890705C

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Showing 1-8 of 8 results for "890705C" within Papers

Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells.

Li Wang et al.

Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)

To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but

Evaluation of the antitumoral effect mediated by IL-12 and HSV-tk genes when delivered by a novel lipid-based system.

H Faneca et al.

Biochimica et biophysica acta, 1768(5), 1093-1102 (2007-02-14)

In the present work, we used a novel albumin-associated lipoplex formulation, containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) and cholesterol (Chol), to evaluate the antitumoral efficacy of two gene therapy strategies: immuno-gene therapy, mediated by IL-12 gene expression, and "suicide" gene

Hydrophobic moiety of cationic lipids strongly modulates their transfection activity.

Rumiana Koynova et al.

Molecular pharmaceutics, 6(3), 951-958 (2009-04-04)

Synthetic cationic lipids are widely used components of nonviral gene carriers, and the factors regulating their transfection efficiency are the subject of considerable interest. In view of the important role that electrostatic interactions with the polyanionic nucleic acids play in

Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA.

Rumiana Koynova et al.

Biochimica et biophysica acta, 1768(2), 375-386 (2006-12-13)

Lipoplexes containing a mixture of cationic phospholipids dioleoylethylphosphatidylcholine (EDOPC) and dilauroylethylphosphatidylcholine (EDLPC) are known to be far more efficient agents in transfection of cultured primary endothelial cells than are lipoplexes containing either lipid alone. The large magnitude of the synergy

MicroRNA modulation combined with sunitinib as a novel therapeutic strategy for pancreatic cancer.

Marta Passadouro et al.

International journal of nanomedicine, 9, 3203-3217 (2014-07-26)

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and mortal cancer, characterized by a set of known mutations, invasive features, and aberrant microRNA expression that have been associated with hallmark malignant properties of PDAC. The lack of effective PDAC treatment

Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency.

Boris G Tenchov et al.

Biochimica et biophysica acta, 1778(10), 2405-2412 (2008-08-30)

Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for

Modulation of fluorophore environment in host membranes of varying charge

Kelkar DA, et al.

Journal of Fluorescence, 13(6), 459-466 (2003)

Phospholipid-Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability.

Wei Zong et al.

Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)

The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes

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