21896 (1991-11-15)
cDNAs encoding human and mouse microtubule-associated protein 4 (MAP 4) were isolated. MAP 4 is encoded by a single gene. Multiple MAP 4 mRNAs are transcribed that are differentially expressed among mouse tissues. Open reading frames for the human and
Valérie Ducharme et al.
The Journal of heart valve disease, 22(2), 142-149 (2013-06-27)
Calcific aortic valve stenosis (AS) affects 2-5% of the population aged > 65 years. Functional DNA variants at the NOTCH1 locus result in bicuspid aortic valve (BAV) and severe valve calcification. The contribution of these variants to AS in the
H Abdallah et al.
Journal of chromatography. A, 1355, 61-72 (2014-06-25)
A new high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) method was developed for a simultaneous multi-residue analysis of 22 sulfonamides (SAs) and their metabolites in edible animal (pig, beef, sheep and chicken) tissues. Sample preparation was optimized on the
Sheng Liu et al.
Frontiers in microbiology, 11, 845-845 (2020-05-28)
Mycobacterium tuberculosis (M. tb) evades the surveillance of immune responses for survival in macrophages. However, the precise mechanism and toxins/proteins encoded by M. tb involved in the bacterial escape remain elusive. The function of Rv1768 protein (also referred to as
Mark B Abelson et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 18(5), 475-488 (2002-11-07)
Patients with allergic conjunctivitis may experience several debilitating symptoms, particularly ocular itching. The objective of this study was to evaluate the efficacy and safety of pemirolast potassium 0.1% ophthalmic solution (Alamast trade mark ), a novel mast-cell stabilizer, for preventing
Karina Portillo et al.
Archivos de bronconeumologia, 46(3), 129-134 (2010-01-26)
Mutations of the gene that code bone morphogenic protein type 2 receptor (BMPR2) are involved in the pathogenesis of pulmonary arterial hypertension (PAH), both in its familial (FPAH) and its idiopathic (IPAH) forms. With the aim of increasing the knowledge
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