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Christine Lin Chin et al.
BMC biotechnology, 15, 44-44 (2015-06-03)
Expression vector engineering technology is one of the most convenient and timely method for cell line development to meet the rising demand of novel production cell line with high productivity. Destabilization of dihydrofolate reductase (dhfr) selection marker by addition of
Jian Sun et al.
Hepatology (Baltimore, Md.), 59(4), 1283-1292 (2014-01-03)
An optimization strategy based on the Roadmap concept is supposed to improve the clinical outcomes of patients with suboptimal antiviral response. The aim of this study was to prove the concept with a multicenter, open-label, randomized, controlled study. In all
Z Han et al.
Journal of viral hepatitis, 20 Suppl 1, 58-64 (2013-03-15)
The aim of this study was to evaluate the efficacy and safety of telbivudine 600 mg/day compared with lamivudine 100 mg/day for 48 weeks of treatment in patients with hepatitis B-related cirrhosis. Data were reviewed retrospectively from 165 hepatitis B-related
Yunxin Liu et al.
Endocrine-related cancer, 21(4), 639-651 (2014-07-13)
Patients with ulcerative colitis are at a very high risk of developing colorectal cancer. Corticotrophin-releasing hormone (CRH) family peptides and their receptors (CRHRs) are found to modulate inflammation and tumor cell growth. However, the role of CRH family peptides and
Keon-Il Im et al.
Journal of immunology (Baltimore, Md. : 1950), 194(11), 5223-5232 (2015-04-26)
Graft-versus-host disease (GVHD) is a major complication associated with allogeneic hematopoietic stem cell transplantation. Despite the prominent role of the adaptive immune system, the importance of controlling the innate immune system in the pathogenesis of GVHD has recently been rediscovered.
Qing Song Hu et al.
Biomedical and environmental sciences : BES, 28(4), 253-262 (2015-05-15)
This study was aimed to investigate the effects of carbon monoxide releasing molecule (CORM-2), a novel carbon monoxide carrier, on the reendothelialization of carotid artery in rat endothelial denudation model. Male rats subjected to carotid artery balloon injury were treated
Ending vertical transmission of hepatitis B: the third trimester intervention.
Monika Sarkar et al.
Hepatology (Baltimore, Md.), 60(2), 448-451 (2014-03-29)
Maja Mustapic et al.
Human molecular genetics, 23(23), 6375-6384 (2014-07-06)
Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Changes in DBH expression or activity have been implicated in the pathogenesis of cardiovascular and neuropsychiatric disorders. Genetic determination of DBH enzymatic activity and its secretion are only incompletely
Justus Reunanen et al.
Applied and environmental microbiology, 81(11), 3655-3662 (2015-03-22)
Akkermansia muciniphila is a Gram-negative mucin-degrading bacterium that resides in the gastrointestinal tracts of humans and animals. A. muciniphila has been linked with intestinal health and improved metabolic status in obese and type 2 diabetic subjects. Specifically, A. muciniphila has
Eivind Valen Egeland et al.
Clinical & experimental metastasis, 32(8), 755-767 (2015-09-10)
S100A4 promotes metastasis in several types of cancer, but the involved molecular mechanisms are still incompletely described. The protein is associated with a wide variety of biological functions and it locates to different subcellular compartments, including nuclei, cytoplasm and extracellular
Nan Li et al.
Molecular medicine reports, 12(2), 3177-3183 (2015-05-09)
Sonodynamic therapy (SDT) with 5-aminolevulinic acid (5-ALA) can effectively inhibit various types of tumor in vitro and in vivo. However, the association between the efficacy of SDT and the phase of the cell cycle remains to be elucidated. 5-ALA may
M Ailenberg et al.
British journal of pharmacology, 172(15), 3748-3763 (2015-04-09)
Dynasore has been used extensively as an inhibitor of clathrin-mediated endocytosis. While studying the role of endocytosis in LPS-induced signalling events, we discovered that dynasore itself induced activation of NF-κB, independently of its effects on endocytosis and without involving the
Lucía Vigezzi et al.
Reproductive toxicology (Elmsford, N.Y.), 52, 83-92 (2015-02-11)
We assessed the long-term effect of perinatal exposure to bisphenol A (BPA) on the rat uterus and the uterine response to estrogen (E2) replacement therapy. BPA (0.5 or 50μg/kg/day) was administered in the drinking water from gestational day 9 until
Juozas Nainys et al.
BMC biotechnology, 14, 100-100 (2014-12-10)
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a
Vincenzo Cuccurullo et al.
Current radiopharmaceuticals, 6(1), 41-47 (2013-03-09)
The skeleton is one of the preferential sites for metastases of solid tumors, and metastatic disease is the most common malignancy of the bone. Diagnosis and evaluation of skeletal metastases require more frequently a combined approach of different diagnostic methods.
Ashraf S Al-Madhoun et al.
Mini reviews in medicinal chemistry, 4(4), 341-350 (2004-05-12)
Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1
Thomas H King et al.
PloS one, 9(7), e101904-e101904 (2014-07-23)
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based
Junichi Hoshino et al.
Journal of nanoscience and nanotechnology, 13(7), 4593-4600 (2013-08-02)
Thymidine derivatives with carboxylic acid and pyridyl groups were synthesized for constructing one-dimensional network structure based on hydrogen bonding in crystalline state. The solid sate structures and hydrogen bonding networks of the thymidine derivatives were characterized by single X-ray diffraction
Wei Chen et al.
Molecular medicine reports, 12(5), 7712-7720 (2015-10-16)
A previous nationwide Chinese epidemiological study revealed through isolation of A‑B+ Clostridium difficile strains, which produce toxin B (TcdB), but not toxin A TcdA, that the strains are widespread and more frequent in east Asian countries,. The development of a
Formation of thymidine, cyclic deoxyguanosine and cyclic deoxycytidine adducts of the mutagen 2-bromoacrolein and their role in mutagenicity and clastogenicity.
J H Meerman et al.
IARC scientific publications, (125)(125), 449-452 (1994-01-01)
Hsiang-Chen Chou et al.
eLife, 10 (2021-02-02)
The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using
Su Zhang et al.
Current protocols in nucleic acid chemistry, Chapter 4, Unit 4-Unit 4 (2013-03-21)
This unit describes the chemical synthesis of α-L-threofuranosyl nucleic acid (TNA) triphosphates for thymidine (T), guanosine (G), cytidine (C), and the diaminopurine (D) analog of adenosine and their incorporation into TNA oligonucleotides by enzyme-mediated polymerization of a DNA primer-template complex.
Yuhui Sun et al.
Neuropharmacology, 72, 20-28 (2013-05-04)
Antidepressant agents such as fluoxetine have been shown to produce neurogenic effects involving transcriptional and translational changes that direct molecular and cellular plasticity. These cellular and molecular events appear necessary to mediate the therapeutic effects of fluoxetine and may be
Fumitaka Sato et al.
Cellular immunology, 292(1-2), 85-93 (2014-12-03)
We established a novel model of myocarditis induced with Theiler’s murine encephalomyelitis virus (TMEV), which has been used as a viral model for multiple sclerosis and seizure/epilepsy. Following TMEV infection, C3H mice developed severe myocarditis with T cell infiltration, while
Julie M Bailis et al.
Molecular and cellular biology, 28(5), 1724-1738 (2008-01-09)
The minichromosome maintenance (MCM) complex plays essential, conserved roles throughout DNA synthesis: first, as a component of the prereplication complex at origins and, then, as a helicase associated with replication forks. Here we use fission yeast (Schizosaccharomyces pombe) as a
Xiangjing Gao et al.
PloS one, 9(5), e97174-e97174 (2014-05-14)
Paraspeckle protein 1 (PSPC1) was first identified as a structural protein of the subnuclear structure termed paraspeckle. However, the exact physiological functions of PSPC1 are still largely unknown. Previously, using a proteomic approach, we have shown that exposure to cisplatin
Lucia Natarelli et al.
PloS one, 10(11), e0142421-e0142421 (2015-11-07)
Epidemiological studies suggest that moderate and prolonged consumption of coffee is associated with a reduced risk of developing type 2 diabetes but the molecular mechanisms underlying this effect are not known. In this study, we report the effects of physiological
Xiaolong Zhuo et al.
The Journal of cell biology, 210(5), 727-735 (2015-09-02)
During the G2 to M phase transition, a portion of mitotic regulator Plk1 localizes to the kinetochores and regulates the initiation of kinetochore-microtubule attachments for proper chromosome alignment. Once kinetochore-microtubule attachment is achieved, this portion of Plk1 is removed from
Dominique Muschter et al.
Arthritis research & therapy, 17, 169-169 (2015-06-25)
Numerous observations indicate that rheumatoid arthritis (RA) has a bone marrow component. In parallel, local synovial changes depend on neuronal components of the peripheral sympathetic nervous system. Here, we wanted to analyze whether collagen II-induced arthritis (CIA) has an impact
Diogo R M Moreira et al.
Journal of enzyme inhibition and medicinal chemistry, 30(4), 615-621 (2014-11-29)
This study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally related to the naturally-occurring lapachol and lapachone. Of the compounds tested, 3-(3-methylbut-1-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate (1) was the most active against Plasmodium falciparum among both natural
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