CN
Search Within
900889
Applied Filters:
Keyword:'900889'
Showing 1-30 of 43 results for "900889" within Papers
Rie Kjær Christensen et al.
Biomacromolecules, 21(2), 356-365 (2019-12-21)
We present a method for reproducible manufacture of multiassay platforms with tunable mechanical properties for muscle tissue strip analysis. The platforms result from stereolithographic 3D printing of low protein-binding poly(ethylene glycol) diacrylate (PEGDA) hydrogels. Contractile microtissues have previously been engineered
Zachary M Geisterfer et al.
Current biology : CB, 30(15), 3016-3023 (2020-06-13)
The microtubule cytoskeleton plays critically important roles in numerous cellular functions in eukaryotes, and it does so across a functionally diverse and morphologically disparate range of cell types [1]. In these roles, microtubule assemblies must adopt distinct morphologies and physical
Pol Cabanach et al.
Advanced materials (Deerfield Beach, Fla.), 32(42), e2003013-e2003013 (2020-08-31)
Microrobots offer transformative solutions for non-invasive medical interventions due to their small size and untethered operation inside the human body. However, they must face the immune system as a natural protection mechanism against foreign threats. Here, non-immunogenic stealth zwitterionic microrobots
Won Jun Song et al.
Science advances, 7(48), eabg9203-eabg9203 (2021-11-25)
[Figure: see text].
Joshua D McCall et al.
Biomacromolecules, 13(8), 2410-2417 (2012-06-30)
Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG
Younghoon Lee et al.
Science robotics, 5(44) (2020-10-07)
Spiders use adhesive, stretchable, and translucent webs to capture their prey. However, sustaining the capturing capability of these webs can be challenging because the webs inevitably invite contamination, thus reducing its adhesion force. To overcome these challenges, spiders have developed
Greta Leonaviciene et al.
Lab on a chip, 20(21), 4052-4062 (2020-10-03)
Droplet microfluidics technology provides a powerful approach to isolate and process millions of single cells simultaneously. Despite many exciting applications that have emerged based on this technology, workflows based on multi-step operations, including molecular biology and cell-based phenotypic screening assays
Liana Kramer et al.
ALTEX, 37(3), 350-364 (2020-05-11)
Organ-on-a-chip devices that mimic in vivo physiology have the potential to identify effects of chemical and drug exposure in early preclinical stages of drug development while relying less heavily on animal models. We have designed a hydrogel rat nerve-on-a-chip (RNoaC)
Xin Sun et al.
Bioactive materials, 6(3), 757-769 (2020-10-08)
Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in clinical treatment because of dysfunction of macrophage polarization and the inflammatory microenvironment in the bone defect region. Three-dimensional (3D) bioprinted scaffolds loaded with live cells and bioactive
Zhiguang Qiao et al.
Biomaterials, 266, 120385-120385 (2020-10-30)
Despite significant advances in osteochondral tissue engineering, it remains challenging to successfully reconstruct native-like complex tissues organized in three-dimension with spatially varying compositional, structural and functional properties. In this contribution, inspired by the gradients in extracellular matrix (ECM) composition and
Liling Gu et al.
Regenerative biomaterials, 7(2), 195-202 (2020-04-17)
Methacrylated gelatin (GelMA)/bacterial cellulose (BC) composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by photo-crosslinking. The morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure GelMA. The hydrogels had
Puskal Kunwar et al.
3D printing and additive manufacturing, 7(5), 216-221 (2020-11-04)
In the past 5 years, oxygen-permeable films have been widely used for continuous additive manufacturing. These films create a polymerization inhibition zone that facilitates continuous printing in the additive mode of fabrication. Typically, oxygen-permeable films made out of Teflon are
Tiffany Zhang et al.
Scientific reports, 10(1), 15796-15796 (2020-09-27)
Inspired by the interesting natural antimicrobial properties of honey, biohybrid composite materials containing a low-fouling polymer hydrogel network and an encapsulated antimicrobial peroxide-producing enzyme have been developed. These synergistically combine both passive and active mechanisms for reducing microbial bacterial colonization.
Jae-Man Park et al.
Nature communications, 11(1), 4638-4638 (2020-09-17)
Existing gels are mostly polar, whose nature limits their role in soft devices. The intermolecular interactions of nonpolar polymer-liquid system are typically weak, which makes the gel brittle. Here we report highly soft and transparent nonpolar organogels. Even though their
Matthew L Bedell et al.
Chemical reviews, 120(19), 10744-10792 (2020-05-30)
Bioprinting is rapidly being adopted as a major method for fabricating tissue engineering constructs. Through the precise deposition of cell- and bioactive molecule-laden materials, bioprinting offers researchers a means to create biological constructs with enhanced spatial complexity that more closely
Andrew C Daly et al.
Nature communications, 12(1), 753-753 (2021-02-04)
Cellular models are needed to study human development and disease in vitro, and to screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of functional tissue models with requisite cell densities and heterogeneity to appropriately model
Christopher D Davidson et al.
Journal of biomechanical engineering, 142(11) (2020-08-26)
Mechanical interactions between cells and their surrounding extracellular matrix (ECM) guide many fundamental cell behaviors. Native connective tissue consists of highly organized, 3D networks of ECM fibers with complex, nonlinear mechanical properties. The most abundant stromal matrix component is fibrillar
Kavin Kowsari et al.
iScience, 24(11), 103372-103372 (2021-11-27)
To address current unmet needs in terms of scalability and material biocompatibility for future photocrosslinking-based additive manufacturing technologies, emergent platform designs are in inexorable demand. In particular, a shift from the present use of cell-damaging UV light sources in light-based
Pui -Yan Lee et al.
Pharmaceutical research, 37(11), 220-220 (2020-10-15)
Gold porphyrin (AuP) is a complex that has been shown to be potent against various tumors. A biocompatible interpenetrating network (IPN) system comprised of polyethyleneglycol diacrylate (PEGdA) and chemically-modified gelatin has been shown to be an effective implantable drug depot
Yi Shen et al.
Carbohydrate polymers, 235, 115970-115970 (2020-03-04)
In this study, we provide a photocurable chitosan bioink (CHI-MA), which can be used for the digital light processing (DLP) technology. The CHI-MA precursors were facilely synthesized by grafting chitosan molecular chains with methacryloyl groups. We investigated the effect of
Ryan C Locke et al.
Tissue engineering. Part C, Methods, 26(10), 506-518 (2020-09-30)
Tendon injuries are difficult to heal, in part, because intrinsic tendon healing, which is dominated by scar tissue formation, does not effectively regenerate the native structure and function of healthy tendon. Further, many current treatment strategies also fall short of
Reinforced macromolecular micelle-crosslinked hyaluronate gels induced by water/DMSO binary solvent.
Hua Zhang et al.
Soft matter, 16(37), 8647-8654 (2020-08-29)
Introducing macromolecular micelles into a biocompatible hyaluronic acid (HA) hydrogel is a promising strategy to improve its mechanical properties for biomedical applications. However, it is still unclear whether the solvent nature has an influence on the structure and property of
Haichang Ding et al.
Advanced healthcare materials, 9(14), e2000454-e2000454 (2020-06-18)
Stimuli-responsive chitosan (CS) hydrogels exhibit great potential for drug delivery and tissue engineering; however, the structure of these stimuli-responsive CS hydrogels, such as dual pH- and thermo-responsive hydrogels, is difficult to control or needs additional crosslinking agents. Here, a new
Megan E Schroeder et al.
Acta biomaterialia, 119, 197-210 (2020-11-13)
Enzymatically degradable hydrogels were designed for the 3D culture of valvular interstitial cells (VICs), and through the incorporation of various functionalities, we aimed to investigate the role of the tissue microenvironment in promoting the osteogenic properties of VICs and matrix
Devon A Bowser et al.
Biofabrication, 12(1), 015002-015002 (2019-09-06)
The high attrition rate of neuro-pharmaceuticals as they proceed to market necessitates the development of clinically-relevant in vitro neural microphysiological systems that can be utilized during the preclinical screening phase to assess the safety and efficacy of potential compounds. Historically
Yuanyuan Zheng et al.
Biomaterials science, 8(17), 4810-4820 (2020-08-04)
Prolonged inflammatory response and insufficient vascularization cause delayed and poor wound healing. In this study, we fabricated a supramolecular host-guest gelatin (HGM) hydrogel loaded with resveratrol (Res) and histatin-1 (His-1) to suppress inflammation and promote vascularization at skin burn wound
Matthew R Arkenberg et al.
Advanced biosystems, 4(11), e2000129-e2000129 (2020-09-15)
Xeno-free, chemically defined poly(ethylene glycol) (PEG)-based hydrogels are being increasingly used for in vitro culture and differentiation of human induced pluripotent stem cells (hiPSCs). These synthetic matrices provide tunable gelation and adaptable material properties crucial for guiding stem cell fate.
Juliana S Ribeiro et al.
Biomacromolecules, 21(9), 3945-3956 (2020-08-14)
Oral bacterial infection represents the leading cause of the gradual destruction of tooth and periodontal structures anchoring the teeth. Lately, injectable hydrogels have gained increased attention as a promising minimally invasive platform for localized delivery of personalized therapeutics. Here, an
Jonathan H Galarraga et al.
Scientific reports, 9(1), 19987-19987 (2019-12-29)
3D bioprinting is a promising approach for the repair of cartilage tissue after damage due to injury or disease; however, the design of 3D printed scaffolds has been limited by the availability of bioinks with requisite printability, cytocompatibility, and bioactivity.
Kristo Nuutila et al.
Bioactive materials, 8, 296-308 (2021-09-21)
Acute and chronic wounds affect millions of people around the world, imposing a growing financial burden on patients and hospitals. Despite the application of current wound management strategies, the physiological healing process is disrupted in many cases, resulting in impaired
Page 1 of 2